Florfenicol inhibits allergic airway inflammation in mice by p38 MAPK-mediated phosphorylation of GATA 3

Clinical Immunology

Volumn 138, Issue 2, 2011, Pages 231-238

  Xinxin, Ci ^a   Chi, Chen ^a   Xiao, Chu ^a   Xue, Xu ^a   Yongjun, Yang ^a   Junqing, Cui ^b   Xuming, Deng ^a  

^a JILIN UNIVERSITY   (China)

^b PFIZER INC   (United States)

Author keywords

Airway inflammation; Allergic asthma; Florfenicol; GATA 3; MAPK

Indexed keywords

ALCIAN BLUE; DEXAMETHASONE; EOSIN; FLORFENICOL; HEMATOXYLIN; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; MITOGEN ACTIVATED PROTEIN KINASE P38; OVALBUMIN; TRANSCRIPTION FACTOR GATA 3;

AIRWAY; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BAGG ALBINO MOUSE; CELL HYPERPLASIA; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE RESPONSE; FEMALE; GOBLET CELL; HISTOLOGY; IMMUNIZATION; INFLAMMATORY CELL; LUNG LAVAGE; LUNG PARENCHYMA; MOUSE; NONHUMAN; PERIODIC ACID SCHIFF STAIN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TH2 CELL;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DEXAMETHASONE; DISEASE MODELS, ANIMAL; EOSINOPHILS; FEMALE; GATA3 TRANSCRIPTION FACTOR; GOBLET CELLS; IMMUNOGLOBULIN E; LUNG; MACROPHAGES; MICE; MICE, INBRED BALB C; NEUTROPHILS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; TH2 CELLS; THIAMPHENICOL;

EID: 79251596939     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2010.11.008     Document Type: Article

References (35)

