Lactose maldigestion during methotrexate-induced gastrointestinal mucositis in a rat model

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 300, Issue 2, 2011, Pages

  Fijlstra, M ^a   Rings, E H H M ^a   Verkade, H J ^a   Van Dijk, T H ^a   Kamps, W A ^a   Tissing, W J E ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Absorption; Carbohydrate digestion; Chemotherapy; Citrulline; Radiotherapy

Indexed keywords

CARBON 13; CITRULLINE; GLUCOSE; GLYCOSIDASE; LACTASE; LACTOSE; MESSENGER RNA; METHOTREXATE; MYELOPEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIGESTION; ENZYME ACTIVITY; GASTROINTESTINAL DISEASE; GLUCOSE ABSORPTION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INTESTINE VILLUS ATROPHY; JEJUNUM; LACTOSE INTOLERANCE; MALE; MUCOSA INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMALL INTESTINE; SMALL INTESTINE MUCOSA; WISTAR RAT;

ABSORPTION; ANIMALS; CITRULLINE; DIGESTION; GASTROINTESTINAL DISEASES; GLUCOSE; GLYCOSIDE HYDROLASES; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAVENOUS; INTESTINAL MUCOSA; JEJUNUM; LACTASE; LACTOSE; MALE; METHOTREXATE; MICROVILLI; MUCOSITIS; PILOT PROJECTS; RATS; RNA, MESSENGER;

EID: 79251545480     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00462.2010     Document Type: Article

References (42)

