Coronary microcirculatory vasodilator function in relation to risk factors among patients without obstructive coronary disease and low to intermediate Framingham score

European Heart Journal

Volumn 31, Issue 8, 2010, Pages 936-942

  Rubinshtein, Ronen ^a   Yang, Eric H ^a   Rihal, Charanjit S ^a   Prasad, Abhiram ^a   Lennon, Ryan J ^a   Best, Patricia J ^a   Lerman, Lilach O ^a   Lerman, Amir ^a  

^a MAYO CLINIC   (United States)

Author keywords

Coronary atherosclerosis; Endothelial function; Female; Framingham risk score; Microcirculation

Indexed keywords

ACETYLCHOLINE; ADENOSINE; CORONARY VASODILATING AGENT; BIOLOGICAL MARKER;

ADULT; ANGIOCARDIOGRAPHY; ARTERY ENDOTHELIUM; ARTICLE; CARDIOVASCULAR RISK; CORONARY ARTERY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY BLOOD FLOW; CORONARY FLOW RESERVE; DRUG DOSE ESCALATION; FAMILY HISTORY; FEMALE; FRAMINGHAM RISK SCORE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; SCORING SYSTEM; SEX DIFFERENCE; ADRENERGIC SYSTEM; BLOOD; CORONARY ARTERY DISEASE; CORONARY ARTERY OBSTRUCTION; MICROCIRCULATION; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM; VASCULAR RESISTANCE; VASODILATATION;

ADULT; BIOLOGICAL MARKERS; CORONARY ARTERY DISEASE; CORONARY CIRCULATION; CORONARY STENOSIS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; MICROCIRCULATION; MIDDLE AGED; RISK FACTORS; VASCULAR RESISTANCE; VASODILATION; VASOMOTOR SYSTEM;

EID: 79551488618     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehp459     Document Type: Article

References (35)

