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Volumn 5, Issue 7, 2009, Pages 508-514

Designer enzymes for glycosphingolipid synthesis by directed evolution

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSPHINGOLIPID; MUTANT PROTEIN; PHYTOSPHINGOSINE; SPHINGOSINE;

EID: 67650290309     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.191     Document Type: Article
Times cited : (69)

References (32)
  • 1
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: Lessons from sphingolipids
    • Hannun, Y.A. & Obeid, L.M. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat. Rev. Mol. Cell Biol. 9, 139-150 (2008).
    • (2008) Nat. Rev. Mol. Cell Biol , vol.9 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 2
    • 38849154570 scopus 로고    scopus 로고
    • Glycolipids as immunostimulating agents
    • Wu, D., Fujio, M. & Wong, C.H. Glycolipids as immunostimulating agents. Bioorg. Med. Chem. 16, 1073-1083 (2008).
    • (2008) Bioorg. Med. Chem , vol.16 , pp. 1073-1083
    • Wu, D.1    Fujio, M.2    Wong, C.H.3
  • 3
    • 40849088331 scopus 로고    scopus 로고
    • The medium is the message: Glycosphingolipids and their soluble analogues
    • De Rosa, M. et al. The medium is the message: glycosphingolipids and their soluble analogues. Biochim. Biophys. Acta 1780, 347-352 (2008).
    • (2008) Biochim. Biophys. Acta , vol.1780 , pp. 347-352
    • De Rosa, M.1
  • 4
    • 48549100652 scopus 로고    scopus 로고
    • Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease - a review
    • Ariga, T., McDonald, M.P. & Yu, R.K. Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease - a review. J. Lipid Res. 49, 1157-1175 (2008).
    • (2008) J. Lipid Res , vol.49 , pp. 1157-1175
    • Ariga, T.1    McDonald, M.P.2    Yu, R.K.3
  • 6
    • 0034409661 scopus 로고    scopus 로고
    • Chemistry of glycosphingolipids- carbohydrate molecules of biological significance
    • Vankar, Y.D. & Schmidt, R.R. Chemistry of glycosphingolipids- carbohydrate molecules of biological significance. Chem. Soc. Rev. 29, 201-216 (2000).
    • (2000) Chem. Soc. Rev , vol.29 , pp. 201-216
    • Vankar, Y.D.1    Schmidt, R.R.2
  • 7
    • 0032503519 scopus 로고    scopus 로고
    • Glycosynthases: Mutant glycosidases for oligosaccharide synthesis
    • Mackenzie, L.F., Wang, Q., Warren, R.A.J. & Withers, S.G. Glycosynthases: mutant glycosidases for oligosaccharide synthesis. J. Am. Chem. Soc. 120, 5583-5584 (1998).
    • (1998) J. Am. Chem. Soc , vol.120 , pp. 5583-5584
    • Mackenzie, L.F.1    Wang, Q.2    Warren, R.A.J.3    Withers, S.G.4
  • 10
    • 0022971583 scopus 로고
    • A novel glycosphingolipid-degrading enzyme cleaves the linkage between the oligosaccharide and ceramide of neutral and acidic glycosphingolipids
    • Ito, M. & Yamagata, T. A novel glycosphingolipid-degrading enzyme cleaves the linkage between the oligosaccharide and ceramide of neutral and acidic glycosphingolipids. J. Biol. Chem. 261, 14278-14282 (1986).
    • (1986) J. Biol. Chem , vol.261 , pp. 14278-14282
    • Ito, M.1    Yamagata, T.2
  • 11
    • 33646583542 scopus 로고    scopus 로고
    • Glycosynthase-mediated synthesis of glycosphingolipids
    • Vaughan, M.D. et al. Glycosynthase-mediated synthesis of glycosphingolipids. J. Am. Chem. Soc. 128, 6300-6301 (2006).
    • (2006) J. Am. Chem. Soc , vol.128 , pp. 6300-6301
    • Vaughan, M.D.1
  • 12
    • 34347207599 scopus 로고    scopus 로고
    • M3 ganglioside-bound forms
    • M3 ganglioside-bound forms. J. Biol. Chem. 282, 14300-14308 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 14300-14308
    • Caines, M.E.C.1
  • 13
    • 0026046041 scopus 로고
    • Gangliosides inhibit glucosylceramide synthase: A possible role in ganglioside therapy
    • Shukla, G.S., Shukla, A. & Radin, N.S. Gangliosides inhibit glucosylceramide synthase: a possible role in ganglioside therapy. J. Neurochem. 56, 2125-2132 (1991).