1. Annema W, Nijstad N, Tolle M, de Boer JF, Buijs RV, Heeringa P, van der GM, Tietge UJ. Myeloperoxidase and serum amyloid A contribute to impaired in vivo reverse cholesterol transport during the acute phase response but not group IIA secretory phospholipase A(2). J Lipid Res 51: 743-754, 2010.
2. Barr RD, Gibson BE. Nutritional status and cancer in childhood. J Pediatr Hematol Oncol 22: 491-494, 2000.
3. Blijlevens NM, Lutgens LC, Schattenberg AV, Donnelly JP. Citrulline: a potentially simple quantitative marker of intestinal epithelial damage following myeloablative therapy. Bone Marrow Transplant 34: 193-196, 2004.
4. Boukhettala N, Ibrahim A, Claeyssens S, Faure M, Le PF, Vuichoud J, Lavoinne A, Breuille D, Dechelotte P, Coeffier M. A diet containing whey protein, glutamine, and TGFbeta modulates gut protein metabolism during chemotherapy-induced mucositis in rats. Dig Dis Sci 55: 2172-2181, 2010.
5. Carneiro-Filho BA, Lima IP, Araujo DH, Cavalcante MC, Carvalho GH, Brito GA, Lima V, Monteiro SM, Santos FN, Ribeiro RA, Lima AA. Intestinal barrier function and secretion in methotrexate-induced rat intestinal mucositis. Dig Dis Sci 49: 65-72, 2004. (Pubitemid 38183747)
6. Crenn P, Vahedi K, Lavergne-Slove A, Cynober L, Matuchansky C, Messing B. Plasma citrulline: a marker of enterocyte mass in villous atrophy-associated small bowel disease. Gastroenterology 124: 1210-1219, 2003. (Pubitemid 36531797)
7. Dahlqvist A. Assay of intestinal disaccharidases. Scand J Clin Lab Invest 44: 169-172, 1984.
8. de Koning BA, Lindenbergh-Kortleve DJ, Pieters R, Rings EH, Buller HA, Renes IB, Einerhand AW. The effect of cytostatic drug treatment on intestine-specific transcription factors Cdx2, GATA-4 and HNF-1alpha in mice. Cancer Chemother Pharmacol 57: 801-810, 2006.
9. Elting LS, Cooksley C, Chambers M, Cantor SB, Manzullo E, Rubenstein EB. The burdens of cancer therapy. Clinical and economic outcomes of chemotherapy-induced mucositis. Cancer 98: 1531-1539, 2003.
10. Harsha WT, Kalandarova E, McNutt P, Irwin R, Noel J. Nutritional supplementation with transforming growth factor-beta, glutamine, and short chain fatty acids minimizes methotrexate-induced injury. J Pediatr Gastroenterol Nutr 42: 53-58, 2006. (Pubitemid 43061010)
11. He T, Priebe MG, Welling GW, Vonk RJ. Effect of lactose on oro-cecal transit in lactose digesters and maldigesters. Eur J Clin Invest 36: 737-742, 2006. (Pubitemid 44393933)
12. Hooiveld GJ, Vos TA, Scheffer GL, Van GH, Koning H, Bloks V, Loot AE, Meijer DK, Jansen PL, Kuipers F, Muller M. 3-Hydroxy-3- methylglutaryl-coenzyme A reductase inhibitors (statins) induce hepatic expression of the phospholipid translocase mdr2 in rats. Gastroenterology 117: 678-687, 1999. (Pubitemid 29409255)
13. Howarth GS, Francis GL, Cool JC, Xu X, Byard RW, Read LC. Milk growth factors enriched from cheese whey ameliorate intestinal damage by methotrexate when administered orally to rats. J Nutr 126: 2519-2530, 1996.
14. Hyams JS, Batrus CL, Grand RJ, Sallan SE. Cancer chemotherapy-induced lactose malabsorption in children. Cancer 49: 646-650, 1982.
15. Keefe DM, Cummins AG, Dale BM, Kotasek D, Robb TA, Sage RE. Effect of high-dose chemotherapy on intestinal permeability in humans. Clin Sci (Lond) 92: 385-389, 1997.
16. Keefe DM, Schubert MM, Elting LS, Sonis ST, Epstein JB, Raber- Durlacher JE, Migliorati CA, McGuire DB, Hutchins RD, Peterson DE. Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 109: 820-831, 2007.
17. Lange BJ, Gerbing RB, Feusner J, Skolnik J, Sacks N, Smith FO, Alonzo TA. Mortality in overweight and underweight children with acute myeloid leukemia. J Am Med Assoc 293: 203-211, 2005.
18. Laskewitz AJ, van Dijk TH, Bloks VW, Reijngoud DJ, van Lierop MJ, Dokter WH, Kuipers F, Groen AK, Grefhorst A. Chronic prednisolone treatment reduces hepatic insulin sensitivity while perturbing the fed-to-fasting transition in mice. Endocrinology 151: 2171-2178, 2010.
19. Lindsay RJ, Geier MS, Yazbeck R, Butler RN, Howarth GS. Orally administered emu oil decreases acute inflammation and alters selected small intestinal parameters in a rat model of mucositis. Br J Nutr 104: 113-119, 2010.
