Determination of a substance P antagonist in human plasma and urine using high-performance liquid chromatography with ultraviolet absorbance and tandem mass spectrometric detection

Journal of Pharmaceutical and Biomedical Analysis

Volumn 15, Issue 9-10, 1997, Pages 1427-1433

  Zagrobelny, J ^a   Chavez, C ^a   Constanzer, M L ^a   Matuszewski, B K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Absorbance; Biological fluids; Column switching; High performance liquid chromatography assay; Tandem mass spectrometric detection

Indexed keywords

2 [3,5 BIS(TRIFLUOROMETHYL)BENZYLOXY] 4 (3 OXO 1,2,4 TRIAZOL 5 YLMETHYL) 3 PHENYLMORPHOLINE; SUBSTANCE P ANTAGONIST; UNCLASSIFIED DRUG;

BLOOD ANALYSIS; BODY FLUID; CONFERENCE PAPER; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; URINALYSIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MASS SPECTROMETRY; MORPHOLINES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBSTANCE P;

EID: 0030920883     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(96)02038-9     Document Type: Conference Paper

References (11)

1. J.J. Hale, S.G. Mills, M. MacCoss, S.K. Shah, H. Qi, D.J. Mathre, M.A. Cascieri, S. Sadowski, D.D. Strader, D.E. MacIntyre, J.M. Metzger, Journal of Medicinal Chemistry 39 (1996) 1760-1762.
2. J. Zagrobelny, B.K. Matuszewski, Enantiomer, 2(1) (1997) 37-43.
3. J.D. Gilbert, T.V. Olah, A. Barrish, T.F. Greber, Biol. Mass Spectrometry 21 (1992) 341-346.
4. J.D. Gilbert, E.L. Hand, A.S. Yuan, T.V. Olah, T. Covey, Biol. Mass Spectrometry 21 (1992) 63-68.
5. B. Kaye, W.H. Clark, N.J. Cussans, P.V. Maccrae, D.A. Stephen, Biol. Mass Spectrometry 21 (1992) 585-589.
6. D. Wong-Iverson, M.E. Arnold, M. Jemai, A.I. Cohen, Biol. Mass Spectrometry 21 (1992) 189-194.
7. S. Horimoto, M. Mabuchi, K. Banno, T. Sato, Chemical and Pharmaceutical Bulletin 41 (1993) 699-702.
8. M.L. Constanzer, C.M. Chavez, B.K. Matuszewski, Journal of Chromatography B 658 (1994) 281-287.
9. M.L. Constanzer, C.M. Chavez, B.K. Matuszewski, Journal of Chromatography B 666 (1995) 117-126.
10. J. Zagrobelny, C.M. Chavez, M.L. Constanzer, B.K. Matuszewski, Journal of Pharmaceutical and Biomedical Analysis 13 (1995) 1215-1223.
11. C.M. Chavez, M.L. Constanzer, B.K. Matuszewski, Journal of Pharmaceutical Biomedical Analysis 13 (1995) 1179-1184.