HIV-1 enhancing effect of prostatic acid phosphatase peptides is reduced in human seminal plasma

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Martellini, Julie A ^a   Cole, Amy L ^a   Svoboda, Pavel ^b,c   Stuchlik, Olga ^c   Chen, Li Mei ^a   Chai, Karl X ^a   Gangrade, Bhushan K ^d   Sørensen, Ole E ^e   Pohl, Jan ^b,c   Cole, Alexander M ^a  

^a UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^d Center for Reproductive Medicine   (United States)

^e LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE PROSTATE ISOENZYME; ACID PHOSPHATASE PROSTATE ISOENZYME 266; ACID PHOSPHATASE PROSTATE ISOENZYME 286; AMYLOID; MATRIPTASE; PROSTATE SPECIFIC ANTIGEN; UNCLASSIFIED DRUG; PEPTIDE FRAGMENT; PROTEIN TYROSINE PHOSPHATASE; SERINE PROTEINASE;

ANTIVIRAL ACTIVITY; ARTICLE; BODY FLUID; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MALE; NONHUMAN; PROTEIN DEGRADATION; PROVIRUS; SEMINAL PLASMA; VIRUS ACTIVATION; DOSE RESPONSE; DRUG EFFECT; ENHANCER REGION; METABOLISM; PHYSIOLOGY; SPERM; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

AMYLOID; DOSE-RESPONSE RELATIONSHIP, DRUG; HIV ENHANCER; HIV-1; HUMANS; PEPTIDE FRAGMENTS; PROSTATE-SPECIFIC ANTIGEN; PROTEIN TYROSINE PHOSPHATASES; SEMEN; SERINE ENDOPEPTIDASES;

EID: 79251621694     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016285     Document Type: Article

References (35)

