Increased fetal loss in women with heritable thrombophilia

Lancet

Volumn 348, Issue 9032, 1996, Pages 913-916

  Preston, F E ^a   Rosendaal, F R ^b   Walker, I D ^c   Briet E ^d   Berntorp, E ^e   Conard, J ^k   Fontcuberta, J ^f   Makris, M ^a   Mariani, G ^g   Noteboom, W ^b   Pabinger, I ^h   Legnani, C ⁱ   Scharrer, I ^j   Schulman, S ^k   Van Der Meer, F J M ^b  

^a ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c GLASGOW ROYAL INFIRMARY   (United Kingdom)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

^e LUND UNIVERSITY   (Sweden)

^f HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^g SAPIENZA UNIVERSITY OF ROME   (Italy)

^h UNIVERSITY OF VIENNA   (Austria)

ⁱ UNIVERSITY OF BOLOGNA   (Italy)

^j UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^k University Hospital Leiden ^*

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN III; BLOOD CLOTTING FACTOR 5; PROTEIN C; PROTEIN S;

ADULT; AGED; ANTITHROMBIN III DEFICIENCY; ARTICLE; BLOOD CLOTTING FACTOR 5 DEFICIENCY; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; FEMALE; FETUS OUTCOME; FETUS WASTAGE; HEMOSTASIS; HUMAN; INDUCED ABORTION; MAJOR CLINICAL STUDY; PLACENTA FUNCTION; PRIORITY JOURNAL; PROTEIN C DEFICIENCY; PROTEIN S DEFICIENCY; RISK FACTOR; SPONTANEOUS ABORTION; STILLBIRTH; THROMBOPHILIA;

EID: 16044369784     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(96)04125-6     Document Type: Article

References (10)

1. 1 Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognised mechanism characterised by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993; 90: 1004-08.
2. 2 Koster T, Rosendaal FR, de Ronde H, Briët E, Vandenbroucke JP, Bertina RM. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet 1993; 342: 1503-06.
3. 3 Bertina RM, Koeleman RPC, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-67.
4. 4 Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-34.
5. 5 Stirrat GM. Recurrent miscarriage I: definition and epidemiology. Lancet 1990; 336: 673-75.
6. 6 Koeleman RPC, Reitsma PH, Allaart CF, Bertina RM. Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families. Blood 1994; 84: 1031-35.
7. 7 Infante-Rievard C, David M, Gauthier R, Rivard GE. Lupus anticoagulants, anticardiolipin antibodies and fetal loss. N Engl J Med 1991; 325: 1063-66.
8. 8 Malia RG, Kitchen S, Greaves M, Preston FE. Inhibition of activated protein C and its cofactor protein S by antiphospholipid antibodies. Br J Haematol 1990; 76: 101-07.
9. 9 Healy AM, Rayburn HB, Rosenberg RD, Weiler H. Absence of the bloodclotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system. Proc Natl Acad Sci USA 1995; 92: 850-54.
10. 10 Rosendaal FR, Koster T, Vandenbrouke JP, Reitsma PH. High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood 1995; 85: 1504-08.