Design of new benzoxazole-2-thione-derived inhibitors of Streptococcus pneumoniae hyaluronan lyase: Structure of a complex with a 2-phenylindole

Glycobiology

Volumn 16, Issue 8, 2006, Pages 757-765

  Rigden, Daniel J ^a,b   Botzki, Alexander ^c   Nukui, Masatoshi ^a   Mewbourne, R Brandon ^a   Lamani, Ejvis ^a   Braun, Stephan ^c   von Angerer, Erwin ^c   Bernhardt, Günther ^c   Dove, Stefan ^c   Buschauer, Armin ^c   Jedrzejas, Mark J ^a  

^a CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 DECYL 2 (4 SULFAMOYLOXYPHENYL) 1 INDOL 6 YL SULFAMATE; 1,3 DIACETYLBENZIMIDAZOLE 2 THIONINE; 2 PHENYLINDOLE DERIVATIVE; ANTIBIOTIC AGENT; ASCORBIC ACID; ASCORBIC ACID 6 HEXADECANOATE; BENZOXAZOLE 2 THIONE DERIVATIVE; HYALURONAN LYASE; HYALURONIC ACID; LYASE; LYASE INHIBITOR; N (3 PHENYLPROPIONYL)BENZOXAZOLE 2 THIONE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; HYDROPHOBICITY; IC 50; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

BENZOXAZOLES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; POLYSACCHARIDE-LYASES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIONES; WATER; X-RAY DIFFRACTION;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS PNEUMONIAE;

EID: 33747880987     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwj116     Document Type: Article

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