-
1
-
-
0032929520
-
Tumoricidal activity of tumor necrosis factorrelated apoptosis-inducing ligand in vivo
-
Walczak, H. et al. (1999) Tumoricidal activity of tumor necrosis factorrelated apoptosis-inducing ligand in vivo. Nat. Med., 5, 157-163.
-
(1999)
Nat. Med.
, vol.5
, pp. 157-163
-
-
Walczak, H.1
-
2
-
-
0030996297
-
The receptor for the cytotoxic ligand TRAIL
-
Pan, G. et al. (1997) The receptor for the cytotoxic ligand TRAIL. Science, 276, 111-113.
-
(1997)
Science
, vol.276
, pp. 111-113
-
-
Pan, G.1
-
3
-
-
0030880548
-
TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL
-
Walczak, H. et al. (1997) TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J., 16, 5386-5397.
-
(1997)
EMBO J.
, vol.16
, pp. 5386-5397
-
-
Walczak, H.1
-
4
-
-
0030869432
-
Cloning and characterization of TRAILR3, a novel member of the emerging TRAIL receptor family
-
Degli-Esposti, M.A. et al. (1997) Cloning and characterization of TRAILR3, a novel member of the emerging TRAIL receptor family. J. Exp. Med., 186, 1165-1170.
-
(1997)
J. Exp. Med.
, vol.186
, pp. 1165-1170
-
-
Degli-Esposti, M.A.1
-
5
-
-
0031414749
-
The novel receptor TRAIL-R4 induces NF-κB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain
-
Degli-Esposti, M.A. et al. (1997) The novel receptor TRAIL-R4 induces NF-κB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity, 7, 813-820.
-
(1997)
Immunity
, vol.7
, pp. 813-820
-
-
Degli-Esposti, M.A.1
-
6
-
-
7344233085
-
Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL
-
Emery, J.G. et al. (1998) Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J. Biol. Chem., 273, 14363-14367.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14363-14367
-
-
Emery, J.G.1
-
7
-
-
0028883850
-
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
-
Kischkel, F.C. et al. (1995) Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J, 14, 5579-5588.
-
(1995)
EMBO J.
, vol.14
, pp. 5579-5588
-
-
Kischkel, F.C.1
-
8
-
-
0033662433
-
Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5
-
Kischkel, F.C. et al. (2000) Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity, 12, 611-620.
-
(2000)
Immunity
, vol.12
, pp. 611-620
-
-
Kischkel, F.C.1
-
9
-
-
0037291871
-
A unified model for apical caspase activation
-
Boatright, K.M. et al. (2003) A unified model for apical caspase activation. Mol. Cell., 11, 529-541.
-
(2003)
Mol. Cell.
, vol.11
, pp. 529-541
-
-
Boatright, K.M.1
-
10
-
-
0031405585
-
TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB
-
Schneider, P. et al. (1997) TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Immunity, 7, 831-836.
-
(1997)
Immunity
, vol.7
, pp. 831-836
-
-
Schneider, P.1
-
11
-
-
0034353454
-
Inhibition of NF-kappaB activity enhances TRAIL mediated apoptosis in breast cancer cell lines
-
Keane, M.M. et al. (2000) Inhibition of NF-kappaB activity enhances TRAIL mediated apoptosis in breast cancer cell lines. Breast Cancer Res. Treat., 64, 211-219.
-
(2000)
Breast Cancer Res. Treat.
, vol.64
, pp. 211-219
-
-
Keane, M.M.1
-
12
-
-
0034744033
-
NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling
-
Kreuz, S. et al. (2001) NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Mol. Cell. Biol., 21, 3964-3973.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3964-3973
-
-
Kreuz, S.1
-
13
-
-
0032508414
-
NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
-
Wang, C.Y. et al. (1998) NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science, 281, 1680-1683.
-
(1998)
Science
, vol.281
, pp. 1680-1683
-
-
Wang, C.Y.1
-
14
-
-
71149093922
-
The TRAIL to targeted therapy of breast cancer
-
Rahman, M. et al. (2009) The TRAIL to targeted therapy of breast cancer. Adv. Cancer Res., 103, 43-73.
-
(2009)
Adv. Cancer Res.
, vol.103
, pp. 43-73
-
-
Rahman, M.1
-
15
-
-
57749097095
-
TRAIL resistance of breast cancer cells is associated with constitutive endocytosis of death receptors 4 and 5
-
Zhang, Y. et al. (2008) TRAIL resistance of breast cancer cells is associated with constitutive endocytosis of death receptors 4 and 5. Mol. Cancer Res., 6, 1861-1871.
-
(2008)
Mol. Cancer Res.