    • (1991) J. Neurochem , vol.56 , pp. 2125-2132
    • Shukla, G.S.1    Shukla, A.2    Radin, N.S.3
  • 15
    • 0026440345 scopus 로고
    • Structural characteristics of the ceramides of neutral glycosphingolipids in the human female genital tract - their menstrual cycle-associated change in the cervical epithelium and uterine endometrium, and their dissociation in the mucosa of the fallopian tube with the menstrual cycle
    • Takamatsu, K., Mikami, M., Kiguchi, K., Nozawa, S. & Iwamori, M. Structural characteristics of the ceramides of neutral glycosphingolipids in the human female genital tract - their menstrual cycle-associated change in the cervical epithelium and uterine endometrium, and their dissociation in the mucosa of the fallopian tube with the menstrual cycle. Biochim. Biophys. Acta 1165, 177-182 (1992).
    • (1992) Biochim. Biophys. Acta , vol.1165 , pp. 177-182
    • Takamatsu, K.1    Mikami, M.2    Kiguchi, K.3    Nozawa, S.4    Iwamori, M.5
  • 16
    • 0024593126 scopus 로고
    • The glycosphingolipid composition and glycosyltransferase activities of the small intestinal mucosa of testosterone-treated rats
    • Dahiya, R., Ahlawat, R.S. & Sharma, A. The glycosphingolipid composition and glycosyltransferase activities of the small intestinal mucosa of testosterone-treated rats. Biochem. Cell Biol. 67, 42-47 (1989).
    • (1989) Biochem. Cell Biol , vol.67 , pp. 42-47
    • Dahiya, R.1    Ahlawat, R.S.2    Sharma, A.3
  • 17
    • 0025644896 scopus 로고
    • Effect of testosterone on the glycosphingolipid composition of the rat kidney
    • Dahiya, R., Sharma, A. & Narayan, P. Effect of testosterone on the glycosphingolipid composition of the rat kidney. Biomed. Biochim. Acta 49, 1195-1201 (1990).
    • (1990) Biomed. Biochim. Acta , vol.49 , pp. 1195-1201
    • Dahiya, R.1    Sharma, A.2    Narayan, P.3
  • 18
    • 0028110082 scopus 로고
    • Expression of glycosphingolipids in serum-free primary cultures of mouse kidney cells: Male-female differences and androgen sensitivity
    • Gross, S.K., Lyerla, T.A., Evans, J.E. & McCluer, R.H. Expression of glycosphingolipids in serum-free primary cultures of mouse kidney cells: male-female differences and androgen sensitivity. Mol. Cell. Biochem. 137, 25-31 (1994).
    • (1994) Mol. Cell. Biochem , vol.137 , pp. 25-31
    • Gross, S.K.1    Lyerla, T.A.2    Evans, J.E.3    McCluer, R.H.4
  • 19
    • 0024282472 scopus 로고
    • Studies on the binding of bacteria to glycolipids. Two species of Propionibacterium apparently recognize separate epitopes on lactose of lactosylceramide
    • Strömberg, N., Ryd, M., Lindberg, A.A. & Karlsson, K.A. Studies on the binding of bacteria to glycolipids. Two species of Propionibacterium apparently recognize separate epitopes on lactose of lactosylceramide. FEBS Lett. 232, 193-198 (1988).
    • (1988) FEBS Lett , vol.232 , pp. 193-198
    • Strömberg, N.1    Ryd, M.2    Lindberg, A.A.3    Karlsson, K.A.4
  • 20
    • 0041988992 scopus 로고    scopus 로고
    • The lactosylceramide binding specificity of Helicobacter pylori
    • Angström, J. et al. The lactosylceramide binding specificity of Helicobacter pylori. Glycobiology 8, 297-309 (1998).
    • (1998) Glycobiology , vol.8 , pp. 297-309
    • Angström, J.1
  • 21
    • 33646922551 scopus 로고    scopus 로고
    • The major subunit, CfaB, of colonization factor antigen I from enterotoxigenic Escherichia coli is a glycosphingolipid binding protein
    • Jansson, L., Tobias, J., Lebens, M., Svennerholm, A.M. & Teneberg, S. The major subunit, CfaB, of colonization factor antigen I from enterotoxigenic Escherichia coli is a glycosphingolipid binding protein. Infect. Immun. 74, 3488-3497 (2006).
    • (2006) Infect. Immun , vol.74 , pp. 3488-3497
    • Jansson, L.1    Tobias, J.2    Lebens, M.3    Svennerholm, A.M.4    Teneberg, S.5
  • 22
    • 0037124154 scopus 로고    scopus 로고
