FOXP3+ regulatory T-cells are abundant in vulvar Paget's disease and are associated with recurrence

Gynecologic Oncology

Volumn 120, Issue 2, 2011, Pages 296-299

  Press, Joshua Z ^a   Allison, Kimberly H ^a   Garcia, Rochelle ^a   Everett, Elise N ^b   Pizer, Ellen ^c   Swensen, Ron E ^a   Tamimi, Hisham K ^a   Gray, Heidi J ^a   Peters III, William A ^b   Goff, Barbara A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b Pacific Gynecology Specialists   (United States)

^c CellNetix Pathology   (United States)

Author keywords

FOXP3; Regulatory T cells; Vulvar Paget's

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 236A E7; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

AGED; ARTICLE; BLADDER CANCER; BLADDER CARCINOMA; BREAST CANCER; CANCER RECURRENCE; CANCER SURGERY; CANCER TISSUE; CELL COUNT; CLINICAL ARTICLE; CLINICAL FEATURE; COLON CANCER; DERMOEPIDERMAL JUNCTION; ENDOMETRIUM CANCER; FEMALE; FOLLOW UP; FROZEN SECTION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; LICHEN SCLEROSUS ET ATROPHICUS; LUNG CANCER; MELANOMA; NEURODERMATITIS; OVARY CANCER; PAGET SKIN DISEASE; PRIORITY JOURNAL; PROLACTINOMA; QUANTITATIVE ANALYSIS; REFERENCE DATABASE; REGULATORY T LYMPHOCYTE; SKIN CANCER; VULVA CARCINOMA; VULVITIS;

AGED; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM RECURRENCE, LOCAL; PAGET DISEASE, EXTRAMAMMARY; T-LYMPHOCYTES, REGULATORY; VULVAR NEOPLASMS;

EID: 79251597331     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2010.10.019     Document Type: Article

References (21)

1. V. Shepherd, E.J. Davidson, and J. Davies-Humphreys Extramammary Paget's disease BJOG 112 2005 273 279
2. J.E.N. Pierie, U. Choudry, A. Muzikansky, D.M. Finkelstein, and M.J. Ott Prognosis and management of extramammary Paget's disease and the association with secondary malignancies J Am Coll Surg 196 2003 45 50
3. J.P. Curtin, S.C. Rubin, W.B. Jones, W.J. Hoskins, and J.L. Lewis Jr. Paget's disease of the vulva Gynecol Oncol 39 1990 374 377
4. M. Van Seters, M. van Beurden, F.J.W. ten Kate, I. Beckmann, P.C. Ewing, and M.J.C. Eijkemans Treatment of vulvar intraepithelial neoplasia with topical Imiquimod NEJM 348 2008 1465 1473
5. A.R. Clark, S.J. Huang, G.F. Murphy, I.G. Mollet, D. Hijnen, and M. Muthukuru Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T-cells J Exp Med 205 2008 2221 2234
6. S. Hori, T. Nomura, and S. Sakaguchi Control of regulatory T cell development by the transcription factor Foxp3 Science 299 2003 1057 1061
7. S. Read, and F. Powrie CD4(+) regulatory T cells Curr Opin Immunol 13 2001 644 649
8. S.D. Bohling, and K.H. Allison Immunosuppressive regulatory T cells are associated with aggressive breast cancer phenotypes: a potential therapeutic target Mod Pathol 21 2008 1527 1532
9. T.J. Curiel, G. Coukos, L. Zou, X. Alvarez, P. Chen, and P. Mottram Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival Nat Med 10 2004 942 949
10. M. Viguier, F. Lemaitre, O. Verola, M.S. Cho, G. Gorochov, and L. Dubertret Foxp3 expressing CD4 + CD25 (high) regulatory T cells are over-represented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells J Immunol 173 2004 1444 1453
11. J. Fanning, H.C.L. Lambert, T.M. Hale, P.C. Morris, and C. Schuerch Paget's disease of the vulva: prevalence of associated vulvar adenocarcinoma, invasive Paget's disease, and recurrence after surgical excision Am J Obstet Gynecol 180 1999 24 27
12. D.H. Moore, W. Koh, W.P. McGuire, and E.J. Wilkinson Vulva W.J. Hosking, C.A. Perez, R.C. Young, R.R. Barakat, M. Markman, M.E. Randall, Principles and Practice of Gynecologic Oncology 4th ed 2005 Lippincott Williams & Wilkins Philadelphia (PA 679
13. D. Black, C. Tornos, R.A. Soslow, C.S. Awtrey, R.R. Barakat, and D.S. Chi The outcomes of patients with positive margins after excision for intraepithelial Paget's disease of the vulva Gynecol Oncol 104 2007 547 550
14. D.A. Fishman, S.K. Chambers, P.E. Schwartz, E.I. Kohorn, and J.T. Chambers Extramammary Paget's disease of the vulva Gynecol Oncol 56 1995 266 270
15. L.P. Parker, J.R. Parker, D. Bodurka-Bevers, M. Deavers, M.W. Bevers, and J. Shen-Gunther Paget's disease of the vulva: pathology, pathern of involvement, and prognosis Gynecol Oncol 77 2000 183 189
16. R.A. Gunn, and H.S. Gallager Vulvar Paget's disease: a topographic study Cancer 46 1989 590 594
17. S. Kodama, T. Kaneko, M. Saito, N. Yoshinya, S. Honma, and K. Tanaka A clinicopathologic study of 30 patients with Paget's disease of the vulva Gynecol Oncol 56 1995 63 70
18. J.F. Bach Regulatory T cells under scrutiny Nat Rev Immunol 3 2003 189 198
19. K.D. Hatch, and J.R. Davis Complete resolution of Paget disease of the vulva with Imiquimod cream J Low Gen Tract Dis 12 2008 90 94
20. L.C. Wang, A. Blanchard, D.E. Judge, A.A. Lorincz, M.M. Medenica, and S. Busbey Successful treatment of recurrent extramammary Paget's disease of the vulva with topical imiquimod 5% cream J Am Acad Dermatol 49 2003 769 770
21. J.P. Geisler, and K.J. Manahan Imiquimod in vulvar Paget's disease: a case report J Reprod Med 53 2008 811 812