Gastrointestinal stromal tumors: Correlation between symptoms at presentation, tumor location and prognostic factors in 47 consecutive patients

World Journal of Surgical Oncology

Volumn 9, Issue , 2011, Pages

  Caterino, Salvatore ^a   Lorenzon, Laura ^a   Petrucciani, Niccolò ^a   Iannicelli, Elsa ^b   Pilozzi, Emanuela ^b   Romiti, Adriana ^b   Cavallini, Marco ^a   Ziparo, Vincenzo ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ABDOMINAL PAIN; ADULT; AGED; ARTICLE; CANCER SURGERY; CLINICAL ARTICLE; CORRELATION ANALYSIS; FEMALE; GASTROINTESTINAL STROMAL TUMOR; GENE MUTATION; HUMAN; ILEUM TUMOR; INTESTINAL BLEEDING; JEJUNUM TUMOR; MALE; MITOSIS RATE; ONCOGENE C KIT; PREVALENCE; PROGNOSIS; RISK FACTOR; FOLLOW UP; INTESTINE TUMOR; MIDDLE AGED; MITOSIS INDEX; PROSPECTIVE STUDY; STOMACH TUMOR; SURVIVAL RATE;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; FOLLOW-UP STUDIES; GASTROINTESTINAL STROMAL TUMORS; HUMANS; INTESTINAL NEOPLASMS; MALE; MIDDLE AGED; MITOTIC INDEX; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS; STOMACH NEOPLASMS; SURVIVAL RATE;

EID: 79351468942     PISSN: None     EISSN: 14777819     Source Type: Journal    
DOI: 10.1186/1477-7819-9-13     Document Type: Article

References (45)

