Crystal structures of a family 8 polysaccharide lyase reveal open and highly occluded substrate-binding cleft conformations

Proteins: Structure, Function and Bioinformatics

Volumn 79, Issue 3, 2011, Pages 965-974

  Elmabrouk, Zainab H ^a   Vincent, Florence ^b   Zhang, Meng ^a   Smith, Nicola L ^a   Turkenburg, Johan P ^b   Charnock, Simon J ^a   Black, Gary W ^a   Taylor, Edward J ^b  

^a NORTHUMBRIA UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Alternate conformations; Complexed structures; Exolytic; Hyaluronate lyase; Streptomyces coelicolor A3(2)

Indexed keywords

CHONDROITIN DISACCHARIDE; DISACCHARIDE; HYALURONATE LYASE; HYALURONIC ACID; POLYSACCHARIDE LYASE; POLYSACCHARIDE LYASE 8; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME STRUCTURE; ESCHERICHIA COLI; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SIMULATION; STREPTOMYCES COELICOLOR; X RAY CRYSTALLOGRAPHY;

BASE SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DNA PRIMERS; HYDROLYSIS; MODELS, MOLECULAR; POLYSACCHARIDE-LYASES; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; STREPTOMYCES COELICOLOR;

EID: 79551490989     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22938     Document Type: Article

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