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Volumn 186, Issue 3, 2011, Pages 1399-1410

A unique role of the cholera toxin A1-DD adjuvant for long-term plasma and memory B cell development

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXY 3 NITROPHENYL ACETYL CHICKEN GAMMAGLOBULIN; ALUMINUM POTASSIUM SULFATE; B7 ANTIGEN; CD19 ANTIGEN; CHOLERA TOXIN; CHOLERA TOXIN A1 DD; HYBRID PROTEIN; IMJECT ALUM; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOLOGICAL ADJUVANT; PHOSPHORYL LIPID A; RIBI; UNCLASSIFIED DRUG;

EID: 79251591958     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1002881     Document Type: Article
Times cited : (45)

References (61)
  • 1
    • 0030001674 scopus 로고    scopus 로고
    • Immunological memory and protective immunity: Understanding their relation
    • Ahmed, R., and D. Gray. 1996. Immunological memory and protective immunity: understanding their relation. Science 272: 54-60. (Pubitemid 26110754)
    • (1996) Science , vol.272 , Issue.5258 , pp. 54-60
    • Ahmed, R.1    Gray, D.2
  • 2
    • 35848969753 scopus 로고    scopus 로고
    • Duration of humoral immunity to common viral and vaccine antigens
    • Amanna, I. J., N. E. Carlson, and M. K. Slifka. 2007. Duration of humoral immunity to common viral and vaccine antigens. N. Engl. J. Med. 357: 1903-1915.
    • (2007) N. Engl. J. Med. , vol.357 , pp. 1903-1915
    • Amanna, I.J.1    Carlson, N.E.2    Slifka, M.K.3
  • 4
    • 70249085594 scopus 로고    scopus 로고
    • Memory B cells: Effectors of long-lived immune responses
    • Tangye, S. G., and D. M. Tarlinton. 2009. Memory B cells: effectors of long-lived immune responses. Eur. J. Immunol. 39: 2065-2075.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 2065-2075
    • Tangye, S.G.1    Tarlinton, D.M.2
  • 5
    • 84889416771 scopus 로고    scopus 로고
    • Development of vaccine adjuvants: A historical perspective
    • M. Singh, ed. John Wiley & Sons, Hoboken, NJ
    • Ott, G., and G. van Nest. 2006. Development of vaccine adjuvants: a historical perspective. In Vaccine Adjuvants and Delivery Systems. M. Singh, ed. John Wiley & Sons, Hoboken, NJ, p. 1-31.
    • (2006) Vaccine Adjuvants and Delivery Systems , pp. 1-31
    • Ott, G.1    Van Nest, G.2
  • 6
    • 32944478316 scopus 로고    scopus 로고
    • Translating innate immunity into immunological memory: Implications for vaccine development
    • Pulendran, B., and R. Ahmed. 2006. Translating innate immunity into immunological memory: implications for vaccine development. Cell 124: 849-863.
    • (2006) Cell , vol.124 , pp. 849-863
    • Pulendran, B.1    Ahmed, R.2
  • 8
    • 70349451542 scopus 로고    scopus 로고
    • Learning immunology from the yellow fever vaccine: Innate immunity to systems vaccinology
    • Pulendran, B. 2009. Learning immunology from the yellow fever vaccine: innate immunity to systems vaccinology. Nat. Rev. Immunol. 9: 741-747.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 741-747
    • Pulendran, B.1
  • 10
    • 0025370195 scopus 로고
    • Persistence of memory B cells in mice deprived of T cell help
    • Vieira, P., and K. Rajewsky. 1990. Persistence of memory B cells in mice deprived of T cell help. Int. Immunol. 2: 487-494.
