Abnormalities in the tricarboxylic acid (TCA) cycle in the brains of schizophrenia patients

European Neuropsychopharmacology

Volumn 21, Issue 3, 2011, Pages 254-260

  Bubber, P ^a   Hartounian, V ^b   Gibson, G E ^a   Blass, J P ^a  

^a BURKE MEDICAL RESEARCH INSTITUTE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Energy metabolism; Mitochondria; Postmortem interval; Schizophrenia; Tricarboxylic acid cycle

Indexed keywords

ACONITATE HYDRATASE; CHOLINE ACETYLTRANSFERASE; CITRATE SYNTHASE; FUMARATE HYDRATASE; ISOCITRATE DEHYDROGENASE; MALATE DEHYDROGENASE; OXOGLUTARATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE COMPLEX; SUCCINATE DEHYDROGENASE; SUCCINYL COENZYME A SYNTHETASE; TRICARBOXYLIC ACID;

AGED; ARTICLE; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; HUMAN; HUMAN TISSUE; MALE; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA;

ACONITATE HYDRATASE; AGED; AGED, 80 AND OVER; ANIMALS; BRAIN; CITRIC ACID CYCLE; FEMALE; GLUCOSE; HUMANS; MALATE DEHYDROGENASE; MALE; MICE; MIDDLE AGED; OXIDATION-REDUCTION; PREFRONTAL CORTEX; SCHIZOPHRENIA; SEX CHARACTERISTICS; SUCCINATE DEHYDROGENASE; TIME FACTORS;

EID: 79251635665     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2010.10.007     Document Type: Article

References (50)

