Chronic peripheral administration of somatostatin receptor subtype-4 agonist NNC 26-9100 enhances learning and memory in SAMP8 mice

European Journal of Pharmacology

Volumn 654, Issue 1, 2011, Pages 53-59

  Sandoval, Karin E ^a   Farr, Susan A ^b,c   Banks, William A ^d,e   Niehoff, Michael L ^b,c   Morley, John E ^b,c   Crider, Albert M ^a   Witt, Ken A ^a  

^a SOUTHERN ILLINOIS UNIVERSITY EDWARDSVILLE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Learning; Memory; NNC 26 9100; Somatostatin subtype 4 receptor agonist

Indexed keywords

1 [3 [N (5 BROMO 2 PYRIDYL) N (3,4 DICHLOROBENZYL)AMINO]PROPYL] 3 [3 (4 IMIDAZOLYL)PROPYL]THIOUREA; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; SOMATOSTATIN RECEPTOR 4;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG TRANSPORT; EX VIVO STUDY; LEARNING; LONG TERM CARE; MALE; MAZE TEST; MEMORY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE DISTRIBUTION;

AMINOPYRIDINES; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; GENE EXPRESSION REGULATION; MALE; MAZE LEARNING; MEMORY; MICE; PEPTIDE FRAGMENTS; RECEPTORS, SOMATOSTATIN; THIOUREA; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 78951476264     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.12.013     Document Type: Article

References (42)

