Synthesis, characterization and therapeutic efficacy of a biodegradable, thermoresponsive hydrogel designed for application in chronic infarcted myocardium

Biomaterials

Volumn 30, Issue 26, 2009, Pages 4357-4368

  Fujimoto, Kazuro L ^a,b   Ma, Zuwei ^a,b   Nelson, Devin M ^d   Hashizume, Ryotaro ^a,b   Guan, Jianjun ^a,b   Tobita, Kimimasa ^b,c   Wagner, William R ^a,b,d  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^d University of Pittsburgh   (United States)

Author keywords

Biodegradation; Cardiac tissue engineering; Cytotoxicity; Hydrogel; Smooth muscle cell; Thermally responsive material

Indexed keywords

ACRYLIC ACIDS; CAPILLARY DENSITY; CARDIAC TISSUE ENGINEERING; CHEMICAL STRUCTURE; DEGRADATION PRODUCTS; FEED RATIOS; HYDROLYTIC CLEAVAGE; HYDROXYETHYL METHACRYLATE; IN-VITRO; LEFT VENTRICULAR; MONOMER RATIO; MYOCARDIAL INFARCTION; N-ISOPROPYLACRYLAMIDE; PHOSPHATE-BUFFERED SALINES; POLY(TRIMETHYLENE CARBONATE); SMOOTH MUSCLE CELL; SMOOTH MUSCLE CELLS; THERAPEUTIC EFFICACY; THERMALLY RESPONSIVE MATERIAL; THERMORESPONSIVE HYDROGELS; TISSUE IN-GROWTH; VENTRICULAR WALLS; WALL STRESS;

ACRYLIC MONOMERS; AMIDES; BIOCHEMISTRY; BIODEGRADATION; BIOLOGICAL MATERIALS; BIOMATERIALS; CARBOXYLIC ACIDS; CELL MEMBRANES; COPOLYMERIZATION; CYTOTOXICITY; DEGRADATION; GROUP TECHNOLOGY; MICROBIOLOGY; MUSCLE; ORGANIC ACIDS; TISSUE ENGINEERING;

HYDROGELS;

ACRYLIC ACID; BIOMATERIAL; COPOLYMER; MAXON; PHOSPHATE BUFFERED SALINE; POLY(N ISOPROPYLACRYLAMIDE); POLYMACON;

ADULT ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIODEGRADABILITY; CAPILLARY DENSITY; CHEMICAL STRUCTURE; CHRONIC DISEASE; CONTROLLED STUDY; CYTOTOXICITY; ECHOCARDIOGRAPHY; FEMALE; HEART INFARCTION; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE INFARCTION; HEART VENTRICLE WALL; HISTOLOGY; HYDROGEL; HYDROLYSIS; IN VITRO STUDY; INJECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHENOTYPE; POLYMERIZATION; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER; SYNTHESIS; TEMPERATURE; TISSUE ENGINEERING; TISSUE GROWTH;

ANIMALS; BIOCOMPATIBLE MATERIALS; CALMODULIN-BINDING PROTEINS; CELL DEATH; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; FEMALE; HEART FUNCTION TESTS; HYDROGEL; IMMUNOHISTOCHEMISTRY; INJECTIONS; MAGNETIC RESONANCE SPECTROSCOPY; MATERIALS TESTING; MYOCARDIAL INFARCTION; MYOCYTES, SMOOTH MUSCLE; RATS; SOLUTIONS; TEMPERATURE;

RATTUS;

EID: 67650383437     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.04.055     Document Type: Article

References (34)