    • (1990) Int. Immunol. , vol.2 , pp. 487-494
    • Vieira, P.1    Rajewsky, K.2
  • 11
    • 77955648669 scopus 로고    scopus 로고
    • The persistence of memory: A unique niche for IgG memory B cells
    • Cancro, M. P. 2010. The persistence of memory: a unique niche for IgG memory B cells. Proc. Natl. Acad. Sci. USA 107: 12737-12738.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 12737-12738
    • Cancro, M.P.1
  • 12
    • 0038142387 scopus 로고    scopus 로고
    • A role for Toll-like receptors in acquired immunity: Up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells
    • Bernasconi, N. L., N. Onai, and A. Lanzavecchia. 2003. A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood 101: 4500-4504.
    • (2003) Blood , vol.101 , pp. 4500-4504
    • Bernasconi, N.L.1    Onai, N.2    Lanzavecchia, A.3
  • 13
    • 49649112690 scopus 로고    scopus 로고
    • The agonists of TLR4 and 9 are sufficient to activate memory B cells to differentiate into plasma cells in vitro but not in vivo
    • Richard, K., S. K. Pierce, and W. Song. 2008. The agonists of TLR4 and 9 are sufficient to activate memory B cells to differentiate into plasma cells in vitro but not in vivo. J. Immunol. 181: 1746-1752.
    • (2008) J. Immunol. , vol.181 , pp. 1746-1752
    • Richard, K.1    Pierce, S.K.2    Song, W.3
  • 14
    • 69549120041 scopus 로고    scopus 로고
    • Distinction of the memory B cell response to cognate antigen versus bystander inflammatory signals
    • Benson, M. J., R. Elgueta, W. Schpero, M. Molloy, W. Zhang, E. Usherwood, and R. J. Noelle. 2009. Distinction of the memory B cell response to cognate antigen versus bystander inflammatory signals. J. Exp. Med. 206: 2013-2025.
    • (2009) J. Exp. Med. , vol.206 , pp. 2013-2025
    • Benson, M.J.1    Elgueta, R.2    Schpero, W.3    Molloy, M.4    Zhang, W.5    Usherwood, E.6    Noelle, R.J.7
  • 15
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392: 245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 16
    • 0037018097 scopus 로고    scopus 로고
    • Adjuvants of immunity: Harnessing innate immunity to promote adaptive immunity
    • Bendelac, A., and R. Medzhitov. 2002. Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J. Exp. Med. 195: F19-F23.
    • (2002) J. Exp. Med. , vol.195
    • Bendelac, A.1    Medzhitov, R.2
  • 17
    • 34548036949 scopus 로고    scopus 로고
    • Germinal-center organization and cellular dynamics
    • Allen, C. D., T. Okada, and J. G. Cyster. 2007. Germinal-center organization and cellular dynamics. Immunity 27: 190-202.
    • (2007) Immunity , vol.27 , pp. 190-202
    • Allen, C.D.1    Okada, T.2    Cyster, J.G.3
  • 20
    • 34247106805 scopus 로고    scopus 로고
    • Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release
    • Li, H., S. Nookala, and F. Re. 2007. Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release. J. Immunol. 178: 5271-5276. (Pubitemid 46595312)
    • (2007) Journal of Immunology , vol.178 , Issue.8 , pp. 5271-5276
    • Li, H.1    Nookala, S.2    Re, F.3
  • 21
    • 84889414582 scopus 로고    scopus 로고
    • Mechanisms of adjuvant action
    • M. Singh, ed. John Wiley & Sons, Hoboken, NJ
    • Lycke, N. 2006. Mechanisms of adjuvant action. In Vaccine Adjuvants and Delivery Systems. M. Singh, ed. John Wiley & Sons, Hoboken, NJ, p. 53-79.
    • (2006) Vaccine Adjuvants and Delivery Systems , pp. 53-79
    • Lycke, N.1
  • 22
    • 17644371966 scopus 로고    scopus 로고
    • Mucosal immunity and vaccines
    • Holmgren, J., and C. Czerkinsky. 2005. Mucosal immunity and vaccines. Nat. Med. 11(4, Suppl): S45-S53.
    • (2005) Nat. Med. , vol.11 , Issue.4 SUPPL.
