Nicotinic receptors on rat alveolar macrophages dampen ATP-induced increase in cytosolic calcium concentration

Respiratory Research

Volumn 11, Issue , 2010, Pages

  Mikulski, Zbigniew ^a   Hartmann, Petra ^a   Jositsch, Gitte ^a,b   Zasłona, Zbigniew ^a   Lips, Katrin S ^a,b   Pfeil, Uwe ^a   Kurzen, Hjalmar ^c   Lohmeyer, Jürgen ^a   Clauss, Wolfgang G ^b   Grau, Veronika ^a   Fronius, Martin ^b   Kummer, Wolfgang ^a  

^a JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; ALPHA BUNGAROTOXIN; CALCIUM; MESSENGER RNA; NICOTINIC RECEPTOR; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CALCIUM BLOOD LEVEL; CELL FUNCTION; CELL MEMBRANE CONDUCTANCE; CELL STIMULATION; CYTOSOL; EXTRACELLULAR CALCIUM; FEMALE; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MEMBRANE CURRENT; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; C57BL MOUSE; COMPARATIVE STUDY; DRUG ANTAGONISM; METABOLISM; PHYSIOLOGY; WISTAR RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CYTOSOL; FEMALE; MACROPHAGES, ALVEOLAR; MALE; MICE; MICE, INBRED C57BL; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC;

EID: 79551602490     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-11-133     Document Type: Article

References (44)

1. Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkina GI, Watkins LR, Wang H, Abumrad N, Eaton JW, Tracey KJ. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000, 405(6785):458-462. 10.1038/35013070, 10839541.
2. Wang H, Yu M, Ochani M, Amella CA, Tanovic M, Susarla S, Li JH, Yang H, Ulloa L, Al-Abed Y, et al. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 2003, 421(6921):384-388. 10.1038/nature01339, 12508119.
3. de Jonge WJ, van der Zanden EP, The FO, Bijlsma MF, van Westerloo DJ, Bennink RJ, Berthoud HR, Uematsu S, Akira S, van den Wijngaard RM, et al. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat Immunol 2005, 6(8):844-851. 10.1038/ni1229, 16025117.
4. Lukas RJ, Changeux JP, Le Novere N, Albuquerque EX, Balfour DJ, Berg DK, Bertrand D, Chiappinelli VA, Clarke PB, Collins AC, et al. International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. Pharmacol Rev 1999, 51(2):397-401.
5. Peng H, Ferris RL, Matthews T, Hiel H, Lopez-Albaitero A, Lustig LR. Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes. Life Sci 2004, 76(3):263-280. 10.1016/j.lfs.2004.05.031, 15531379.
6. Razani-Boroujerdi S, Boyd RT, Davila-Garcia MI, Nandi JS, Mishra NC, Singh SP, Pena-Philippides JC, Langley R, Sopori ML. T cells express alpha7-nicotinic acetylcholine receptor subunits that require a functional TCR and leukocyte-specific protein tyrosine kinase for nicotine-induced Ca2+ response. J Immunol 2007, 179(5):2889-2898.
7. Hecker A, Mikulski Z, Lips KS, Pfeil U, Zakrzewicz A, Wilker S, Hartmann P, Padberg W, Wessler I, Kummer W, et al. Pivotal Advance: Up-regulation of acetylcholine synthesis and paracrine cholinergic signaling in intravascular transplant leukocytes during rejection of rat renal allografts. J Leukoc Biol 2009, 86(1):13-22. 10.1189/jlb.1107722, 19201987.
8. Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA. Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats. Am J Respir Cell Mol Biol 2007, 37(2):186-192. 10.1165/rcmb.2006-0240OC, 1976545, 17431097.
9. Su X, Matthay MA, Malik AB. Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury. J Immunol 2010, 184(1):401-410. 10.4049/jimmunol.0901808, 19949071.
10. Giebelen IA, van Westerloo DJ, LaRosa GJ, de Vos AF, van der Poll T. Local stimulation of alpha7 cholinergic receptors inhibits LPS-induced TNF-alpha release in the mouse lung. Shock 2007, 28(6):700-703.
11. del Rey A, Renigunta V, Dalpke AH, Leipziger J, Matos JE, Robaye B, Zuzarte M, Kavelaars A, Hanley PJ. Knock-out mice reveal the contributions of P2Y and P2X receptors to nucleotide-induced Ca2+ signaling in macrophages. J Biol Chem 2006, 281(46):35147-35155. 10.1074/jbc.M607713200, 16980298.
12. Mikulski Z, Zaslona Z, Cakarova L, Hartmann P, Wilhelm J, Tecott LH, Lohmeyer J, Kummer W. Serotonin activates murine alveolar macrophages through 5-HT2C receptors. Am J Physiol Lung Cell Mol Physiol 2010, 299(2):L272-80. 10.1152/ajplung.00032.2010, 20495077.
13. Gerard GF, Fox DK, Nathan M, D'Alessio JM. Reverse transcriptase. The use of cloned Moloney murine leukemia virus reverse transcriptase to synthesize DNA from RNA. Mol Biotechnol 1997, 8(1):61-77. 10.1007/BF02762340, 9327398.
14. Krasteva G, Pfeil U, Drab M, Kummer W, Konig P. Caveolin-1 and -2 in airway epithelium: expression and in situ association as detected by FRET-CLSM. Respir Res 2006, 7:108. 10.1186/1465-9921-7-108, 1563466, 16904002.
15. Dijkstra CD, Dopp EA, Joling P, Kraal G. The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3. Immunology 1985, 54(3):589-599. 1453512, 3882559.
16. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227(5259):680-685. 10.1038/227680a0, 5432063.
17. Lips KS, Pfeil U, Kummer W. Coexpression of alpha 9 and alpha 10 nicotinic acetylcholine receptors in rat dorsal root ganglion neurons. Neuroscience 2002, 115(1):1-5. 10.1016/S0306-4522(02)00274-9, 12401316.
18. Matsunaga K, Klein TW, Friedman H, Yamamoto Y. Involvement of nicotinic acetylcholine receptors in suppression of antimicrobial activity and cytokine responses of alveolar macrophages to Legionella pneumophila infection by nicotine. J Immunol 2001, 167(11):6518-6524.
19. Galvis G, Lips KS, Kummer W. Expression of nicotinic acetylcholine receptors on murine alveolar macrophages. J Mol Neurosci 2006, 30(1-2):107-108. 10.1385/JMN:30:1:107, 17192650.
20. Herber DL, Severance EG, Cuevas J, Morgan D, Gordon MN. Biochemical and histochemical evidence of nonspecific binding of alpha7nAChR antibodies to mouse brain tissue. J Histochem Cytochem 2004, 52(10):1367-1376. 10.1369/jhc.4A6319.2004, 15385583.
21. Prasse A, Stahl M, Schulz G, Kayser G, Wang L, Ask K, Yalcintepe J, Kirschbaum A, Bargagli E, Zissel G, et al. Essential role of osteopontin in smoking-related interstitial lung diseases. Am J Pathol 2009, 174(5):1683-1691. 10.2353/ajpath.2009.080689, 2671257, 19359522.
22. Hajos M, Hurst RS, Hoffmann WE, Krause M, Wall TM, Higdon NR, Groppi VE. The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats. J Pharmacol Exp Ther 2005, 312(3):1213-1222. 10.1124/jpet.104.076968, 15523001.
23. Meyer EM, Tay ET, Papke RL, Meyers C, Huang GL, de Fiebre CM. 3-[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat alpha7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner. Brain Res 1997, 768(1-2):49-56. 10.1016/S0006-8993(97)00536-2, 9369300.
