MHC-restricted Ig V region-driven T-B lymphocyte collaboration: B cell receptor ligation facilitates switch to IgG production

Journal of Immunology

Volumn 172, Issue 12, 2004, Pages 7476-7484

  Munthe, Ludvig A ^a,b   Os, Audun ^a   Zangani, Michael ^a   Bogen, Bjarne ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; AUTOANTIBODY; AUTOANTIGEN; B LYMPHOCYTE RECEPTOR; CD4 ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIBODY TITER; ANTIGEN PRESENTATION; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; BACTERIUM; CELL TRANSFER; EXOTIC SPECIES; GERMINAL CENTER; IMMUNOGLOBULIN PRODUCTION; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE FUNCTION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSGENIC MOUSE;

EID: 2942596024     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.12.7476     Document Type: Article

References (61)

1. Weiss, S., and B. Bogen. 1989. B-lymphoma cells process and present their endogenous immunoglobulin to major histocompatibility complex-restricted T cells. Proc. Natl. Acad. Sci. USA 86:282.
2. Weiss, S., and B. Bogen. 1991. MHC class II-restricted presentation of intracellular antigen. Cell 64:767.
3. + T cells in vivo. Eur. J. Immunol. 29:4043.
4. Zhang, X., D. S. Smith, A. Guth, and L. J. Wysocki. 2001. A receptor presentation hypothesis for T cell help that recruits autoreactive B cells. J. Immunol. 166:1562.
5. Snyder, C. M., X. Zhang, and L. J. Wysocki. 2002. Negligible class II MHC presentation of B cell receptor-derived peptides by high density resting B cells. J. Immunol. 168:3865.
6. Rudensky, A. Y., P. Preston-Hurlburt, B. K. al-Ramadi, J. Rothbard, and C. A. J. Janeway. 1992. Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs. Nature 359:429.
7. Chicz, R. M., R. G. Urban, J. C. Gorga, D. A. Vignali, W. S. Lane, and J. L. Strominger. 1993. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J. Exp. Med. 178:27.
8. Newcomb, J. R., and P. Cresswell. 1993. Characterization of endogenous peptides bound to purified HLA-DR molecules and their absence from invariant chain-associated αβ dimers. J. Immunol. 150:499.
9. Lippolis, J. D., F. M. White, J. A. Marto, C. J. Luckey, T. N. Bullock, J. Shabanowitz, D. F. Hunt, and V. H. Engelhard. 2002. Analysis of MHC class II antigen processing by quantitation of peptides that constitute nested sets. J. Immunol. 169:5089.
10. Bogen, B., B. Malissen, and W. Haas. 1986. Idiotope-specific T cell clones that recognize syngeneic immunoglobulin fragments in the context of class II molecules. Eur. J. Immunol. 16:1373.
11. Bogen, B., T. Jorgensen, and K. Hannestad. 1985. T helper cell recognition of idiotopes on λ2 light chains of M315 and T952: evidence for dependence on somatic mutations in the third hypervariable region. Eur. J. Immunol. 15:278.
12. Bogen, B., Z. Dembic, and S. Weiss. 1993. Clonal deletion of specific thymocytes by an immunoglobulin idiotype. EMBO J. 12:357.
13. Eyerman, M. C., X. Zhang, and L. J. Wysocki. 1996. T cell recognition and tolerance of antibody diversity. J. Immunol. 157:1037.
14. Bogen, B., and S. Weiss. 1993. Processing and presentation of idiotypes to MHC-restricted T cells. Int. Rev. Immunol. 10:337.
15. Singh, R. R., and B. H. Hahn. 1998. Reciprocal T-B determinant spreading develops spontaneously in murine lupus: implications for pathogenesis. Immunol. Rev. 164:201.
16. Mitchison, N. A. 1971. The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation. Eur. J. Immunol. 1:18.
17. Lanzavecchia, A. 1985. Antigen-specific interaction between T and B cells. Nature 314:537.
18. Cook, M. C., A. Basten, and D. S. Fazekas. 1997. Outer periarteriolar lymphoid sheath arrest and subsequent differentiation of both naive and tolerant immunoglobulin transgenic B cells is determined by B cell receptor occupancy. J. Exp. Med. 186:631.