    • Holmgren, J.1    Czerkinsky, C.2
  • 23
    • 0031569528 scopus 로고    scopus 로고
    • Genetically engineered nontoxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit
    • Agren, L. C., L. Ekman, B. Löwenadler, and N. Y. Lycke. 1997. Genetically engineered nontoxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit. J. Immunol. 158: 3936-3946.
    • (1997) J. Immunol. , vol.158 , pp. 3936-3946
    • Agren, L.C.1    Ekman, L.2    Löwenadler, B.3    Lycke, N.Y.4
  • 24
    • 0034660136 scopus 로고    scopus 로고
    • The ADP-ribosylating CTA1-DD adjuvant enhances T cell-dependent and independent responses by direct action on B cells involving antiapoptotic Bcl-2- And germinal center-promoting effects
    • Agren, L., E. Sverremark, L. Ekman, K. Schön, B. Löwenadler, C. Fernandez, and N. Lycke. 2000. The ADP-ribosylating CTA1-DD adjuvant enhances T cell-dependent and independent responses by direct action on B cells involving antiapoptotic Bcl-2- and germinal center-promoting effects. J. Immunol. 164: 6276-6286.
    • (2000) J. Immunol. , vol.164 , pp. 6276-6286
    • Agren, L.1    Sverremark, E.2    Ekman, L.3    Schön, K.4    Löwenadler, B.5    Fernandez, C.6    Lycke, N.7
  • 25
    • 4344665014 scopus 로고    scopus 로고
    • The cholera toxin-derived CTA1-DD vaccine adjuvant administered intranasally does not cause inflammation or accumulate in the nervous tissues
    • Eriksson, A. M., K. M. Schön, and N. Y. Lycke. 2004. The cholera toxin-derived CTA1-DD vaccine adjuvant administered intranasally does not cause inflammation or accumulate in the nervous tissues. J. Immunol. 173: 3310-3319.
    • (2004) J. Immunol. , vol.173 , pp. 3310-3319
    • Eriksson, A.M.1    Schön, K.M.2    Lycke, N.Y.3
  • 26
    • 0037035853 scopus 로고    scopus 로고
    • A dilemma for mucosal vaccination: Efficacy versus toxicity using enterotoxin-based adjuvants
    • Fujihashi, K., T. Koga, F. W. van Ginkel, Y. Hagiwara, and J. R. McGhee. 2002. A dilemma for mucosal vaccination: efficacy versus toxicity using enterotoxin-based adjuvants. Vaccine 20: 2431-2438.
    • (2002) Vaccine , vol.20 , pp. 2431-2438
    • Fujihashi, K.1    Koga, T.2    Van Ginkel, F.W.3    Hagiwara, Y.4    McGhee, J.R.5
  • 27
    • 1342268100 scopus 로고    scopus 로고
    • Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland
    • Mutsch, M., W. Zhou, P. Rhodes, M. Bopp, R. T. Chen, T. Linder, C. Spyr, and R. Steffen. 2004. Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland. N. Engl. J. Med. 350: 896-903.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 896-903
    • Mutsch, M.1    Zhou, W.2    Rhodes, P.3    Bopp, M.4    Chen, R.T.5    Linder, T.6    Spyr, C.7    Steffen, R.8
  • 28
    • 24144483089 scopus 로고    scopus 로고
    • Targeted vaccine adjuvants based on modified cholera toxin
    • Lycke, N. 2005. Targeted vaccine adjuvants based on modified cholera toxin. Curr. Mol. Med. 5: 591-597.
    • (2005) Curr. Mol. Med. , vol.5 , pp. 591-597
    • Lycke, N.1
  • 29
    • 58149401439 scopus 로고    scopus 로고
    • CTA1-DD adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization
    • Sundling, C., K. Schön, A. Mörner, M. N. Forsell, R. T. Wyatt, R. Thorstensson, G. B. Karlsson Hedestam, and N. Y. Lycke. 2008. CTA1-DD adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization. J. Gen. Virol. 89: 2954-2964.
