-
1
-
-
59149106151
-
Toxicity testing in the 21st century: bringing the vision to life
-
Andersen, M. E., and Krewski, D. (2009). Toxicity testing in the 21st century: bringing the vision to life. Toxicol. Sci. 107, 324-330.
-
(2009)
Toxicol. Sci.
, vol.107
, pp. 324-330
-
-
Andersen, M.E.1
Krewski, D.2
-
2
-
-
18544381407
-
Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months
-
Butenhoff, J., Costa, G., Elcombe, C., Farrar, D., Hansen, K., Iwai, H., Jung, R., Kennedy, G., Jr., Lieder, P., Olsen, G., et al. (2002). Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months. Toxicol. Sci. 69, 244-257.
-
(2002)
Toxicol. Sci.
, vol.69
, pp. 244-257
-
-
Butenhoff, J.1
Costa, G.2
Elcombe, C.3
Farrar, D.4
Hansen, K.5
Iwai, H.6
Jung, R.7
Kennedy Jr., G.8
Lieder, P.9
Olsen, G.10
-
3
-
-
57149114316
-
Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines
-
Choy, E., Yelensky, R., Bonakdar, S., Plenge, R. M., Saxena, R., De Jager, P. L., Shaw, S. Y., Wolfish, C. S., Slavik, J. M., Cotsapas, C., et al. (2008). Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines. PLoS Genet. 4, e1000287.
-
(2008)
PLoS Genet
, vol.4
-
-
Choy, E.1
Yelensky, R.2
Bonakdar, S.3
Plenge, R.M.4
Saxena, R.5
De Jager, P.L.6
Shaw, S.Y.7
Wolfish, C.S.8
Slavik, J.M.9
Cotsapas, C.10
-
4
-
-
33644870082
-
Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54
-
Coecke, S., Ahr, H., Blaauboer, B. J., Bremer, S., Casati, S., Castell, J., Combes, R., Corvi, R., Crespi, C. L., Cunningham, M. L., et al. (2006). Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54. Altern. Lab. Anim. 34, 49-84.
-
(2006)
Altern. Lab. Anim.
, vol.34
, pp. 49-84
-
-
Coecke, S.1
Ahr, H.2
Blaauboer, B.J.3
Bremer, S.4
Casati, S.5
Castell, J.6
Combes, R.7
Corvi, R.8
Crespi, C.L.9
Cunningham, M.L.10
-
5
-
-
39349118236
-
Toxicology. Transforming environmental health protection
-
Collins, F. S., Gray, G. M., and Bucher, J. R. (2008). Toxicology. Transforming environmental health protection. Science 319, 906-907.
-
(2008)
Science
, vol.319
, pp. 906-907
-
-
Collins, F.S.1
Gray, G.M.2
Bucher, J.R.3
-
6
-
-
48349112805
-
The application of genetic information for regulatory standard setting under the clean air act: a decision-analytic approach
-
Cullen, A. C., Corrales, M. A., Kramer, C. B., and Faustman, E. M. (2008). The application of genetic information for regulatory standard setting under the clean air act: a decision-analytic approach. Risk Anal. 28, 877-890.
-
(2008)
Risk Anal
, vol.28
, pp. 877-890
-
-
Cullen, A.C.1
Corrales, M.A.2
Kramer, C.B.3
Faustman, E.M.4
-
7
-
-
3042616025
-
Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity
-
Dolan, M. E., Newbold, K. G., Nagasubramanian, R., Wu, X., Ratain, M. J., Cook, E. H., Jr., and Badner, J. A. (2004). Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity. Cancer Res. 64, 4353-4356.
-
(2004)
Cancer Res
, vol.64
, pp. 4353-4356
-
-
Dolan, M.E.1
Newbold, K.G.2
Nagasubramanian, R.3
Wu, X.4
Ratain, M.J.5
Cook Jr., E.H.6
Badner, J.A.7
-
8
-
-
35348983887
-
A second generation human haplotype map of over 3.1 million SNPs
-
Frazer, K. A., Ballinger, D. G., Cox, D. R., Hinds, D. A., Stuve, L. L., Gibbs, R. A., Belmont, J. W., Boudreau, A., Hardenbol, P., Leal, S. M., et al. (2007). A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851-861.
-
(2007)
Nature
, vol.449
, pp. 851-861
-
-
Frazer, K.A.1
Ballinger, D.G.2
Cox, D.R.3
Hinds, D.A.4
Stuve, L.L.5
Gibbs, R.A.6
Belmont, J.W.7
Boudreau, A.8
Hardenbol, P.9
Leal, S.M.10
-
9
-
-
29544437778
-
Gene expression profiles in rat liver treated with perfluorooctanoic acid (PFOA)
-
Guruge, K. S., Yeung, L. W., Yamanaka, N., Miyazaki, S., Lam, P. K., Giesy, J. P., Jones, P. D., and Yamashita, N. (2006).Gene expression profiles in rat liver treated with perfluorooctanoic acid (PFOA). Toxicol. Sci. 89, 93-107.
-
(2006)
Toxicol. Sci.
, vol.89
, pp. 93-107
-
-
Guruge, K.S.1
Yeung, L.W.2
Yamanaka, N.3
Miyazaki, S.4
Lam, P.K.5
Giesy, J.P.6
Jones, P.D.7
Yamashita, N.8
-
10
-
-
56749122303
-
Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity
-
Harrill, A. H., and Rusyn, I. (2008). Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity. Expert Opin. Drug Metab. Toxicol. 4, 1379-1389.
-
(2008)
Expert Opin. Drug Metab. Toxicol.
, vol.4
, pp. 1379-1389
-
-
Harrill, A.H.1
Rusyn, I.2
-
11
-
-
70349292567
-
Are in vitro tests suitable for regulatory use?
