Roscovitine, a small molecule CDK inhibitor induces apoptosis in multidrug-resistant human multiple myeloma cells

Journal of Experimental Therapeutics and Oncology

Volumn 9, Issue 1, 2011, Pages 27-35

  Komina, Oxane ^a   Noßke, Ellen ^a   Maurer, Margarita ^a   Wȩsierska Ga̧dek, Jozefa ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Caspase 3 activation; Doxorubicin; MDR1; P gp; RPMI 8226 cells; ts p53 mutant; wt p53

Indexed keywords

CYCLIN DEPENDENT KINASE; DOXORUBICIN; GLYCOPROTEIN P; PROTEIN BCL 2; PROTEIN MCL 1; ROSCOVITINE; SURVIVIN;

APOPTOSIS; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DRUG EXPOSURE; DRUG MEGADOSE; HUMAN; HUMAN CELL; HUMAN TISSUE; MULTIDRUG RESISTANCE; MULTIPLE MYELOMA; MYELOMA CELL; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CYCLIN-DEPENDENT KINASES; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; MULTIPLE MYELOMA; P-GLYCOPROTEIN; PROTEIN KINASE INHIBITORS; PURINES; TUMOR CELLS, CULTURED;

EID: 79251526198     PISSN: 13594117     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Borer, R. A., Lehner, C. F., Eppenberger, H. M., & Nigg, E. A. (1989). Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell, 56(3), 379-390.
2. Cai, D., Byth, K. F., & Shapiro, G. I. (2006). AZ703, an imidazo[1,2-a]pyridine inhibitor of cyclin-dependent kinases 1 and 2, induces E2F-1-dependent apoptosis enhanced by depletion of cyclin-dependent kinase 9. Cancer Res, 66(1), 435-444.
3. Dalton, W. S., Durie, B. G., Alberts, D. S., Gerlach, J. H., & Cress, A. E. (1986). Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein. Cancer Res, 46(10), 5125-5130.
4. Demidenko, Z. N., & Blagosklonny, M. V. (2004). Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor. Cancer Res, 64(10), 3653-3660.
5. Feuerstein, N., Chan, P. K., & Mond, J. J. (1988). Identification of numatrin, the nuclear matrix protein associated with induction of mitogenesis, as the nucleolar protein B23. Implication for the role of the nucleolus in early transduction of mitogenic signals. J Biol Chem, 263(22), 10608-10612.
6. Gao, N., Kramer, L., Rahmani, M., Dent, P., & Grant, S. (2006). The three-substituted indolinone cyclin-dependent kinase 2 inhibitor 3-[1-(3H-imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-on e (SU9516) kills human leukemia cells via down-regulation of Mcl-1 through a transcriptional mechanism. Mol Pharmacol, 70(2), 645-655.
7. Hideshima, T., Bergsagel, P. L., Kuehl, W. M., & Anderson, K. C. (2004). Advances in biology of multiple myeloma: clinical applications. Blood, 104(3), 607-618.
8. Jia, L. Q., Osada, M., Ishioka, C., Gamo, M., Ikawa, S., Suzuki, T., et al. (1997). Screening the p53 status of human cell lines using a yeast functional assay. Mol Carcinog, 19(4), 243-253. (Pubitemid 27392003)
9. Jiang, P. S., & Yung, B. Y. (1999). Down-regulation of nucleophosmin/B23 mRNA delays the entry of cells into mitosis. Biochem Biophys Res Commun, 257(3), 865-870.
10. Jourdan, M., Veyrune, J. L., De Vos, J., Redal, N., Couderc, G., & Klein, B. (2003). A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells. Oncogene, 22(19), 2950-2959.
11. Komina, O., & Wesierska-Gadek, J. (2008). Action of resveratrol alone or in combination with roscovitine, a CDK inhibitor, on cell cycle progression in human HL-60 leukemia cells. Biochem Pharmacol, 76(11), 1554-1562.
12. Lim, M. J., & Wang, X. W. (2006). Nucleophosmin and human cancer. Cancer Detect Prev, 30(6), 481-490.
13. Liu, H., Huang, J., Wang, J., Jiang, S., Bailey, A. S., Goldman, D. C., et al. (2008). Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphoma. J Exp Med, 205(8), 1843-1858.