19. Cook, M. C., A. Basten, and D. S. Fazekas. 1998. Influence of B cell receptor ligation and TCR affinity on T-B collaboration in vitro. Eur. J. Immunol. 28:4037.
20. Lang, P., J. C. Stolpa, B. A. Freiberg, F. Crawford, J. Kappler, A. Kupfer, and J. C. Cambier. 2001. TCR-induced transmembrane signaling by peptide/MHC class II via associated Ig-α/β dimers. Science 291:1537.
21. Lankar, D., H. Vincent-Schneider, V. Briken, T. Yokozeki, G. Raposo, and C. Bonnerot. 2002. Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation. J. Exp. Med. 195:461.
22. Bogen, B., and S. Weiss. 1991. A rearranged λ2 light gene chain retards but does not exclude κ and λ1 expression. Eur. J. Immunol. 21:2391.
23. Bogen, B., L. Gleditsch, S. Weiss, and Z. Dembic. 1992. Weak positive selection of transgenic T cell receptor-bearing thymocytes: importance of major histocompatibility complex class II, T cell receptor and CD4 surface molecule densities. Eur. J. Immunol. 22:703.
24. Blichfeldt, E., L. A. Munthe, J. S. Rotnes, and B. Bogen. 1996. Dual T cell receptor T cells have a decreased sensitivity to physiological ligands due to reduced density of each T cell receptor. Eur. J. Immunol. 26:2876.
25. low thymocytes in vivo. Science 250:1720.
26. Bogen, B., G. F. Lauritzsen, and S. Weiss. 1990. A stimulatory monoclonal antibody detecting T cell receptor diversity among idiotype-specific, major histocompatibility complex-restricted T cell clones. Eur. J. Immunol. 20:2359.
27. Parker, D. C. 1993. T cell-dependent B cell activation. Annu. Rev. Immunol. 11:331.
28. Lassila, O., O. Vainio, and P. Matzinger. 1988. Can B cells turn on virgin T cells? Nature 334:253.
29. Fuchs, E. J., and P. Matzinger. 1992. B cells turn off virgin but not memory T cells. Science 258:1156.
30. + T cells. J. Exp. Med. 179:1539.
31. Croft, M., D. D. Duncan, and S. L. Swain. 1992. Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements. J. Exp. Med. 176:1431.
32. Eynon, E. E., and D. C. Parker. 1992. Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens. J. Exp. Med. 175:131.
33. DeFranco, A. L., J. D. Ashwell, R. H. Schwartz, and W. E. Paul. 1984. Polyclonal stimulation of resting B lymphocytes by antigen-specific T lymphocytes. J. Exp. Med. 159:861.
34. Owens, T. 1988. A noncognate interaction with anti-receptor antibody-activated helper T cells induces small resting murine B cells to proliferate and to secrete antibody. Eur. J. Immunol. 18:395.
35. Evans, D. E., M. W. Munks, J. M. Purkerson, and D. C. Parker. 2000. Resting B lymphocytes as APC for naive T lymphocytes: dependence on CD40 ligand/CD40. J. Immunol. 164:688.
36. Fazekas de St, G. B., M. C. Cook, A. L. Smith, M. E. Wikstrom, and A. Basten. 1997. Role of dendritic cells in induction of tolerance and immunity in vivo. Adv. Exp. Med. Biol. 417:255.
37. Poltorak, A., X. He, I. Smimova, M. Y. Liu, C. Van Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, et al. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085.
38. Krieg, A. M. 2002. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20:709.
39. Bernasconi, N. L., E. Traggiai, and A. Lanzavecchia. 2002. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 298:2199.
40. Dembic, Z., J. A. Rottingen, J. Dellacasagrande, K. Schenck, and B. Bogen. 2001. Phagocytic dendritic cells from myelomas activate tumor-specific T cells at a single cell level. Blood 97:2808.
41. Mason, D. 1998. A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol. Today 19:395.
42. Snodgrass, H. R., A. M. Fisher, E. Bruyns, and B. Bogen. 1992. Restricted α/β receptor gene usage of idiotype-specific major histocompatibility complex-restricted T cells: selection for CDR3-related sequences. Eur. J. Immunol. 22:2169.