24. Baker ER, Zwart R, Sher E, Millar NS. Pharmacological properties of alpha 9 alpha 10 nicotinic acetylcholine receptors revealed by heterologous expression of subunit chimeras. Mol Pharmacol 2004, 65(2):453-460. 10.1124/mol.65.2.453, 14742688.
25. Reynolds PR, Hoidal JR. Temporal-spatial expression and transcriptional regulation of alpha7 nicotinic acetylcholine receptor by thyroid transcription factor-1 and early growth response factor-1 during murine lung development. J Biol Chem 2005, 280(37):32548-32554. 10.1074/jbc.M502231200, 16033766.
26. Grau V, Wilker S, Hartmann P, Lips KS, Grando SA, Padberg W, Fehrenbach H, Kummer W. Administration of keratinocyte growth factor (KGF) modulates the pulmonary expression of nicotinic acetylcholine receptor subunits alpha7, alpha9 and alpha10. Life Sci 2007, 80(24-25):2290-2293. 10.1016/j.lfs.2007.01.024, 17291541.
27. Heeschen C, Weis M, Aicher A, Dimmeler S, Cooke JP. A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors. J Clin Invest 2002, 110(4):527-536. 150415, 12189247.
28. Moser N, Mechawar N, Jones I, Gochberg-Sarver A, Orr-Urtreger A, Plomann M, Salas R, Molles B, Marubio L, Roth U, et al. Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures. J Neurochem 2007, 102(2):479-492. 10.1111/j.1471-4159.2007.04498.x, 17419810.
29. Millar NS, Gotti C. Diversity of vertebrate nicotinic acetylcholine receptors. Neuropharmacology 2009, 56(1):237-246. 10.1016/j.neuropharm.2008.07.041, 18723036.
30. Vetter DE, Liberman MC, Mann J, Barhanin J, Boulter J, Brown MC, Saffiote-Kolman J, Heinemann SF, Elgoyhen AB. Role of alpha9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation. Neuron 1999, 23(1):93-103. 10.1016/S0896-6273(00)80756-4, 10402196.
31. Vetter DE, Katz E, Maison SF, Taranda J, Turcan S, Ballestero J, Liberman MC, Elgoyhen AB, Boulter J. The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system. Proc Natl Acad Sci USA 2007, 104(51):20594-20599. 10.1073/pnas.0708545105, 2154476, 18077337.
32. Zhang GH, Helmke RJ, Mork AC, Martinez JR. Regulation of cytosolic free Ca2+ in cultured rat alveolar macrophages (NR8383). J Leukoc Biol 1997, 62(3):341-348.
33. Wikstrom MA, Lawoko G, Heilbronn E. Cholinergic modulation of extracellular ATP-induced cytoplasmic calcium concentrations in cochlear outer hair cells. J Physiol Paris 1998, 92(5-6):345-349. 10.1016/S0928-4257(99)80003-5, 9789835.
34. Dasgupta P, Rastogi S, Pillai S, Ordonez-Ercan D, Morris M, Haura E, Chellappan S. Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways. J Clin Invest 2006, 116(8):2208-2217. 10.1172/JCI28164, 1513051, 16862215.
35. Blanchet MR, Israel-Assayag E, Daleau P, Beaulieu MJ, Cormier Y. Dimethyphenylpiperazinium, a nicotinic receptor agonist, downregulates inflammation in monocytes/macrophages through PI3K and PLC chronic activation. Am J Physiol Lung Cell Mol Physiol 2006, 291(4):L757-763. 10.1152/ajplung.00409.2005, 16782754.
36. Khakh BS, Zhou X, Sydes J, Galligan JJ, Lester HA. State-dependent cross-inhibition between transmitter-gated cation channels. Nature 2000, 406(6794):405-410. 10.1038/35019066, 10935636.
37. Khakh BS, Fisher JA, Nashmi R, Bowser DN, Lester HA. An angstrom scale interaction between plasma membrane ATP-gated P2X2 and alpha4beta2 nicotinic channels measured with fluorescence resonance energy transfer and total internal reflection fluorescence microscopy. J Neurosci 2005, 25(29):6911-6920. 10.1523/JNEUROSCI.0561-05.2005, 16033901.
38. Myrtek D, Muller T, Geyer V, Derr N, Ferrari D, Zissel G, Durk T, Sorichter S, Luttmann W, Kuepper M, et al. Activation of human alveolar macrophages via P2 receptors: coupling to intracellular Ca2+ increases and cytokine secretion. J Immunol 2008, 181(3):2181-2188.
39. Gavala ML, Pfeiffer ZA, Bertics PJ. The nucleotide receptor P2RX7 mediates ATP-induced CREB activation in human and murine monocytic cells. J Leukoc Biol 2008, 84(4):1159-1171. 10.1189/jlb.0907612, 2538603, 18625910.
40. Idzko M, Hammad H, van Nimwegen M, Kool M, Willart MA, Muskens F, Hoogsteden HC, Luttmann W, Ferrari D, Di Virgilio F, et al. Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat Med 2007, 13(8):913-919. 10.1038/nm1617, 17632526.
41. Stokes L, Surprenant A. Purinergic P2Y2 receptors induce increased MCP-1/CCL2 synthesis and release from rat alveolar and peritoneal macrophages. J Immunol 2007, 179(9):6016-6023.
42. Maus UA, Koay MA, Delbeck T, Mack M, Ermert M, Ermert L, Blackwell TS, Christman JW, Schlondorff D, Seeger W, et al. Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice. Am J Physiol Lung Cell Mol Physiol 2002, 282(6):L1245-1252.
43. Maus UA, Waelsch K, Kuziel WA, Delbeck T, Mack M, Blackwell TS, Christman JW, Schlondorff D, Seeger W, Lohmeyer J. Monocytes are potent facilitators of alveolar neutrophil emigration during lung inflammation: role of the CCL2-CCR2 axis. J Immunol 2003, 170(6):3273-3278.
44. Kurzen H, Berger H, Jager C, Hartschuh W, Naher H, Gratchev A, Goerdt S, Deichmann M. Phenotypical and molecular profiling of the extraneuronal cholinergic system of the skin. J Invest Dermatol 2004, 123(5):937-949. 10.1111/j.0022-202X.2004.23425.x, 15482483.