    • (2008) J. Gen. Virol. , vol.89 , pp. 2954-2964
    • Sundling, C.1    Schön, K.2    Mörner, A.3    Forsell, M.N.4    Wyatt, R.T.5    Thorstensson, R.6    Karlsson Hedestam, G.B.7    Lycke, N.Y.8
  • 30
    • 47549116006 scopus 로고    scopus 로고
    • Vaccines: Correlates of vaccine-induced immunity
    • Plotkin, S. A. 2008. Vaccines: correlates of vaccine-induced immunity. Clin. Infect. Dis. 47: 401-409.
    • (2008) Clin. Infect. Dis. , vol.47 , pp. 401-409
    • Plotkin, S.A.1
  • 31
    • 47849101644 scopus 로고    scopus 로고
    • FDA/NIH/WHO public workshop on immune correlates of protection against influenza a viruses in support of pandemic vaccine development, Bethesda, Maryland, US, December 10-11, 2007
    • Eichelberger, M., H. Golding, M. Hess, J. Weir, K. Subbarao, C. J. Luke, M. Friede, and D. Wood. 2008. FDA/NIH/WHO public workshop on immune correlates of protection against influenza A viruses in support of pandemic vaccine development, Bethesda, Maryland, US, December 10-11, 2007. Vaccine 26: 4299-4303.
    • (2008) Vaccine , vol.26 , pp. 4299-4303
    • Eichelberger, M.1    Golding, H.2    Hess, M.3    Weir, J.4    Subbarao, K.5    Luke, C.J.6    Friede, M.7    Wood, D.8
  • 33
    • 34548660561 scopus 로고    scopus 로고
    • Antibodies and B Cell Memory in Viral Immunity
    • DOI 10.1016/j.immuni.2007.09.002, PII S1074761307004207
    • Dörner, T., and A. Radbruch. 2007. Antibodies and B cell memory in viral immunity. Immunity 27: 384-392. (Pubitemid 47418684)
    • (2007) Immunity , vol.27 , Issue.3 , pp. 384-392
    • Dorner, T.1    Radbruch, A.2
  • 34
    • 37549015263 scopus 로고    scopus 로고
    • Germinal centres: Role in B-cell physiology and malignancy
    • Klein, U., and R. Dalla-Favera. 2008. Germinal centres: role in B-cell physiology and malignancy. Nat. Rev. Immunol. 8: 22-33.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 22-33
    • Klein, U.1    Dalla-Favera, R.2
  • 36
  • 37
    • 0037073930 scopus 로고    scopus 로고
    • Maintenance of serological memory by polyclonal activation of human memory B cells
    • Bernasconi, N. L., E. Traggiai, and A. Lanzavecchia. 2002. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 298: 2199-2202.
    • (2002) Science , vol.298 , pp. 2199-2202
    • Bernasconi, N.L.1    Traggiai, E.2    Lanzavecchia, A.3
  • 38
    • 17144418984 scopus 로고    scopus 로고
    • Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1
    • Gatto, D., T. Pfister, A. Jegerlehner, S. W. Martin, M. Kopf, and M. F. Bachmann. 2005. Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1. J. Exp. Med. 201: 993-1005.
    • (2005) J. Exp. Med. , vol.201 , pp. 993-1005
    • Gatto, D.1    Pfister, T.2    Jegerlehner, A.3    Martin, S.W.4    Kopf, M.5    Bachmann, M.F.6
  • 40
    • 0032476611 scopus 로고    scopus 로고
    • Human immunoglobulin (Ig)M+ IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells
    • Klein, U., K. Rajewsky, and R. Küppers. 1998. Human immunoglobulin (Ig)M+ IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J. Exp. Med. 188: 1679-1689.
    • (1998) J. Exp. Med. , vol.188 , pp. 1679-1689
    • Klein, U.1    Rajewsky, K.2    Küppers, R.3
  • 42
    • 34548383012 scopus 로고    scopus 로고
    • New markers for murine memory B cells that define mutated and unmutated subsets
    • Anderson, S. M., M. M. Tomayko, A. Ahuja, A. M. Haberman, and M. J. Shlomchik. 2007. New markers for murine memory B cells that define mutated and unmutated subsets. J. Exp. Med. 204: 2103-2114.
