Hemoglobin α and β are ubiquitous in the human lung, decline in idiopathic pulmonary fibrosis but not in COPD

Respiratory Research

Volumn 11, Issue , 2010, Pages

  Ishikawa, Nobuhisa ^a,b   Ohlmeier, Steffen ^c   Salmenkivi, Kaisa ^d   Myllärniemi, Marjukka ^a   Rahman, Irfan ^e   Mazur, Witold ^a   Kinnula, Vuokko L ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b HIROSHIMA UNIVERSITY   (Japan)

^c UNIVERSITY OF OULU   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

^e UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; HEMOGLOBIN A; HEMOGLOBIN BETA CHAIN; MONOMER; TETRAMER; BETA GLOBIN; BETA(A T87Q) GLOBIN; BETA(A-T87Q) GLOBIN; BIOLOGICAL MARKER; HEMOGLOBIN; HEMOGLOBIN ALPHA CHAIN FRAGMENTS (123 136); HEMOGLOBIN ALPHA-CHAIN FRAGMENTS (123-136); PEPTIDE FRAGMENT;

ADULT; AGED; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; FEMALE; FIBROSING ALVEOLITIS; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LUNG ALVEOLUS EPITHELIUM; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MASS SPECTROMETRY; MOLECULAR WEIGHT; MORPHOMETRICS; NITROSATIVE STRESS; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN SECRETION; PROTEOMICS; SPUTUM ANALYSIS; SUPERNATANT; WESTERN BLOTTING; BIOSYNTHESIS; BLOOD; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DIFFERENTIAL DIAGNOSIS; IMMUNOLOGY; LUNG; METABOLISM; MIDDLE AGED; PATHOLOGY; RESPIRATORY TRACT MUCOSA;

ADULT; AGED; BETA-GLOBINS; BIOLOGICAL MARKERS; BRONCHOALVEOLAR LAVAGE FLUID; DIAGNOSIS, DIFFERENTIAL; FEMALE; HEMOGLOBINS; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; LUNG; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY MUCOSA;

EID: 79551609994     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-11-123     Document Type: Article

References (47)

