c9t11-Conjugated linoleic acid-rich oil fails to attenuate wasting in colon-26 tumor-induced late-stage cancer cachexia in male CD2F1 mice

Molecular Nutrition and Food Research

Volumn 55, Issue 2, 2011, Pages 268-277

  Tian, Min ^a   Kliewer, Kara L ^a   Asp, Michelle L ^a   Stout, Michael B ^a   Belury, Martha A ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Adipose atrophy; Cancer cachexia; Colon 26 adenocarcinoma; Conjugated linoleic acid; Muscle

Indexed keywords

ADIPONECTIN; ADIPONECTIN, MOUSE; AUTACOID; CIS 9, TRANS 11 CONJUGATED LINOLEIC ACID; CIS-9, TRANS-11-CONJUGATED LINOLEIC ACID; CONJUGATED LINOLEIC ACID; MESSENGER RNA; MUSCLE PROTEIN; TRIM63 PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

ADENOCARCINOMA; ADIPOCYTE; ANIMAL; ARTICLE; ATROPHY; BAGG ALBINO MOUSE; CACHEXIA; CANCER TRANSPLANTATION; CELL SIZE; COLON TUMOR; DBA MOUSE; DIET; DIET THERAPY; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; QUADRICEPS FEMORIS MUSCLE; RANDOMIZATION; WHITE ADIPOSE TISSUE;

ADENOCARCINOMA; ADIPOCYTES; ADIPONECTIN; ADIPOSE TISSUE, WHITE; ANIMALS; ATROPHY; CACHEXIA; CELL SIZE; COLONIC NEOPLASMS; DIET; GENE EXPRESSION REGULATION; INFLAMMATION MEDIATORS; LINOLEIC ACIDS, CONJUGATED; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; MUSCLE PROTEINS; NEOPLASM TRANSPLANTATION; QUADRICEPS MUSCLE; RANDOM ALLOCATION; RNA, MESSENGER; UBIQUITIN-PROTEIN LIGASES;

MUS;

EID: 79551507895     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201000176     Document Type: Article

References (57)

