Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor

Molecular and Cellular Biochemistry

Volumn 337, Issue 1-2, 2010, Pages 259-266

  Chen, Mengqian ^a,c   Chen, Li Mei ^a   Lin, Chen Yong ^b   Chai, Karl X ^a  

^a UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c ORDWAY RESEARCH INSTITUTE   (United States)

Author keywords

Epithelial; Extracellular; Growth factor receptor; Protease inhibitor; Proteolytic activation; Serine protease

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; HEPSIN; MATRIPTASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROSTASIN; PROTEASE NEXIN I;

ARTICLE; CONTROLLED STUDY; COVALENT BOND; EPITHELIUM CELL; HUMAN; HUMAN CELL; POSITIVE FEEDBACK; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

CELLS, CULTURED; ENZYME ACTIVATION; EPITHELIUM; EXTRACELLULAR SPACE; HUMANS; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPIDERMAL GROWTH FACTOR; SERINE ENDOPEPTIDASES; TYROSINE;

EID: 77949657431     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-009-0307-y     Document Type: Article

References (25)

1. S Netzel-Arnett BM Currie R Szabo CY Lin LM Chen KX Chai TM Antalis TH Bugge K List 2006 Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation J Biol Chem 281 32941 32945 10.1074/jbc.C600208200 10.1074/jbc.C600208200 1:CAS:528:DC%2BD28XhtFegsLnN 16980306 (Pubitemid 46036678)
2. K List CC Haudenschild R Szabo W Chen SM Wahl W Swaim LH Engelholm N Behrendt TH Bugge 2002 Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis Oncogene 21 3765 3779 10.1038/sj/onc/1205502 10.1038/sj.onc.1205502 1:CAS:528:DC%2BD38Xks1OjsL4%3D 12032844 (Pubitemid 34620539)
3. C Leyvraz RP Charles I Rubera M Guitard S Rotman B Breiden K Sandhoff E Hummler 2005 The epidermal barrier function is dependent on the serine protease CAP1/Prss8 J Cell Biol 170 487 496 10.1083/jcb.200501038 10.1083/jcb.200501038 1:CAS:528:DC%2BD2MXntVarsr0%3D 16061697 (Pubitemid 41126947)
4. I Seitz S Hess H Schulz R Eckl G Busch HP Montens R Brandl S Seidl A Schömig I Ott 2007 Membrane-type serine protease-1/matriptase induces interleukin-6 and -8 in endothelial cells by activation of protease-activated receptor-2: potential implications in atherosclerosis Arterioscler Thromb Vasc Biol 27 769 775 10.1161/01.ATV.0000258862.61067.14 10.1161/01.ATV.0000258862. 61067.14 1:CAS:528:DC%2BD2sXislCrsrs%3D 17255532 (Pubitemid 46606705)
5. M Chen LM Chen CY Lin KX Chai 2008 The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase-Prostasin serine protease cascade in cultured epithelial cells Biochim Biophys Acta 1783 896 903 10.1016/j.bbamcr.2007.10.019 10.1016/j.bbamcr.2007.10.019 1:CAS:528: DC%2BD1cXkvVOgsL0%3D 18054338
6. + channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit J Biol Chem 282 6153 6160 10.1074/jbc.M610636200 10.1074/jbc.M610636200 1:CAS:528:DC%2BD2sXitVCju7g%3D 17199078 (Pubitemid 47100869)
7. + channel by peptidases Curr Top Dev Biol 78 23 46 10.1016/S0070-2153(06)78002-4 10.1016/S0070-2153(06)78002-4 17338914
8. R Szabo A Molinolo K List TH Bugge 2007 Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development Oncogene 26 1546 1556 10.1038/sj.onc.1209966 10.1038/sj.onc.1209966 1:CAS:528:DC%2BD2sXisFynsbY%3D 16983341 (Pubitemid 46398747)
9. B Fan TD Wu W Li D Kirchhofer 2005 Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin J Biol Chem 280 34513 34520 10.1074/jbc.M502119200 10.1074/jbc.M502119200 1:CAS:528:DC%2BD2MXhtVyksr%2FI 16103126 (Pubitemid 41504581)
10. S Herter DE Piper W Aaron T Gabriele G Cutler P Cao AS Bhatt Y Choe CS Craik N Walker D Meininger T Hoey RJ Austin 2005 Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers Biochem J 390 125 136 10.1042/BJ20041955 10.1042/BJ20041955 1:CAS:528:DC%2BD2MXntFGmsrg%3D 15839837 (Pubitemid 41192238)