1. Miettinen M, Lasota J. Gastrointestinal Stromal Tumors. Review on Morphology, Molecular pathology, Prognosis, and Differential Diagnosis. Arch Pathol Lab Med 2006, 130(10):1466-78.
2. Miettinen M, Lasota J. Gastrointestinal Stromal Tumors - definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch 2001, 438:1-12. 10.1007/s004280000338, 11213830.
3. Nilsson B, Bumming P, Meis-Kindblom JM, Odén A, Dortok A, Gustavsson B, Sablinska K, Kindblom LG. Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era - a population-based study in western Sweden. Cancer 2005, 103:821-829. 10.1002/cncr.20862, 15648083.
4. Burkill GJ, Badran M, Al-Muderis O, Meirion Thomas J, Judson IR, Fisher C, Moskovic EC. Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread. Radiology 2003, 226:527-532. 10.1148/radiol.2262011880, 12563150.
5. Duffaud F, Blay JY. Gastrointestinal stromal tumors: biology and treatment. Oncology 2003, 65:187-197. 10.1159/000074470, 14657591.
6. De Matteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors. Recurrence patterns and prognostic factors for survival. Ann Surg 2000, 231:51-58. 10.1097/00000658-200001000-00008, 1420965, 10636102.
7. Lewis JJ, Brennan MF. Soft tissue sarcomas. Curr Probl Surg 1996, 33:817-872. 10.1016/S0011-3840(96)80013-X, 8885853.
8. Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, Kawano K, Hanada M, Kurata A, Takeda M, Muhammad Tunio G, Matsuzawa Y, Kanakura Y, Shinomura Y, Kitamura Y. Gain-of-function muatations of c-kit in human gastrointestinal stromal tumors. Science 1998, 279:577-580. 10.1126/science.279.5350.577, 9438854.
9. Kitamura Y, Hirota S. Kit as a human oncogenic tyrosine kinase. Cell Mol Life Sci 2004, 61:2924-2931. 10.1007/s00018-004-4273-y, 15583854.
10. Pawson T. Regulation and targets of receptor tyrosine kinases. Eur J Cancer 2002, 38(Suppl 5):S3-S10. 10.1016/S0959-8049(02)80597-4, 12528767.
11. Rubin BP, Singer S, Tsao C, Duensing A, Lux ML, Ruiz R, Hibbard MK, Chen CJ, Xiao S, Tuveson DA, Demetri GD, Fletcher CD, Fletcher JA. KIT activation is ubiquitous feature of gastrointestinal stromal tumors. Cancer Res 2001, 61:8118-8121.
12. Reith JD, Goldblum JR, Lyles RH, Weiss SW. Extragastrointestinal (soft tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome. Mod Pathol 2000, 13:577-585. 10.1038/modpathol.3880099, 10824931.
13. Lee CH, Liang CW, Espinosa I. The utility of discovered on gastrointestinal stromal tumor 1 (DOG1) antibody in surgical pathology-the GIST of it. Adv Anat Pathol 2010, 17(3):222-32. 10.1097/PAP.0b013e3181d973c2, 20418677.
14. Miettinen M, Majidi M, Lasota J. Pathology and diagnostic criteria of gastrointestinal stromal tumors (GISTs): A review. Eur J Cancer 2002, 38:S39-51. 10.1016/S0959-8049(02)80602-5, 12528772.
15. Emory TS, Sobin LH, Lukes L, Lee DH, O'Leary TJ. Prognosis of gastrointestinal smoothmuscle (stromal) tumors: Dependence on anatomic site. Am J Surg Pathol 1999, 23:82-87. 10.1097/00000478-199901000-00009, 9888707.
16. Gupta P, Tewari M, Shukla HS. Gastrointestinal stromal tumor. Surg Oncol 2008, 17:129-138. 10.1016/j.suronc.2007.12.002, 18234489.
17. Blay JY, Le Cesne A. ESMO Guidelines Working Group Gastrointestinal stromal tumors: ESMO Clinical Recommendations for diagnosis, treatment and follow-up. Ann Oncol 2007, 18(Suppl 2):ii27-9. ESMO Guidelines Working Group.
18. Lopez M, Comandone A, Adamo V, Apice G, Bearzi I, Bracci R, Carlini M, Carpano S, Condorelli S, Covello R, Cucchiara G, Di Filippo F, Doglietto GB, Ficorella C, Garofalo A, Gebbia N, Giuliani F, Massidda B, Messerini L, Palmirotta R, Tonelli F, Vidiri A. Raccomandazioni cliniche per la diagnosi, la terapia ed il follow-up dei tumori stromali gastrointestinali. Clin Ter 2006, 157(3):283-299.
19. Casali PG, Jost L, Reichardt P, Schlemmer M, Blay JY, . ESMO Guidelines Working Group Gastrointestinal stromal tumors: ESMO Clinical Reccomendations for diagnosis, treatment and follow-up. Ann Oncol 2008, 19(Suppl 2):ii35-38. 10.1093/annonc/mdn080, 18456761, ESMO Guidelines Working Group.
20. Joensuu H, Roberts PJ, Sarlomo-Rikala M, Andersson LC, Tervahartiala P, Tuveson D, Silberman S, Capdeville R, Dimitrijevic S, Druker B, Demetri GD. Effect of the tyrosine kinase inhibitor STI 571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med 2001, 344:1052-1056. 10.1056/NEJM200104053441404, 11287975.
21. Rutkowski P, Symonides M, Zdzienicki M, Siedlecki JA. Developments in targeted therapy of advanced gastrointestinal stromal tumors. Recent Pat Anticancer Drug Discov 2008, 3:88-99. 10.2174/157489208784638749, 18537751.
22. Joensuu H. Risk stratification of patients diagnosed with gastrointestinal stromal tumor. Hum Pathol 2008, 39(10):1411-9. 10.1016/j.humpath.2008.06.025, 18774375.
23. Zhang L, Smyrki TC, Young WF, Stratakis CA, Carney JA. Gastrointestinal stromal tumors in Carney triad are different clinically, pathologically, and behaviorally from sporadic gastric gastrointestinal stromal tumors: findings in 104 cases. Am J Surg Pathol 2010, 34(1):53-64. 10.1097/PAS.0b013e3181c20f4f, 19935059.
24. Blanke CD, Demetri GD, von Mehren M, Heinrich MC, Eisenberg B, Fletcher JA, Corless CL, Fletcher CD, Roberts PJ, Heinz D, Wehre E, Nikolova Z, Joensuu H. Long-term results from a randomized phase II trial of standard-versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT. J Clin Oncol 2008, 26(4):620-5. 10.1200/JCO.2007.13.4403, 18235121.
