PKC-alpha inhibitor MT477 slows tumor growth with minimal toxicity in in vivo model of non-Ras-mutated cancer via induction of apoptosis

Investigational New Drugs

Volumn 29, Issue 1, 2011, Pages 33-40

  Jasinski, Piotr ^a,b   Zwolak, Pawel ^a   Terai, Kaoru ^a   Borja Cacho, Daniel ^a   Dudek, Arkadiusz Z ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Actin structure; In vivo toxicity; MT477; New drug development; Protein kinase C alpha

Indexed keywords

CISPLATIN; ENZASTAURIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MT 477; PROTEIN KINASE B; PROTEIN KINASE C ALPHA; PROTEIN KINASE C ALPHA INHIBITOR; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA I; PROTEIN KINASE C BETA II; PROTEIN KINASE C GAMMA; RAS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLOOD CHEMISTRY; CANCER CELL CULTURE; CANCER INHIBITION; CELL ADHESION; CONTROLLED STUDY; DOSAGE SCHEDULE COMPARISON; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG NON SMALL CELL CANCER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; STRESS FIBER; TOXICITY TESTING; TUMOR VOLUME;

ANIMALS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FOCAL ADHESIONS; HUMANS; ISOENZYMES; MICE; MICROFILAMENTS; MODELS, BIOLOGICAL; MUTATION; NEOPLASMS; PHOSPHORYLATION; PROTEIN KINASE C-ALPHA; PROTO-ONCOGENE PROTEINS C-AKT; QUINOLINES; RAS PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79151472115     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-009-9330-9     Document Type: Article

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