1. Dewys, W. D., Begg, C., Lavin, P. T., Band, P. R. et al., Prognostic effect of weight loss prior to chemotherapy in cancer patients. Am. J. Med. 1980, 69, 491-497.
2. Argilés, J. M., López Soriano, F. J., The role of cytokines in cancer cachexia. Med. Res. Rev. 1999, 19, 223-248.
3. Rydén, M., Agustsson, T., Laurencikiene, J., Britton, T. et al., Lipolysis--not inflammation, cell death, or lipogenesis--is involved in adipose tissue loss in cancer cachexia. Cancer 2008, 113, 1695-1697.
4. Attaix, D., Combaret, L., Béchet, D., Taillandier, D., Role of the ubiquitin-proteasome pathway in muscle atrophy in cachexia. Curr. Opin. Support. Palliat. Care. 2008, 2, 262-266.
5. Greenberg, A. S., Nordan, R. P., McIntosh, J., Calvo, J. C. et al., Interleukin 6 reduces lipoprotein lipase activity in adipose tissue of mice in vivo and in 3T3-L1 adipocytes: a possible role for interleukin 6 in cancer cachexia. Cancer Res. 1992, 52, 4113-4116.
6. Trujillo, M. E., Sullivan, S., Harten, I., Schneider, S. H. et al., Interleukin-6 regulates human adipose tissue lipid metabolism and leptin production in vitro. J. Clin. Endocrinol. Metab. 2004, 89, 5577-5582.
7. Rydén, M., Arvidsson, E., Blomqvist, L., Perbeck, L. et al., Targets for TNF-alpha-induced lipolysis in human adipocytes. Biochem. Biophys. Res. Commun. 2004, 318, 168-175.
8. Tisdale, M. J., Wasting in cancer. J. Nutr. 1999, 129, 243S-246S.
9. Tisdale, M. J., Cachexia in cancer patients. Nat. Rev. Cancer 2002, 2, 862-971.
10. Plomgaard, P., Fischer, C. P., Ibfeh, T., Pedersen, B. K., Van Hall, G., Tumor necrosis factor-alpha modulates human in vivo lipolysis. J. Clin. Endocrinol. Metab. 2008, 93, 543-549.
11. DeJong, C. H., Busquets, S., Moses, A. G., Schrauwen, P. et al., Systemic inflammation correlates with increased expression of skeletal muscle ubiquitin but not uncoupling proteins in cancer cachexia. Oncol. Rep. 2005, 14, 257-263.
12. Argilés, J. M., Busquets, S., López-Soriano, F. J., The pivotal role of cytokines in muscle wasting during cancer. Int. J. Biochem. Cell. Biol. 2005, 37, 2036-2046.
13. Tisdale, M. J., The ubiquitin-proteasome pathway as a therapeutic target for muscle wasting. J. Support. Oncol. 2005, 3, 209-217.
14. Argilés, J. M., Almendro, V., Busquets, S., López-Soriano, F. J., The pharmacological treatment of cachexia. Curr. Drug Targets 2004, 5, 265-277.
15. McCarthy, D. O., Rethinking nutritional support for persons with cancer cachexia. Biol. Res. Nurs. 2003, 5, 3-17.
16. Pariza, M. W., Ha, Y. L., Conjugated dienoic derivatives of linoleic acid: a new class of anticarcinogens. Med. Oncol. Tumor Pharmacother. 1990, 7, 169-171.
17. Bhattacharya, A., Banu, J., Rahman, M., Causey, J., Fernandes, G., Biological effects of conjugated linoleic acids in health and disease. J. Nutr. Biochem. 2006, 17, 789-810.
18. Belury, M. A., Inhibition of carcinogenesis by conjugated linoleic acid: potential mechanisms of action. J. Nutr. 2002, 132, 2995-2998.
19. Lee, K. W., Lee, H. J., Cho, H. Y., Kim, Y. J., Role of the conjugated linoleic acid in the prevention of cancer. Crit. Rev. Food Sci. Nutr. 2005, 45, 135-144.
20. Ip, M. M., Masso-Welch, P. A., Ip, C., Prevention of mammary cancer with conjugated linoleic acid: role of the stroma and the epithelium. J. Mammary Gland Biol. Neoplasia 2003, 8, 103-118.
21. Ip, M. M., McGee, S. O., Masso-Welch, P. A., Ip, C. et al., The t10, c12 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice over-expressing erbB2 in the mammary epithelium. Carcinogenesis 2007, 28, 1269-1276.
22. Pariza, M. W., Park, Y., Cook, M. E., Conjugated linoleic acid and the control of cancer and obesity. Toxicol. Sci. 1999, 52, 107-110.
23. Yang, M., Cook, M. E., Dietary conjugated linoleic acid decreased cachexia, macrophage tumor necrosis factor-alpha production, and modifies splenocyte cytokines production. Exp. Biol. Med. 2003, 228, 51-58.
24. Larsen, A. E., Crowe, T. C., Effects of conjugated linoleic acid on myogenic and inflammatory responses in a human primary muscle and tumor coculture model. Nutr. Cancer 2009, 61, 687-695.
25. Zulet, M. A., Marti, A., Parra, M. D., Martínez, J. A., Inflammation and conjugated linoleic acid: mechanisms of action and implications for human health. J. Physiol. Biochem. 2005, 61, 483-494.
26. McCarthy, D. O., Graves, E., Conjugated linoleic acid preserves muscle mass in mice bearing the Lewis lung carcinoma, but not the B16 melanoma. Res. Nurs. Health 2006, 29, 98-104.
27. Graves, E., Hitt, A., Pariza, M. W., Cook, M. E., McCarthy, D. O., Conjugated linoleic acid preserves gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. Res. Nurs. Health 2005, 28, 48-55.
28. Evans, M., Brown, J., McIntosh, M., Isomer-specific effects of conjugated linoleic acid (CLA) on adiposity and lipid metabolism. J. Nutr. Biochem. 2002, 13, 508-516.
29. Brown, J. M., McIntosh, M. K., Conjugated linoleic acid in humans: regulation of adiposity and insulin sensitivity. J. Nutr. 2003, 133, 3041-3046.
30. Poirier, H., Shapiro, J. S., Kim, R. J., Lazar, M. A., Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue. Diabetes 2006, 55, 1634-1641.
31. Chung, S., Brown, J. M., Provo, J. N., Hopkins, R., McIntosh, M. K., Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production. J. Biol. Chem. 2005, 280, 38445-38456.