25. Wardelmann E, Merkelbach-Bruse S, Pauls K, Thomas N, Schildhaus HU, Heinicke T, Speidel N, Pietsch T, Buettner R, Pink D, Reichardt P, Hohenberger P. Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate. Clin Can Res 2006, 12(6):1743-1749.
26. Bulusu VR, Jephcott CR, Fawcett S, Cook N, Hatcher H, Moyle P, Carroll N, Earl H, Save V, Hardwick R. RECIST and Choi criteria for response assessment (RA) in patients with inoperable and metastatic gastrointestinal stromal tumors (GISTs) on imatinib mesylate. Cambridge GIST study group experience. J Clin Oncol ASCO MEETING ABSTRACTS 2007, 25(18 S):10019.
27. Fletcher C, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, Miettinen M, O'Leary TJ, Remotti H, Rubin BP, Shmookler B, Sobin LH, Weiss SW. Diagnosis of gastrointestinal stromal tumors; a consensus approach. Human Pathol 2002, 33:459-465.
28. Miettinen M, Lasota J. Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol 2006, 23:70-83. 10.1053/j.semdp.2006.09.001, 17193820.
29. Liu YJ, Yang Z, Hao LS, Xia L, Jia QB, Wu XT. Synchronous incidental gastrointestinal stromal and epithelial malignant tumors. World J Gastroenterol 2009, 15(16):2027-2031. 10.3748/wjg.15.2027, 2675096, 19399938.
30. Horowitz J, Spellman JE, Driscoll DL, Velez AF, Karakousis CP. An institutional review of sarcomas of the large and small intestine. J Am Coll Surg 1995, 180:465-71.
31. DeMatteo RP. The GIST targeted cancer therapy: a tumor (gastrointestinal stromal tumor) a mutated gene (c-kit), and a molecular inhibitor (STI571). Ann Surg Oncol 2002, 9(9):831-839. 10.1007/BF02557518, 12417503.
32. Scarpa M, Bertin M, Ruffolo C, Polese L, D'Amico DF, Angriman I. A systematic review on the clinical diagnosis of gastrointestinal stromal tumors. J Surg Oncol 2008, 98:384-392. 10.1002/jso.21120, 18668671.
33. El-Zohairy M, Khalil E, Fakhr I, El-Shahawy M, Gouda I. Gastrointestinal stromal tumor (GIST)'s surgical treatment, NCI experience. J Egypt Natl Canc Inst 2005, 17:56-66.
34. Pierie JP, Choudry U, Muzikansky A, Yeap BY, Souba WW, Ott MJ. The effect of surgery and grade on outcome of gastrointestinal stromal tumors. Arch Surg 2001, 136:383-389. 10.1001/archsurg.136.4.383, 11296107.
35. Darnell A, Dalmau E, Pericay C, Musulén E, Martín J, Puig J, Malet A, Saigí E, Rey M. Gastrointestinal stromal tumors. Abdom Imaging 2006, 31:387-399. 10.1007/s00261-004-0092-8, 16465584.
36. Aparicio T, Boige V, Sabourin JC, Crenn P, Ducreux M, Le Cesne A, Bonvalot S. Prognostic factors after surgery of primary resectable gastrointestinal stromal tumours. Eur J Surg Oncol 2004, 30:1098-1103. 10.1016/j.ejso.2004.06.016, 15522557.
37. Rajappa S, Muppavarapu KM, Uppin S, Digumarti R. Gastrointestinal stromal tumors: a single institution experience of 50 cases. Indian J Gastroenterol 2007, 26:225-229.
38. Tryggvason G, Gislason HG, Magnusson MK, Jónasson JG. Gastrointestinal stromal tumors in Iceland, 1990-2003: the Icelandic GIST study, a population-based incidence and pathologic risk stratification study. Int J Cancer 2005, 117:289-293. 10.1002/ijc.21167, 15900576.
39. Goh BK, Chow PK, Yap WM, Kesavan SM, Song IC, Paul PG, Ooi BS, Chung YF, Wong WK. Which is the optimal risk stratification system for surgically treated localized primary GIST? Comparison of three contemporary prognostic criteria in 171 tumors and a proposal for a modified Armed Forces Institute of Pathology risk criteria. Ann Surg Oncol 2008, 15(8):2153-63. 10.1245/s10434-008-9969-z, 18546045.
40. Ahmed I, Welch NT, Parsons SL. Gastrointestinal stromal tumours (GIST) - 17 years experience from Mid Trent Region (United Kingdom). Eur J Surg Oncol 2008, 34:445-449.
41. Hassan I, You YN, Shyyan R, Dozois EJ, Smyrk TC, Okuno SH, Schleck CD, Hodge DO, Donohue JH. Surgically managed gastrointestinal stromal tumors: a comparative and prognostic analysis. Ann Surg Oncol 2008, 15:52-59. 10.1245/s10434-007-9633-z, 18000711.
42. Gronchi A, Fiore M, Miselli F, Lagonigro MS, Coco P, Messina A, Pilotti S, Casali PG. Surgery of the residual disease following molecular-target therapy with imatinib mesylate in advanced/matastatic GIST. Ann Surg 2007, 245(3):341-346. 10.1097/01.sla.0000242710.36384.1b, 1877023, 17435538.
43. Iwahashi M, Takifuji K, Ojima T, Nakamura M, Nakamori M, Nakatani Y, Ueda K, Ishida K, Naka T, Ono K, Yamaue H. Surgical management of small gastrointestinal stromal tumors of the stomach. World J Surg 2006, 30:28-35. 10.1007/s00268-005-7944-4, 16369707.
44. Demetri GD, Benjamin RS, Blanke CD, Blay JY, Casali P, Choi H, Corless CL, Debiec-Rychter M, DeMatteo RP, Ettinger DS, Fisher GA, Fletcher CDM, Gronchi A, Hohenberger P, Hughes M, Joensuu H, Judson I, Le Cesne A, Maki RG, Morse M, Pappo AS, Pisters PWT, Raut CP, Reichardt P, Tyler DS, Van den Abbeele AD, von Mehren M, Wayne JD, Zalcberg J. NCCN Task Force Report: Optimal management of patients with Gastrointestinal Stromal Tumor (GIST--Update of the NCCN Clinical Practice Guidelines. J Natl Compr Canc Netw 2007, 5(Suppl 2):S1-29.
45. Demetri GD, von Mehren M, Antonescu CR, DeMatteo RP, Ganjoo KN, Maki RG, Pisters PWT, Raut CP, Riedel RF, Schuetze S, Sundar HM, Trent JC, Wayne JD. NCCN Task Force Report: Update on the management of patients with Gastrointestinal Stromal Tumors. J Natl Compr Canc Netw 2010, 8(Suppl 2):S1-41.