1. Bonow RO, Smaha LA, Smith SC Jr, Mensah GA, Lenfant C. World Heart Day 2002: the International Burden of Cardiovascular Disease: responding to the Emerging Global Epidemic. Circulation 2002;106:1602-1605.
2. Kannel WB, Dawber TR, Kagan A, Revotskie N, Stokes J. Factors of risk in the development of coronary heart disease - six years follow-up experience: the Framingham Study. Ann Intern Med 1961;55:33-50.
3. Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation 1998;97:1837-1847. (Pubitemid 28213628)
4. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486-2497.
5. Ridker PM, Buring JE, Rifai N, Cook NR. Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. JAMA 2007;297:611-609.
6. Nasir K, Michos ED, Blumenthal RS, Raggi P. Detection of high-risk young adults and women by coronary calcium and National Cholesterol Education Program Panel III guidelines. J Am Coll Cardiol 2005;46:1931-1936. (Pubitemid 41579818)
7. Grewal J, Anand S, Islam S, Lonn E, SHARE SHARE-AP Investigators. Prevalence and predictors of subclinical atherosclerosis among asymptomatic 'low risk' individuals in a multiethnic population. Atherosclerosis 2008;197:435-442. (Pubitemid 351273265)
8. Michos ED, Nasir K, Braunstein JB, Rumberger JA, Budoff MJ, Post WS, Blumenthal RS. Framingham risk equation underestimates subclinical atherosclerosis risk in asymptomatic women. Atherosclerosis 2006;184:201-206. (Pubitemid 41721089)
9. Shah PK. New insights into the pathogenesis and prevention of acute coronary syndromes. Am J Cardiol 1997;79:17-23. (Pubitemid 27305157)
10. Lerman A, Holmes DR, Herrman J, Gersh BJ. Microcirculatory dysfunction in ST-elevation myocardial infarction: cause, consequence, or both? Eur Heart J 2007;28:788-797. (Pubitemid 47343589)
11. Lerman A, Zeiher AM. Endothelial function: cardiac events. Circulation 2005;111: 363-368. (Pubitemid 40165345)
12. Targonski PV, Bonetti PO, Pumper GM, Higano ST, Holmes DR Jr, Lerman A. Coronary endothelial dysfunction is associated with an increased risk of cerebro-vascular events. Circulation 2003;107:2805-2809. (Pubitemid 36705990)
13. Suwaidi JA, Hamasaki S, Higano ST, Nishimura RA, Holmes DR Jr, Lerman A. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 2000;101:948-954. (Pubitemid 30131694)
14. Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 2000;101:1899-1906. (Pubitemid 30225269)
15. Halcox JP, Schenke WH, Zalos G, Mincemoyer R, Prasad A, Waclawiw MA, Nour KR, Quyyumi AA. Prognostic value of coronary vascular endothelial dysfunction. Circulation 2002;106:653-658. (Pubitemid 34851922)
16. Kaufmann PA, Gnecchi-Ruscone T, Schäfers KP, Lüscher TF, Camici PG. Low density lipoprotein cholesterol and coronary microvascular dysfunction in hypercholesterolemia. J Am Coll Cardiol 2000;36:103-109. (Pubitemid 30466119)
17. Kaufmann PA, Gnecchi-Ruscone T, di Terlizzi M, Schäfers KP, Lüscher TF, Camici PG. Coronary heart disease in smokers: vitamin C restores coronary microcirculatory function. Circulation 2000;102:1233-1238.
18. Yokoyama I, Momomura S, Ohtake T, Yonekura K, Nishikawa J, Sasaki Y, Omata M. Reduced myocardial flow reserve in non-insulin-dependent diabetes mellitus. J Am Coll Cardiol 1997;30:1472-1477. (Pubitemid 27486464)
19. Hasdai D, Gibbons RJ, Holmes DR Jr, Higano ST, Lerman A. Coronary endothelial dysfunction in humans is associated with myocardial perfusion defects. Circulation 1997;96:3390-3395. (Pubitemid 27513410)
20. Lavi S, Parsad A, Yang EH, Mathew V, Simari RD, Rihal CS, Lerman LO, Lerman A. Smoking is associated with epicardial coronary endothelial dysfunction and elevated white blood cell count in patients with chest pain and early coronary artery disease. Circulation 2007;115:2621-2627. (Pubitemid 46791360)
21. Pries AR, Habazettl H, Ambrosio G, Hansen PR, Kaski JC, Schächinger V, Tillmanns H, Vassalli G, Tritto I, Weis M, de Wit C, Bugiardini R. A review of methods for assessment of coronary microvascular disease in both clinical and experimental setting. Cardiovasc Res 2008;80:165-174.
22. Al Suwaidi J, Higano ST, Holmes DR Jr, Rihal CS, Lerman A. Measuring maximal percent area stenosis post stent placement with intracoronary Doppler and the continuity equation and correlation with intracoronary ultrasound and angiography. Am J Cardiol 1999;84:650-654. (Pubitemid 29417955)
23. Braunwald E. Epilogue: what do clinicians expect from imagers? J Am Coll Cardiol 2006;47(Suppl. 8):C101-C103.
24. Camici PG, Crea F. Coronary microvascular dysfunction. N Engl J Med 2007;356: 830-840.
25. Yang EH, McConnell JP, Lennon RJ, Barsness GW, Pumper G, Hartman SJ, Rihal CS, Lerman LO, Lerman A. Lipoprotein-associated phospholipase A2 is an independent marker for coronary endothelial dysfunction in humans. Arterioscler Thromb Vasc Biol 2006;26:106-111. (Pubitemid 43732235)
26. Elesber AA, Solomon H, Lennon RJ, Mathew V, Prasad A, Pumper G, Nelson RE, McConnell JP, Lerman LO, Lerman A. Coronary endothelial dysfunction is associated with erectile dysfunction and elevated asymmetric dimethylarginine in patients with early atherosclerosis. Eur Heart J 2006;27:824-831.
27. Wöhrle J, Nusser T, Merkle N, Kestler HA, Grebe OC, Marx N, Höher M, Kochs M, Hombach V. Myocardial perfusion reserve in cardiovascular magnetic resonance: correlation to coronary microvascular dysfunction. J Cardiovasc Magn Reson 2006;8:781-787. (Pubitemid 44630047)
28. Bugiardini R, Bairey Merz CN. Angina with 'normal' coronary arteries: a changing philosophy. JAMA 2005;293:477-484.
29. Larsen AI, Galbraith PD, Ghali WA, Norris CM, Graham MM, Knudtson ML, APPROACH Investigators. Characteristics and outcomes of patients with acute myocardial infarction and angiographically normal coronary arteries. Am J Cardiol 2005;95:261-263. (Pubitemid 40092096)
30. Ong P, Athanasiadis A, Hill S, Vogelsberg H, Voehringer M, Sechtem U. Coronary artery spasm as a frequent cause of acute coronary syndrome: The CASPAR (Coronary Artery Spasm in Patients With Acute Coronary Syndrome) Study. J Am Coll Cardiol 2008;52:523-527.
31. Kirma C, Akcakoyun M, Esen AM, Barutcu I, Karakaya O, Saglam M, Kargin R, Turkmen M, Boztosun B, Izgi A, Sonmez K. Relationship between endothelial function and coronary risk factors in patients with stable coronary artery disease. Circ J 2007;71:698-702. (Pubitemid 46683360)
32. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486-2497.
33. Lerman A, Sopko G. Women and cardiovascular heart disease: clinical implications from the Women's Ischemia Syndrome Evaluation (WISE) Study. Are we smarter? J Am Coll Cardiol 2006;47(Suppl. 3):S59-S62.
34. Johnson BD, Shaw LJ, Buchthal SD, Bairey Merz CN, Kim HW, Scott KN, Doyle M, Olson MB, Pepine CJ, den Hollander J, Sharaf B, Rogers WJ, Mankad S, Forder JR, Kelsey SF, Pohost GM, National Institutes of Health-National Heart, Lung, Blood Institute. Prognosis in women with myocardial ischemia in the absence of obstructive coronary disease: results from the National Institutes of Health-National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation 2004;109: 2993-2999. (Pubitemid 38808322)
35. Han SH, Bae JH, Holmes DR Jr, Lennon RJ, Eeckhout E, Barsness GW, Rihal CS, Lerman A. Sex differences in atheroma burden and endothelial function in patients with early coronary atherosclerosis. Eur Heart J 2008;29:1359-1369. (Pubitemid 351806481)