Role of heat shock protein 27 in transforming growth factor-β- stimulated vascular endothelial growth factor release in osteoblasts

International Journal of Molecular Medicine

Volumn 27, Issue 3, 2011, Pages 423-428

  Kato, Kenji ^a,b   Tokuda, Haruhiko ^b,c   Adachi, Seiji ^b   Matsushima Nishiwaki, Rie ^b   Yamauchi, Junichi ^b   Natsume, Hideo ^a,b   Minamitani, Chiho ^a   Mizutani, Jun ^a   Otsuka, Takanobu ^a   Kozawa, Osamu ^b  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

Heat shock protein 27; Osteoblast; Transforming growth factor ; Vascular endothelial growth factor

Indexed keywords

HEAT SHOCK PROTEIN 27; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

ANIMAL CELL; ARTICLE; BONE METABOLISM; CONTROLLED STUDY; GENE SILENCING; GENETIC TRANSFECTION; IMMUNOFLUORESCENCE MICROSCOPY; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN SECRETION;

ANIMALS; CELL LINE; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HSP27 HEAT-SHOCK PROTEINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; OSTEOBLASTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79551574940     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.595     Document Type: Article

References (34)

1. Hendrick JP and Hartl FU: Molecular chaperone functions of heat-shock proteins. Annu Rev Biochem 62: 349-384, 1993.
2. Inaguma Y, Goto S, Shinohara H, Hasegawa K, Ohshima K and Kato K: Physiological and pathological changes in levels of the two small stress proteins, HSP27 and alpha B crystallin, in rat hindlimb muscles. J Biochem 114: 378-384, 1993.
3. Benjamin IJ and McMillan DR: Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease. Circ Res 83: 117-132, 1998.
4. Gaestel M, Schroder W, Benndorf R, Lippmann C, Buchner K, Hucho F, Erdmann VA and Bielka H: Identification of the phosphorylation sites of the murine small heat shock protein hsp25. J Biol Chem 266: 14721-14724, 1991.
5. Landry J, Lambert H, Zhou M, Lavoie JN, Hickey E, Weber LA and Anderson CW: Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II. J Biol Chem 267: 794-803, 1992.
6. Salinthone S, Tyagi M and Gerthoffer WT: Small heat shock proteins in smooth muscle. Pharmacol Ther 119: 44-54, 2008.
7. Kostenko S, Johannessen M and Moens U: PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5. Cell Signal 21: 712-718, 2009.
8. Nijweide PJ, Burger EH and Feyen JH: Cells of bone: proliferation, differentiation, and hormonal regulation. Physiol Rev 66: 855-886, 1986.
9. Kawamura H, Otsuka T, Matsuno H, Niwa M, Matsui N, Kato K, Uematsu T and Kozawa O: Endothelin-1 stimulates heat shock protein 27 induction in osteoblasts: involvement of p38 MAP kinase. Am J Physiol 277: E1046-E1054, 1999. (Pubitemid 30045999)
10. Tokuda H, Niwa M, Ishisaki A, Nakajima K, Ito H, Kato K and Kozawa O: Involvement of stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK) in prostaglandin F2α-induced heat shock protein 27 in osteoblasts. Prostaglandins Leukot Essent Fatty Acids 70: 441-447, 2004.
11. Kozawa O, Otsuka T, Hatakeyama D, Niwa M, Matsuno H, Ito H, Kato K, Matsui N and Uematsu T: Mechanism of prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts. Cell Signal 13: 535-541, 2001.
12. Kozawa O, Niwa M, Matsuno H, Ishisaki A, Kato K and Uematsu T: Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts: role of protein kinase C. Arch Biochem Biophys 388: 237-242, 2001.
13. Shakoori AR, Oberdorf AM, Owen TA, Weber LA, Hickey E, Stein JL, Lian JB and Stein GS: Expression of heat shock genes during differentiation of mammalian osteoblasts and promyelocytic leukemia cells. J Cell Biochem 48: 277-287, 1992.
14. Massague J, Blain SW and Lo RS: TGF-β signaling in growth control, cancer, and heritable disorders. Cell 103: 295-309, 2000.
15. Miyazono K, ten Dijke P and Heldin CH: TGF-β signaling by Smad proteins. Adv Immunol 75: 115-157, 2000.
