Signaling cascades in radiation-induced apoptosis: Roles of protein kinase C in the apoptosis regulation

Medical Science Monitor

Volumn 12, Issue 10, 2006, Pages

  Nakajima, Tetsuo ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

Anti apoptotic signaling; Protein kinase C; Radiation sensitivity; Radiation induced apoptosis

Indexed keywords

PROTEIN KINASE C; PROTEIN SERINE KINASE; THREONINE;

APOPTOSIS; ARTICLE; ATAXIA TELANGIECTASIA; BIOLOGICAL ACTIVITY; CANCER CELL; CARCINOGENESIS; CELL CYCLE; CELL DAMAGE; CELL FUNCTION; CELL POPULATION; CONTROLLED STUDY; GENETIC DISORDER; HUMAN; HUMAN CELL; KILLER CELL; PROTEIN DEGRADATION; RADIOSENSITIVITY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HUMANS; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 33749673749     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Takai Y, Kishimoto A, Iwase Y et al: Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids. J Biol Chem, 1979; 254: 3692-95
2. Nishizuka Y: Protein kinase C and lipid signaling for sustained cellular responses. FASEB J, 1995; 9: 484-96
3. Parekh DB, Ziegler W, Parker PJ: Multiple pathways control protein kinase C phosphorylation. EMBO J, 2000; 19: 496-503
4. Newton AC: Protein kinase C: Structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem Rev, 2001; 101: 2353-64
5. Nishizuka Y: Discovery and prospect of protein kinase C research: Epilogue. J Biochem, 2003; 133: 155-58
6. Endo K, Oki E, Biedermann V et al: Proteolytic cleavage and activation of protein kinase C μ by caspase-3 in the apoptotic response of 1-β-D-arabinofuranosylcytosine and other genotoxic agents. J Biol Chem, 2000; 275: 18476-81
7. Martin PM, Hussaini IM: PKCη as a therapeutic target in glioblastoma multiforme. Expert Opin Ther Targets, 2005; 9: 299-313
8. Musashi M, Ota S, Shiroshita N: The role of protein kinase C isoforms in cell proliferation and apoptosis. Int J Hematol, 2000; 72: 12-19
9. Hallahan DE, Virudachalam S, Schwartz JL et al: Inhibition of protein kinases sensitizes human tumor cells to ionizing radiation. Radiat Res, 1992; 129: 345-50
10. Hallahan DE, Virudachalam S, Sherman ML et al: Tumor Necrosis Factor Gene Expression Is Mediated by Protein Kinase C following Activation by Ionizing Radiation. Cancer Res, 1991; 51: 4565-69
11. Belka C, Jendrossek V, Pruschy M et al: Apoptosis-modulating agents in combination with radiotherapy - current status and outlook. Int J Radiat Oncol Biol Phys, 2004; 58: 542-54
12. Spitaler M, Wiesenhofer B, Biedermann V et al: The involvement of protein kinase C isoenzymes α, ε and ζ in the sensitivity to antitumor treatment and apoptosis induction. Anticancer Res, 1999; 19: 3969-76
13. Shi CM, Su YP, Cheng TM: Recent advances in the pathological basis and experimental management of impaired wound healing due to total-body irradiation. Med Sci Monit, 2006; 12(1): RA1-4
14. Haimovitz-Friedman A, Balaban N, McLoughlin M et al: Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis. Cancer Res, 1994; 54: 2591-97
15. Kelly ML, Tang Y,, Rosensweig N et al: Granulocyte-macrophage colony-stimulating factor rescues TF-1 leukemia cells from ionizing radiation-induced apoptosis through a pathway mediated by protein kinase Cα. Blood, 1998; 92: 416-24
16. Nakajima T, Yukawa O, Azuma C et al: Involvement of protein kinase C-related anti-apoptosis signaling in radiation-induced apoptosis in murine thymic lymphoma (3SBH5) cells. Radiat Res, 2004; 161: 528-34
17. Lee Y-J, Soh J-W, Jeoung D-I et al: PKCε-mediated ERK1/2 activation involved in radiation-induced cell death in NIH3T3 cells. Biochim Biophys Acta, 2003; 1593: 219-29
18. Soh J-W, Lee Y-S, Weinstein IB: Effects of regulatory domains of specific isoforms of protein kinase C on growth control and apoptosis in MCF-7 breast cancer cells. J Exp Ther Oncol, 2003; 3: 115-26
19. Frutos S, Moscat J, Diaz-Meco MT: Cleavage of ζPKC but not λ/ι PKC by Caspase-3 during UV-induced Apoptosis. J Biol Chem, 1999; 274: 10765-70
20. Hei TK, Krauss RS, Liu SX et al: Effects of increased expression of protein kinase C on radiation-induced cell transformation. Carcinogenesis, 1994; 15: 365-70
21. Mackay HJ, Twelves CJ: Protein kinase C: a target for anticancer drugs? Endocr Relat Cancer, 2003; 10: 389-96
22. Emoto Y, Manome Y, Meinhardt G et al: Proteolytic activation of protein kinase Cδ by an ICE-like protease in apoptotic cells. EMBO J, 1995; 14: 6148-56
23. Yoshida K, Wang H-G, Miki Y, Kufe D: Protein kinase Cδ is responsible for constitutive and DNA damage-induced phosphorylation of Rad9. EMBO J, 2003; 22: 1431-41
24. Nakajima T, Yukawa O, Tsuji H et al: Regulation of radiation-induced protein kinase Cδ activation in radiation-induced apoptosis differs between radiosensitive and radioresistant mouse thymic lymphoma cell lines. Mutation Res, 2006; 595: 29-36
25. Denning MF, Wang Y, Nickoloff BJ, Wrone-Smith T: Protein kinase Cδ is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of human keratinocytes. J Biol Chem, 1998; 273: 29995-30002
26. Leverrier S, Vallentin A, Joubert D: Positive feedback of protein kinase C proteolytic activation during apoptosis. Biochem J, 2002; 368: 905-13
27. Majumder PK, Pandey P, Sun X et al: Mitochondrial translocation of protein kinase Cδ in phorbol ester-induced cytochrome C release and apoptosis. J Biol Chem, 2000; 275: 21793-96
28. Datta R, Kojima H, Yoshida K, Kufe D: Caspase-3-mediated cleavage of protein kinase Cθ in induction of apoptosis. J Biol Chem, 1997; 272: 20317-320
29. Berra E, Municio MM, Sanz L et al: Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade. Mol Cell Biol, 1997; 17: 4346-54
30. Savitsky K, Bar-Shira A, Gilad S et al: A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science, 1995; 268: 1749-53
31. Xu Y, Baltimore D: Dual roles of ATM in the cellular response to radiation and in cell growth control. Genes Dev, 1996; 10: 2401-10
32. Herzog K-H, Chong MJ, Kapsetaki M et al: Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science, 1998; 280: 1089-91
33. Truman J-P, Gueven N, Lavin M, Leibel S et al: Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis. J Biol Chem, 2005; 280: 23262-72
34. Bradshaw PS, Stavropoulos DJ, Meyn MS: Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage. Nature Genetics, 2005; 37: 193-97