1. Pfeffer M.A., and Braunwald E. Ventricular remodeling after myocardial infarction: experimental observations and clinical implications. Circulation 81 (1990) 1161-1172
2. Mann D.L., and Bristow M.R. Mechanisms and models in heart failure: the biomechanical model and beyond. Circulation 111 (2005) 2837-2849
3. Lloyd-Jones D.M., Larson M.G., Leip E.P., Beiser A., D'Agostino R.B., Kannel W.B., et al. Lifetime risk for developing congestive heart failure: the Framingham Heart Study. Circulation 106 (2002) 3068-3072
4. Batista R.J., Verde J., Nery P., Bocchino L., Takeshita N., Bhayana J.N., et al. Partial left ventriculectomy to treat end-stage heart disease. Ann Thorac Surg 64 (1997) 634-638
5. Dor V., Sabatier M., DiDonato M., Montiglio F., Toso A., and Maioli M. Efficacy of endoventricular patch plasty in large postinfarction akinetic scar and severe left ventricular dysfunction: comparison with a series of large dyskinetic scars. J Thorac Cardiovasc Surg 116 (1998) 50-59
6. Kawaguchi A.T., Suma H., Konertz W., Gradinac S., Bergsland J., Dowling R.D., et al. International and Regional Registry Task Force, The Society for Cardiac Volume Reduction. Left ventricular volume reduction surgery: the 4th International Registry Report 2004. J Card Surg 20 (2005) S5-S11
7. Chaudhry P.A., Mishima T., Sharov V.G., Hawkins J., Alferness C., Paone G., et al. Passive epicardial containment prevents ventricular remodeling in heart failure. Ann Thorac Surg 70 (2000) 1275-1280
8. Magovern J.A. Experimental and clinical studies with the Paracor cardiac restraint device. Semin Thorac Cardiovasc Surg 17 (2005) 364-368
9. Fujimoto K.L., Tobita K., Merryman W.D., Guan J., Momoi N., Stolz D.B., et al. An elastic, biodegradable cardiac patch induces contractile smooth muscle and improves cardiac remodeling and function in subacute myocardial infarction. J Am Coll Cardiol 49 (2007) 2292-2300
10. Wall S.T., Walker J.C., Healy K.E., Ratcliffe M.B., and Guccione J.M. Theoretical impact of the injection of material into the myocardium: a finite element model simulation. Circulation 114 (2006) 2627-2635
11. Ohya S., Nakayama Y., and Matsuda T. Thermoresponsive artificial extracellular matrix for tissue engineering: hyaluronic acid bioconjugated with poly(N-isopropylacrylamide) grafts. Biomacromolecules 2 (2001) 856-863
12. Ohya S., and Matsuda T. Poly(N-isopropylacrylamide) (PNIPAM)-grafted gelatin as thermoresponsive three-dimensional artificial extracellular matrix: molecular and formulation parameters vs. cell proliferation potential. J Biomater Sci Polym Ed 16 (2005) 809-827
13. Kim S., Chung E.H., Gilbert M., and Healy K.E. Synthetic MMP-13 degradable ECMs based on poly(N-isopropylacrylamide-co-acrylic acid) semi-interpenetrating polymer networks. I. Degradation and cell migration. J Biomed Mater Res A 75 (2005) 73-88
14. Li F., Carlsson D., Lohmann C., Suuronen E., Vascotto S., Kobuch K., et al. Cellular and nerve regeneration within a biosynthetic extracellular matrix for corneal transplantation. Proc Nat Acad Sci U S A 100 (2003) 15346-15351
15. Lee B.H., and Vernon B. Copolymers of N-isopropylacrylamide, HEMA-lactate and acrylic acid with time-dependent lower critical solution temperature as a bioresorbable carrier. Polym Int 54 (2005) 418-422
16. Guan J., Hong Y., Ma Z., and Wagner W.R. Protein-reactive, thermoresponsive copolymers with high flexibility and biodegradability. Biomacromolecules 9 (2008) 1283-1292