, vol.6
, pp. 1861-1871
-
-
Zhang, Y.1
-
16
-
-
33749004024
-
Flavopiridol induces cellular FLICE-inhibitory protein degradation by the proteasome and promotes TRAIL-induced early signaling and apoptosis in breast tumor cells
-
Palacios, C. et al. (2006) Flavopiridol induces cellular FLICE-inhibitory protein degradation by the proteasome and promotes TRAIL-induced early signaling and apoptosis in breast tumor cells. Cancer Res., 66, 8858-8869.
-
(2006)
Cancer Res.
, vol.66
, pp. 8858-8869
-
-
Palacios, C.1
-
17
-
-
0037018277
-
Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression
-
Fulda, S. et al. (2002) Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression. Oncogene, 21, 2283-2294.
-
(2002)
Oncogene
, vol.21
, pp. 2283-2294
-
-
Fulda, S.1
-
18
-
-
0033083990
-
Chemotherapy augments TRAIL-induced apoptosis in breast cell lines
-
Keane, M.M. et al. (1999) Chemotherapy augments TRAIL-induced apoptosis in breast cell lines. Cancer Res., 59, 734-741.
-
(1999)
Cancer Res.
, vol.59
, pp. 734-741
-
-
Keane, M.M.1
-
19
-
-
0141705424
-
Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo
-
Singh, T.R. et al. (2003) Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo. Cancer Res., 63, 5390-5400.
-
(2003)
Cancer Res.
, vol.63
, pp. 5390-5400
-
-
Singh, T.R.1
-
20
-
-
0037007179
-
A novel cyclodextrin-derived tellurium compound with glutathione peroxidase activity
-
Ren, X. et al. (2002) A novel cyclodextrin-derived tellurium compound with glutathione peroxidase activity. Chembiochem, 3, 356-363.
-
(2002)
Chembiochem
, vol.3
, pp. 356-363
-
-
Ren, X.1
-
21
-
-
0346731228
-
Cyclodextrin-derived diorganyl tellurides as glutathione peroxidase mimics and inhibitors of thioredoxin reductase and cancer cell growth
-
McNaughton, M. et al. (2004) Cyclodextrin-derived diorganyl tellurides as glutathione peroxidase mimics and inhibitors of thioredoxin reductase and cancer cell growth. J. Med. Chem., 47, 233-239.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 233-239
-
-
McNaughton, M.1
-
22
-
-
17544373267
-
The molecular mechanism of protecting cells against oxidative stress by 2-selenium-bridged beta-cyclodextrin with glutathione peroxidase activity
-
Sun, Y. et al. (2005) The molecular mechanism of protecting cells against oxidative stress by 2-selenium-bridged beta-cyclodextrin with glutathione peroxidase activity. Biochim. Biophys. Acta., 1743, 199-204.
-
(2005)
Biochim. Biophys. Acta.
, vol.1743
, pp. 199-204
-
-
Sun, Y.1
-
23
-
-
0038206990
-
Towards more efficient glutathione peroxidase mimics: substrate recognition and catalytic group assembly
-
Luo, G.M. et al. (2003) Towards more efficient glutathione peroxidase mimics: substrate recognition and catalytic group assembly. Curr. Med. Chem., 10, 1151-1183.
-
(2003)
Curr. Med. Chem.
, vol.10
, pp. 1151-1183
-
-
Luo, G.M.1
-
24
-
-
0027533505
-
Ebselen, a selenoorganic compound as glutathione peroxidase mimic
-
Sies, H. (1993) Ebselen, a selenoorganic compound as glutathione peroxidase mimic. Free Radic. Biol. Med., 14, 313-323.
-
(1993)
Free Radic. Biol. Med.
, vol.14
, pp. 313-323
-
-
Sies, H.1
-
25
-
-
33646184635
-
Cyclodextrin-derived mimic of glutathione peroxidase exhibiting enzymatic specificity and high catalytic efficiency
-
Dong, Z.Y. et al. (2006) Cyclodextrin-derived mimic of glutathione peroxidase exhibiting enzymatic specificity and high catalytic efficiency. Chemistry, 12, 3575-3579.
-
(2006)
Chemistry
, vol.12
, pp. 3575-3579
-
-
Dong, Z.Y.1
-
26
-
-
11444256090
-
Aryl thiol substrate 3-carboxy-4-nitrobenzenethiol strongly stimulating thiol peroxidase activity of glutathione peroxidase mimic 2,2'-ditellurobis(2-deoxy-beta-cyclodextrin)
-
Dong, Z. et al. (2004) Aryl thiol substrate 3-carboxy-4-nitrobenzenethiol strongly stimulating thiol peroxidase activity of glutathione peroxidase mimic 2,2'-ditellurobis(2-deoxy-beta-cyclodextrin). J. Am. Chem. Soc., 126, 16395-16404.
