In vitro biotransformation, in vivo efficacy and pharmacokinetics of antimalarial chalcones

Pharmacology

Volumn 87, Issue 1-2, 2011, Pages 96-104

  Gutteridge, Clare E ^a   Thota, Darshan S ^a   Curtis, Sean M ^a,b   Kozar, Michael P ^b   Li, Qigui ^b   Xie, Lisa ^b   Zhang, Jing ^b   Melendez, Victor ^b   Asher, Constance O ^b   Luong, Thulan T ^b   Gerena, Lucia ^b   Nichols, Daniel A ^b   Montip, Gettayacamin ^c  

^a UNITED STATES NAVAL ACADEMY   (United States)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c ARMED FORCES RESEARCH INSTITUTE OF MEDICAL SCIENCES   (Thailand)

Author keywords

4' Butoxy 2,4 dimethoxy chalcone; 4 n Butoxy 2,4 dimethoxy chalcone; Antiprotozoal activity; Biotransformation; Chalcone; Malaria; Microsomal digest; Pharmacokinetics

Indexed keywords

4' (1 HYDROXY N BUTOXY) 2,4 DIMETHOXY CHALCONE; 4' N BUTOXY 2,4 DIMETHOXY CHALCONE; 4' N BUTOXY 4 HYDROXY 2 METHOXY CHALCONE; ANTIMALARIAL AGENT; CHALCONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG EXCRETION; DRUG METABOLISM; DRUG TRANSFORMATION; IN VITRO STUDY; IN VIVO STUDY; MALARIA; MALE; MOUSE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; TREATMENT OUTCOME;

ANIMALS; ANTIMALARIALS; BIOTRANSFORMATION; CHALCONES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; HALF-LIFE; HUMANS; INHIBITORY CONCENTRATION 50; MALARIA; MALE; MICE; MICE, INBRED ICR; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PLASMODIUM BERGHEI; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SURVIVAL ANALYSIS; TANDEM MASS SPECTROMETRY;

EID: 79251560646     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000322532     Document Type: Article

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