The Enigma of ENIGMA-I

Anesthesia and Analgesia

Volumn 112, Issue 2, 2011, Pages 255-257

  Beattie, W Scott ^a   Badner, Neal H ^b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b WESTERN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; FOLIC ACID; HOMOCYSTEINE; METOPROLOL; NITROUS OXIDE; PLACEBO; VITAMIN B GROUP;

ABDOMINAL SURGERY; ANESTHESIA; ATELECTASIS; DRUG SAFETY; ENDOTHELIAL DYSFUNCTION; GENERAL ANESTHESIA; HEART INFARCTION; HIGH RISK PATIENT; HUMAN; HYPERHOMOCYSTEINEMIA; INTENSIVE CARE UNIT; LIFESTYLE; PNEUMONIA; POSTOPERATIVE INFECTION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; REVIEW; RISK FACTOR; RISK REDUCTION; STROKE; SURGICAL MORTALITY; SURGICAL PATIENT; SURGICAL RISK; SURVIVAL RATE; TREATMENT OUTCOME; VASODILATATION; VOMITING; WOUND INFECTION;

EID: 79251582828     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e3182032521     Document Type: Editorial

References (21)

1. Weiser TG, Regenbogen SG, Thompson KD, Haynes AB, Lipsitz SR, Berry WR, Gawanda AA. An estimation of the global volume of surgery: a modelling strategy based on available data. Lancet 2008;372:139-44
2. Wijeysundera DN, Austin PC, Beattie WS, Hux JE, Laupacis A. Outcomes and processes of care related to preoperative medical consultation. Arch Intern Med 2010:170; 1365-74
3. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I. Hyperhomocysteinemia: a risk factor for vascular disease. N Engl J Med 1991;324:1149-55
4. Chambers JC, McGregor A, Jean-Marie J, Obeid OA, Kooner JS. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. Circulation 1999;99:1156-60
5. Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 2002;325:1202-8
6. Mayer EL, Jacobsen DW, Robinson K. Homocysteine and coronary atherosclerosis. J Am Coll Cardiol 1996;27:517-27
7. Badner NH, Drader K, Freeman D, Spence JD. The use of intraoperative nitrous oxide leads to postoperative elevations in plasma homocysteine. Anesth Analg 1998;87:711-3
8. Badner NH, Beattie WS, Freeman D, Spence JD. Nitrous oxide-induced elevated homocysteine concentrations are associated with increased myocardial ischemia in patients undergoing carotid endarterectomy. Anesth Analg 2000;91:1073-9
9. Badner NH, Freeman D, Spence JD. Preoperative oral B vitamins prevent nitrous oxide-induced postoperative plasma homocysteine increases. Anesth Analg 2001;93:1507-10
10. Nagele P, Zeugswetter B, Wiener C, Burger H, Hüpfl M, Mittlböck M, Födinger M. Influence of methylenetetrahydrofolate reductase gene polymorphisms on homocysteine concentrations after nitrous oxide anesthesia. Anesthesiology 2008;109:36-43
11. Myles PS, Leslie K, Chan MTV, Forbes A, Paech MJ, Peyton P, Silbert BS, Pascoe E. Avoidance of nitrous oxide for patients undergoing major surgery. Anesthesiology 2007;107:221-31
12. Hynes MD. Catecholamine mechanisms in the stimulation of mouse locomotor activity by nitrous oxide and morphine. Eur J Pharmacol 1983;90:109-14
13. Myles PS, Chan MTV, Leslie K, Peyton P, Paech M, Forbes A. Effect of nitrous oxide on plasma homocysteine and folate in patients undergoing major surgery. Br J Anaesth 2008;100:780-6
14. Myles PS, Chan MTV, McIlory D, Lau C, Symons J, Chen S. Effect of nitrous oxide anesthesia on plasma homocysteine and endothelial function. Anesthesiology 2008;109:657-63
15. Leslie K, Myles PS, Chan MTV, Forbes A, Paech M, Peyton P, Silbert BS, Williamson E. Nitrous oxide and long-term morbidity and mortality in the ENIGMA trial. Anesth Analg 2011;112:387-93
16. Geng EH, Bangsberg DR, Musinguzi N. Understanding reasons for and outcomes of patients lost to follow-up in antiretroviral therapy programs in Africa through a sampling-based approach. J Acquir Immune Defic Syndr 2010;53:405-11
17. POISE Study Group, Devereaux PJ, Yang H, Yusuf S, Guyatt G, Leslie K, Villar JC, Xavier D, Chrolavicius S, Greenspan L, Pogue J, Pais P, Liu L, Xu S, Málaga G, Avezum A, Chan M, Montori VM, Jacka M, Choi P. Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomized controlled trial. Lancet 2008;371:1839-47
18. Mangano D, Layug EL, Wallace A, Tateo I. Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. N Engl J Med 1996;335:1713-20
19. Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group, Armitage JM, Bowman L, Clarke RJ, Wallendszus K, Bulbulia R, Rahimi K, Haynes R, Parish S, Sleight P, Peto R, Collins R. Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors. JAMA 2010;303:2486-94
20. EVAR trial participants. Endovascular aneurysm repair vs open repair in patients with abdominal aortic aneurysm (EVAR trial 1): randomised controlled trial. Lancet 2005;365:2179-86
21. Myles PS, Leslie K, Peyton P, Paech M, Forbes A, Chan MTV, Sessler D, Devereaux PJ, Silbert BS, Jamrozik K, Beattie S, Badner N, Tomlinson J, Wallace S; ANZCA Trials Group. Nitrous Oxide and Perioperative Cardiac Morbidity (ENIGMA-II) Trial: rationale and design. Am Heart J 2009;157:488-94