    • (2007) J. Exp. Med. , vol.204 , pp. 2103-2114
    • Anderson, S.M.1    Tomayko, M.M.2    Ahuja, A.3    Haberman, A.M.4    Shlomchik, M.J.5
  • 44
    • 0025601012 scopus 로고
    • The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response
    • Weiss, U., and K. Rajewsky. 1990. The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response. J. Exp. Med. 172: 1681-1689.
    • (1990) J. Exp. Med. , vol.172 , pp. 1681-1689
    • Weiss, U.1    Rajewsky, K.2
  • 45
    • 0033557754 scopus 로고    scopus 로고
    • Adjuvanticity of the cholera toxin A1-based gene fusion protein, CTA1-DD, is critically dependent on the ADP-ribosyltransferase and Ig-binding activity
    • Agren, L. C., L. Ekman, B. Löwenadler, J. G. Nedrud, and N. Y. Lycke. 1999. Adjuvanticity of the cholera toxin A1-based gene fusion protein, CTA1-DD, is critically dependent on the ADP-ribosyltransferase and Ig-binding activity. J. Immunol. 162: 2432-2440.
    • (1999) J. Immunol. , vol.162 , pp. 2432-2440
    • Agren, L.C.1    Ekman, L.2    Löwenadler, B.3    Nedrud, J.G.4    Lycke, N.Y.5
  • 46
    • 0027533532 scopus 로고
    • Soluble antigen profoundly reduces memory B-cell numbers even when given after challenge immunization
    • Nossal, G. J., M. Karvelas, and B. Pulendran. 1993. Soluble antigen profoundly reduces memory B-cell numbers even when given after challenge immunization. Proc. Natl. Acad. Sci. USA 90: 3088-3092.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3088-3092
    • Nossal, G.J.1    Karvelas, M.2    Pulendran, B.3
  • 47
    • 0022802257 scopus 로고
    • Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP
    • Cumano, A., and K. Rajewsky. 1986. Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP. EMBO J. 5: 2459-2468.
    • (1986) EMBO J. , vol.5 , pp. 2459-2468
    • Cumano, A.1    Rajewsky, K.2
  • 48
    • 0023161406 scopus 로고
    • Mutation drift and repertoire shift in the maturation of the immune response
    • Berek, C., and C. Milstein. 1987. Mutation drift and repertoire shift in the maturation of the immune response. Immunol. Rev. 96: 23-41.
    • (1987) Immunol. Rev. , vol.96 , pp. 23-41
    • Berek, C.1    Milstein, C.2
  • 50
    • 77952557954 scopus 로고    scopus 로고
    • PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells
    • Good-Jacobson, K. L., C. G. Szumilas, L. Chen, A. H. Sharpe, M. M. Tomayko, and M. J. Shlomchik. 2010. PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat. Immunol. 11: 535-542.
    • (2010) Nat. Immunol. , vol.11 , pp. 535-542
    • Good-Jacobson, K.L.1    Szumilas, C.G.2    Chen, L.3    Sharpe, A.H.4    Tomayko, M.M.5    Shlomchik, M.J.6
  • 52
    • 0037128644 scopus 로고    scopus 로고
    • Short-lived and long-lived bone marrow plasma cells are derived from a novel precursor population
    • O'Connor, B. P., M. Cascalho, and R. J. Noelle. 2002. Short-lived and long-lived bone marrow plasma cells are derived from a novel precursor population. J. Exp. Med. 195: 737-745.
