Persistence of gut mucosal innate immune defenses by enteric α-defensin expression in the simian immunodeficiency virus model of AIDS

Journal of Immunology

Volumn 186, Issue 3, 2011, Pages 1589-1597

  Zaragoza, Melinda M ^a   Sankaran Walters, Sumathi ^a   Canfield, Don R ^b   Hung, Jason K S ^a   Martinez, Enrique ^a   Ouellette, André J ^c   Dandekar, Satya ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; MESSENGER RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CRYPT CELL; DISEASE COURSE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INNATE IMMUNITY; INTESTINE LYMPHATIC TISSUE; JEJUNUM MUCOSA; MUCOSAL IMMUNITY; NONHUMAN; PANETH CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; RHESUS MONKEY; SECRETORY GRANULE; SIMIAN IMMUNODEFICIENCY VIRUS; T CELL DEPLETION; VIRUS REPLICATION;

ALPHA-DEFENSINS; ANIMALS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4-POSITIVE T-LYMPHOCYTES; CELL COUNT; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, VIRAL; IMMUNITY, INNATE; INTESTINAL MUCOSA; JEJUNUM; LONGITUDINAL STUDIES; LYMPHOCYTE DEPLETION; MACACA MULATTA; PANETH CELLS; RNA, MESSENGER; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; UP-REGULATION;

EID: 79251551681     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1002021     Document Type: Article

References (30)

