The use of intraoperative nitrous oxide leads to postoperative increases in plasma homocysteine

Anesthesia and Analgesia

Volumn 87, Issue 3, 1998, Pages 711-713

  Badner, Neal H ^a,b   Drader, Keith ^a   Freeman, David ^a   Spence, J D ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HOMOCYSTEINE; METHIONINE; METHIONINE SYNTHASE; NITROUS OXIDE;

ADULT; AGED; ARTICLE; CEREBROVASCULAR DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CRANIOTOMY; DRUG MECHANISM; ELECTIVE SURGERY; FEMALE; GENERAL ANESTHESIA; HUMAN; HYPERHOMOCYSTEINEMIA; INTRAOPERATIVE PERIOD; MALE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR;

EID: 0031688736     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/00000539-199809000-00041     Document Type: Article

References (15)

1. Clarke R, Daly L, Robinson K, et al. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 1991;324:1149-55.
2. Robinson K, Mayer EL, Miller DP, et al. Hyperhomocysteinemia and low pyridoxal phosphate: common and independent risk factors for coronary artery disease. Circulation 1995;92:2825-30.
3. Mayer EL, Jacobsen DW, Robinson K. Homocysteine and coronary atherosclerosis. J Am Coll Cardiol 1996;27:517-27.
4. 12. Br J Anaesth 1987;59:3-13.
5. Christensen B, Refsum H, Garras A, Ueland PM. Homocysteine remethylation during nitrous oxide exposure of cells cultured in media containing various concentrations of folates. J Pharmacol Exp Ther 1992;261:1096-105.
6. Koblin DD, Waskell L, Watson JE, et al. Nitrous oxide inactivates methionine synthetase in human liver. Anesth Analg 1982; 61:75-8.
7. Christensen B, Guttormsen AB, Schneede J, et al. Preoperative methionine loading enhances restoration of the cobalamin-dependent enzyme methionine synthase after nitrous oxide anesthesia. Anesthesiology 1994;80:1046-56.
8. Ermens AA, Refsum H, Ruprecht J. Monitoring cobalamin inactivation during nitrous oxide anesthesia by determination of homocysteine and folate in plasma and urine. Clin Pharm Ther 1991;9:385-93.
9. Badner NH, Knill RL, Brown JE, et al. Myocardial infarction after noncardiac surgery. Anesthesiology 1998;88:572-8.
10. Marshall BE, Longnecker DE. General anesthetics. In: Hardman JG, Limbird LE, Malinoff PB, et al., eds. Goodman & Gilman's the pharmacological basis of therapeutics. 9th ed. New York: McGraw-Hill, 1995:307-30.
11. Jacobsen DW, Gatoutis VJ, Green R, et al. Rapid HPLC determination of total homocysteine and other thiols in serum and plasma: sex differences and correlation with cobalamin and folate concentrations in healthy subjects. Clin Chem 1991;40:873-81.
12. Chambers JC, McGregor A, Jean-Marie J, Kooner JS. Acute hyperhomocysteinaemia and endothelial dysfunction. Lancet 1998;51:36-7.
13. Stamler JS, Osborne JA, Jaraki O, et al. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest 1993;91:308-18.
14. Ubbink JB, Vermaak WJH, van der Merwe A, et al. Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J Nutr 1994;124:1927-33.
15. Peterson JC, Spence JD. Vitamins and progression of atherosclerosis in hyper-homocyst(e)inemia. Lancet 1998;351:263.