14. MacCallum, D. E., Melville, J., Frame, S., Watt, K., Anderson, S., Gianella-Borradori, A., et al. (2005). Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1. Cancer Res, 65(12), 5399-5407.
15. Morris, S. W., Kirstein, M. N., Valentine, M. B., Dittmer, K. G., Shapiro, D. N., Saltman, D. L., et al. (1994). Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science, 263(5151), 1281-1284.
16. Okuda, M., Horn, H. F., Tarapore, P., Tokuyama, Y., Smulian, A. G., Chan, P. K., et al. (2000). Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell, 103(1), 127-140.
17. Paprskarova, M., Krystof, V., Jorda, R., Dzubak, P., Hajduch, M., Wesierska-Gadek, J., et al. (2009). Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine. J Cell Biochem, 107(3), 428-437.
18. Patterson, S. D., Grossman, J. S., D'Andrea, P., & Latter, G. I. (1995). Reduced numatrin/B23/nucleophosmin labeling in apoptotic Jurkat T-lymphoblasts. J Biol Chem, 270(16), 9429-9436.
19. Puthier, D., Derenne, S., Barille, S., Moreau, P., Harousseau, J. L., Bataille, R., et al. (1999). Mcl-1 and Bcl-xL are co-regulated by IL-6 in human myeloma cells. Br J Haematol, 107(2), 392-395. (Pubitemid 29530231)
20. Raab, M. S., Podar, K., Breitkreutz, I., Richardson, P. G., & Anderson, K. C. (2009). Multiple myeloma. Lancet, 374(9686), 324-339.
21. Raje, N., Kumar, S., Hideshima, T., Roccaro, A., Ishitsuka, K., Yasui, H., et al. (2005). Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma. Blood, 106(3), 1042-1047.
22. Redner, R. L., Rush, E. A., Faas, S., Rudert, W. A., & Corey, S. J. (1996). The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion. Blood, 87(3), 882-886.
23. Rogalinska, M., Blonski, J. Z., Komina, O., Goralski, P., Zolnierczyk, J. D., Piekarski, H., et al. (2010). R-roscovitine (Seliciclib) affects CLL cells more strongly than combinations of fludarabine or cladribine with cyclophosphamide: Inhibition of CDK7 sensitizes leukemic cells to caspase-dependent apoptosis. J Cell Biochem, 109(1), 217-235.
24. Sanchez-Aguilera, A., Delgado, J., Camacho, F. I., Sanchez-Beato, M., Sanchez, L., Montalban, C., et al. (2004). Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas. Blood, 103(6), 2351-2357.
25. Verschraagen, M., Koks, C. H., Schellens, J. H. & Beijnen, J. H. (1999). P-glycoprotein system as a determinant of drug interactions: the case of digoxin-verapamil. Pharmacol Res. 40(4), 301-306. (Pubitemid 29472055)
26. Vindelov, L. L., Christensen, I. J., & Nissen, N. I. (1983). A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. Cytometry, 3(5), 323-327.
27. Wesierska-Gadek, J. (2005). Major contribution of the multidrug transporter P-glycoprotein to reduced susceptibility of poly(ADP-ribose) polymerase-1 knock-out cells to doxorubicin action. J Cell Biochem, 95(5), 1012-1028.
28. Wesierska-Gadek, J., Gueorguieva, M., & Horky, M. (2005). Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells. Mol Cancer Ther, 4(1), 113-124.
29. Wesierska-Gadek, J., & Schmid, G. (2000). Overexpressed poly (ADP-ribose) polymerase delays the release of rat cells from p53-mediated G(1) checkpoint. J Cell Biochem, 80(1), 85-103.
30. Wesierska-Gadek, J., Schmitz, M. L., & Ranftler, C. (2007). Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells. J Cell Biochem, 100(4), 865-874.
31. Wojciechowski, J., Horky, M., Gueorguieva, M., & Wesierska-Gadek, J. (2003). Rapid onset of nucleolar disintegration preceding cell cycle arrest in roscovitine-induced apoptosis of human MCF-7 breast cancer cells. Int J Cancer, 106(4), 486-495. (Pubitemid 36969788)
32. Yoneda-Kato, N., Look, A. T., Kirstein, M. N., Valentine, M. B., Raimondi, S. C., Cohen, K. J., et al. (1996). The t(3;5) (q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. Oncogene, 12(2), 265-275. (Pubitemid 26042564)