17. Lee B.H., and Vernon B. In situ-gelling, erodible N-isopropylacrylamide copolymers. Macromol Biosci 5 (2005) 629-635
18. Wang T., Wu D.Q., Jiang X.J., Zhang X.Z., Li X.Y., Zhang J.F., et al. Novel thermosensitive hydrogel injection inhibits post-infarct ventricle remodeling. Eur J Heart Fail 11 (2009) 14-19
19. Wu D.Q., Qiu F., Wang T., Jiang X.J., Zhang X.Z., and RX Z. Toward the development of partially biodegradable and injectable thermoresponsive hydrogels for potential biomedical applications. ACS Appl Mater Interf 2 (2009) 312-327
20. Ray J.L., Leach R., Herbert J.M., and Benson M. Isolation of vascular smooth muscle cells from a single murine aorta. Methods Cell Sci 23 (2001) 185-188
21. Matsubayashi K., Fedak P.W., Mickle D.A., Weisel R.D., Ozawa T., and Li R.K. Improved left ventricular aneurysm repair with bioengineered vascular smooth muscle grafts. Circulation 108 (2003) 219-225
22. Fujimoto K.L., Guan J., Oshima H., Sakai T., and Wagner W.R. In vivo evaluation of a porous, elastic, biodegradable patch for reconstructive cardiac procedures. Ann Thorac Surg 83 (2007) 648-654
23. Oshima H., Payne T.R., Urish K.L., Sakai T., Ling Y., Gharaibeh B., et al. Differential myocardial infarct repair with muscle stem cells compared to myoblasts. Mol Ther 12 (2005) 1130-1141
24. Rzaev Z.M.O., Dincer S., and Piskin E. Functional copolymers of N-isopropylacrylamide for bioengineering applications. Prog Polym Sci 32 (2007) 534-595
25. Mukherjee R., Zavadzkas J.A., Saunders S.M., McLean J.E., Jeffords L.B., Beck C., et al. Targeted myocardial microinjections of a biocomposite material reduces infarct expansion in pigs. Ann Thorac Surg 86 (2008) 1268-1277
26. Yu J., Christman K.L., Chin E., Sievers R.E., Saeed M., and Lee R.J. Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathy. J Thorac Cardiovasc Surg 137 (2009) 180-187
27. Tsur-Gang O., Ruvinov E., Landa N., Holbova R., Feinberg M.S., Leor J., et al. The effects of peptide-based modification of alginate on left ventricular remodeling and function after myocardial infarction. Biomaterials 30 (2009) 189-195
28. Yu J., Gu Y., Du K.T., Mihardja S., Sievers R.E., and Lee R.J. The effect of injected RGD modified alginate on angiogenesis and left ventricular function in a chronic rat infarct model. Biomaterials 30 (2009) 751-756
29. Jiang XJ, Wang T, Li XY, Wu DQ, Zheng ZB, Zhang JF, et al. Injection of a novel synthetic hydrogel preserves left ventricle function after myocardial infarction. J Biomed Mater Res A, in press, doi:10.1002/jbm.a.32118.
30. Hsieh P.C., Davis M.E., Gannon J., MacGillivray C., and Lee R.T. Controlled delivery of PDGF-BB for myocardial protection using injectable self-assembling peptide nanofibers. J Clin Invest 116 (2006) 237-248
31. Dubois G., Segers V.F., Bellamy V., Sabbah L., Peyrard S., Bruneval P., et al. Self-assembling peptide nanofibers and skeletal myoblast transplantation in infarcted myocardium. J Biomed Mater Res B Appl Biomater 87 (2008) 222-228
32. Holmes J.W., Borg T.K., and Covell J.W. Structure and mechanics of healing myocardial infarcts. Annu Rev Biomed Eng 7 (2005) 223-253
33. Goldstein S., Ali A.S., and Sabbah H. Ventricular remodeling: Mechanisms and prevention. Cardiol Clin 16 (1998) 623-632
34. Hayakawa K., Takemura G., Kanoh M., Li Y., Koda M., Kawase Y., et al. Inhibition of granulation tissue cell apoptosis during the subacute stage of myocardial infarction improves cardiac remodeling and dysfunction at the chronic stage. Circulation 108 (2003) 104-109