The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 22, 2009, Pages 9033-9038

  Hauber, Ilona ^a   Hohenberg, Heinrich ^a   Holstermann, Barbara ^a   Hunstein, Werner ^b   Hauber, Joachim ^a  

^a LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

EGCG; Microbicide; Prostatic acidic phosphatase; SEVI; Sexual transmission

Indexed keywords

GREEN TEA EXTRACT; POLYPHENOL EPIGALLOCATECHIN 3 GALLATE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DEGRADATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEMEN MEDIATED ENHANCEMENT OF HIV 1 INFECTION; SEXUAL TRANSMISSION; SPERM; TEA; VIRUS TRANSMISSION;

AMYLOID; ANTI-HIV AGENTS; CAMELLIA SINENSIS; CATECHIN; CELLS, CULTURED; HIV INFECTIONS; HIV-1; HUMANS; MALE; PEPTIDE FRAGMENTS; PROTEIN TYROSINE PHOSPHATASES; SEMEN;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 67049115575     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0811827106     Document Type: Article

References (28)

1. UNAIDS (2007) AIDS epidemic update. Available at http://data.unaids.org/ pub/EPISlides/2007/071118-epi-regional%20factsheet-en.pdf. Accessed November 17, 2008.
2. Shattock RJ, Moore JP (2003) Inhibiting sexual transmission of HIV-1 infection. Nat Rev Microbiol 1:25-34.
3. Klasse PJ, Shattock R, Moore JP (2008) Antiretroviral drug-based microbicides to prevent HIV-1 sexual transmission. Annu Rev Med 59:455-471. (Pubitemid 351287949)
4. Münch J, et al. (2007) Semen-derived amyloid fibrils drastically enhance HIV infection. Cell 131:1059-1071. (Pubitemid 350235017)
5. Rönnberg L, Vihko P, Sajanti E, Vihko R (1981) Clomiphene citrate administration to normogonadotropic subfertile men: Blood hormone changes and activation of acid phosphatase in seminal fluid. Int J Androl 4:372-378. (Pubitemid 12197137)
6. Roan NR, Greene WC (2007) A seminal finding for understanding HIV transmission. Cell 131:1044-1046. (Pubitemid 350235031)
7. Roan NR, et al. (2009) The cationic properties of SEVI underlie its ability to enhance HIV infection. J Virol 83:73-80.
8. Haase AT (2005) Perils at mucosal front lines for HIV and SIV and their hosts. Nat Rev Immunol 5:783-792. (Pubitemid 41400852)
9. Grant RM, et al. (2008) Whither or wither microbicides? Science 321:532-534.
10. Dobson CM (2003) Protein folding and misfolding. Nature 426:884-890. (Pubitemid 38056880)
11. Rochet JC, Lansbury PT, Jr (2000) Amyloid fibrillogenesis: Themes and variations. Curr Opin Struct Biol 10:60-68.
12. Taylor JP, Hardy J, Fischbeck KH (2002) Toxic proteins in neurodegenerative disease. Science 296:1991-1995. (Pubitemid 34627514)
13. Sacchettini JC, Kelly JW (2002) Therapeutic strategies for human amyloid diseases. Nat Rev Drug Discov 1:267-275. (Pubitemid 37361443)
14. Ehrnhoefer DE, et al. (2008) EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers. Nat Struct Mol Biol 15:558-566. (Pubitemid 351799141)
15. Yang CS, Maliakal P, Meng X (2002) Inhibition of carcinogenesis by tea. Annu Rev Pharmacol Toxicol 42:25-54. (Pubitemid 34160518)
16. Nance CL, Shearer WT (2003) Is green tea good for HIV-1 infection? J Allergy Clin Immunol 112:851-853. (Pubitemid 37412050)
17. Cabrera C, Artacho R, Gimenez R (2006) Beneficial effects of green tea - a review. J Am Coll Nutr 25:79-99. (Pubitemid 46939847)
18. Frid P, Anisimov SV, Popovic N (2007) Congo red and protein aggregation in neurodegenerative diseases. Brain Res Rev 53:135-160. (Pubitemid 44854214)
19. Aguilar-Cordova E, Chinen J, Donehower L, Lewis DE, Belmont JW (1994) A sensitive reporter cell line for HIV-1 tat activity, HIV-1 inhibitors, and T cell activation effects. AIDS Res Hum Retroviruses 10:295-301. (Pubitemid 24116786)
20. Fassina G, et al. (2002) Polyphenolic antioxidant (-)-epigallocatechin-3- gallate from green tea as a candidate anti-HIV agent. AIDS 16:939-941. (Pubitemid 34409024)
21. Yamaguchi K, Honda M, Ikigai H, Hara Y, Shimamura T (2002) Inhibitory effects of (-)-epigallocatechin gallate on the life cycle of human immunodeficiency virus type 1 (HIV-1). Antiviral Res 53:19-34. (Pubitemid 33001552)
22. Kawai K, et al. (2003) Epigallocatechin gallate, the main component of tea polyphenol, binds to CD4 and interferes with gp120 binding. J Allergy Clin Immunol 112:951-957. (Pubitemid 37412065)
23. Williamson MP, McCormick TG, Nance CL, Shearer WT (2006) Epigallocatechin gallate, the main polyphenol in green tea, binds to the T-cell receptor, CD4: Potential for HIV-1 therapy. J Allergy Clin Immunol 118:1369-1374. (Pubitemid 44854123)
24. Liu S, et al. (2005) Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41. Biochim Biophys Acta 1723:270-281. (Pubitemid 40744696)
25. Hauber I, et al. (2005) Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy. J Clin Invest 115:76-85. (Pubitemid 40385507)
26. Wei X, et al. (2002) Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy. Antimicrob Agents Chemother 46:1896-1905. (Pubitemid 34535213)
27. Zhu QY, Zhang A, Tsang D, Huang Y, Chen ZY (2008) Stability of green tea catechins. J Agric Food Chem 45:4624-4628. (Pubitemid 127485815)
28. Hohenberg H, Mannweiler K, Muller M (1994) High-pressure freezing of cell suspensions in cellulose capillary tubes. J Microsc 175:34-43. (Pubitemid 24246592)