1. Ganz T, Weiss J (1997) Antimicrobial peptides of phagocytes and epithelia. Semin Hematol 34(4): 343-354.
2. Klotman ME, Chang TL (2006) Defensins in innate antiviral immunity. Nat Rev Immunol 6(6): 447-456.
3. Cole AM (2003) Minidefensins and other antimicrobial peptides: candidate anti- HIV microbicides. Expert Opin Ther Targets 7(3): 329-341.
4. Ganz T, Selsted ME, Szklarek D, Harwig SS, Daher K, et al. (1985) Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest 76(4): 1427-1435.
5. Mangoni ME, Aumelas A, Charnet P, Roumestand C, Chiche L, et al. (1996) Change in membrane permeability induced by protegrin 1: implication of disulphide bridges for pore formation. FEBS Lett 383(1-2): 93-98.
6. Taylor PW, Morgan HR (1952) Antibacterial substances in human semen and prostatic fluid. Surg Gynecol Obstet 94(6): 662-668.
7. Mardh PA, Colleen S (1975) Antimicrobial activity of human seminal fluid. Scand J Urol Nephrol 9(1): 17-23.
8. Bourgeon F, Evrard B, Brillard-Bourdet M, Colleu D, Jegou B, et al. (2004) Involvement of semenogelin-derived peptides in the antibacterial activity of human seminal plasma. Biol Reprod 70(3): 768-774.
9. Com E, Bourgeon F, Evrard B, Ganz T, Colleu D, et al. (2003) Expression of antimicrobial defensins in the male reproductive tract of rats, mice, and humans. Biol Reprod 68(1): 95-104.
10. von Horsten HH, Derr P, Kirchhoff C (2002) Novel antimicrobial peptide of human epididymal duct origin. Biol Reprod 67(3): 804-813.
11. Zhao H, Lee WH, Shen JH, Li H, Zhang Y (2008) Identification of novel semenogelin I-derived antimicrobial peptide from liquefied human seminal plasma. Peptides 29(4): 505-511.
12. Edstrom AM, Malm J, Frohm B, Martellini JA, Giwercman A, et al. (2008) The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins. J Immunol 181(5): 3413-3421.
13. Martellini JA, Cole AL, Venkataraman N, Quinn GA, Svoboda P, et al. (2009) Cationic polypeptides contribute to the anti-HIV-1 activity of human seminal plasma. Faseb J 23(10): 3609-3618.
14. Christopher-Hennings J, Nelson EA, Althouse GC, Lunney J (2008) Comparative antiviral and proviral factors in semen and vaccines for preventing viral dissemination from the male reproductive tract and semen. Anim Health Res Rev. pp 1-11.
15. Kelly RW (1995) Immunosuppressive mechanisms in semen: implications for contraception. Hum Reprod 10(7): 1686-1693.
16. Munch J, Rucker E, Standker L, Adermann K, Goffinet C, et al. (2007) Semenderived amyloid fibrils drastically enhance HIV infection. Cell 131(6): 1059-1071.
17. Roan NR, Munch J, Arhel N, Mothes W, Neidleman J, et al. (2009) The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection. J Virol 83(1): 73-80.
18. Lilja H (1988) Structure and function of prostatic- and seminal vesicle-secreted proteins involved in the gelation and liquefaction of human semen. Scand J Clin Lab Invest Suppl 191: 13-20.
19. Malm J, Hellman J, Hogg P, Lilja H (2000) Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tightbinding inhibitor. Prostate 45(2): 132-139.
20. Lilja H (1993) Structure, function, and regulation of the enzyme activity of prostate-specific antigen. World J Urol 11(4): 188-191.
21. Robert M, Gibbs BF, Jacobson E, Gagnon C (1997) Characterization of prostate-specific antigen proteolytic activity on its major physiological substrate, the sperm motility inhibitor precursor/semenogelin I. Biochemistry 36(13): 3811-3819.
22. Brillard-Bourdet M, Rehault S, Juliano L, Ferrer M, Moreau T, et al. (2002) Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates. Eur J Biochem 269(1): 390-395.
23. Yu JX, Chao L, Chao J (1994) Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland. J Biol Chem 269(29): 18843-18848.
24. Wang JK, Lee MS, Tseng IC, Chou FP, Chen YW, et al. (2009) Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibition. Am J Physiol Cell Physiol 297(2): C459-470.
25. Hauber I, Hohenberg H, Holstermann B, Hunstein W, Hauber J (2009) The main green tea polyphenol epigallocatechin-3-gallate counteracts semenmediated enhancement of HIV infection. Proc Natl Acad Sci U S A 106(22): 9033-9038.
26. Chen LM, Skinner ML, Kauffman SW, Chao J, Chao L, et al. (2001) Prostasin is a glycosylphosphatidylinositol-anchored active serine protease. J Biol Chem 276(24): 21434-21442.
27. Chen M, Chen LM, Lin CY, Chai KX (2010) Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor. Mol Cell Biochem 337(1-2): 259-266.
28. Moulaei T, Stuchlik O, Reed M, Yuan W, Pohl J, et al. (2010) Topology of the disulfide bonds in the antiviral lectin scytovirin. Protein Sci.
29. Kim KA, Yolamanova M, Zirafi O, Roan NR, Staendker L, et al. (2010) Semenmediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI. Retrovirology 7: 55.
30. Lilja H, Jeppsson JO (1985) Amino acid sequence of the predominant basic protein in human seminal plasma. FEBS Lett 182(1): 181-184.
31. Rochet JC, Lansbury PT, Jr. (2000) Amyloid fibrillogenesis: themes and variations. Curr Opin Struct Biol 10(1): 60-68.
32. Harper JD, Lansbury PT, Jr. (1997) Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins. Annu Rev Biochem 66: 385-407.
33. Ye Z, French KC, Popova LA, Lednev IK, Lopez MM, et al. (2009) Mechanism of fibril formation by a 39-residue peptide (PAPf39) from human prostatic acidic phosphatase. Biochemistry 48(48): 11582-11591.
34. Sorensen OE, Gram L, Johnsen AH, Andersson E, Bangsboll S, et al. (2003) Processing of seminal plasma hCAP-18 to ALL-38 by gastricsin: a novel mechanism of generating antimicrobial peptides in vagina. J Biol Chem 278(31): 28540-28546.
35. Galvin SR, Cohen MS (2004) The role of sexually transmitted diseases in HIV transmission. Nat Rev Microbiol 2(1): 33-42.