1. M. Ankersen, A.M. Crider, S. Liu, B. Ho, H.S. Andersen, and C.E. Stidsen Discovery of a novel non-peptide somatostatin agonist with SST4 selectivity J. Am. Chem. Soc. 120 1998 1368 1373
2. W.A. Banks Characteristics of compounds that cross the blood-brain barrier BMC Neurol. 9 Suppl 1 2009 S3
3. W.A. Banks, S.A. Farr, J.E. Morley, K.M. Wolf, V. Geylis, and M. Steinitz Anti-amyloid beta protein antibody passage across the blood-brain barrier in the SAMP8 mouse model of Alzheimer's disease: an age-related selective uptake with reversal of learning impairment Exp. Neurol. 206 2007 248 256
4. W.A. Banks, S.M. Robinson, R. Diaz-Espinoza, A. Urayama, and C. Soto Transport of prion protein across the blood-brain barrier Exp. Neurol. 218 2009 162 167
5. J.F. Bruno, Y. Xu, J. Song, and M. Berelowitz Molecular cloning and functional expression of a brain-specific somatostatin receptor Proc. Natl Acad. Sci. USA 89 1992 11151 11155
6. E. Burgos-Ramos, A. Hervas-Aguilar, D. Aguado-Llera, L. Puebla-Jimenez, A.M. Hernandez-Pinto, V. Barrios, and E. Arilla-Ferreiro Somatostatin and Alzheimer's disease Mol. Cell. Endocrinol. 286 2008 104 111
7. D. Cervia, and P. Bagnoli An update on somatostatin receptor signaling in native systems and new insights on their pathophysiology Pharmacol. Ther. 116 2007 322 341
8. H.X. Chen, M. Jiang, D. Akakin, and S.N. Roper Long-term potentiation of excitatory synapses on neocortical somatostatin-expressing interneurons J. Neurophysiol. 102 2009 3251 3259
9. A.M. Crider, S. Liu, T. Li, S. Mahajan, M. Ankersen, and C.E. Stidsen Somatostatin receptor subtype 4 (sst4) ligands: synthesis and evaluation of indol-3-yl- and 2-pyridyl-thioureas Lett. Drug Des. Discovery 1 2004 84 87
10. P. Davies, R. Katzman, and R.D. Terry Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa Nature 288 1980 279 280
11. J. Epelbaum, J.L. Guillou, F. Gastambide, D. Hoyer, E. Duron, and C. Viollet Somatostatin, Alzheimer's disease and cognition: an old story coming of age? Prog. Neurobiol. 89 2009 153 161
12. S.A. Farr, W.A. Banks, M.E. La Scola, J.F. Flood, and J.E. Morley Permanent and temporary inactivation of the hippocampus impairs T-maze footshock avoidance acquisition and retention Brain Res. 872 2000 242 249
13. M.A. Findeis The role of amyloid beta peptide 42 in Alzheimer's disease Pharmacol. Ther. 116 2007 266 286
14. J.F. Flood, and J.E. Morley Age-related changes in footshock avoidance acquisition and retention in senescence accelerated mouse (SAM) Neurobiol. Aging 14 1993 153 157
15. Freir, D.B., Fedriani, R., Scully, D., Smith, I.M., Selkoe, D.J., Walsh, D.M., Regan, C.M., in press. Abeta oligomers inhibit synapse remodelling necessary for memory consolidation. Neurobiol Aging doi:10.1016/j. neurobiolaging.2010.01.001.
16. F. Gastambide, G. Lepousez, C. Viollet, C. Loudes, J. Epelbaum, and J.L. Guillou Cooperation between hippocampal somatostatin receptor subtypes 4 and 2: functional relevance in interactive memory systems Hippocampus 20 2009 745 757
17. F. Gastambide, C. Viollet, G. Lepousez, J. Epelbaum, and J.L. Guillou Hippocampal SSTR4 somatostatin receptors control the selection of memory strategies Psychopharmacology 202 2009 153 163
18. N. Iwata, M. Higuchi, and T.C. Saido Metabolism of amyloid-beta peptide and Alzheimer's disease Pharmacol. Ther. 108 2005 129 148
19. N. Iwata, S. Tsubuki, Y. Takaki, K. Shirotani, B. Lu, N.P. Gerard, C. Gerard, E. Hama, H.J. Lee, and T.C. Saido Metabolic regulation of brain Abeta by neprilysin Science 292 2001 1550 1552
20. N. Iwata, S. Tsubuki, Y. Takaki, K. Watanabe, M. Sekiguchi, E. Hosoki, M. Kawashima-Morishima, H.J. Lee, E. Hama, Y. Sekine-Aizawa, and T.C. Saido Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition Nat. Med. 6 2000 143 150
21. H. Kanemitsu, T. Tomiyama, and H. Mori Human neprilysin is capable of degrading amyloid beta peptide not only in the monomeric form but also the pathological oligomeric form Neurosci. Lett. 350 2003 113 116
22. V.B. Kumar, S.A. Farr, J.F. Flood, V. Kamlesh, M. Franko, W.A. Banks, and J.E. Morley Site-directed antisense oligonucleotide decreases the expression of amyloid precursor protein and reverses deficits in learning and memory in aged SAMP8 mice Peptides 21 2000 1769 1775
23. T.A. Lanz, and J.B. Schachter Demonstration of a common artifact in immunosorbent assays of brain extracts: development of a solid-phase extraction protocol to enable measurement of amyloid-beta from wild-type rodent brain J. Neurosci. Meth. 157 2006 71 81
24. S. Lesne, M.T. Koh, L. Kotilinek, R. Kayed, C.G. Glabe, A. Yang, M. Gallagher, and K.H. Ashe A specific amyloid-beta protein assembly in the brain impairs memory Nature 440 2006 352 357
25. N. Matsuoka, S. Kaneko, and M. Satoh Somatostatin augments long-term potentiation of the mossy fiber-CA3 system in guinea-pig hippocampal slices Brain Res. 553 1991 188 194
26. L.N. Moller, C.E. Stidsen, B. Hartmann, and J.J. Holst Somatostatin receptors Biochim. Biophys. Acta 1616 2003 1 84
27. J.E. Morley The SAMP8 mouse: a model of Alzheimer disease? Biogerontology 3 2002 57 60
28. J.E. Morley, S.A. Farr, and J.F. Flood Antibody to amyloid beta protein alleviates impaired acquisition, retention, and memory processing in SAMP8 mice Neurobiol. Learn. Mem. 78 2002 125 138
29. J.E. Morley, V.B. Kumar, A.E. Bernardo, S.A. Farr, K. Uezu, N. Tumosa, and J.F. Flood Beta-amyloid precursor polypeptide in SAMP8 mice affects learning and memory Peptides 21 2000 1761 1767
30. W.H. Oldendorf Lipid solubility and drug penetration of the blood brain barrier Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y 147 1974 813 815
31. C.S. Patlak, R.G. Blasberg, and J.D. Fenstermacher Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data J. Cereb. Blood Flow Metab. 3 1983 1 7
32. H.F. Poon, G. Joshi, R. Sultana, S.A. Farr, W.A. Banks, J.E. Morley, V. Calabrese, and D.A. Butterfield Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice Brain Res. 1018 2004 86 96
33. T. Saito, N. Iwata, S. Tsubuki, Y. Takaki, J. Takano, S.M. Huang, T. Suemoto, M. Higuchi, and T.C. Saido Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation Nat. Med. 11 2005 434 439
34. M. Sano, H. Grossman, and K. Van Dyk Preventing Alzheimer's disease: separating fact from fiction CNS Drugs 22 2008 887 902
35. D.J. Selkoe Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior Behav. Brain Res. 192 2008 106 113
36. M. Strittmatter, H. Cramer, C. Reuner, D. Strubel, G. Hamann, and K. Schimrigk Molecular forms of somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with senile dementia of the Alzheimer type Biol. Psychiatry 41 1997 1124 1130
37. M.K. Tallent Somatostatin in the dentate gyrus Prog. Brain Res. 163 2007 265 284
38. K. Tomobe, and Y. Nomura Neurochemistry, neuropathology, and heredity in SAMP8: a mouse model of senescence Neurochem. Res. 34 2009 660 669
39. D. Triguero, J. Buciak, and W.M. Pardridge Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins J. Neurochem. 54 1990 1882 1888
40. K. Yasojima, H. Akiyama, E.G. McGeer, and P.L. McGeer Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide Neurosci. Lett. 297 2001 97 100
41. K. Yasojima, E.G. McGeer, and P.L. McGeer Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain Brain Res. 919 2001 115 121
42. A. Zupa-Fernandez, A.M. Rozzi, H.M. Arnold, K.M. Felsenstein, A. Rowley, G. Treton, and G. Yohrling Optimization of soluble amyloid beta extraction from non-transgenic rodents to facilitate the testing of gamma-secretase modulators Society for Neuroscience, 37th 2007 San Diego