1. Bochner B.S., Undem B.J., Lichtenstein L.M. Immunological aspects of allergic asthma. Annu. Rev. Immunol. 1994, 12:295-335.
2. Zhu J.F., Paul W.E. CD4 T cells: fates, functions, and faults. Blood 2008, 112:1557-1569.
3. Punnonen J., Aversa G., Cocks B.G., Vries J.E. Role of interleukin-4 and interleukin-13 in synthesis of IgE and expression of CD23 by human B cells. Allergy 1994, 49:576-586.
4. Santoni D., Pedicini M., Castiglione F. Implementation of a regulatory gene network to simulate the TH1/2 differentiation in an agent-based model of hypersensitivity reactions. Bioinformatics 2008, 24:1374-1380.
5. Lee G.R., Fields P.E., Flavell R.A. Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level. Immunity 2001, 14:447-459.
6. Takemoto N., Arai K., Miyatake S. Cutting edge: the differential involvement of the N-finger of GATA-3 in chromatin remodeling and transactivation during Th2 development. J. Immunol. 2002, 169:4103-4107.
7. Schwenger G.T., Fournier R., Kok C.C., Mordvinov V.A., Yeoman D. GATA-3 has dual regulatory functions in human interleukin-5 transcription. J. Biol. Chem. 2001, 276:48502-48509.
8. Maneechotesuwan K., Xin Y., Ito K., Jazrawi E., Lee K.Y. Regulation of Th2 Cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3. J. Immunol. 2007, 178:2491-2498.
9. Inoue H., Kato R., Fukuyama S., Nonami A., Taniguchi K., Matsumoto K., Nakano T., Tsuda M., Matsumura M., Kubo M., Ishkawa F., Moon B., Takatsu K., Nakanishi Y., Yoshimura A. Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness. J. Exp. Med. 2005, 201:73-82.
10. Beasley R.J., Lai C.K., Pearce N. Prevalence and etiology of asthma. J. Allergy Clin. Immunol. 2000, 105:466-472.
11. Nagai H., Shishido H., Yoneda R., Yamaguchi E., Tamura A., Kurashima A. Long-term low-dose administration of erythromycin to patients with diffuse panbronch-iolitis. Respiration 1991, 58:145-149.
12. Ci X.X., Song Y., Zeng F.Q., Zhang X.M., Li H.Y., Wang X.R., Cui J.Q., Deng X.M. Ceftiofur impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK. Biochem. Biophys. Res. Commun. 2008, 372:73-77.
13. Kaplan M.A., Goldin M. The use of triacetyloleandomycin in chronic infectious asthma. Antibiotic. Annual. 1958-1959, 6:273-276.
14. Shin S.J., Kang S.G., Nabin R., Kang M.L., Yoo H.S. Evaluation of the antimicrobial activity of florfenicol against bacteria isolated from bovine and porcine respiratory disease. Vet. Microbiol. 2005, 106:73-77.
15. Liu J.Z., Fung K.F., Chen Z.L., Zeng Z.L., Zhang J. Pharmacokinetics of florfenicol in healthy pigs and in pigs experimentally infected with actinobacillus pleuropneumoniae. Antimicrob. Agents Chemother. 2003, 47:820-823.
16. O'Connor A.M., Wellman N.G., Evans R.B., Roth D.R. A review of randomized clinical trials reporting antibiotic treatment of infectious bovine keratoconjunctivitis in cattle. Anim. Health Res. Rev. 2006, 7:119-127.
17. Angelos J.A., Dueger E.L., George L.W., Carrier T.K., Mihalyi J.E., Cosgrove S.B. Efficacy of florfenicol for treatment of naturally occurring infectious bovine keratoconjunctivitis. J. Am. Vet. Med. Assoc. 2000, 216:62-64.
18. Zhang X.M., Song Y., Ci X.X., An N., Fan J.W., Cui J.Q., Deng X.M. Effects of florfenicol on early cytokine responses and survival in murine endotoxemia. Int. Immunopharmacol. 2008, 8:982-988.
19. Zhang X.M., Song K.J., Xiong H.Z., Chu X., Deng X.M. Protective effect of florfenicol on acute lung injury induced by lipopolysaccharide in mice. Int. Immunopharmacol. 2009, 9:1525-1529.
20. McKay A., Leung B.P., Mcinnes I.B. A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma. J. Immunol. 2004, 172:2586-2594.
21. Edwan J.H., Perry G., Talmadge J.E., Agrawal D.K. Flt-3 ligand reverses late allergic response and airway hyper-responsiveness in a mouse model of allergic inflammation. J. Immunol. 2004, 172:5016-5023.
22. Bao Z., Lim S., Liao W., Lin Y., Thiemermann C., Leung B.P., Wong W.S.F. Glycogen synthase kinase-3b inhibition attenuates asthma in mice. Am. J. Respir. Crit. Care Med. 2007, 176:431-438.
23. Ito K., Jazrawi E., Cosio B., Barnes P.J., Adcock I.M. p65-activated histone acetyltransferase activity is repressed by glucocorticoids: mifepristone fails to recruit HDAC2 to the p65/HAT complex. J. Biol. Chem. 2001, 276:30208-30215.
24. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Biotechnology 1992, 24:145-149.
25. Kostadima E., Tsiodras S., Alexopoulos E.I., Kaditis A.G., Mavrou I., Georgatou N., Papamichalopoulos A. Clarithromycin reduces the severity of bronchial hyperresponsiveness in patients with asthma. Eur. Respir. J. 2004, 23:714-717.
26. Piacentini G.L., Peroni D.G., Bodini A., Pigozzi R., Costella S., Loiacono A., Boner A.L. Azithromycin reduces bronchial hyperresponsiveness and neutrophilic airway inflammation in asthmatic children: a preliminary report. Allergy Asthma Proc. 2007, 28:194-198.
27. Bisset L.R., Schmid-Grendelmeier P. Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective. Curr. Opin. Pulm. Med. 2005, 11:35-42.
28. Lee C.M., Chang J.H., et al. Lycopene suppresses ovalbumin-induced airway inflammation in a murine model of asthma. Biochem. Biophys. Res. Commun. 2008, 374:248-252.
29. Beigelman A., Gunsten S., et al. Azithromycin attenuates airway inflammation in a noninfectious mouse model of allergic asthma. Chest 2009, 136:498-506.
30. Boška H., Berislav B., et al. Clarithromycin suppresses airway hyperresponsiveness and inflammation in mouse models of asthma. Eur. J. Pharmacol. 2009, 15:236-243.
31. Fish S.C., Donaldson D.D., Goldman S.J., Williams C.M., Kasaian M.T. IgE generation and mast cell effector function in mice deficient in IL-4 and IL-13. J. Immunol. 2005, 174:7716-7724.
32. Barnes P.J. Corticosteroids, IgE, and atopy. J. Clin. Invest. 2001, 107:265-266.
33. Marsha W.K. Interleukin-13 in asthma pathogenesis. Immunol. Rev. 2004, 202:175-190.
34. Li X.S., Wang G.Q., Du X.D., Cui B.A., Zhang S.M., Shen J.Z. Antimicrobial susceptibility and molecular detection of chloramphenicol and florfenicol resistance among Escherichia coli isolates from diseased chickens. J. Vet. Sci. 2007, 8(3):243-247.
35. White D.G., Hudson C., Maurer J.J., Ayers S., Zhao S.H., Lee M.D., Bolton L., Foley T., Sherwood J. Characterization of chloramphenicol and florfenicol resistance in Escherichia coli associated with bovine diarrhea. J. Clin. Microbiol. 2000, 12:4593-4598.