AT1 receptors in the paraventricular nucleus mediate the hyperthermia-induced reflex reduction of renal blood flow in rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 300, Issue 2, 2011, Pages

  Chen, Feng ^a   Liu, Fang ^a,b   Badoer, Emilio ^a  

^a RMIT UNIVERSITY   (Australia)

^b FOSHAN UNIVERSITY   (China)

Author keywords

Angiotensin ii; Body temperature; Brain; Hypothalamus

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; LOSARTAN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; SODIUM CHLORIDE;

ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONDUCTANCE; CORE TEMPERATURE; HEART RATE; HYPERTHERMIA; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; KIDNEY BLOOD FLOW; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RENAL VASCULAR CONDUCTANCE; ANIMAL; BODY TEMPERATURE; DRUG EFFECT; FEVER; HISTOLOGY; KIDNEY CIRCULATION; PATHOPHYSIOLOGY; PHYSIOLOGY; REFLEX; SPRAGUE DAWLEY RAT;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BLOOD PRESSURE; BODY TEMPERATURE; FEVER; HEART RATE; LOSARTAN; MALE; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1; REFLEX; RENAL CIRCULATION; SODIUM CHLORIDE;

EID: 79551507982     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00604.2010     Document Type: Article

References (39)

1. Allen AM, Paxinos G, Song KF, Mendelsohn FAO. Localization of angiotensin II receptor binding sites in the rat brain. In: Handbook of Chemical Neuroanatomy, edited by Bjorklund A, Hokfelt T, and Kuhar MJ. Amsterdam, The Netherlands: Elsevier Science, 1992, p. 1-37.
2. American Physiological Society. Guiding principles for research involving animals and human beings. Am J Physiol Regul Integr Comp Physiol 283: R281-R283, 2002.
3. Bachtell RK, Tsivkovskaia NO, Ryabinin AE. Identification of temperature-sensitive neural circuits in mice using c-Fos expression mapping. Brain Res 960: 157-164, 2003.
4. Badoer E. Cardiovascular role of parvocellular neurones in the paraventricular nucleus of the hypothalamus. News Physiol Sci 11: 43-47, 1996.
5. Badoer E. Hypothalamic paraventricular nucleus and cardiovascular regulation. Clin Exp Pharmacol Physiol 28: 95-99, 2001.
6. Badoer E. The role of the hypothalamic PVN in the regulation of renal sympathetic nerve activity and blood flow during hyperthermia and in heart failure. Am J Physiol Renal Physiol 298: F839-F846, 2010.
7. Cham J, Badoer E. Exposure to a hot environment can activate rostral ventrolateral medulla-projecting neurones in the hypothalamic paraventricular nucleus in conscious rats. Exp Physiol 93: 64-74, 2008.
8. Cham J, Badoer E. Hypothalamic paraventricular nucleus is critical for renal vasoconstriction elicited by elevations in body temperature. Am J Physiol Renal Physiol 294: F309-F315, 2008.
9. Cham JL, Klein R, Owens NC, Mathai ML, McKinley MJ, Badoer E. Activation of spinally-projecting and nitrergic neurons in the PVN following heat exposure. Am J Physiol Regul Integr Comp Physiol 291: R91-R101, 2006.
10. Chen F, Dworak M, Wang Y, Cham J, Badoer E. Role of the hypothalamic PVN in the reflex reduction in mesenteric blood flow elicited by hyperthermia. Am J Physiol Regul Integr Comp Physiol 295:R1874-R1881, 2008.
11. Coote JH, Yang Z, Pyner S, Deering J. Control of sympathetic outflows by the hypothalamic paraventricular nucleus. Clin Exp Pharmacol Physiol 25: 461-463, 1998.
12. Cuadra AE, Shan Z, Sumners C, Raizada M, K. A current view of brain renin-angiotensin system: Is the (pro)renin receptor the missing link? Pharmacol Ther 125: 27-38, 2010.
13. Culman J, Hohle S, Qadri F, Edling O, Blume A, Lebrun C, Unger T. Angiotensin as neuromodulator/neurotransmitter in central control of body fluid and electrolyte homeostasis. Clin Exp Hypertens 17: 281-293, 1995.
14. DiBona GF, Jones SY, Sawin LL. Effect of endogenous angiotensin II on renal nerve activity and its arterial baroreflex regulation. Am J Physiol Regul Integr Comp Physiol 271: R361-R367, 1996.
15. Ferguson AV, Washburn DLS. Angiotensin II-A peptidergic neurotransmitter in central autonomic pathways. Prog Neurobiol 54: 169-192, 1998.
16. Goldsmith SR. Baroreceptor mediated suppression of osmotically stimulated vasopressin in normal humans. J Appl Physiol 65: 1226-1230, 1988.
