Longitudinal studies of patients with ANCA vasculitis demonstrate concurrent reactivity to complementary PR3 protein segments cPR3m and cPR3C and with no reactivity to cPR3N

Autoimmunity

Volumn 44, Issue 2, 2011, Pages 98-106

  Hewins, Peter ^a   Belmonte, Frances ^a   Charles Jennette, J ^a   Falk, Ronald J ^a   Preston, Gloria A ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

ANCA vasculitis; anti idiotypic antibodies; Autoantigen complementarity; complementary protein pairs; PR3

Indexed keywords

EPITOPE; PLASMINOGEN; PR3 PROTEIN; PROTEINASE; UNCLASSIFIED DRUG;

ADULT; AGED; AMINO ACID SEQUENCE; ANCA ASSOCIATED VASCULITIS; ANTIGEN ANTIBODY REACTION; ARTICLE; BINDING SITE; COHORT ANALYSIS; CONTROLLED STUDY; CROSS REACTION; DISEASE ASSOCIATION; EMBRYO; HUMAN; HUMAN CELL; LONGITUDINAL STUDY; MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE;

ADOLESCENT; ADULT; AGED; AMINO ACID SEQUENCE; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; AUTOANTIBODIES; AUTOANTIGENS; BASE SEQUENCE; CELL LINE; CHILD; DNA, COMPLEMENTARY; EPITOPE MAPPING; HUMANS; LONGITUDINAL STUDIES; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MYELOBLASTIN; VASCULITIS; YOUNG ADULT;

EID: 79551545347     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916934.2010.491843     Document Type: Article

References (18)

1. Shoenfeld Y. The idiotypic network in autoimmunity: Antibodies that bind antibodies that bind antibodies. Nat Med 2004;10:17-18.
2. McGuire KL, Holmes DS. Role of complementary proteins in autoimmunity: An old idea re-emerges with new twists. Trends Immunol 2005;26:367-372.
3. Pendergraft WF, III, Preston GA, Shah RR, Tropsha A, Carter CW, Jr., Jennette JC, Falk RJ. Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3. Nat Med 2004;10:72-79.
4. Heal JR, Roberts GW, Raynes JG, Bhakoo A, Miller AD. Specific interactions between sense and complementary peptides: The basis for the proteomic code. Chembiochem 2002;3:136-151.
5. Yang J, Bautz DJ, Lionaki S, Hogan SL, Chin H, Tisch RM, Schmitz JL, Pressler BM, Jennette JC, Falk RJ, Preston GA. ANCA patients have T cells responsive to complementary PR-3 antigen. Kidney Int 2008;74:1159-1169.
6. Bautz DJ, Preston GA, Lionaki S, Hewins P, Wolberg AS, Yang JJ, Hogan SL, Chin H, Moll S, Jennette JC, Falk RJ. Antibodies with dual reactivity to plasminogen and complementary PR3 in PR3-ANCA vasculitis. J Am Soc Nephrol 2008;19:2421-2429.
7. Selga D, Segelmark M, Wieslander J, Gunnarsson L, Hellmark T. Epitope mapping of anti-PR3 antibodies using chimeric human/mouse PR3 recombinant proteins. Clin Exp Immunol 2004;135:164-172.
8. Rarok AA, van der Geld YM, Stegeman CA, Limburg PC, Kallenberg CG. Diversity of PR3-ANCA epitope specificity in Wegener's granulomatosis. Analysis using the biosensor technology. J Clin Immunol 2003;23:460-468.
9. Williams RC, Jr., Staud R, Malone CC, Payabyab J, Byres L, Underwood D. Epitopes on proteinase-3 recognized by antibodies from patients with Wegener's granulomatosis. J Immunol 1994;152:4722-4737.
10. Van Der Geld YM, Simpelaar A, Van Der Zee R, Tervaert JW, Stegeman CA, Limburg PC, Kallenberg CG. Antineutrophil cytoplasmic antibodies to proteinase 3 in Wegener's granulomatosis: Epitope analysis using synthetic peptides. Kidney Int 2001;59:147-159.
11. Griffith ME, CoulthartA, Pemberton S, George AJ, PuseyCD. Anti-neutrophil cytoplasmic antibodies (ANCA) from patients with systemic vasculitis recognize restricted epitopes of proteinase 3 involving the catalytic site. Clin Exp Immunol 2001;123:170-177.
12. Erlanger BF, Cleveland WL, Wassermann NH, Ku HH, Hill BL, Sarangarajan R, Rajagopalan R, Cayanis E, Edelman IS, Penn AS. Auto-anti-idiotype: A basis for autoimmunity and a strategy for anti-receptor antibodies. Immunol Rev 1986;94: 23-37.
13. Hill BL, Erlanger BF. Monoclonal antibodies to the thyrotropin receptor raised by an autoantiidiotypic protocol and their relationship to monoclonal autoantibodies from Graves' patients. Endocrinology 1988;122:2840-2850.
14. Erlanger BF. Auto-anti-idiotypy, autoimmunity and some thoughts on the structure of internal images. Int Rev Immunol 1989;5:131-137.
15. Shoenfeld Y. Idiotypic induction of autoimmunity: A new aspect of the idiotypic network. FASEB J 1994;8:1296-1301.
16. Munthe LA, Kyte JA, Bogen B. Resting small B cells present endogenous immunoglobulin variable-region determinants to idiotope-specific CD4 T cells in vivo. Eur J Immunol 1999; 29:4043-4052.
17. Munthe LA, Os A, Zangani M, Bogen B. MHC-restricted Ig V region-driven T-B lymphocyte collaboration: B cell receptor ligation facilitates switch to IgG production. J Immunol 2004; 172:7476-7484.
18. Huelseweh B, Kohl B, Hentschel H, Kinne RK, Werner A. Translated anti-sense product of the Na/phosphate cotransporter (NaPi-II). Biochem J 1998;332(Pt 2):483-489.