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 16395-16404
-
-
Dong, Z.1
-
27
-
-
0034447210
-
Water-soluble organotellurium compounds inhibit thioredoxin reductase and the growth of human cancer cells
-
Engman, L. et al. (2000) Water-soluble organotellurium compounds inhibit thioredoxin reductase and the growth of human cancer cells. Anticancer Drug Des., 15, 323-330.
-
(2000)
Anticancer Drug Des.
, vol.15
, pp. 323-330
-
-
Engman, L.1
-
28
-
-
33751181030
-
On the potential of thioredoxin reductase inhibitors for cancer therapy
-
Urig, S. et al. (2006) On the potential of thioredoxin reductase inhibitors for cancer therapy. Semin. Cancer Biol., 16, 452-465.
-
(2006)
Semin. Cancer Biol.
, vol.16
, pp. 452-465
-
-
Urig, S.1
-
29
-
-
84984583119
-
Organoselenium and organotellurium compounds: toxicology and pharmacology
-
Nogueira, C.W. et al. (2004) Organoselenium and organotellurium compounds: toxicology and pharmacology. Chem. Rev., 104, 6255-6285.
-
(2004)
Chem. Rev.
, vol.104
, pp. 6255-6285
-
-
Nogueira, C.W.1
-
30
-
-
36749022747
-
Thioredoxin and thioredoxin reductase as redox-sensitive molecular targets for cancer therapy
-
Pennington, J.D. et al. (2007) Thioredoxin and thioredoxin reductase as redox-sensitive molecular targets for cancer therapy. Curr. Pharm. Des., 13, 3368-3377.
-
(2007)
Curr. Pharm. Des.
, vol.13
, pp. 3368-3377
-
-
Pennington, J.D.1
-
31
-
-
67649414928
-
Effect of 2-TeCD on the expression of adhesion molecules in human umbilical vein endothelial cells under the stimulation of tumor necrosis factor-alpha
-
Wang, K. et al. (2009) Effect of 2-TeCD on the expression of adhesion molecules in human umbilical vein endothelial cells under the stimulation of tumor necrosis factor-alpha. Int. Immunopharmacol., 9, 1087-1091.
-
(2009)
Int. Immunopharmacol.
, vol.9
, pp. 1087-1091
-
-
Wang, K.1
-
32
-
-
0035798180
-
Promoter structure and transcription initiation sites of the human death receptor 5/TRAIL-R2 gene
-
Yoshida, T. et al. (2001) Promoter structure and transcription initiation sites of the human death receptor 5/TRAIL-R2 gene. FEBS Lett., 507, 381-385.
-
(2001)
FEBS Lett.
, vol.507
, pp. 381-385
-
-
Yoshida, T.1
-
33
-
-
85047692516
-
Signalling pathways of the TNF superfamily: a double-edged sword
-
Aggarwal, B.B. (2000) Signalling pathways of the TNF superfamily: a double-edged sword. Nat. Rev. Immunol., 3, 745-756.
-
(2000)
Nat. Rev. Immunol.
, vol.3
, pp. 745-756
-
-
Aggarwal, B.B.1
-
34
-
-
0025266685
-
Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B
-
Ghosh, S. et al. (1990) Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B. Nature, 344, 678-682.
-
(1990)
Nature
, vol.344
, pp. 678-682
-
-
Ghosh, S.1
-
35
-
-
0034812659
-
Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: characterization of in vivo efficacy, pharmacokinetics, and safety
-
Kelley, S.K. et al. (2001) Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: characterization of in vivo efficacy, pharmacokinetics, and safety. J. Pharmacol. Exp. Ther., 299, 31-38.
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.299
, pp. 31-38
-
-
Kelley, S.K.1
-
36
-
-
0035963273
-
Constitutive activation of nuclear factor-kappaB prevents TRAIL-induced apoptosis in renal cancer cells
-
Oya, M. et al. (2001) Constitutive activation of nuclear factor-kappaB prevents TRAIL-induced apoptosis in renal cancer cells. Oncogene, 20, 3888-3896.
-
(2001)
Oncogene
, vol.20
, pp. 3888-3896
-
-
Oya, M.1
-
37
-
-
0034660880
-
The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase
-
Li, S. et al. (2000) The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase. Cancer Res., 60, 3927-3939.
-
(2000)
Cancer Res.
, vol.60
, pp. 3927-3939
-
-
Li, S.1
-
38
-
-
51649089169
-
Ebselen sensitizes glioblastoma cells to Tumor Necrosis Factor (TNFalpha)-induced apoptosis through two distinct pathways involving NF-kappaB downregulation and Fas-mediated formation of death inducing signaling complex
-
Sharma, V. et al. (2008) Ebselen sensitizes glioblastoma cells to Tumor Necrosis Factor (TNFalpha)-induced apoptosis through two distinct pathways involving NF-kappaB downregulation and Fas-mediated formation of death inducing signaling complex. Int. J. Cancer., 123, 2204-2212.
