New insights into the pathogenesis and prevention of acute coronary syndromes

American Journal of Cardiology

Volumn 79, Issue 12 B, 1997, Pages 17-23

  Shah, Prediman K ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE HEART INFARCTION; ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; CONFERENCE PAPER; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY DISEASE; DYSLIPIDEMIA; HEART MUSCLE ISCHEMIA; HUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; UNSTABLE ANGINA PECTORIS;

CORONARY DISEASE; HUMANS; SYNDROME; THROMBOSIS;

EID: 0030834172     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(97)00381-0     Document Type: Conference Paper

References (75)

1. Myocardial infarction and coronary deaths in the World Health Organization Monica Project: registration procedures, event rates, and care-fatality rates in 38 populations from 21 countries in 4 continents. Circulation. 90:1994;583-612.
2. Davies MJ, Thomas AC. Plaque fissuring - the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina. Br Heart J. 53:1985;363-373.
3. Falk E, Shah PK, Fuster V. Coronary plaque disruption. Circulation. 92:1995;657-671.
4. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes. N Engl J Med. 326:1992;242, 310-250, 318.
5. Fuster V, Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology. Circulation. 90:1994;2126-2146.
6. Shah PK, Moreno P, Falk E. Pathophysiology of plaque rupture. J Vasc Med Biol. 5:1995;244-258.
7. Shah PK. Pathophysiology of plaque rupture and the concept of plaque stabilization. Cardiol Clin. 14:1996;17-29.
8. Farb A, Burke AP, Tang AL, Liang TY, Mannan P, Smialek J, Virmani R. Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death. Circulation. 93:1996;13.
9. Alderman EL, Corley SD, Fisher LD, Chaitman BR, Faxon DP, Foster ED, Killip T, Sosa JA, Bourassa MG. 5-year angiographic follow-up of factors associated with progression of coronary artery disease in the Coronary Artery Surgery Study (CASS) CASS participating investigators and staff. J Am Coll Cardiol. 22:1993;1141-1154.
10. Nobuyoshi M, Tanaka M, Nosaka H, Kimura T, Yokoi H, Hamasaki N, Kim K, Shindo T, Kimura K. Progression of coronary atherosclerosis: is coronary spasm related to progression? J Am Coll Cardiol. 18:1991;904-910.
11. Giroud D, Li JM, Urban P, Meier B, Rutishauer W. Relation of the site of acute myocardial infarction to the most severe coronary arterial stenosis at prior angiography. Am J Cardiol. 69:1992;729-732.
12. Ambrose JA, Tannenbaum MA, Alexopoulos D, Hjemdahl-Monsen CE, Leavy J, Weiss M, Borrico S, Gorlin R, Fuster V. Angiographic progression of coronary artery disease and the development of myocardial infarction. J Am Coll Cardiol. 12:1988;56-62.
13. Little WC, Constantinescu M, Applegate RJ, Kutcher MA, Burrows MT, Kahl FR, Santamore WP. Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease? Circulation. 78:1988;1157-1166.
14. Danchin N. Is myocardial revascularisation for tight coronary stenoses always necessary? Viewpoint. Lancet. 342:1993;224-225.
15. Lundberg B. Chemical composition and physical state of lipid deposits in atherosclerosis. Atherosclerosis. 56:1985;93-110.
16. Small DM. Progression and regression of atherosclerotic lesions: insights from lipid physical biochemistry. Arteriosclerosis. 8:1988;103-129.
17. Guyton JR, Klemp KF. Development of the atherosclerotic core region: chemical and ultrastructural analysis of microdissected atherosclerotic lesions from human aorta. Arterioscler Thromb Vasc Biol. 14:1994;1305-1314.
18. Wight TN. Cell biology of arterial proteoglycans. Arteriosclerosis. 9:1989;1-20.
19. Witztum JL. The oxidation hypothesis of atherosclerosis. Lancet. 344:1994;793-795.
20. Davies MJ, Richardson PD, Woolf N, Katz DR, Mann J. Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content. Br Heart J. 69:1993;377-381.
21. Burleigh MC, Briggs AD, Lendon CL, Davies MJ, Born GV, Richardson PD. Collagen types I and III, collagen content, GAGs and mechanical strength of human atherosclerotic plaque caps: span-wise variations. Atherosclerosis. 96:1992;71-81.
22. Kaartinen M, Pentilla A, Kovanen PT. Accumulation of activated mast cells in the shoulder region of human coronary atheroma: the predilection site of atheromatous rupture. Circulation. 90:1994;1669-1678.
23. Kragel AH, Reddy SG, Wittes JT, Roberts WC. Morphometric analysis of the composition of atherosclerotic plaques in the 4 major epicardial coronary arteries in acute myocardial infarction and in sudden coronary death. Circulation. 80:1989;1747-1756.