1. Greenson, J. K., P. C. Belitsos, J. H. Yardley, and J. G. Bartlett. 1991. AIDS enteropathy: occult enteric infections and duodenal mucosal alterations in chronic diarrhea. Ann. Intern. Med. 114: 366-372.
2. René, E., C. Marche, B. Regnier, A. G. Saimot, J. L. Vilde, C. Perrone, C. Michon, M. Wolf, T. Chevalier, T. Vallot, et al. 1989. Intestinal infections in patients with acquired immunodeficiency syndrome: a prospective study in 132 patients. Dig. Dis. Sci. 34: 773-780.
3. Guadalupe, M., E. Reay, S. Sankaran, T. Prindiville, J. Flamm, A. McNeil, and S. Dandekar. 2003. Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy. J. Virol. 77: 11708-11717.
4. Heeney, J. L. 2002. The critical role of CD4(+) T-cell help in immunity to HIV. Vaccine 20: 1961-1963.
5. Levy, J. A. 2006. HIV pathogenesis: knowledge gained after two decades of research. Adv. Dent. Res. 19: 10-16.
6. Bevins, C. L. 2005. Events at the host-microbial interface of the gastrointestinal tract. V. Paneth cell alpha-defensins in intestinal host defense. Am. J. Physiol. Gastrointest. Liver Physiol. 289: G173-G176.
7. Llenado, R. A., C. S. Weeks, M. J. Cocco, and A. J. Ouellette. 2009. Electro-positive charge in alpha-defensin bactericidal activity: functional effects of Lysfor-Arg substitutions vary with the peptide primary structure. Infect. Immun. 77: 5035-5043.
8. Jones, D. E., and C. L. Bevins. 1992. Paneth cells of the human small intestine express an antimicrobial peptide gene. J. Biol. Chem. 267: 23216-23225.
9. Tanabe, H., J. Yuan, M. M. Zaragoza, S. Dandekar, A. Henschen-Edman, M. E. Selsted, and A. J. Ouellette. 2004. Paneth cell alpha-defensins from rhesus macaque small intestine. Infect. Immun. 72: 1470-1478.
10. Salzman, N. H., K. Hung, D. Haribhai, H. Chu, J. Karlsson-Sjöberg, E. Amir, P. Teggatz, M. Barman, M. Hayward, D. Eastwood, et al. 2010. Enteric defensins are essential regulators of intestinal microbial ecology. Nat. Immunol. 11: 76-83.
11. Ganz, T. 2000. Paneth cells: guardians of the gut cell hatchery. Nat. Immunol. 1: 99-100.
12. Ouellette, A. J. 2005. Paneth cell alpha-defensins: peptide mediators of innate immunity in the small intestine. Springer Semin. Immunopathol. 27: 133-146.
13. D'Agostino, C., M. Lichtner, C. M. Mastroianni, G. Ceccarelli, M. Iannetta, S. Antonucci, V. Vullo, and A. P. Massetti. 2009. In vivo release of alpha-defensins in plasma, neutrophils and CD8 T-lymphocytes of patients with HIV infection. Curr. HIV Res. 7: 650-655.
14. Zapata, W., B. Rodriguez, J. Weber, H. Estrada, M. E. Quiñones-Mateu, P. A. Zimermman, M. M. Lederman, and M. T. Rugeles. 2008. Increased levels of human beta-defensins mRNA in sexually HIV-1 exposed but uninfected individuals. Curr. HIV Res. 6: 531-538.
15. Heise, C., P. Vogel, C. J. Miller, C. H. Halsted, and S. Dandekar. 1993. Simian immunodeficiency virus infection of the gastrointestinal tract of rhesus macaques: functional, pathological, and morphological changes. Am. J. Pathol. 142: 1759-1771.
16. Smit-McBride, Z., J. J. Mattapallil, M. McChesney, D. Ferrick, and S. Dandekar. 1998. Gastrointestinal T lymphocytes retain high potential for cytokine responses but have severe CD4(+) T-cell depletion at all stages of simian immunodeficiency virus infection compared to peripheral lymphocytes. J. Virol. 72: 6646-6656.
17. Smit-McBride, Z., J. J. Mattapallil, F. Villinger, A. A. Ansari, and S. Dandekar. 1998. Intracellular cytokine expression in the CD4+ and CD8+ T cells from intestinal mucosa of simian immunodeficiency virus infected macaques. J. Med. Primatol. 27: 129-140.
18. Tsai, C. C., K. E. Follis, A. Sabo, T. W. Beck, R. F. Grant, N. Bischofberger, R. E. Benveniste, and R. Black. 1995. Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine. Science 270: 1197-1199.
19. George, M. D., E. Reay, S. Sankaran, and S. Dandekar. 2005. Early antiretroviral therapy for simian immunodeficiency virus infection leads to mucosal CD4+ T-cell restoration and enhanced gene expression regulating mucosal repair and regeneration. J. Virol. 79: 2709-2719.
20. Leutenegger, C. M., J. Higgins, T. B. Matthews, A. F. Tarantal, P. A. Luciw, N. C. Pedersen, and T. W. North. 2001. Real-time TaqMan PCR as a specific and more sensitive alternative to the branched-chain DNA assay for quantitation of simian immunodeficiency virus RNA. AIDS Res. Hum. Retroviruses 17: 243-251.
21. George, M. D., S. Sankaran, E. Reay, A. C. Gelli, and S. Dandekar. 2003. High-throughput gene expression profiling indicates dysregulation of intestinal cell cycle mediators and growth factors during primary simian immunodeficiency virus infection. Virology 312: 84-94.
22. Singh, I. 1971. The distribution of Paneth cells in the human small intestine. Anat. Anz. 128: 60-65.
23. Heise, C., C. J. Miller, A. Lackner, and S. Dandekar. 1994. Primary acute simian immunodeficiency virus infection of intestinal lymphoid tissue is associated with gastrointestinal dysfunction. J. Infect. Dis. 169: 1116-1120.
24. Raffatellu, M., R. L. Santos, D. E. Verhoeven, M. D. George, R. P. Wilson, S. E. Winter, I. Godinez, S. Sankaran, T. A. Paixao, M. A. Gordon, et al. 2008. Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Nat. Med. 14: 421-428.
25. Brenchley, J. M., D. A. Price, T. W. Schacker, T. E. Asher, G. Silvestri, S. Rao, Z. Kazzaz, E. Bornstein, O. Lambotte, D. Altmann, et al. 2006. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat. Med. 12: 1365-1371.
26. -/- mice. Dev. Biol. 338: 270-279.
27. Ullrich, R., W. Heise, C. Bergs, M. L'age, E. O. Riecken, and M. Zeitz. 1992. Effects of zidovudine treatment on the small intestinal mucosa in patients infected with the human immunodeficiency virus. Gastroenterology 102: 1483-1492.
28. Lori, F., M. G. Lewis, J. Xu, G. Varga, D. E. Zinn, Jr., C. Crabbs, W. Wagner, J. Greenhouse, P. Silvera, J. Yalley-Ogunro, et al. 2000. Control of SIV rebound through structured treatment interruptions during early infection. Science 290: 1591-1593.
29. Kelly, P., R. Feakins, P. Domizio, J. Murphy, C. Bevins, J. Wilson, G. McPhail, R. Poulsom, and W. Dhaliwal. 2004. Paneth cell granule depletion in the human small intestine under infective and nutritional stress. Clin. Exp. Immunol. 135: 303-309.
30. Aley, S. B., M. Zimmerman, M. Hetsko, M. E. Selsted, and F. D. Gillin. 1994. Killing of Giardia lamblia by cryptdins and cationic neutrophil peptides. Infect. Immun. 62: 5397-5403.