Bolus arginine supplementation affects neither muscle blood flow nor muscle protein synthesis in young men at rest or after resistance exercise

Journal of Nutrition

Volumn 141, Issue 2, 2011, Pages 195-200

  Tang, Jason E ^a   Lysecki, Paul J ^a   Manolakos, Joshua J ^a   MacDonald, Maureen J ^a   Tarnopolsky, Mark A ^b   Phillips, Stuart M ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ENDOTHELIN 1; ESSENTIAL AMINO ACID; GLYCINE; GROWTH HORMONE; HISTIDINE; ISOLEUCINE; LEUCINE; LYSINE; METHIONINE; MUSCLE PROTEIN; NITRATE; NITRIC OXIDE; NITRITE; PHENYLALANINE; THREONINE; TRYPTOPHAN; VALINE;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOPPLER FLOWMETRY; FEMORAL ARTERY FLOW; GROUPS BY AGE; GROWTH HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; LEG EXERCISE; MALE; MUSCLE BLOOD FLOW; NORMAL HUMAN; PROTEIN SYNTHESIS; RESISTANCE TRAINING; SKELETAL MUSCLE;

ARGININE; DIETARY SUPPLEMENTS; ENDOTHELIN-1; EXERCISE; FEMORAL ARTERY; HUMAN GROWTH HORMONE; HUMANS; MALE; MUSCLE PROTEINS; MUSCLE, SKELETAL; MYOFIBRILS; NITRATES; NITRIC OXIDE; NITRITES; PROTEIN BIOSYNTHESIS; REGIONAL BLOOD FLOW; RESISTANCE TRAINING; REST; YOUNG ADULT;

EID: 79251475599     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.110.130138     Document Type: Article

References (42)