17. Hirooka Y, Potts PD, Dampney RA. Role of angiotensin II receptor subtypes in mediating the sympathoexcitatory effects of exogenous and endogenous angiotensin peptides in the rostral ventrolateral medulla of the rabbit. Brain Res 772: 107-114, 1997.
18. Hofbauer KG, Studer W, Mah SC, Michel JB, Wood JM, Stalder R. The significance of vasopressin as a pressor agent. J Cardiovasc Pharmacol 6: S429-S436, 1984.
19. Hubschle T, Mathai M, McKinley M, Oldfield B. Multisynaptic neuronal pathways from the submandibular and sublingual glands to the lamina terminalis in the rat: a model for the role of the lamina terminalis in the control of osmo- and thermoregulatory behaviour. Clin Exp Pharmacol Physiol 28: 558-569, 2001.
20. Inenaga K, Osaka T, Yamashita H. Thermosensitivity of neurons in the paraventricular nucleus of the rat slice preparation. Brain Res 424: 126-132, 1987.
21. Kannan H, Hayashida Y, Yamashita H. Increase in sympathetic outflow by paraventricular nucleus stimulation in awake rats. Am J Physiol Regul Integr Comp Physiol 256: R1325-R1330, 1989.
22. Kenney MJ, Barney CC, Hirai T, Gisolfi CV. Sympathetic nerve responses to hyperthermia in the anaesthetised rat. J Appl Physiol 78: 881-889, 1995.
23. Kregel K, Wall P, Gisolfi C. Peripheral vascular responses to hyperthermia in the rat. J Appl Physiol 64: 2582-2588, 1988.
24. Kregel KC, Stauss H, Unger T. Modulation of autonomic nervous system adjustments to heat stress by central ANG II receptor antagonism. Am J Physiol Regul Integr Comp Physiol 266: R1985-R1991, 1994.
25. Li Y, Wang W, Mayhan WG, Patel KP. Angiotensin-mediated increase in renal sympathetic nerve discharge within the PVN: role of nitric oxide. Am J Physiol Regul Integr Comp Physiol 290: R1035-R1043, 2006.
26. Madden CJ, Morrison SF. Neurons in the paraventricular nucleus of the hypothalamus inhibit sympathetic outflow to brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 296: R831-R843, 2009.
27. Maruyama M, Nishi M, Konishi M, Takashige Y, Nagashima K, Kiyohara T, Kanosue K. Brain regions expressing Fos during thermoregulatory behavior in rats. Am J Physiol Regul Integr Comp Physiol 285: R1116-R1123, 2003.
28. Mathai ML, Hubschle T, McKinley MJ. Central angiotensin receptor blockade impairs thermolytic and dipsogenic responses to heat exposure in rats. Am J Physiol Regul Integr Comp Physiol 279: R1821-R1826, 2000.
29. McKinley MJ, Albiston AL, Allen AM, Mathai ML, May CN, McAllen RM, Oldfield BJ, Mendelsohn FA, Chai SY. The brain renin-angiotensin system: location and physiological roles. Int J Biochem Cell Biol 35: 901-918, 2003.
30. Oldfield B, Giles ME, Watson A, Anderson CR, Colvill L, McKinley MJ. The neurochemical characterisation of hypothalamic pathways projecting to brown adipose tissue in the rat. Neuroscience 110: 515-526, 2002.
31. Patel KP. Role of paraventricular nucleus in mediating sympathetic outflow in heart failure. Heart Fail Rev 5: 73-86, 2000.
32. Shafton AD, Ryan AR, Badoer E. Neurons in the hypothalamic paraventricular nucleus send collaterals to the spinal cord and to the rostal ventrolateral medulla in the rat. Brain Res 801: 239-243, 1998.
33. Shido O, Nagasaka T. Effects of intraventricular angiotensin II on heat balance at various ambient temperatures in rats. Jpn J Physiol 32: 163-167, 1985.
34. Sly DJ, McKinley MJ, Oldfield B. Activation of kidney-directed neurons in the lamina terminalis by alterations in body fluid balance. Am J Physiol Regul Integr Comp Physiol 281: R1637-R1646, 2001.
35. Strack AM, Sawyer LM, Hughes JH, Platt KB, Loewy AD. A general pattern of CNS innervation of the sympathetic outflow demonstrated by transneuronal pseudorabies viral infections. Brain Res 455: 187-191, 1989.
36. Swanson LW, Sawchenko PE. Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. Ann Rev Neurosci 6: 269-324, 1983.
37. Wilson KM, Fregly MJ. Angiotensin II-induced hypothermia in rats. J Appl Physiol 58: 534-554, 1985.
38. Wright JW, Harding JW. Brain angiotensin receptor subtypes in the control of physiological and behavioral responses. Neurosci Biobehav Rev 18: 21-53, 1994.
39. Zheng H, LIYF, Wang W, Patel KP. Enhanced angiotensin-mediated excitation of renal sympathetic nerve activity within the paraventricular nucleus of anesthetized rats with heart failure. Am J Physiol Regul Integr Comp Physiol 297: R1364-R1374, 2009.