1. Andreazza A.C., Shao L., Wang J.F., Young L.T. Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder. Arch. Gen. Psychiatry 2010, 67:360-368.
2. Bai C., Fernandez E., Yang H., Chen R. Purification and stabilization of a monomeric isocitrate dehydrogenase from Corynebacterium glutamicum. Protein Expr. Purif. 1999, 15(3):344-348.
3. Ben-Shachar D. Mitochondrial dysfunction in schizophrenia: a possible linkage to dopamine. J. Neurochem. 2002, 83(6):1241-1251.
4. Berman K.F., Torrey E.F., Daniel D.G., Weinberger D.R. Regional cerebral blood flow in monozygotic twins discordant and concordant for schizophrenia. Arch. Gen. Psychiatry 1992, 49(12):927-934.
5. Blass J.P., Brown A.M. Lower activity of Krebs cycle enzymes than of electron transport in human brain: disease implications. Neurobiol. Aging 2000, 21(Suppl):81.
6. Blass J.P., Gibson G.E., Hoyer S. The role of the metabolic lesion in Alzheimer's disease. J. Alzheimers Dis. 2002, 4(3):225-232.
7. Bonilla E., Tanji K., Hirano M., Vu T.H., DiMauro S., Schon E.A. Mitochondrial involvement in Alzheimer's disease. Biochim. Biophys. Acta 1999, 1410(2):171-182.
8. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
9. Bubber P., Tang J., Haroutunian V., Xu H., Davis K.L., Blass J.P., Gibson G.E. Mitochondrial enzymes in schizophrenia. J. Mol. Neurosci. 2004, 24(2):315-321.
10. Clark D., Dedova I., Cordwell S., Matsumoto I. A proteome analysis of the anterior cingulate cortex gray matter in schizophrenia. Mol. Psychiatry 2006, 11(5):459-470.
11. Dracheva S., Marras S.A., Elhakem S.L., Kramer F.R., Davis K.L., Haroutunian V. N-methyl-d-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia. Am. J. Psychiatry 2001, 158(12):2107.
12. Fedotcheva N.I., Sokolov A.P., Kondrashova M.N. Nonezymatic formation of succinate in mitochondria under oxidative stress. Free Radic. Biol. Med. 2006, 41(1):56-64.
13. Friedman J.I., Harvey P.D., Kemether E., Byne W., Davis K.L. Cognitive and functional changes with aging in schizophrenia. Biol. Psychiatry 1999, 46(7):921-928.
14. Fucetola R., Newcomer J.W., Craft S., Melson A.K. Age- and dose-dependent glucose-induced increases in memory and attention in schizophrenia. Psychiatry Res. 1999, 88(1):1-13.
15. Gibson G.E., Sheu K.F., Blass J.P., Baker A., Carlson K.C., Harding B., Perrino P. Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease. Arch. Neurol. 1988, 45(8):836-840.
16. Gibson G.E., Toral-Barza L., Manger T., Freeman G. Neurotransmitters and calcium during hypoxia. Cerebral Ischemia and Calcium 1989, 215-222. Springer-Verlag, N.Y. A. Hartman, W. Kuschinsky (Eds.).
17. Gibson G.E., Blass J.P., Huang H.-M., Freeman G.B. The cellular basis of delirium and its relevance to age related disorders including Alzheimer's disease. Int. Psychogeriatr. 1991, 3(2):373-395.
18. Gluck M.R., Thomas R.G., Davis K.L., Haroutunian V. Increased phosphate-activated glutaminase and glutamic acid decarboxylase activities in dorsolateral prefrontal cortex of aged schizophrenics: implications for altered glutamate and GABA metabolism in schizophrenia. Am. J. Psychiatry 2002, 159(7):1165-1173.
19. Hakak Y., Walker J.R., Li C., Wong W.H., Davis K.L., Buxbaum J.D., Haroutunian V., Fienberg A.A. Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc. Natl Acad. Sci. USA 2001, 98(8):4746-4751.
20. Haroutunian V., Davidson M., Kanof P.D., Perl D.P., Powchik P., Losonczy M., McCrystal J., Purohit D.P., Bierer L.M., Davis K.L. Cortical cholinergic markers in schizophrenia. Schizophr. Res. 1994, 12(2):137-144.
21. Hill R.L., Bradshaw R.A. Fumarase. Meth. Enzymol. 1969, 13:91-92.
22. Jacobsen L.K., Hamburger S.D., Van Horn J.D., Vaituzis A.C., McKenna K., Frazier J.A., Gordon C.T., Lenane M.C., Rapoport J.L., Zametkin A.J. Cerebral glucose metabolism in childhood onset schizophrenia. Psychiatry Res. 1997, 75(3):131-144.
23. Joseph J.A., Gibson G.E. Coupling of neuronal function to oxygen and glucose metabolism through changes in neurotransmitter dynamics as revealed with aging, hypoglycemia and hypoxia. Handbook of Neurochemistry and Molecular Biology 2007, 297-320. Springer. 3rd edition. G.E. Gibson, G. Dienel (Eds.).
24. Kirkpatrick B., Fernandez-Egea E., Garcia-Rizo C., Bernardo M. Differences in glucose tolerance between deficit and nondeficit schizophrenia. Schizophr. Res. 2009, 107:122-127.
25. Kitto G.B. Intra and extramitochondrial malate dehydrogenases from chicken and tuna heart. Meth. Enzymol. 1969, 13:106-116.
