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Volumn 118, Issue 7, 1996, Pages 1608-1616

Interaction of sapphyrin with phosphorylated species of biological interest

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC CMP; CYCLIC GMP; DOUBLE STRANDED DNA; POLYNUCLEOTIDE; PORPHYRIN DERIVATIVE; SAPPHYRIN DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0029968902     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja952961x     Document Type: Article
Times cited : (83)

References (63)
  • 10
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    • The Guanidinium Group: Its Biological Role and Synthetic Analogs
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    • (b) Hannon. C. L.; Anslyn, E. V. The Guanidinium Group: Its Biological Role and Synthetic Analogs. In Bioorganic Chemistry Frontiers, Dugas. H., Schmidtchen. F. P., Eds.; Springer Heidelberg. 1993: Vol. 3. pp 193-255.
    • (1993) Bioorganic Chemistry Frontiers , vol.3 , pp. 193-255
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  • 24
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    • note
    • -.
  • 27
    • 0001127763 scopus 로고
    • and references therein
    • max of 1 resembles that previously proposed for acridine orange. In the case of acridine orange, the monomeric form absorbs at a higher wavelength than the dimer which, in turn, absorbs at higher wavelength than an extensively aggregated form. A similar effect is seen on the surface of polyanions. While we maintain that the underlying mode of DNA recognition for sapphyrin differs from that of acridine orange, we nonetheless recognize that the underlying photophysics for these two system are similar. See: Bradley. D. F.; Wolf. M. K. Proc. Nail. Acad. Sci. U.S.A. 1959. 45. 944-952, and references therein.
    • (1959) Proc. Nail. Acad. Sci. U.S.A. , vol.45 , pp. 944-952
    • Bradley, D.F.1    Wolf, M.K.2
  • 28
    • 13344264486 scopus 로고    scopus 로고
    • note
    • max, of two or more overlapping absorption bands.
  • 29
    • 13344254350 scopus 로고    scopus 로고
    • note
    • The titrations were conducted in 10 mM bis-Tris buffer at pH 6.1. Details of the titration and curve-fitting procedures can be found in the supporting information.
  • 30
    • 13344264490 scopus 로고    scopus 로고
    • note
    • 31P NMR studies could not be conducted with nucleic acids.
  • 31
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    • note
    • lt was necessary to use an organic cosolvent in these studies to avoid problems involving the coprecipitation of sapphyrin and these nucleotides in aqueous solution in the millimolar concentration regime needed for the NMR work
  • 34
    • 13344267079 scopus 로고
    • Dolphin, D., Ed; Academic Press: New York.
    • White. W. I. In the Porphyrins: Dolphin, D., Ed; Academic Press: New York. 1978. Vol. 5. p 334.
    • (1978) The Porphyrins , vol.5 , pp. 334
    • White, W.I.1
  • 38
    • 13344251529 scopus 로고    scopus 로고
    • note
    • The higher apparent affinity for ssDNA (as opposed to simple phosphates) may reflect the fact that once 1 is complexed to the polyanionic backbone of ssDNA. u is bound to a two-dimensional array of phosphodiester anions. Consequently, because of the high effective concentration of anions present. 1 may have a considerably slower off rate than when bound to a nucleotide monomer in solution.
  • 48
    • 13344254346 scopus 로고    scopus 로고
    • note
    • In some cases, a small absorption band resembling that seen with ssDNA was seen at ca. 450 nm at very high P/S ratios (>300) of dsDNA. The appearance of this band was found to be dependent on the batch of dsDNA used and likely reflects the fact that double-stranded calf thymus DNA inevitably contains trace amounts of unpaired single strands. As a result, there is likely some hydrophobic interaction, as discussed in the case of ssDNA. with exposed nucleobases
  • 57
    • 0024238645 scopus 로고
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    • (1988) Biochemistry , vol.27 , pp. 8870-8878
    • Strickland, J.A.1    Marzilli, L.G.2    Gay, K.M.3    Wilson, W.D.4
  • 58
    • 0000607156 scopus 로고
    • While groove binding could no! be rigorously ruled oui. similar electrostatic arguments were employed to explain the high degree of selectivity for [poly(dA-dT)]2 over [poly(dG-dC)]: seen for certain cationic porphyrins containing peripherally) attached methy lated pyridinium cations. see: (a) Strickland.J. A., Marzilli. L. G.; Gay. K. M ; Wilson. W D. Biochemistry 1988. 27. 8870-8878. (b) Lin. M.; Lee. M.; Yue. K- T.; Marzilli. L. G. Inorg Chem. 1993. 32. 3217-3226 (c) Mukundan. N. E . Petho. G : Dixcon, D. W ., Marzilli. L. G. Inorg Chem. 1995. 34. 3677-3687.
    • (1993) Inorg Chem. , vol.32 , pp. 3217-3226
    • Lin, M.1    Lee, M.2    Yue, K.T.3    Marzilli, L.G.4
  • 59
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    • While groove binding could no! be rigorously ruled oui. similar electrostatic arguments were employed to explain the high degree of selectivity for [poly(dA-dT)]2 over [poly(dG-dC)]: seen for certain cationic porphyrins containing peripherally) attached methy lated pyridinium cations. see: (a) Strickland.J. A., Marzilli. L. G.; Gay. K. M ; Wilson. W D. Biochemistry 1988. 27. 8870-8878. (b) Lin. M.; Lee. M.; Yue. K- T.; Marzilli. L. G. Inorg Chem. 1993. 32. 3217-3226 (c) Mukundan. N. E . Petho. G : Dixcon, D. W ., Marzilli. L. G. Inorg Chem. 1995. 34. 3677-3687.
    • (1995) Inorg Chem. , vol.34 , pp. 3677-3687
    • Mukundan, N.E.1    Petho, G.2    Dixcon, D.W.3    Marzilli, L.G.4
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.