24. Kragel AH, Reddy SG, Wittes JT, Roberts WC. Morphometric analysis of the composition of coronary arterial plaques in isolated unstable angina pectoris with pain at rest. Am J Cardiol. 66:1990;562-567.
25. Rosenschein U, Ellis SG, Yakubov SJ. Histopathologic correlates of coronary lesion angiographic morphology: lessons from a directional atherectomy experience. Coron Artery Dis. 3:1992;953-961.
26. Lacraz S, Isler P, Vey E, Welgus HG, Dayer JM. Direct contact between T-lymphocytes and monocytes is a major pathway for reduction of metalloproteinase expression. J Biol Chem. 269:1994;22027-22033.
27. Lendon CL, Davies MJ, Born GVR, Richardson PD. Atherosclerotic plaque caps are locally weakened when macrophages density is increased. Atherosclerosis. 87:1991;87-90.
28. Shah PK, Falk E, Badimon JJ, Fernandez-Ortiz A, Mailhac A, Villareal-Levy G, Fallon JT, Regnstrom J, Fuster V. Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques: potential role of matrix-degrading metalloproteinases and implications of plaque rupture. Circulation. 92:1995;1565-1569.
29. Brown DL, Hibbs MS, Kearney M. Expression and cellular localization of 92 kDa gelatinase in coronary lesions of patients with unstable angina. (Abstr.). J Am Coll Cardiol. 23:((suppl)):1994;436A.
30. Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest. 94:1994;2493-2503.
31. Henney AM, Wakeley PR, Davies MJ, Foster K, Hembry R, Murphy G, Humphries S. Localization of stromelysin gene expression in atherosclerotic plaques by in situ hybridization. Proc Natl Acad Sci USA. 88:1991;8154-8158.
32. Libby P. Molecular basis of acute coronary syndromes. Circulation. 91:1995;2844-2850.
33. Xu XP, Melsel SR, Cercek B, Ong JM, Sharifi B, Radpavar K, Shah PK. Differential effects of modified low-density lipoprotein on matrix metalloproteinases and their tissue inhibitors in human monocyte-derived macrophages. (Abstr.). Circulation. 94:((suppl I)):1996;I-396.
34. Rajagopaian S, Meng X, Harrison DG, Galis ZS. Modulation of matrix metalloproteinase activity by reactive oxygen species released by foam cells. (Abstr.). Circulation. 94:((suppl I)):1996;I-17.
35. MacIssac AI, Thomas JD, Topol EJ. Toward the quiescent coronary plaque. J Am Coll Cardiol. 22:1993;1228-1241.
36. Lee RT, Kamm RD. Vascular mechanics for the cardiologist. J Am Coll Cardiol. 23:1994;1289-1295.
37. Richardson PD, Davies MJ, Born GVR. Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques. Lancet. ii:1989;941-944.
38. Loree HM, Kamm RD, Stringfellow RG, Lee RT. Effects of fibrous cap thickness on peak circumferential stress in model atherosclerotic vessels. Circ Res. 71:1992;850-858.
39. Cheng GC, Loree HM, Kamm RD, Fishbein MC, Lee RT. Distribution of circumferential stress in ruptured and stable atherosclerotic lesions. A structural analysis with histopathological correlation. Circulation. 87:1993;1179-1187.
40. Gertz SD, Roberts WC. Hemodynamic shear force in rupture of coronary arterial atherosclerotic plaques. Am J Cardiol. 66:1990;1368-1372.
41. Mizushige K, Reisman M, Buchbinder M. Atheroma deformation during the cardiac cycle: evaluation by intracoronary ultrasound. Circulation. 88:((suppl I)):1993;I-550.
42. Friedman M. The coronary thrombus: its origin and fate. Hum Pathol. 2:1971;81-128.
43. Lin CS, Penha PD, Zak FG, Lin JC. Morphodynamic interpretation of acute coronary thrombosis, with special reference to volcano-like eruption of atheromatous plaque caused by coronary artery spasm. Angiology. 39:1988;535-547.
44. Kaski JC, Tousoulis D, McFadden E, Crea F, Pereira WI, Maseri A. Variant angina pectoris. Role of coronary spasm in the development of fixed coronary obstructions. Circulation. 85:1992;619-626.
45. Constantinides P. Cause of thrombosis in human atherosclerotic arteries. Am J Cardiol. 66:((suppl)):1990;37G-40G.
46. Falk E. Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis: characteristics of coronary atherosclerotic plaques underlying fatal occlusive thrombi. Br Heart J. 50:1983;127-134.
47. van der Wal AC, Becker AE, van der Loos CM, Das PK. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation. 89:1994;36-44.
48. Davies MJ, Thomas A. Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death. N Engl J Med. 310:1984;1137-1140.
49. Moreno PR, Falk E, Palacios IF, Newell JB, Fuster V, Fallon JT. Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture. Circulation. 90:1994;775-778.