    • Identification of target tissue glycosphingolipid receptors for uropathogenic, F1C-fimbriated Escherichia coli and its role in mucosal inflammation
    • Bäckhed, F. et al. Identification of target tissue glycosphingolipid receptors for uropathogenic, F1C-fimbriated Escherichia coli and its role in mucosal inflammation. J. Biol. Chem. 277, 18198-18205 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 18198-18205
    • Bäckhed, F.1
  • 23
    • 36749020130 scopus 로고    scopus 로고
    • Protein engineers turned evolutionists
    • Peisajovich, S.G. & Tawfik, D.S. Protein engineers turned evolutionists. Nat. Methods 4, 991-994 (2007).
    • (2007) Nat. Methods , vol.4 , pp. 991-994
    • Peisajovich, S.G.1    Tawfik, D.S.2
  • 24
    • 33746439461 scopus 로고    scopus 로고
    • High-throughput screening methodology for the directed evolution of glycosytransferases
    • Aharoni, A. et al. High-throughput screening methodology for the directed evolution of glycosytransferases. Nat. Methods 3, 609-614 (2006).
    • (2006) Nat. Methods , vol.3 , pp. 609-614
    • Aharoni, A.1
  • 25
    • 5644249284 scopus 로고    scopus 로고
    • Directed evolution of a glycosynthase from Agrobacterium sp. increases its catalytic activity dramatically and expands its substrate reportoire
    • Kim, Y.-W., Lee, S.S., Warren, R.A.J. & Withers, S.G. Directed evolution of a glycosynthase from Agrobacterium sp. increases its catalytic activity dramatically and expands its substrate reportoire. J. Biol. Chem. 279, 42787-42793 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 42787-42793
    • Kim, Y.-W.1    Lee, S.S.2    Warren, R.A.J.3    Withers, S.G.4
  • 26
    • 0034999624 scopus 로고    scopus 로고
    • Directed evolution of new glycosynthases from Agrobacterium β-glucosidase: A general screen to detect enzymes for oligosaccharide synthesis
    • Mayer, C. et al. Directed evolution of new glycosynthases from Agrobacterium β-glucosidase: a general screen to detect enzymes for oligosaccharide synthesis. Chem. Biol. 8, 437-443 (2001).
    • (2001) Chem. Biol , vol.8 , pp. 437-443
    • Mayer, C.1
  • 27
    • 9344270529 scopus 로고    scopus 로고
    • Directed evolution of a glycosynthase via chemical complementation
    • Lin, H., Tao, H. & Cornish, V.W. Directed evolution of a glycosynthase via chemical complementation. J. Am. Chem. Soc. 126, 15051-15059 (2004).
    • (2004) J. Am. Chem. Soc , vol.126 , pp. 15051-15059
    • Lin, H.1    Tao, H.2    Cornish, V.W.3
  • 28
    • 34548685673 scopus 로고    scopus 로고
    • Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution
    • Williams, G.J., Zhang, C. & Thorson, J.S. Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution. Nat. Chem. Biol. 3, 657-662 (2007).
    • (2007) Nat. Chem. Biol , vol.3 , pp. 657-662
    • Williams, G.J.1    Zhang, C.2    Thorson, J.S.3
  • 29
    • 44949117607 scopus 로고    scopus 로고
    • A universal screening assay for glyco-synthases: Directed evolution of glycosynthase XynB2(E335G) suggests a general path to enhance activity
    • Ben-David, A., Shoham, G. & Shoham, Y. A universal screening assay for glyco-synthases: directed evolution of glycosynthase XynB2(E335G) suggests a general path to enhance activity. Chem. Biol. 15, 546-551 (2008).
    • (2008) Chem. Biol , vol.15 , pp. 546-551
    • Ben-David, A.1    Shoham, G.2    Shoham, Y.3
  • 30
    • 51449087103 scopus 로고    scopus 로고
    • High-throughput screening of cell lysates for ganglioside synthesis
    • Hancock, S.M., Tarling, C.A. & Withers, S.G. High-throughput screening of cell lysates for ganglioside synthesis. Anal. Biochem. 382, 48-54 (2008).
    • (2008) Anal. Biochem , vol.382 , pp. 48-54
    • Hancock, S.M.1    Tarling, C.A.2    Withers, S.G.3
  • 31
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254 (1976).
    • (1976) Anal. Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1


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