1. Rennie MJ, Tipton KD. Protein and amino acid metabolism during and after exercise and the effects of nutrition. Annu Rev Nutr. 2000;20:457-83.
2. Rennie MJ, Wackerhage H, Spangenburg EE, Booth FW. Control of the size of the human muscle mass. Annu Rev Physiol. 2004;66:799-828.
3. Phillips SM. Protein requirements and supplementation in strength sports. Nutrition. 2004;20:689-95.
4. Tipton KD, Ferrando AA, Phillips SM, Doyle D Jr, Wolfe RR. Postexercise net protein synthesis in human muscle from orally administered amino acids. Am J Physiol. 1999;276:E628-34.
5. Biolo G, Tipton KD, Klein S, Wolfe RR. An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am J Physiol. 1997;273:E122-9.
6. Bohe J, Low A, Wolfe RR, Rennie MJ. Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response study. J Physiol. 2003;552:315-24.
7. Smith K, Reynolds N, Downie S, Patel A, Rennie MJ. Effects of flooding amino acids on incorporation of labeled amino acids into human muscle protein. Am J Physiol. 1998;275:E73-8.
8. Tipton KD, Gurkin BE, Matin S, Wolfe RR. Nonessential amino acids are not necessary to stimulate net muscle protein synthesis in healthy volunteers. J Nutr Biochem. 1999;10:89-95.
9. Wilkinson SB, Tarnopolsky MA, MacDonald MJ, Macdonald JR, Armstrong D, Phillips SM. Consumption of fluid skim milk promotes greater muscle protein accretion following resistance exercise than an isonitrogenous and isoenergetic soy protein beverage. Am J Clin Nutr. 2007;85:1031-40.
10. Tang JE, Moore DR, Kujbida GW, Tarnopolsky MA, Phillips SM. Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men. J Appl Physiol. 2009;107:987-92.
11. Miller SL, Tipton KD, Chinkes DL, Wolf SE, Wolfe RR. Independent and combined effects of amino acids and glucose after resistance exercise. Med Sci Sports Exerc. 2003;35:449-55.
12. Borsheim E, Tipton KD, Wolf SE, Wolfe RR. Essential amino acids and muscle protein recovery from resistance exercise. Am J Physiol Endocrinol Metab. 2002;283:E648-57.
13. Volpi E, Kobayashi H, Sheffield-Moore M, Mittendorfer B, Wolfe RR. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr. 2003;78:250-8.
14. Rasmussen BB, Tipton KD, Miller SL, Wolf SE, Wolfe RR. An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise. J Appl Physiol. 2000;88:386-92.
15. Cuthbertson D, Smith K, Babraj J, Leese G, Waddell T, Atherton P, Wackerhage H, Taylor PM, Rennie MJ. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J. 2005;19:422-4.
16. Moore DR, Robinson MJ, Fry JL, Tang JE, Glover EI, Wilkinson SB, Prior T, Tarnopolsky MA, Phillips SM. Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. Am J Clin Nutr. 2009;89:161-8.
17. Fujita S, Rasmussen BB, Cadenas JG, Grady JJ, Volpi E. Effect of insulin on human skeletal muscle protein synthesis is modulated by insulin-induced changes in muscle blood flow and amino acid availability. Am J Physiol Endocrinol Metab. 2006;291:E745-54.
18. Fleming I, Busse RNO. The primary EDRF. J Mol Cell Cardiol. 1999;31:5-14.
19. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med. 1993;329:2002-12.
20. Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. 1988;333:664-6.
21. Paddon-Jones D, Borsheim E, Wolfe RR. Potential ergogenic effects of arginine and creatine supplementation. J Nutr. 2004;134:S2888-94.
22. Zhang XJ, Chinkes DL, Wolfe RR. The anabolic effect of arginine on proteins in skin wound and muscle is independent of nitric oxide production. Clin Nutr. 2008;27:649-56.
23. Canadian Institutes of Health Research, Social Sciences and Humanities Research Council of Canada. Tri-Council policy statement: ethical conduct for research involving humans. Available from: http://pre.ethics. gc.ca/pdf/eng/tcps2/TCPS-2-FINAL-Web.pdf as of Dec, 2010.
24. Moore DR, Tang JE, Burd NA, Rerecich T, Tarnopolsky MA, Phillips SM. Differential stimulation of myofibrillar and sarcoplasmic protein synthesis with protein ingestion at rest and after resistance exercise. J Physiol. 2009;597:897-904.
25. Bode-Böger S. Effect of L-arginine supplementation on NO production in man. Eur J Clin Pharmacol. 2006;62:91-9.
26. Rakobowchuk M, McGowan CL, de Groot PC, Hartman JW, Phillips SM, MacDonald MJ. Endothelial function of young healthy males following whole body resistance training. J Appl Physiol. 2005;98:2185-90.
27. Mittendorfer B, Andersen JL, Plomgaard P, Saltin B, Babraj JA, Smith K, Rennie MJ. Protein synthesis rates in human muscles: neither anatomical location nor fibre-type composition are major determinants. J Physiol. 2005;563:203-11.
28. Miller BF, Olesen JL, Hansen M, Dossing S, Crameri RM, Welling RJ, Langberg H, Flyvbjerg A, Kjaer M, et al. Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise. J Physiol. 2005;567:1021-33.
29. Miranda KM, Espey MG, Wink DA. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide. 2001;5:62-71.
30. Phillips SM, Tipton KD, Aarsland A, Wolf SE, Wolfe RR. Mixed muscle protein synthesis and breakdown after resistance exercise in humans. Am J Physiol. 1997;273:E99-107.
31. Wolfe RR, Chinkes D. Isotope tracers in metabolic research. New York: John Wiley and Sons Ltd.; 2005.
32. Biolo G, Maggi SP, Williams BD, Tipton KD, Wolfe RR. Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans. Am J Physiol. 1995;268:E514-20.
33. Andersen P, Saltin B. Maximal perfusion of skeletal muscle in man. J Physiol. 1985;366:233-49.
34. Bode-Boger SM, Boger RH, Galland A, Tsikas D, Frolich JC. L-arginine- induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship. Br J Clin Pharmacol. 1998;46:489-97.
35. Bode-Boger SM, Boger RH, Creutzig A, Tsikas D, Gutzki FM, Alexander K, Frolich JC. L-arginine infusion decreases peripheral arterial resistance and inhibits platelet aggregation in healthy subjects. Clin Sci (Lond). 1994;87:303-10.
36. Giugliano D, Marfella R, Verrazzo G, Acampora R, Nappo F, Ziccardi P, Coppola L, D'Onofrio F. L-arginine for testing endothelium-dependent vascular functions in health and disease. Am J Physiol. 1997;273:E606-12.
37. Granger DL, Taintor RR, Boockvar KS, Hibbs JB Jr. Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction. Methods Enzymol. 1996;268:142-51.
38. Thorin E, Webb DJ. Endothelium-derived endothelin-1. Pflugers Arch. 2010;459:951-8.
39. Kraemer WJ, Ratamess NA. Hormonal responses and adaptations to resistance exercise and training. Sports Med. 2005;35:339-61.
40. Mauras N. Growth hormone and sex steroids. Interactions in puberty. Endocrinol Metab Clin North Am. 2001;30:529-44.
41. Doessing S, Heinemeier KM, Holm L, Mackey AL, Schjerling P, RennieM, Smith K, Reitelseder S, Kappelgaard AM, et al. Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis. J Physiol. 2010;588:341-51.
42. West DW, Kujbida GW, Moore DR, Atherton P, Burd NA, Padzik JP, De Lisio M, Tang JE, Parise G, et al. Resistance exercise-induced increases in putative anabolic hormones do not enhance muscle protein synthesis or intracellular signalling in young men. J Physiol. 2009;587:5239-47.