26. Ksiezak-Reding H., Blass J.P., Gibson G.E. Studies on the pyruvate dehydrogenase complex in brain with the arylamine acetyltransferase-coupled assay. J. Neurochem. 1982, 38:1627-1636.
27. Kung L., Roberts R.C. Mitochondrial pathology in human schizophrenic striatum: a postmortem ultrastructural study. Synapse 1999, 31(1):67-75.
28. Lyubarev A.E., Kurganov B.I. Supramolecular organization of tricarboxylic acid cycle enzymes. Biosystems 1989, 22:91-102.
29. Martins-de-Souza D., Gattaz W.F., Schmitt A., Novello J.C., Marangoni S., Turck C.W., Dias-Neto E. Proteomic analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation. BMC Psychiatry 2009, 30:9-17.
30. Maurer I., Zierz S., Möller H. Evidence for a mitochondrial oxidative phosphorylation defect in brains from patients with schizophrenia. Schizophr. Res. 2001, 48(1):125-136.
31. McCormack J.G., Denton R.M. Influence of calcium ions on mammalian intramitochondrial dehydrogenases. Meth. Enzymol. 1989, 174:95-118.
32. Mirnics K., Middleton F.A., Marquez A., Lewis D.A., Levitt P. Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron 2000, 28(1):53-67.
33. Molina V., Solera S., Sanz J., Sarramea F., Luque R., Rodriguez R., Jimenez-Arriero M.A., Palomo T. Association between cerebral metabolic and structural abnormalities and cognitive performance in schizophrenia. Psychiatry Res. 2009, 173:88-93.
34. Morton R.L., Ikle D., White C.W. Loss of lung mitochondrial aconitase activity due to hyperoxia in bronchopulmonary dysplasia in primates. Am. J. Physiol. 1998, 274(1 Pt 1):L127-L133.
35. Prabakaran S., Swatton J.E., Ryan M.M., Huffaker S.J., Huang J.T., Griffin J.L., Wayland M., Freeman T., Dudbridge F., Lilley K.S., Karp N.A., Hester S., Tkachev D., Mimmack M.L., Yolken R.H., Webster M.J., Torrey E.F., Bahn S. Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. Mol. Psychiatry 2004, 9(7):684-697. 643.
36. Prasad K.N., Cole W.C., Prasad K.C. Risk factors for Alzheimer's disease: role of multiple antioxidants, non-steroidal anti-inflammatory and cholinergic agents alone or in combination in prevention and treatment. J. Am. Coll. Nutr. 2002, 21(6):506-522.
37. Purohit D.P., Perl D.P., Haroutunian V., Powchik P., Davidson M., Davis K.L. Alzheimer disease and related neurodegenerative diseases in elderly patients with schizophrenia. Arch. Gen. Psychiatry 1998, 55:205-211.
38. Reddy R.D., Yao J.K. Free radical pathology in schizophrenia: a review. Prostaglandins Leukot. Essent. Fatty Acids 1996, 55(1-2):33-43.
39. Regenold W.T., Phatak P., Marano C.M., Sassan A., Conley R.R., Kling M.A. Elevated cerebrospinal fluid lactate concentrations in patients with bipolar disorder and schizophrenia: implications for the mitochondrial dysfunction hypothesis. Biol. Psychiatry 2009, 65:489-494.
40. Rezin G.T., Amboni G., Zugno A.I., Quevedo J., Streck E.L. Mitochondrial dysfunction and psychiatric disorders. Neurochem. Res. 2009, 34(6):1021-1029.
41. Rose I.A., O'Connell E.L. Mechanism of aconitase action. I. The hydrogen transfer reaction. J. Biol. Chem. 1967, 242(8):1870-1879.
42. Ryan M.C., Collins P., Thakore J.H. Impaired fasting glucose tolerance in first episode, drug naïve patients with schizophrenia. Am. J. Psychiatry 2003, 160:284-289.
43. Santos S.S., Gibson G.E., Cooper A.J., Denton T.T., Thompson C.M., Bunik V.I., Alves P.M., Sonnewald U. Inhibitors of the alpha-ketoglutarate dehydrogenase complex alter [1-13C]glucose and [U-13C]glutamate metabolism in cerebellar granule neurons. J. Neurosci. Res. 2006, 83:450-458.
44. Shepherd D., Garland P.B. Citrate synthase from rat liver. Meth. Enzymol. 1969, 13:11-13.
45. Shi Q., Risa O., Sonnewald U., Gibson G.E. Mild reduction in the activity of the alpha-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis. J. Neurochem. 2009, 109(Suppl 1):214-221.
46. Stone W.S., Faraone S.V., Su J., Tarbox S.I., Van Eerdewegh P., Tsuang M.T. Evidence for linkage between regulatory enzymes in glycolysis and schizophrenia in a multiplex sample. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004, 127(1):5-10.
47. Sungman Cha Succinate thiokinase from pig heart. Meth. Enzymol. 1969, 13:62-65.
48. Tretter L., Adam-Vizi V. Inhibition of Krebs cycle enzymes by hydrogen peroxide: a key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress. J. Neurosci. 2000, 20(24):8972-8979.
49. Veeger C., Der Vartanian D.V., Zeylemaker W.P. Succinate dehydrogenase. Meth. Enzymol. 1969, 13:106-116.
50. Velot C., Mixon M.B., Teige M., Srere P.A. Model of a quinary structure between Krebs TCA cycle enzymes: a model for the metabolon. Biochemistry 1997, 36(47):14271-14276.