N-Alkylidenearylcarboxamides as new potent and selective CB2 cannabinoid receptor agonists with good oral bioavailability

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 22, 2007, Pages 6299-6304

  Ohta, Hiroshi ^a   Ishizaka, Tomoko ^a   Tatsuzuki, Makoto ^a   Yoshinaga, Mitsukane ^a   Iida, Izumi ^a   Tomishima, Yasumitsu ^a   Toda, Yoshihisa ^a   Saito, Shuji ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Amide; Cannabinoid; CB2 receptor agonist; SAR

Indexed keywords

4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; ALKYL GROUP; AMIDE; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; SULFONAMIDE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; IC 50; LIVER MICROSOME; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; RAT; RECEPTOR AFFINITY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; AMIDES; ANIMALS; BIOLOGICAL AVAILABILITY; CELL LINE; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MOLECULAR STRUCTURE; RATS; RECEPTOR, CANNABINOID, CB2; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 35048814909     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.09.004     Document Type: Article

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