1. American Thoracic Society Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS). Am J Respir Crit Care Med 2000, 161:646-64. American Thoracic Society.
2. American Thoracic Society European Respiratory Society. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 2002, 165:277-304. American Thoracic Society.
3. Selman M, King TE, Pardo A. American Thoracic Society; European Respiratory Society; American College of Chest Physicians. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 2001, 134:136-151.
4. Selman M, Pardo A. Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers. Proc Am Thorac Soc 2006, 3:364-372. 10.1513/pats.200601-003TK, 16738202.
5. Demedts M, Behr J, Buhl R, Costabel U, Dekhuijzen R, Jansen HM, MacNee W, Thomeer M, Wallaert B, Laurent F, Nicholson AG, Verbeken EK, Verschakelen J, Flower CD, Capron F, Petruzzelli S, De Vuyst P, van den Bosch JM, Rodriguez-Becerra E, Corvasce G, Lankhorst I, Sardina M, Montanari M. IFIGENIA Study Group. High-dose acetylcysteine in idiopathic pulmonary fibrosis. N Engl J Med 2005, 353:2229-42. 10.1056/NEJMoa042976, 16306520.
6. Kinnula VL, Fattman CL, Tan RJ, Oury TD. Oxidative stress in pulmonary fibrosis: a possible role for redox modulatory therapy. Am J Respir Crit Care Med 2005, 172:417-22. 10.1164/rccm.200501-017PP, 2718525, 15894605.
7. Koli K, Myllärniemi M, Keski-Oja J, Kinnula VL. Transforming growth factor-beta activation in the lung: focus on fibrosis and reactive oxygen species. Antioxid Redox Signal 2008, 10:333-342. 10.1089/ars.2007.1914, 17961070.
8. Rahman I. Antioxidant therapeutic advances in COPD. Ther Adv Respir Dis 2008, 2:351-74. 10.1177/1753465808098224, 2744584, 19124382.
9. Rahman I, Adcock IM. Oxidative stress and redox regulation of lung inflammation in COPD. Eur Respir J 2006, 28:219-42. 10.1183/09031936.06.00053805, 16816350.
10. Ohlmeier S, Vuolanto M, Toljamo T, Vuopala K, Salmenkivi K, Myllärniemi M, Kinnula VL. Proteomics of Human Lung Tissue Identifies Surfactant Protein A as a Marker of Chronic Obstructive Pulmonary Disease. J Proteome Res 2008, 7:5125-5132. 10.1021/pr800423x, 19367700.
11. Ohlmeier S, Mazur W, Salmenkivi K, Myllärniemi M, Bergmann U, Kinnula VL. Proteomics of human lung identifies specific RAGE variants in idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Proteomics Clin Appl 2010, 4:97-105. 10.1002/prca.200900128, 21137019.
12. Gladwin MT, Lancaster JR, Freeman BA, Schechter AN. Nitric oxide's reactions with hemoglobin: a view through the SNO-storm. Nat Med 2003, 9:496-500. 10.1038/nm0503-496, 12724752.
13. Gladwin MT, Kim-Shapiro DB. The functional nitrite reductase activity of the heme-globins. Blood 2008, 112:2636-47. 10.1182/blood-2008-01-115261, 2556603, 18596228.
14. Allen BW, Stamler JS, Piantadosi CA. Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation. Trends Mol Med 2009, 15:452-60. 10.1016/j.molmed.2009.08.002, 2785508, 19781996.
15. National Institutes of Health, National Heart Lung and Blood Institute (2009): Global initiative for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. , http://www.goldcopd.com
16. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C, Zielinski J. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2007, 176:532-555. 10.1164/rccm.200703-456SO, 17507545.
17. Vuorinen K, Myllärniemi M, Lammi L, Piirilä P, Rytilä P, Salmenkivi K, Kinnula VL. Elevated matrilysin levels in bronchoalveolar lavage fluid do not distinguish idiopathic pulmonary fibrosis from other interstitial lung diseases. APMIS 2007, 115:969-75. 10.1111/j.1600-0463.2007.apm_697.x, 17696954.
18. Paggiaro PL, Chanez P, Holz O, Ind PW, Djukanović R, Maestrelli P, Sterk PJ. Sputum induction. Eur Respir J 2002, 37(Suppl):3s-8s.
19. Rytilä P, Rehn T, Ilumets H, Rouhos A, Sovijärvi A, Myllärniemi M, Kinnula VL. Increased oxidative stress in asymptomatic current chronic smokers and GOLD Stage 0 COPD. Respir Res 2006, 7:69. 10.1186/1465-9921-7-69, 1524947, 16646959.
20. Lehtonen ST, Ohlmeier S, Kaarteenaho-Wiik R, Harju T, Pääkkö P, Soini Y, Kinnula VL. Does the oxidative stress in chronic obstructive pulmonary disease cause thioredoxin/peroxiredoxin oxidation?. Antioxid Redox Signal 2008, 10:813-819. 10.1089/ars.2007.1952, 18179358.
21. Peltoniemi MJ, Rytilä PH, Harju TH, Soini YM, Salmenkivi KM, Ruddock LW, Kinnula VL. Modulation of glutaredoxin in the lung and sputum of cigarette smokers and chronic obstructive pulmonary disease. Respir Res 2006, 7:133. 10.1186/1465-9921-7-133, 1633737, 17064412.
22. Vuorinen K, Ohlmeier S, Leppäranta O, Salmenkivi K, Myllärniemi M, Kinnula VL. Peroxiredoxin II expression and its association with oxidative stress and cell proliferation in human idiopathic pulmonary fibrosis. J Histochem Cytochem 2008, 56:951-9. 10.1369/jhc.2008.951806, 2544621, 18606608.
23. Lehtonen ST, Markkanen PM, Peltoniemi M, Kang SW, Kinnula VL. Variable overoxidation of peroxiredoxins in human lung cells in severe oxidative stress. Am J Physiol Lung Cell Mol Physiol 2005, 288:L997-1001. 10.1152/ajplung.00432.2004, 15626747.