16. Bonewald LF and Mundy GR: Role of transforming growth factor-β in bone remodeling. Clin Orthop Relat Res: 261-276, 1990.
17. Hatakeyama D, Kozawa O, Niwa M, Matsuno H, Ito H, Kato K, Tatematsu N, Shibata T and Uematsu T: Upregulation by retinoic acid of transforming growth factor-β-stimulated heat shock protein 27 induction in osteoblasts: involvement of mitogen-activated protein kinases. Biochim Biophys Acta 1589: 15-30, 2002.
18. Hayashi K, Takai S, Matsushima-Nishiwaki R, Hanai Y, Kato K, Tokuda H and Kozawa O: (-)-Epigallocatechin gallate reduces transforming growth factor β-stimulated HSP27 induction through the suppression of stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts. Life Sci 82: 1012-1017, 2008.
19. Ferrara N: Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 25: 581-611, 2004.
20. Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z and Ferrara N: VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 5: 623-628, 1999.
21. Goad DL, Rubin J, Wang H, Tashjian AH Jr and Patterson C: Enhanced expression of vascular endothelial growth factor in human SaOS-2 osteoblast-like cells and murine osteoblasts induced by insulin-like growth factor I. Endocrinology 137: 2262-2268, 1996.
22. Wang DS, Yamazaki K, Nohtomi K, Shizume K, Ohsumi K, Shibuya M, Demura H and Sato K: Increase of vascular endothelial growth factor mRNA expression by 1,25-dihydroxyvitamin D3 in human osteoblast-like cells. J Bone Miner Res 11: 472-479, 1996.
23. Schlaeppi JM, Gutzwiller S, Finkenzeller G and Fournier B: 1,25-Dihydroxyvitamin D3 induces the expression of vascular endothelial growth factor in osteoblastic cells. Endocr Res 23: 213-229, 1997
24. Tokuda H, Hatakeyama D, Akamatsu S, Tanabe K, Yoshida M, Shibata T and Kozawa O: Involvement of MAP kinases in TGF-β-stimulated vascular endothelial growth factor synthesis in osteoblasts. Arch Biochem Biophys 415: 117-125, 2003. (Pubitemid 36687924)
25. Kanno Y, Ishisaki A, Yoshida M, Tokuda H, Numata O and Kozawa O: SAPK/JNK plays a role in transforming growth factor-β-induced VEGF synthesis in osteoblasts. Horm Metab Res 37: 140-145, 2005.
26. Sudo H, Kodama HA, Amagai Y, Yamamoto S and Kasai S: In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J Cell Biol 96: 191-198, 1983.
27. Kozawa O, Suzuki A, Tokuda H and Uematsu T: Prostaglandin F2α stimulates interleukin-6 synthesis via activation of PKC in osteoblast-like cells. Am J Physiol 272: E208-E211, 1997.
28. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
29. Kato K, Ito H, Hasegawa K, Inaguma Y, Kozawa O and Asano T: Modulation of the stress-induced synthesis of hsp27 and αB-crystallin by cyclic AMP in C6 rat glioma cells. J Neurochem 66: 946-950, 1996.
30. Simpson DA, Feeney S, Boyle C and Stitt AW: Retinal VEGF mRNA measured by SYBR green I fluorescence: a versatile approach to quantitative PCR. Mol Vis 6: 178-183, 2000.
31. Adachi S, Shimizu M, Shirakami Y, Yamauchi J, Natsume H, Matsushima-Nishiwaki R, To S, Weinstein IB, Moriwaki H and Kozawa O: (-)-Epigallocatechin gallate downregulates EGF receptor via phosphorylation at Ser1046/1047 by p38 MAPK in colon cancer cells. Carcinogenesis 30: 1544-1552, 2009.
32. Ferguson C, Alpern E, Miclau T and Helms JA: Does adult fracture repair recapitulate embryonic skeletal formation? Mech Dev 87: 57-66, 1999.
33. Villars F, Bordenave L, Bareille R and Amedee J: Effect of human endothelial cells on human bone marrow stromal cell phenotype: role of VEGF? J Cell Biochem 79: 672-685, 2000.
34. Chen YJ, Wurtz T, Wang CJ, Kuo YR, Yang KD, Huang HC and Wang FS: Recruitment of mesenchymal stem cells and expression of TGF-β 1 and VEGF in the early stage of shock wave-promoted bone regeneration of segmental defect in rats. J Orthop Res 22: 526-534, 2004.