20. Lukovac S, Los EL, Stellaard F, Rings EH, Verkade HJ. Essential fatty acid deficiency in mice impairs lactose digestion. Am J Physiol Gastrointest Liver Physiol 295: G605-G613, 2008.
21. Lutgens LC, Blijlevens NM, Deutz NE, Donnelly JP, Lambin P, de Pauw BE. Monitoring myeloablative therapy-induced small bowel toxicity by serum citrulline concentration: a comparison with sugar permeability tests. Cancer 103: 191-199, 2005.
22. Lutgens LC, Deutz N, Granzier-Peeters M, Beets-Tan R, De RD, Gueulette J, Cleutjens J, Berger M, Wouters B, von MM, Lambin P. Plasma citrulline concentration: a surrogate end point for radiation-induced mucosal atrophy of the small bowel. A feasibility study in 23 patients. Int J Radiat Oncol Biol Phys 60: 275-285, 2004.
23. Moe PJ, Holen A. High-dose methotrexate in childhood all. Pediatr Hematol Oncol 17: 615-622, 2000.
24. Picton SV. Aspects of altered metabolism in children with cancer. Int J Cancer Suppl 11: 62-64, 1998. (Pubitemid 29021999)
25. Quaroni A, Isselbacher KJ. Study of intestinal cell differentiation with monoclonal antibodies to intestinal cell surface components. Dev Biol 111: 267-279, 1985.
26. Rings EH, Grand RJ, Buller HA. Lactose intolerance and lactase deficiency in children. Curr Opin Pediatr 6: 562-567, 1994.
27. Sala A, Pencharz P, Barr RD. Children, cancer, and nutrition: a dynamic triangle in review. Cancer 100: 677-687, 2004.
28. Sonis ST. A biological approach to mucositis. J Support Oncol 2: 21-32, 2004.
29. Sonis ST. The pathobiology of mucositis. Nat Rev Cancer 4: 277-284, 2004.
30. Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer- Jensen M, Bekele BN, Raber-Durlacher J, Donnelly JP, Rubenstein EB. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100: 1995-2025, 2004.
31. Taminiau JA, Gall DG, Hamilton JR. Response of the rat small-intestine epithelium to methotrexate. Gut 21: 486-492, 1980.
32. Tooley KL, Howarth GS, Lymn KA, Lawrence A, Butler RN. Oral ingestion of streptococcus thermophilus diminishes severity of small intestinal mucositis in methotrexate treated rats. Cancer Biol Ther 5: 593-600, 2006.
33. Van Beers EH, Buller HA, Grand RJ, Einerhand AW, Dekker J. Intestinal brush border glycohydrolases: structure, function, and development. Crit Rev Biochem Mol Biol 30: 197-262, 1995.
34. van Dijk TH. Computational Analysis of Carbohydrate Metabolism: Stable Isotope Techniques in Small Laboratory Animals (Dissertation). Groningen, The Netherlands: University Medical Center Groningen, 2010.
35. van Dijk TH, Boer TS, Havinga R, Stellaard F, Kuipers F, Reijngoud DJ. Quantification of hepatic carbohydrate metabolism in conscious mice using serial blood and urine spots. Anal Biochem 322: 1-13, 2003.
36. van Dijk TH, Grefhorst A, Oosterveer MH, Bloks VW, Staels B, Reijngoud DJ, Kuipers F. An increased flux through the glucose 6-phosphate pool in enterocytes delays glucose absorption in Fxr-/- mice. J Biol Chem 284: 10315-10323, 2009.
37. van Eijk HM, Rooyakkers DR, Deutz NE. Rapid routine determination of amino acids in plasma by high-performance liquid chromatography with a 2-3 microns Spherisorb ODS II column. J Chromatogr 620: 143-148, 1993.
38. van Vliet MJ, Tissing WJ, Rings EH, Koetse HA, Stellaard F, Kamps WA, de Bont ES. Citrulline as a marker for chemotherapy induced mucosal barrier injury in pediatric patients. Pediatr Blood Cancer 53: 1188-1194, 2009.
39. Verburg M, Renes IB, Meijer HP, Taminiau JA, Buller HA, Einerhand AW, Dekker J. Selective sparing of goblet cells and paneth cells in the intestine of methotrexate-treated rats. Am J Physiol Gastrointest Liver Physiol 279: G1037-G1047, 2000.
40. Verburg M, Renes IB, Van Nispen DJ, Ferdinandusse S, Jorritsma M, Buller HA, Einerhand AW, Dekker J. Specific responses in rat small intestinal epithelial mRNA expression and protein levels during chemotherapeutic damage and regeneration. J Histochem Cytochem 50: 1525-1536, 2002.
41. Vesa TH, Marteau P, Korpela R. Lactose intolerance. J Am Coll Nutr 19: 165S-175S, 2000.
42. Yeh KY, Yeh M, Holt PR. Thyroxine and cortisone cooperate to modulate postnatal intestinal enzyme differentiation in the rat. Am J Physiol Gastrointest Liver Physiol 260: G371-G378, 1991.