-
(2008)
Int. J. Cancer.
, vol.123
, pp. 2204-2212
-
-
Sharma, V.1
-
39
-
-
0029999693
-
Inhibition of IkB-a phosphorylation and degradation and subsequent NF-kB activation by glutathione peroxidase overexpression
-
Kretz-Remy, C. et al. (1996) Inhibition of IkB-a phosphorylation and degradation and subsequent NF-kB activation by glutathione peroxidase overexpression. J. Cell Biol., 133, 1083-1093.
-
(1996)
J. Cell Biol.
, vol.133
, pp. 1083-1093
-
-
Kretz-Remy, C.1
-
40
-
-
0034936463
-
GPx-1 gene delivery modulates NFkappaB activation following diverse environmental injuries through a specific subunit of the IKK complex
-
Li, Q. et al. (2001) GPx-1 gene delivery modulates NFkappaB activation following diverse environmental injuries through a specific subunit of the IKK complex. Antioxid. Redox Signal., 3, 415-432.
-
(2001)
Antioxid. Redox Signal.
, vol.3
, pp. 415-432
-
-
Li, Q.1
-
41
-
-
0035895885
-
c-Jun NH2-terminal kinase-mediated redox-dependent degradation of IkappaB: role of thioredoxin in NF-kappaB activation
-
Das, K.C. (2001) c-Jun NH2-terminal kinase-mediated redox-dependent degradation of IkappaB: role of thioredoxin in NF-kappaB activation. J. Biol. Chem., 276, 4662-4670.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 4662-4670
-
-
Das, K.C.1
-
42
-
-
0027217531
-
Oxidoreductive regulation of nuclear factor kappa B Involvement of a cellular reducing catalyst thioredoxin
-
Hayashi, T. et al. (1993) Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin. J. Biol. Chem., 268, 11380-11388.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 11380-11388
-
-
Hayashi, T.1
-
43
-
-
0031253977
-
KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene
-
Wu, G.S. et al. (1997) KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nat. Genet., 17, 141-143.
-
(1997)
Nat. Genet.
, vol.17
, pp. 141-143
-
-
Wu, G.S.1
-
44
-
-
55749086991
-
15-deoxy-Delta12 14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription
-
Su, R.Y. et al. (2008) 15-deoxy-Delta12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription. Mol. Cancer Ther., 7, 3429-3440.
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 3429-3440
-
-
Su, R.Y.1
-
45
-
-
6444242600
-
Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells
-
Kim, Y.H. et al. (2004) Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells. Carcinogenesis, 25, 1813-1820.
-
(2004)
Carcinogenesis
, vol.25
, pp. 1813-1820
-
-
Kim, Y.H.1
-
46
-
-
44449107683
-
Inhibition of Yin Yang 1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL enhanced apoptosis in cancer cells
-
Baritaki, S. et al. (2008) Inhibition of Yin Yang 1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL enhanced apoptosis in cancer cells. J. Immunol., 180, 6199-6210.
-
(2008)
J. Immunol.
, vol.180
, pp. 6199-6210
-
-
Baritaki, S.1
-
47
-
-
0346422479
-
Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-terminal kinase-dependent pathway involving Sp1
-
Higuchi, H. et al. (2004) Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-terminal kinase-dependent pathway involving Sp1. J. Biol. Chem., 279, 51-60.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 51-60
-
-
Higuchi, H.1
-
48
-
-
27744597128
-
Histone deacetylase inhibitors modulate renal cell carcinoma sensitivity to TRAIL/Apo-2L-induced apoptosis by enhancing TRAIL-R2 expression
-
VanOosten,R.L. et al. (2005) Histone deacetylase inhibitors modulate renal cell carcinoma sensitivity to TRAIL/Apo-2L-induced apoptosis by enhancing TRAIL-R2 expression. Cancer Biol. Ther., 4, 1104-1112.
-
(2005)
Cancer Biol. Ther.
, vol.4
, pp. 1104-1112
-
-
VanOosten, R.L.1
-
49
-
-
38749127515
-
Sp1 is involved in 8-chloro-adenosine-upregulated death receptor 5 expression in human hepatoma cells
-
Sun, M. et al. (2008) Sp1 is involved in 8-chloro-adenosine-upregulated death receptor 5 expression in human hepatoma cells. Oncol. Rep., 19, 177-185.
-
(2008)
Oncol. Rep.
, vol.19
, pp. 177-185
-
-
Sun, M.1
-
50
-
-
57349169369
-
Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation
-
Kim, J.Y. et al. (2008) Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation. J. Cell. Biochem., 105, 1386-1398.
-
(2008)
J. Cell. Biochem.
, vol.105
, pp. 1386-1398
-
-
Kim, J.Y.1
|