11. F Béliveau A Désilets R Leduc 2009 Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptides FEBS J 276 2213 2226 10.1111/j.1742-4658.2009. 06950.x 10.1111/j.1742-4658.2009.06950.x 19302215
12. LM Chen ML Skinner SW Kauffman J Chao L Chao CD Thaler KX Chai 2001 Prostasin is a glycosylphosphatidylinositol-anchored active serine protease J Biol Chem 276 21434 21442 10.1074/jbc.M011423200 10.1074/jbc.M011423200 1:CAS:528:DC%2BD3MXksFGlur0%3D 11274175
13. M Chen YY Fu CY Lin LM Chen KX Chai 2007 Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3 Biochim Biophys Acta 1773 1133 1140 10.1016/j.bbamcr.2007.04.013 10.1016/j.bbamcr.2007.04.013 1:CAS:528: DC%2BD2sXmsFKhurw%3D 17532063 (Pubitemid 46898672)
14. Q Wu D Yu J Post M Halks-Miller JE Sadler J Morser 1998 Generation and characterization of mice deficient in hepsin, a hepatic transmembrane serine protease J Clin Invest 101 321 326 10.1172/JCI1617 10.1172/JCI1617 1:CAS:528:DyaK1cXmtF2juw%3D%3D 9435303
15. K List JP Hobson A Molinolo TH Bugge 2007 Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase J Cell Physiol 213 237 245 10.1002/jcp.21115 10.1002/jcp.21115 1:CAS:528:DC%2BD2sXhtVehtLnO 17471493 (Pubitemid 47378812)
16. V Vasioukhin 2004 Hepsin paradox reveals unexpected complexity of metastatic process Cell Cycle 3 1394 1397 1:CAS:528:DC%2BD2MXhtleku7bL 15539945
17. V Srikantan M Valladares JS Rhim JW Moul S Srivastava 2002 HEPSIN inhibits cell growth/invasion in prostate cancer cells Cancer Res 62 6812 6816 1:CAS:528:DC%2BD38XpsVahsrg%3D 12460890
18. H Tanimoto Y Yan J Clarke S Korourian K Shigemasa TH Parmley GP Parham TJ O'Brien 1997 Hepsin, a cell surface serine protease identified in hepatoma cells, is overexpressed in ovarian cancer Cancer Res 57 2884 2887 1:CAS:528:DyaK2sXkslOktL0%3D 9230195
19. T Matsuo K Nakamura N Takamoto J Kodama A Hongo F Abrzua Y Nasu H Kumon Y Hiramatsu 2008 Expression of the serine protease hepsin and clinical outcome of human endometrial cancer Anticancer Res 28 159 164 1:CAS:528: DC%2BD1cXjslWht78%3D 18383840
20. H Betsunoh S Mukai Y Akiyama T Fukushima N Minamiguchi Y Hasui Y Osada H Kataoka 2007 Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type 2 expression in renal cell carcinoma Cancer Sci 98 491 498 10.1111/j.1349-7006.2007.00412.x 10.1111/j.1349-7006.2007.00412.x 1:CAS:528:DC%2BD2sXksVWmsLc%3D 17309599 (Pubitemid 46562738)
21. J Miao D Mu B Ergel R Singavarapu Z Duan S Powers E Oliva S Orsulic 2008 Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model Int J Cancer 123 2041 2047 10.1002/ijc.23726 10.1002/ijc.23726 1:CAS:528:DC%2BD1cXht1Chs73E 18726901
22. K Nakamura N Takamoto F Abarzua A Hongo J Kodama Y Nasu H Kumon Y Hiramatsu 2008 Hepsin inhibits the cell growth of endometrial cancer Int J Mol Med 22 389 397 1:CAS:528:DC%2BD1cXhtF2qtbfJ 18698500
23. LM Chen GB Hodge LA Guarda JL Welch NM Greenberg KX Chai 2001 Down-regulation of prostasin serine protease: a potential invasion suppressor in prostate cancer Prostate 48 93 103 10.1002/pros.1085 1:CAS:528: DC%2BD3MXlsVynu7Y%3D 11433419 (Pubitemid 32613872)
24. LM Chen KX Chai 2002 Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation Int J Cancer 97 323 329 10.1002/ijc.1601 10.1002/ijc.1601 1:CAS:528: DC%2BD38XhvVWltQ%3D%3D 11774283 (Pubitemid 34049022)
25. LM Chen C Wang M Chen MR Marcello J Chao L Chao KX Chai 2006 Prostasin attenuates inducible nitric oxide synthase expression in lipopolysaccharide- induced urinary bladder inflammation Am J Physiol Renal Physiol 291 F567 F577 10.1152/ajprenal.00047.2006 10.1152/ajprenal.00047.2006 1:CAS:528: DC%2BD28XhtVSks7jJ 16638913 (Pubitemid 44343738)