Low-molecular-weight heparins have no place in recurrent miscarriage: Debate - For the motion

Thrombosis Research

Volumn 127, Issue SUPPL. 3, 2011, Pages

  Middeldorp, Saskia ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Antiphospholipid syndrome; Low molecular weight heparin; Pregnancy failure; Recurrent miscarriage; Thrombophilia

Indexed keywords

ACETYLSALICYLIC ACID; DALTEPARIN; ENOXAPARIN; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; NADROPARIN;

ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CLINICAL EFFECTIVENESS; HUMAN; LOW DRUG DOSE; PREGNANCY COMPLICATION; PRIORITY JOURNAL; SPONTANEOUS ABORTION; THROMBOPHILIA;

ABORTION, HABITUAL; ANTICOAGULANTS; ANTIPHOSPHOLIPID SYNDROME; FEMALE; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; PREGNANCY; THROMBOPHILIA;

EID: 79251475242     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(11)70028-7     Document Type: Article

References (42)

1. S Miyakis, MD Lockshin, T Atsumi, DW Branch, RL Brey, R Cervera International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) J Thromb Haemost 4 2 2006 295 306
2. BJ Sanson, PW Friederich, P Simioni, S Zanardi, MV Huisman, A Girolami The risk of abortion and stillbirth in antithrombin-, protein C-, and protein S-deficient women Thromb Haemost 75 3 1996 387 388
3. FE Preston, FR Rosendaal, ID Walker, E Briet, E Berntorp, J Conard Increased fetal loss in women with heritable thrombophilia Lancet 348 1996 9136
4. JR Meinardi, S Middeldorp, PJ de Kam, MMW Koopman, ECM van Pampus, K Hamulyak Increased risk for fetal loss in carriers of the factor V Leiden mutation Ann Int Med 130 9 1999 May 4 736 739
5. E Rey, SR Kahn, M David, I Shrier Thrombophilic disorders and fetal loss: a meta-analysis Lancet 361 2003 Mar 15 901 908
6. L Robertson, O Wu, P Langhorne, S Twaddle, P Clark, GDO Lowe Thrombophilia in pregnancy: a systematic review Br J Haematol 132 2 2006 171 196
7. M Coppens, JA van Mourik, CM Eckmann, HR Buller, S Middeldorp Current practice of testing for hereditary thrombophilia in The Netherlands J Thromb Haemost 5 2007 Jan 9 1979 1981
8. RG Farquharson, E Jauniaux, N Exalto Updated and revised nomenclature for description of early pregnancy events Hum Reprod 20 11 2005 Nov 3008 3011
9. NJ Sebire, L Regan, R Rai Biology and pathology of the placenta in relation to antiphospholipid antibody-associated pregnancy failure Lupus 11 10 2002 6413
10. S Quenby, S Mountfield, JE Cartwright, GS Whitley, L Chamley, G Vince Antiphospholipid antibodies prevent extravillous trophoblast differentiation Fertil Steril 83 3 2005 Mar 691 698
11. P Bose, Blacks, M Kadyrov, U Weissenborn, J Neulen, L Regan Heparinand aspirin attenuate placental apoptosis in vitro: implications for early pregnancy failure Am J Obstet Gynecol 192 1 2005 Jan 23 30
12. B Isermann, R Sood, R Pawlinski, M Zogg, S Kalloway, JL Degen The thrombomodulin-protein C system is essential for the maintenance of pregnancy Nat Med 9 3 2003 Mar 331 337
13. S Middeldorp Thrombophilia and pregnancy complications: cause or association? J Thromb Haemost 5 Suppl 1 2007 276 282
14. MA Rodger, MJ Paidas, C Mclintock, S Middeldorp, SR Kahn, I Martinelli Inherited thrombophilia and pregnancy complications revisited: association not proven causal and antithrombotic prophylaxis is experimental Obstet Gynecol 112 2 2008 320 324
15. JP Vandenbroucke When are observational studies as credible as randomised trials? Lancet 363 9422 2004 May 22 1728 1731
16. KF Schulz, I Chalmers, RJ Hayes, DG Altman Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials JAMA 273 5 1995 Feb 1 408 412
17. P Juni, DG Altman, M Egger Systematic reviews in health care: Assessing the quality of controlled clinical trials BMJ 323 7303 2001 Jul 7 42 46
18. WH Kutteh Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone Am J Obstet Gynecol 174 5 1996 May 1584 1589
19. R Rai, H Cohen, M Dave, L Regan Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies) [see comments] BMJ 314 7076 1997 Jan 25 253 257
20. N Goel, A Tuli, R Choudhry The role of aspirin versus aspirin and heparin in cases of recurrent abortions with raised anticardiolipin antibodies Med Sci Monit 12 3 2006 Mar CR132 CR136