50. Flugelman MY, Virmani R, Correa R, Yu ZX, Farb A, Leon MB, Elami A, Fu YM, Casscells W, Epstein SE. Smooth muscle cell abundance and fibroblast growth factors in coronary lesions of patients with nonfatal unstable angina. A clue to the mechanism of transformation from the stable to the unstable clinical state. Circulation. 88:1993;2493-2500.
51. Bogaty P, Hackett D, Davies G, Maseri A. Vasoreactivity of culprit lesions. Circulation. 91:1995;563-564.
52. Anderson P, Arneson H, Hjermann I. Hyperlipoproteinemia and reduced fibrinolytic activity in healthy coronary high-risk men. Acta Med Scand. 209:1981;199-202.
53. Egashira K, Inou T, Hiroka Y, Yamada A, Maruoka Y, Kai H, Sugimachi M, Suzuki S, Takeshita A. Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions. J Clin Invest. 91:1993;29-37.
54. O'Brien KD, Allen MD, McDonald TO, Chait A, Harlan JM, Fishbein D, McCarty J, Ferguson M, Hudkins K, Benjamin CD. Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques: implications for the mode of progression of advanced coronary atherosclerosis. J Clin Invest. 92:1993;945-951.
55. Stiko-Rahm A, Wiman B, Hamsten A, Nilsson J. Secretion of plasminogen activator inhibitor-1 from cultured human umbilical vein endothelial cells is induced by very low-density lipoprotein. Arteriosclerosis. 10:1990;1067-1073.
56. Weis JR, Pitas RE, Wilson BD, Rodgers GM. Oxidated low-density lipoprotein increased cultured human endothelial cell tissue factor activity and reduced protein C activation. FASEB J. 5:1991;2459-2465.
57. Davies MJ. A macro and micro view of coronary vascular insult in ischemic heart disease. Circulation. 82:((suppl II)):1990;38-46.
58. el Fawal MA, Berg GA, Wheatley DJ, Harland WA. Sudden coronary death in Glasgow: nature and frequency of acute coronary lesions. Br Heart J. 57:1987;329-335.
59. Qiao JH, Fishbein MC. The severity of coronary atherosclerosis at sites of plaque rupture with occlusive thrombosis. J Am Coll Cardiol. 17:1991;1138-1142.
60. Bruschke AVG, Kramer JR, Bal ET, Haque IU, Detrano RC, Goormastic M. The dynamics of progression of coronary atherosclerosis studied in 168 medically treated patients who underwent coronary arteriography 3 times. Am Heart J. 117:1989;296-305.
61. Muller JE, Abela GS, Nesto RW, Tofler GH. Triggers, acute risk factors and vulnerable plaques: the lexicon of a new frontier. J Am Coll Cardiol. 23:1994;809-813.
62. Willich SN, Maclure M, Mittleman M, Arntz HR, Muller JE. Sudden cardiac death: support for a role of triggering in causation. Circulation. 87:1993;1442-1450.
63. Tofler GH, Stone PH, Maclure M, Edelman E, Davis VG, Robertson T, Antman EM, Muller JE. Analysis of possible triggers of acute myocardial infarction (the MILIS study). Am J Cardiol. 66:1990;22-27.
64. Gelernt MD, Hochman JS. Acute myocardial infarction triggered by emotional stress. Am J Cardiol. 69:1992;1512-1513.
65. Willich SN, Lewis M, Lowell H, Arntz HR, Schubert F, Schroder R. Physical exertion as a trigger of acute myocardial infarction. Triggers and Mechanisms of Myocardial Infarction Study Group. N Engl J Med. 329:1993;1684-1690.
66. Gnecchi-Ruscone T, Piccaluga E, Guzzetti S, Contini M, Montano N, Nicolis E. Morning and Monday: critical periods for the onset of acute myocardial infarction. The GISSI 2 Study Experience. Eur Heart J. 15:1994;882-887.
67. Curfman GD. Is exercise beneficial-or hazardous-to your heart. N Engl J Med. 329:1993;1730-1731.
68. Yusuf S, Peto J, Lewis J, Collins R, Sleight P. β -blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis. 27:1985;335-371.
69. Willich SN, Linderer T, Wegscheider K, Leizorovicz A, Alamercery I, Schroder R. Increased morning incidence of myocardial infarction in the ISAM Study: absence with prior β -adrenergic blockade. Circulation. 80:1989;853-858.
70. Quyyumi AA, Panza JA, Diodati JG, Lakatos E, Epstein SE. Circadian variation in ischemic threshold: mechanisms underlying the circadian variation in ischemic events. Circulation. 86:1992;22-28.
71. Brown BG, Zhao X-Q, Sacco DE, Albers JJ. Lipid lowering and plaque regression: new insights into prevention of plaque disruption and clinical events in coronary disease. Circulation. 87:1993;1781-1791.
72. Effect of simvastatin on coronary atheroma: the Multicentre Anti-Atheroma Study (MASS). Lancet. 344:1994;633-638.
73. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 344:1994;1383-1389.
74. Waters D, Craven TE, Lesperance J. Prognostic significance of progression of coronary atherosclerosis. Circulation. 87:1993;1067-1075.
75. Cashin-Hemphill L, Mack W, LaBree L. Coronary progression predicts future cardiac events. Circulation. 88:((suppl I)):1993;I-363.