Quantitative determination of Orlistat (tetrahydrolipostatin, Ro 18-0647) in human plasma by high-performance liquid chromatography coupled with ion spray tandem mass spectrometry

Journal of Mass Spectrometry

Volumn 32, Issue 7, 1997, Pages 739-749

  Bennett, Patrick K ^a   Li, Yu Tsyir ^b   Edom, Richard ^c,d   Henion, Jack ^a  

^a Adv BioAnalytical Services Inc   (United States)

^b ARQULE INC   (United States)

^c HOFFMANN LA ROCHE INC   (United States)

^d PharmaKnowledge Inc   (United States)

Author keywords

Ionspray; Liquid chromatography tandem mass spectrometry; Orlistat; Plasma; Quantitation

Indexed keywords

TETRAHYDROLIPSTATIN;

ACCURACY; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; INSTRUMENT; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ASSAY; TECHNIQUE; ULTRAVIOLET SPECTROPHOTOMETRY;

CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; ENZYME INHIBITORS; HUMANS; LACTONES; LIPASE; MASS SPECTROMETRY; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS;

EID: 0030845115     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9888(199707)32:7<739::AID-JMS526>3.0.CO;2-C     Document Type: Article

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