Detection of free base surface enrichment of a pharmaceutical salt by X-ray photoelectron spectroscopy (XPS)

Journal of Pharmaceutical Sciences

Volumn 100, Issue 3, 2011, Pages 942-948

  Stevens, Joanna S ^a   Byard, Stephen J ^b   Zlotnikov, Evgeny ^c   Schroeder, Sven L M ^a,d  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b Sanofi Synthelabo Inc   (United Kingdom)

^c SANOFI   (France)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Analysis; Analytical chemistry; Crystallization; Drying; Mechanical properties; Milling; Physical characterization; Solid state; Solid state stability; Surface chemistry

Indexed keywords

AMINE; BASE; CARBOXYL GROUP; FREE RADICAL; FUMARIC ACID; NITROGEN; PROTON;

ARTICLE; CRYSTALLIZATION; DECARBOXYLATION; DRUG DEGRADATION; DRUG IMPURITY; DRUG QUALITY; IRRADIATION; PROCESS OPTIMIZATION; RESIDUE ANALYSIS; SURFACE PROPERTY; X RAY PHOTOELECTRON SPECTROSCOPY;

EID: 79251548564     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22334     Document Type: Article

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