Synthesis and secretion of hemoglobin by retinal pigment epithelium

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 4, 2009, Pages 1911-1919

  Tezel, Tongalp H ^a   Geng, Lijun ^a   Lato, Ewa Bodek ^a   Schaal, Shlomit ^a   Liu, Yongqing ^a   Dean, Douglas ^a   Klein, Jon B ^a   Kaplan, Henry J ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; MESSENGER RNA; OXYGEN; PROTEOME; ALPHA GLOBIN; BETA GLOBIN;

ADULT; AGED; ANIMAL TISSUE; ARTICLE; BRUCH MEMBRANE; CONTROLLED STUDY; CYTOSOL; ERYTHROBLAST; GENE EXPRESSION; HEMOGLOBIN SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXYGEN TRANSPORT; PHAGOCYTOSIS; PIGMENT CELL; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEOMICS; RAT; ANIMAL; BIOSYNTHESIS; BROWN NORWAY RAT; C57BL MOUSE; CELL LINE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; IMMUNOHISTOCHEMISTRY; MASS SPECTROMETRY; METABOLISM; MIDDLE AGED; PEPTIDE MAPPING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TWO DIMENSIONAL GEL ELECTROPHORESIS; ULTRASTRUCTURE; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; ALPHA-GLOBINS; ANIMALS; BETA-GLOBINS; BLOTTING, WESTERN; BRUCH MEMBRANE; CELL LINE; CYTOSOL; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; ERYTHROBLASTS; HEMOGLOBINS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MIDDLE AGED; PEPTIDE MAPPING; PROTEOMICS; RATS; RATS, INBRED BN; RETINAL PIGMENT EPITHELIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 64049094689     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.07-1372     Document Type: Article

References (38)