43. Singh, R. R., F. M. Ebling, D. A. Albuquerque, V. Saxena, V. Kumar, E. H. Giannini, T. N. Marion, F. D. Finkelman, and B. H. Hahn. 2002. Induction of autoantibody production is limited in nonautoimmune mice. J. Immunol. 169:587.
44. Singh, R. R., B. H. Hahn, B. P. Tsao, and F. M. Ebling. 1998. Evidence for multiple mechanisms of polyclonal T cell activation in murine lupus. J. Clin. Invest. 102:1841.
45. Singh, R. R., V. Kumar, F. M. Ebling, S. Southwood, A. Sette, E. E. Sercarz, and B. H. Hahn. 1995. T cell determinants from autoantibodies to DNA can upregulate autoimmunity in murine systemic lupus erythematosus. J. Exp. Med. 181:2017.
46. van Elven, E. H., F. M. van der Veen, A. G. Rolink, P. Issa, T. M. Duin, and E. Gleichmann. 1981. Diseases caused by reactions of T lymphocytes to incompatible structures of the major histocompatibility complex. V. High titers of IgG autoantibodies to double-stranded DNA. J. Immunol. 127:2435.
47. Morris, S. C., R. L. Cheek, P. L. Cohen, and R. A. Eisenberg. 1990. Autoantibodies in chronic graft versus host result from cognate T-B interactions. J. Exp. Med. 171:503.
48. Hunziker, L., M. Recher, A. J. Macpherson, A. Ciurea, S. Freigang, H. Hengartner, and R. M. Zinkernagel. 2003. Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections. Nat. Immunol. 4:343.
49. Mourad, W., P. Scholl, A. Diaz, R. Geha, and T. Chatila. 1989. The staphylococcal toxic shock syndrome toxin I triggers B cell proliferation and differentiation via major histocompatibility complex-unrestricted cognate T/B cell interaction. J. Exp. Med. 170:2011.
50. Tumang, J. R., D. N. Posnett, B. C. Cole, M. K. Crow, and S. M. Friedman. 1990. Helper T cell-dependent human B cell differentiation mediated by a mycoplasmal superantigen bridge. J. Exp. Med. 171:2153.
51. Schiffenbauer, J., J. Soos, and H. Johnson. 1998. The possible role of bacterial superantigens in the pathogenesis of autoimmune disorders. Immunol. Today 19:117.
52. Bos, N. A., C. G. Meeuwsen, H. Hooijkaas, R. Benner, B. S. Wostmann, and J. R. Pleasants. 1987. Early development of Ig-secreting cells in young of germ-free BALB/c mice fed a chemically defined ultrafiltered diet. Cell. Immunol. 105:235.
53. Ochsenbein, A. F., T. Fehr, C. Lutz, M. Suter, F. Brombacher, H. Hengartner, and R. M. Zinkernagel. 1999. Control of early viral and bacterial distribution and disease by natural antibodies. Science 286:2156.
54. Malanchere, E., M. A. Marcos, A. Nobrega, and A. Coutinho. 1995. Studies on the T cell dependence of natural IgM and IgG antibody repertoires in adult mice. Eur. J. Immunol. 25:1358.
55. Bachmann, M. F., and R. M. Zinkernagel. 1997. Neutralizing antiviral B cell responses. Annu. Rev. Immunol. 15:235.
56. Matsumoto, I., A. Staub, C. Benoist, and D. Mathis. 1999. Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Science 286:1732.
57. Shlomchik, M. J., J. E. Craft, and M. J. Mamula. 2001. From T to B and back again: positive feedback in systemic autoimmune disease. Nat. Rev. Immunol. 1:147.
58. Marrack, P., J. Kappler, and B. L. Kotzin. 2001. Autoimmune disease: why and where it occurs. Nat. Med. 7:899.
59. van Schooten, W. C., D. Devereux, C. H. Ho, J. Quan, B. A. Aguilar, and C. J. Rust. 1994. Joint-derived T cells in rheumatoid arthritis react with self-immunoglobulin heavy chains or immunoglobulin-binding proteins that copurify with immunoglobulin. Eur. J. Immunol. 24:93.
60. Williams, W. M., N. A. Staines, S. Muller, and D. A. Isenberg. 1995. Human T cell responses to autoantibody variable region peptides. Lupus 4:464.
61. Dayan, M., R. Segal, Z. Sthoeger, A. Waisman, N. Brosh, O. Elkayarn, E. Eilat, M. Fridkin, and E. Mozes. 2000. Immune response of SLE patients to peptides based on the complementarity determining regions of a pathogenic anti-DNA monoclonal antibody. J. Clin. Immunol. 20:187.