32. Risérus, U., Vessby, B., Arner, P., Zethelius, B., Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity. Diabetologia 2004, 47, 1016-1019.
33. Risérus, U., Basu, S., Jovinge, S., Fredrikson, G. N. et al., Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: a potential link to fatty acid-induced insulin resistance. Circulation 2002, 106, 1925-1929.
34. Ahn, I. S., Choi, B. H., Ha, J. H., Byun, J. M. et al., Isomer-specific effect of conjugated linoleic acid on inflammatory adipokines associated with fat accumulation in 3T3-L1 adipocytes. J. Med. Food 2006, 9, 307-312.
35. Jaudszus, A., Foerster, M., Kroegel, C., Wolf, I., Jahreis, G., Cis-9, trans-11-CLA exerts anti-inflammatory effects in human bronchial epithelial cells and eosinophils: comparison to trans-10, cis-12-CLA and to linoleic acid. Biochim. Biophys. Acta 2005, 1737, 111-118.
36. Halade, G. V., Rahman, M. M., Fernandes, G., Differential effects of conjugated linoleic acid isomers in insulin-resistant female C57Bl/6J mice. J. Nutr. Biochem. 2010, 21, 332-337.
37. Tanaka, Y., Eda, H., Tanaka, T., Udagawa, T. et al., Experimental cancer cachexia induced by transplantable colon 26 adenocarcinoma in mice. Cancer Res. 1990, 50, 2290-2295.
38. Strassmann, G., Fong, M., Kenney, J. S., Jacob, C. O., Evidence for the involvement of interleukin 6 in experimental cancer cachexia. J. Clin. Invest. 1992, 89, 1681-1684.
39. Livak, K. J., Schmittgen, T. D., Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25, 402-408.
40. Asp, M. L., Tian, M., Wendel, A. A., Belury, M. A., Evidence for the contribution of insulin resistance to the development of cachexia in tumor-bearing mice. Int. J. Cancer 2010, 126, 756-763.
41. West, D. B., DeLany, J. P., Camet, P. M., Blohm, F. et al., Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. Am. J. Physiol. Regul. Integr. Comp. Physiol. 1998, 275, R667-R672.
42. Ladner, K. J., Caligiuri, M. A., Guttridge, D. C., Tumor necrosis factor-regulated biphasic activation of NF-kB is required for cytokine-induced loss of skeletal muscle gene products. J. Biol. Chem. 2003, 278, 2294-2303.
43. Muller, W. A., New mechanisms and pathways for monocyte recruitment. J. Exp. Med. 2001, 194, F47-F51.
44. Lieffers, J. R., Mourtzakis, M., Hall, K. D., McCargar, L. J. et al., A viscerally driven cachexia syndrome in patients with advanced colorectal cancer: contributions of organ and tumor mass to whole-body energy demands. Am. J. Clin. Nutr. 2009, 89, 1173-1179.
45. McCarthy-Beckett, D. O., Dietary supplementation with conjugated linoleic acid does not improve nutritional status of tumor-bearing rats. Res. Nurs. Health 2002, 25, 49-57.
46. Wong, M. W., Chew, B. P., Wong, T. S., Hosick, H. L. et al., Effects of dietary conjugated linoleic acid on lymphocyte function and growth of mammary tumors in mice. Anticancer Res. 1997, 17, 987-993.
47. Bing, C., Russell, S., Becket, E., Pope, M. et al., Adipose atrophy in cancer cachexia: morphologic and molecular analysis of adipose tissue in tumour-bearing mice. Br. J. Cancer 2006, 95, 1028-1037.
48. Bing, C., Bao, Y., Jenkins, J., Sanders, P. et al., Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia. Proc. Natl. Acad. Sci. USA 2004, 101, 2500-2505.
49. Bing, C., Taylor, S., Tisdale, M. J., Williams, G., Cachexia in MAC16 adenocarcinoma: suppression of hunger despite normal regulation of leptin, insulin and hypothalamic neuropeptide Y. J. Neurochem. 2001, 79, 1004-1012.
50. Machado, A. P., Costa Rosa, L. F., Seelaender, M. C., Adipose tissue in Walker 256 tumour-induced cachexia: possible association between decreased leptin concentration and mononuclear cell infiltration. Cell Tissue Res. 2004, 318, 503-514.
51. Bing, C., Brown, M., King, P., Collins, P. et al., Increased gene expression of brown fat uncoupling protein (UCP) 1 and skeletal muscle UCP2 and UCP3 in MAC16-induced cancer cachexia. Cancer Res. 2000, 60, 2405-2410.
52. Park, Y., Storkson, J. M., Albright, K. J., Liu, W., Pariza, M. W., Evidence that trans-10, cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 1999, 34, 235-241.
53. Hargrave, K. M., Meyer, B. J., Li, C., Azain, M. J. et al., Influence of dietary conjugated linoleic acid and fat source on body fat and apoptosis in mice. Obes. Res. 2004, 12, 1435-1444.
54. Fouladiun, M., Körner, U., Bosaeus, I., Daneryd, P. et al., Body composition and time course changes in regional distribution of fat and lean tissue in unselected cancer patients on palliative care--correlations with food intake, metabolism, exercise capacity, and hormones. Cancer 2005, 103, 2189-2198.
55. Acharyya, S., Ladner, K. J., Nelsen, L. L., Damrauer, J. et al., Cancer cachexia is regulated by selective targeting of skeletal muscle gene products. J. Clin. Invest. 2004, 114, 370-378.
56. Peterson, J. M., Feeback, K. D., Baas, J. H., Pizza, F. X., Tumor necrosis factor-alpha promotes the accumulation of neutrophils and macrophages in skeletal muscle. J. Appl. Physiol. 2006, 101, 1394-1399.
57. Dumont, N., Bouchard, P., Frenette, J., Neutrophil-induced skeletal muscle damage: a calculated and controlled response following hindlimb uploading and reloading. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008, 295, R1831-R1838.