21. RG Farquharson, S Quenby, M Greaves Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment Obstetrics & Gynecology 100 3 2002 Sep 408 413
22. CA Laskin, KA Spitzer, CA Clark, MR Crowther, JS Ginsberg, GA Hawker Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA Trial J Rheumatol 36 2 2009 Feb 279 287
23. M Dolitzky, A Inbal, Y Segal, A Weiss, B Brenner, H Carp A randomized study of thromboprophylaxis in women with unexplained consecutive recurrent miscarriages Fertil Steril 86 2 2006 Aug 362 366
24. AM Badawy, M Khiary, LS Sherif, M Hassan, A Ragab, I Abdelall Low-molecular weight heparin in patients with recurrent early miscarriages of unknown aetiology J Obstet Gynaecol 28 3 2008 Apr 280 284
25. M Fawzy, T Shokeir, M El-Tatongy, O Warda, AA El-Refaiey, A Mosbah Treatment options and pregnancy outcome in women with idiopathic recurrent miscarriage: a randomized placebo-controlled study Arch Gynecol Obstet 278 1 2008 Jul 33 38
26. P Clark, ID Walker, P Langhorne, L Crichton, A Thomson, M Greaves SPIN: the Scottish Pregnancy Intervention Study: a multicentre randomised controlled trial of low molecular weight heparin and low dose aspirin in women with recurrent miscarriage Blood 115 21 2010 May 27 4162 4167
27. SP Kaandorp, M Goddijn, JA van der Post, BA Hütten, HR Verhoeve, K Hamulyak Aspirin plus heparin or aspirin alone in women with recurrent miscarriage N Engl J Med 362 17 2010 Apr 29 1586 1596
28. MD Stephenson, PJ Ballem, R Tsang, S Purkiss, S Ensworth, E Houlihan Treatment of antiphospholipid antibody syndrome (APS) in pregnancy: a randomized pilot trial comparing low molecular weight heparin to unfractionated heparin J Obstet Gynaecol Can 26 8 2004 Aug 729 734
29. LS Noble, WH Kutteh, N Lashey, RD Franklin, J Herrada Antiphospholipid antibodies associated with recurrent pregnancy loss: prospective, multicenter, controlled pilot study comparing treatment with low-molecular-weight heparin versus unfractionated heparin Fertil Steril 83 3 2005 Mar 684 690
30. M Empson, M Lassere, JC Craig, JR Scott Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant Cochrane Database Syst Rev 2005 CD002859.
31. SM Bates, IA Greer, J Hirsh, JS Ginsberg Use of antithrombotic agents during pregnancy. The seventh ACCP conference on antithrombotic and thrombolytic therapy Chest 126 Suppl 2004 627S 644S (Pubitemid 39297966)
32. E Jauniaux, RG Farquharson, OB Christiansen, N Exalto Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage Hum Reprod 21 9 2006 2116 2222
33. B Brenner Antithrombotic prophylaxis for women with thrombophilia and pregnancy complications - Yes J Thromb Haemost 1 10 2003 Oct 2070 2072
34. JC Gris, P Mares The long and winding road towards LMWH for pregnancy loss J Thromb Haemost 3 2 2005 224 226
35. S Middeldorp Antithrombotic prophylaxis for women with thrombophilia and pregnancy complications - No J Thromb Haemost 1 2003 Oct 2073 2074
36. PG Lindqvist, J Merlo Low molecular weight heparin for repeated pregnancy loss - is it based on solid evidence? J Thromb Haemost 3 2 2005 221 223
37. SA Brigham, C Conlon, RG Farquharson A longitudinal study of pregnancy outcome following idiopathic recurrent miscarriage Hum Reprod 14 11 1999 Nov 2868 2871
38. N Riyazi, M Leeda, JI de Vries, PC Huijgens, HP van Geijn, GA Dekker Low-molecular-weight heparin combined with aspirin in pregnant women with thrombophilia and a history of preeclampsia or fetal growth restriction: a preliminary study Eur J Obstet Gynecol Reprod Biol 80 1 1998 Sep 49 54
39. H Carp, M Dolitzky, A Inbal Thromboprophylaxis improves the live birth rate in women with consecutive recurrent miscarriages and hereditary thrombophilia J Thromb Haemost 1 3 2003 Mar 433 438
40. B Brenner, R Hoffman, H Carp, M Dulitzky, J Younis, for the LIVE-ENOX Investigators Efficacy and safety of two doses of enoxaparin in women with thrombophilia and recurrent pregnancy loss: the LIVE-ENOX study J Thromb Haemost 3 2 2005 227 229
41. S Middeldorp The use of LMWH in pregnancies at risk: new evidence or perception? J Thromb Haemost 3 4 2005 Apr 788 789
42. S Middeldorp Pregnancy failure and heritable thrombophilia Semin Hematol 44 2 2007 Apr 93 97