1. Lee PP, Feldman ZW, Ostermann J, Brown DS, Sloan FA. Longitudinal prevalence of major eye diseases. Arch Ophthalmol. 2003; 121(9):1303-1310.
2. Honda M, Sakamoto T, Ishibashi T, Inomata H, Ueno H. Experimental subretinal neovascularization is inhibited by adenovirus-mediated soluble VEGF/flt-1 receptor gene transfection: a role of VEGF and possible treatment for SRN in age-related macular degeneration. Gene Ther. 2000;7(11):978-985.
3. Epstein P. Trials that matter: two faces of progress in the treatment of age-related macular degeneration. Ann Intern Med. 2007; 146(7):532-534.
4. Grunwald JE, Metelitsina TI, Dupont JC, Ying GS, Maguire MG. Reduced foveolar choroidal blood flow in eyes with increasing AMD severity. Invest Ophthalmol Vis Sci. 2005;46(3):1033-1038.
5. Loureiro RM, D'Amore PA. Transcriptional regulation of vascular endothelial growth factor in cancer. Cytokine Growth Factor Rev. 2005;16(1):77-89.
6. van Leeuwen R, Klaver CC, Vingerling JR, Hofman A, de Jong PT. Epidemiology of age-related maculopathy: a review. Eur J Epide-miol. 2003;18(9):845-854.
7. Wangsa-Wirawan ND, Linsenmeier RA. Retinal oxygen: fundamental and clinical aspects. Arch Ophthalmol. 2003;121(4):547-557.
8. Kang Derwent J, Linsenmeier RA. Effects of hypoxemia on the a-and b-waves of the electroretinogram in the cat retina. Invest Ophthalmol Vis Sci. 2000;41(11):3634-3642.
9. Royer WEJ. Structures of red blood cell hemoglobins. In: Mangum CP, ed. Advances in Comparative and Environmental Physiology. Heidelberg, Germany: Springer-Verlag: 1992;87-116.
10. Newton DA, Rao KM, Dluhy RA, Baatz JE. Hemoglobin is expressed by alveolar epithelial cells. J Biol Chem. 2006;281(9): 5668-5676.
11. Bhaskaran M, Chen H, Chen Z, Liu L. Hemoglobin is expressed in alveolar epithelial type II cells. Biochem Biophys Res Commun. 2005;333(4):1348-1352.
12. Tezel TH, Del Priore LV, Kaplan HJ. Harvest and storage of adult human retinal pigment epithelial sheets. Curr Eye Res. 1997;16(8): 802-809.
13. Tezel TH, Del Priore LV. Reattachment to a substrate prevents apoptosis of human retinal pigment epithelium. Graefes Arch Clin Exp Ophthalmol. 1997;235(1):41-47.
14. Klein JB, Barati MT, Wu R, et al Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins. J Biol Chem. 2005;280(36):31870-31881.
15. Thongboonkerd V, Barati MT, McLeish KR, et al. Alterations in the renal elastin-elastase system in type 1 diabetic nephropathy iden-tified by proteomic analysis. J Am Soc Nephrol. 2004;15(3):650-662.
16. Pappin DJ. Peptide mass fingerprinting using MALDI-TOF mass spectrometry. Methods Mol Biol. 1997;64:165-173.
17. Norwitz ER, Tsen LC, Park JS, et al. Discriminatory proteomic biomarker analysis identifies free hemoglobin in the cerebrospinal fluid of women with severe preeclampsia. Am J Obstet Gynecol. 2005;193:957-964.
18. Wang X, Tanus-Santos JE, Reiter CD, et al. Biological activity of nitric oxide in the plasmatic compartment. Proc Natl Acad Sci USA.2004;101(31):11477-11482.
19. Chomczynski P. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques. 1993;15(3):532-534, 536-537.
20. Marrs JA, Andersson-Fisone C, Jeong MC, et al. Plasticity in epithelial cell phenotype: modulation by expression of different cadherin cell adhesion molecules. J Cell Biol. 1995;129(2):507-519.
21. Tezel TH, Del Priore LV, Kaplan HJ. Reengineering of aged Bruch's membrane to enhance retinal pigment epithelium repopulation. Invest Ophthalmol Vis Sci. 2004;45(9):3337-3348.
22. Witt O, Monkemeyer S, Ronndahl G, et al. Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin. Blood. 2003;101(5):2001-2007.
23. Moench T, Mehrazar K, Cone R, Blumenthal P. Sensitive methods to detect epithelial disruption: tests for microhemorrhage in cervicovaginal lavages. J Acquir Immune Defic Syndr. 2004;37(suppl 3):S194-S200.
24. Daniel W. Biostatistics: A Foundation for Analysis in the Health Sciences. 6th ed. New York: John Wiley & Sons; 1995;273-352.
25. Silva MM, Rogers PH, Arnone A. A third quaternary structure of human hemoglobin A at 1.7-A resolution. J Biol Chem. 1992; 267(24):17248-17256.
26. Safo MK, Abraham DJ. The enigma of the liganded hemoglobin end state: a novel quaternary structure of human carbonmonoxy hemoglobin. Biochemistry. 2005;44(23):8347-8359.
27. Jena BP. Discovery of the porosome: revealing the molecular mechanism of secretion and membrane fusion in cells. J Cell Mol Med. 2004;8(1):1-21.
28. Umeda S, Suzuki MT, Okamoto H, et al. Molecular composition of drusen and possible involvement of anti-retinal autoimmunity in two different forms of macular degeneration in cynomolgus mon-key (Macaca fascicularis). FASEB J. 2005;19(12):1683-1685.
29. West KA, Yan L, Shadrach K, et al. Protein database, human retinal pigment epithelium. Mol Cell Proteomics. 2003;2(1):37-49.
30. Liu L, Zeng M, Stamler JS. Hemoglobin induction in mouse macrophages. Proc Natl Acad Sci U S A. 1999;96(12):6643-6647.
31. Padnick-Silver L, Linsenmeier RA. Quantification of in vivo anaerobic metabolism in the normal cat retina through intraretinal pH measurements. Vis Neurosci. 2002;19(6):793-806.
32. Marmor MF, Structure, function, and disease of the retinal pigment epithelium. In: Marmor MF, Wolfensberger TJ, eds. The Retinal Pigment Epithelium. New York: Oxford University Press; 1998; 3-12.
33. Noe DA, Weedn V, Bell WR. Direct spectrophotometry of serum hemoglobin: an Allen correction compared with a three-wave-length polychromatic analysis. Clin Chem. 1984;30(5):627-630.
34. Orchard GE, Calonje E. The effect of melanin bleaching on immunohistochemical staining in heavily pigmented melanocytic neoplasms. Am J Dermatopathol. 1998;20(4):357-361.
35. Breuer B, Militzer WE. A micrometer for the determination of iron in blood. J Biol Chem. 1938;126:561-566.
36. Sorhaug S, Steinshamn S, Nilsen OG, Waldum HL. Chronic inhalation of carbon monoxide: effects on the respiratory and cardiovas-cular system at doses corresponding to tobacco smoking. Toxicology. 2006; 228(2-3):280-290.
37. Carmella SG, Chen M, Villalta PW, Gurney JG, Hatsukami DK, Hecht SS. Ethylation and methylation of hemoglobin in smokers and non-smokers. Carcinogenesis. 2002;23(11):1903-1910.
38. Stepuro TL, Zinchuk VV. Nitric oxide effect on the hemoglobin-oxygen affinity. J Physiol Pharmacol. 2006;57(1):29-38.