24. Glare EM, Divjak M, Bailey MJ, Walters EH. beta-Actin and GAPDH housekeeping gene expression in asthmatic airways is variable and not suitable for normalising mRNA levels. Thorax 2002, 57:765-770. 10.1136/thorax.57.9.765, 1746418, 12200519.
25. Ishii T, Wallace AM, Zhang X, Gosselink J, Abboud RT, English JC, Paré PD, Sandford AJ. Stability of housekeeping genes in alveolar macrophages from COPD patients. Eur Respir J 2006, 27:300-306. 10.1183/09031936.06.00090405, 16452584.
26. Casado B, Iadarola P, Pannell LK, Luisetti M, Corsico A, Ansaldo E, Ferrarotti I, Boschetto P, Baraniuk JN. Protein expression in sputum of smokers and chronic obstructive pulmonary disease patients: a pilot study by CapLC-ESI-Q-TOF. J Proteome Res 2007, 6:4615-4623. 10.1021/pr070440q, 17973440.
27. Myllärniemi M, Vuorinen K, Pulkkinen V, Kankaanranta H, Aine T, Salmenkivi K, Keski-Oja J, Koli K, Kinnula V. Gremlin localization and expression levels partially differentiate idiopathic interstitial pneumonia severity and subtype. J Pathol 2008, 214:456-63. 10.1002/path.2300, 18072275.
28. Davis KL, Martin E, Turko IV, Murad F. Novel effects of nitric oxide. Annu Rev Pharmacol Toxicol 2001, 41:203-36. 10.1146/annurev.pharmtox.41.1.203, 11264456.
29. Lakari E, Soini Y, Säily M, Koistinen P, Pääkkö P, Kinnula VL. Inducible nitric oxide synthase, but not xanthine oxidase, is highly expressed in interstitial pneumonias and granulomatous diseases of human lung. Am J Clin Pathol 2002, 117:132-42. 10.1309/W7T9-HW9V-V94B-R9KM, 11789718.
30. Herbert B, Galvani M, Hamdan M, Olivieri E, MacCarthy J, Pedersen S, Righetti PG. Reduction and alkylation of proteins in preparation of two-dimensional map analysis: why, when, and how?. Electrophoresis 2001, 22:2046-57. 10.1002/1522-2683(200106)22:10<2046::AID-ELPS2046>3.0.CO;2-C, 11465505.
31. Foster MW, Hess DT, Stamler JS. Protein S-nitrosylation in health and disease: a current perspective. Trends Mol Med 2009, 15:391-404. 10.1016/j.molmed.2009.06.007, 19726230.
32. Benhar M, Forrester MT, Stamler JS. Protein denitrosylation: enzymatic mechanisms and cellular functions. Nat Rev Mol Cell Biol 2009, 10:721-32.
33. Puhakka AR, Harju TH, Pääkkö PK, Soini YM, Kinnula VL. Nitric oxide synthases are associated with bronchial dysplasia. Lung Cancer 2006, 51:275-82. 10.1016/j.lungcan.2005.11.005, 16420964.
34. Kinnula VL, Ishikawa N, Bergmann U, Ohlmeier S. Proteomic approaches for studying human parenchymal lung diseases. Expert Reviews of Proteomics 2009, 6:619-29.
35. Schechter AN. Hemoglobin research and the origins of molecular medicine. Blood 2008, 112:3927-3938. 10.1182/blood-2008-04-078188, 2581994, 18988877.
36. Liu L, Zeng M, Stamler JS. Hemoglobin induction in mouse macrophages. Proc Natl Acad Sci USA 1999, 96:6643-6647. 10.1073/pnas.96.12.6643, 21968, 10359765.
37. Wride MA, Mansergh FC, Adams S, Everitt R, Minnema SE, Rancourt DE, Evans MJ. Expression profiling and gene discovery in the mouse lens. Mol Vis 2003, 9:360-396.
38. Bhaskaran M, Chen H, Chen Z, Liu L. Hemoglobin is expressed in alveolar epithelial type II cells. Biochem Biophys Res Commun 2005, 333:1348-1352. 10.1016/j.bbrc.2005.06.042, 1314978, 15979582.
39. Newton DA, Rao KM, Dluhy RA, Baatz JE. Hemoglobin is expressed by alveolar epithelial cells. J Biol Chem 2006, 281:5668-5676. 10.1074/jbc.M509314200, 16407281.
40. Nishi H, Inagi R, Kato H, Tanemoto M, Kojima I, Son D, Fujita T, Nangaku M. Hemoglobin is expressed by mesangial cells and reduces oxidant stress. J Am Soc Nephrol 2008, 19:1500-1508. 10.1681/ASN.2007101085, 2488266, 18448584.
41. Dassen H, Kamps R, Punyadeera C, Dijcks F, de Goeij A, Ederveen A, Dunselman G, Groothuis P. Haemoglobin expression in human endometrium. Hum Reprod 2008, 23:635-641. 10.1093/humrep/dem430, 18216035.
42. Tezel TH, Geng L, Lato EB, Schaal S, Liu Y, Dean D, Klein JB, Kaplan HJ. Synthesis and secretion of hemoglobin by retinal pigment epithelium. Invest Ophthalmol Vis Sci 2009, 50:1911-9. 10.1167/iovs.07-1372, 19060278.
43. Tezel G, Yang X, Luo C, Cai J, Kain A, Powell D, Kuehn MH, Pierce W. Hemoglobin Expression and Regulation in Glaucoma: Insights into Retinal Ganglion Cell Oxygenation. Invest Ophthalmol Vis Sci 2010, 51:907-19. 10.1167/iovs.09-4014, 2868450, 19741249.
44. Ghio AJ, Hilborn ED, Stonehuerner JG, Dailey LA, Carter JD, Richards JH, Crissman KM, Foronjy RF, Uyeminami DL, Pinkerton KE. Particulate matter in cigarette smoke alters iron homeostasis to produce a biological effect. Am J Respir Crit Care Med 2008, 178:1130-8. 10.1164/rccm.200802-334OC, 18723436.
45. Gray RD, MacGregor G, Noble D, Imrie M, Dewar M, Boyd AC, Innes JA, Porteous DJ, Greening AP. Sputum proteomics in inflammatory and suppurative respiratory diseases. Am J Respir Crit Care Med 2008, 178:444-52. 10.1164/rccm.200703-409OC, 2643212, 18565957.
46. Schaer DJ, Alayash AI. Clearance and control mechanisms of hemoglobin from cradle to grave. Antioxid Redox Signal 2010, 12:181-4. 10.1089/ars.2009.2923, 19788393.
47. McMahon TJ, Moon RE, Luschinger BP, Carraway MS, Stone AE, Stolp BW, Gow AJ, Pawloski JR, Watke P, Singel DJ, Piantadosi CA, Stamler JS. Nitric oxide in the human respiratory cycle. Nat Med 2002, 8:711-7.