Metallation of pentaphyrin with Lu(III) dramatically increases reactive-oxygen species production and cell phototoxicity

European Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2011, Pages 712-720

  Ballico, Maurizio ^a   Rapozzi, Valentina ^a   Xodo, Luigi E ^a   Comuzzi, Clara ^a  

^a UNIVERSITY OF UDINE   (Italy)

Author keywords

Cell proliferation; Lu(III); PDT; Pentaphyrin; ROS

Indexed keywords

20 [[4' ( TRIMETHYLSILYL)ETHOXYCARBONYL]PHENYL 2,13 DIMETHYL 3,12 DIETHYL [24] ISOPENTAPHYRIN; HEAVY METAL; LUTETIUM; METAL COMPLEX; PHOTOSENSITIZING AGENT; PORPHYRIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PHOTOTOXICITY; COMPLEX FORMATION; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; METALLATION; MOUSE; NONHUMAN; PHOTOTOXICITY;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; LUTETIUM; METALLOPORPHYRINS; MICE; MOLECULAR STRUCTURE; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; REACTIVE OXYGEN SPECIES; STEREOISOMERISM; ZINC;

EID: 79151485517     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.12.007     Document Type: Article

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