    • (2002) J. Exp. Med. , vol.195 , pp. 737-745
    • O'Connor, B.P.1    Cascalho, M.2    Noelle, R.J.3
  • 54
    • 56749098376 scopus 로고    scopus 로고
    • How to cope with pathogenic long-lived plasma cells in autoimmune diseases
    • Hoyer, B. F., I. M. Mumtaz, T. Yoshida, F. Hiepe, and A. Radbruch. 2008. How to cope with pathogenic long-lived plasma cells in autoimmune diseases. Ann. Rheum. Dis. 67(Suppl 3): iii87-iii89.
    • (2008) Ann. Rheum. Dis. , vol.67 , Issue.SUPPL. 3
    • Hoyer, B.F.1    Mumtaz, I.M.2    Yoshida, T.3    Hiepe, F.4    Radbruch, A.5
  • 55
    • 0036721767 scopus 로고    scopus 로고
    • RGS13 regulates germinal center B lymphocytes responsiveness to CXC chemokine ligand (CXCL)12 and CXCL13
    • Shi, G. X., K. Harrison, G. L. Wilson, C. Moratz, and J. H. Kehrl. 2002. RGS13 regulates germinal center B lymphocytes responsiveness to CXC chemokine ligand (CXCL)12 and CXCL13. J. Immunol. 169: 2507-2515.
    • (2002) J. Immunol. , vol.169 , pp. 2507-2515
    • Shi, G.X.1    Harrison, K.2    Wilson, G.L.3    Moratz, C.4    Kehrl, J.H.5
  • 56
    • 68649108084 scopus 로고    scopus 로고
    • Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses
    • Gatto, D., D. Paus, A. Basten, C. R. Mackay, and R. Brink. 2009. Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity 31: 259-269.
    • (2009) Immunity , vol.31 , pp. 259-269
    • Gatto, D.1    Paus, D.2    Basten, A.3    Mackay, C.R.4    Brink, R.5
  • 57
    • 73349126428 scopus 로고    scopus 로고
    • Taking advantage: High-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells
    • Anderson, S. M., A. Khalil, M. Uduman, U. Hershberg, Y. Louzoun, A. M. Haberman, S. H. Kleinstein, and M. J. Shlomchik. 2009. Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells. J. Immunol. 183: 7314-7325.
    • (2009) J. Immunol. , vol.183 , pp. 7314-7325
    • Anderson, S.M.1    Khalil, A.2    Uduman, M.3    Hershberg, U.4    Louzoun, Y.5    Haberman, A.M.6    Kleinstein, S.H.7    Shlomchik, M.J.8
  • 58
    • 8444222647 scopus 로고    scopus 로고
    • B cells expressing Bcl-2 and a signaling-impaired BAFF-specific receptor fail to mature and are deficient in the formation of lymphoid follicles and germinal centers
    • Rahman, Z. S., and T. Manser. 2004. B cells expressing Bcl-2 and a signaling-impaired BAFF-specific receptor fail to mature and are deficient in the formation of lymphoid follicles and germinal centers. J. Immunol. 173: 6179-6188.
    • (2004) J. Immunol. , vol.173 , pp. 6179-6188
    • Rahman, Z.S.1    Manser, T.2
  • 59
    • 0034686497 scopus 로고    scopus 로고
    • Analysis of immunoglobulin (Ig) isotype diversity and IgM/D memory in the response to phenyl-oxazolone
    • White, H., and D. Gray. 2000. Analysis of immunoglobulin (Ig) isotype diversity and IgM/D memory in the response to phenyl-oxazolone. J. Exp. Med. 191: 2209-2220.
    • (2000) J. Exp. Med. , vol.191 , pp. 2209-2220
    • White, H.1    Gray, D.2
  • 60
    • 0031861905 scopus 로고    scopus 로고
    • Long-lived plasma cells: A mechanism for maintaining persistent antibody production
    • Slifka, M. K., and R. Ahmed. 1998. Long-lived plasma cells: a mechanism for maintaining persistent antibody production. Curr. Opin. Immunol. 10: 252-258.
    • (1998) Curr. Opin. Immunol. , vol.10 , pp. 252-258
    • Slifka, M.K.1    Ahmed, R.2


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