-
Hartung, T., and Daston, G. (2009). Are in vitro tests suitable for regulatory use? Toxicol. Sci. 111, 233-237.
-
(2009)
Toxicol. Sci.
, vol.111
, pp. 233-237
-
-
Hartung, T.1
Daston, G.2
-
12
-
-
41849099259
-
Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening
-
Huang, R., Southall, N., Cho, M. H., Xia, M., Inglese, J., and Austin, C. P. (2008). Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening. Chem. Res. Toxicol. 21, 659-667.
-
(2008)
Chem. Res. Toxicol.
, vol.21
, pp. 659-667
-
-
Huang, R.1
Southall, N.2
Cho, M.H.3
Xia, M.4
Inglese, J.5
Austin, C.P.6
-
13
-
-
34547438105
-
A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity
-
Huang, R. S., Duan, S., Bleibel, W. K., Kistner, E. O., Zhang, W., Clark, T. A., Chen, T. X., Schweitzer, A. C., Blume, J. E., Cox, N. J., et al. (2007). A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity. Proc. Natl. Acad. Sci. U.S.A. 104, 9758-9763.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 9758-9763
-
-
Huang, R.S.1
Duan, S.2
Bleibel, W.K.3
Kistner, E.O.4
Zhang, W.5
Clark, T.A.6
Chen, T.X.7
Schweitzer, A.C.8
Blume, J.E.9
Cox, N.J.10
-
14
-
-
0141853958
-
Transcriptional response of lymphoblastoid cells to ionizing radiation
-
Jen, K. Y., and Cheung, V. G. (2003). Transcriptional response of lymphoblastoid cells to ionizing radiation. Genome Res. 13, 2092-2100.
-
(2003)
Genome Res
, vol.13
, pp. 2092-2100
-
-
Jen, K.Y.1
Cheung, V.G.2
-
15
-
-
66349120133
-
The toxicity data landscape for environmental chemicals
-
Judson, R., Richard, A., Dix, D. J., Houck, K., Martin, M., Kavlock, R., Dellarco, V., Henry, T., Holderman, T., Sayre, P., et al. (2009). The toxicity data landscape for environmental chemicals. Environ. Health Perspect. 117, 685-695.
-
(2009)
Environ. Health Perspect.
, vol.117
, pp. 685-695
-
-
Judson, R.1
Richard, A.2
Dix, D.J.3
Houck, K.4
Martin, M.5
Kavlock, R.6
Dellarco, V.7
Henry, T.8
Holderman, T.9
Sayre, P.10
-
16
-
-
0036079158
-
The human genome browser at UCSC
-
Kent, W. J., Sugnet, C. W., Furey, T. S., Roskin, K. M., Pringle, T. H., Zahler, A. M., and Haussler, D. (2002). The human genome browser at UCSC. Genome Res. 12, 996-1006.
-
(2002)
Genome Res
, vol.12
, pp. 996-1006
-
-
Kent, W.J.1
Sugnet, C.W.2
Furey, T.S.3
Roskin, K.M.4
Pringle, T.H.5
Zahler, A.M.6
Haussler, D.7
-
17
-
-
0034040714
-
Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gene expression in human blood cells
-
Krovat, B. C., Tracy, J. H., and Omiecinski, C. J. (2000). Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gene expression in human blood cells. Toxicol. Sci. 55, 352-360.
-
(2000)
Toxicol. Sci.
, vol.55
, pp. 352-360
-
-
Krovat, B.C.1
Tracy, J.H.2
Omiecinski, C.J.3
-
18
-
-
0037139402
-
Sex hormoneregulated renal transport of perfluorooctanoic acid
-
Kudo, N., Katakura, M., Sato, Y., and Kawashima, Y. (2002). Sex hormoneregulated renal transport of perfluorooctanoic acid. Chem. Biol. Interact. 139, 301-316.
-
(2002)
Chem. Biol. Interact.
, vol.139
, pp. 301-316
-
-
Kudo, N.1
Katakura, M.2
Sato, Y.3
Kawashima, Y.4
-
19
-
-
13544267711
-
CEPH individuals are representative of the European American population: implications for pharmacogenetics
-
Meucci, M. A., Marsh, S., Watters, J. W., and McLeod, H. L. (2005). CEPH individuals are representative of the European American population: implications for pharmacogenetics. Pharmacogenomics 6, 59-63.
-
(2005)
Pharmacogenomics
, vol.6
, pp. 59-63
-
-
Meucci, M.A.1
Marsh, S.2
Watters, J.W.3
McLeod, H.L.4
-
20
-
-
77950458649
-
Transcriptome genetics using second generation sequencing in a caucasian population
-
Montgomery, S. B., Sammeth, M., Gutierrez-Arcelus, M., Lach, R. P., Ingle, C., Nisbett, J., Guigo, R., and Dermitzakis, E. T. (2010). Transcriptome genetics using second generation sequencing in a caucasian population. Nature 464, 773-777.
-
(2010)
Nature
, vol.464
, pp. 773-777
-
-
Montgomery, S.B.1
Sammeth, M.2
Gutierrez-Arcelus, M.3
Lach, R.P.4
Ingle, C.5
Nisbett, J.6
Guigo, R.7
Dermitzakis, E.T.8
-
22
-
-
61349184579
-
-
National Research Council (NRC). National Academies Press, Washington, DC
-
National Research Council (NRC). (2008). Science and Decisions: Advancing Risk Assessment. National Academies Press, Washington, DC.
-
(2008)
Science and Decisions: Advancing Risk Assessment
-
-
-
23
-
-
77954133026
-
Estimation of effect size distribution from genome-wide association studies and implications for future discoveries
-
Park, J. H., Wacholder, S., Gail, M. H., Peters, U., Jacobs, K. B., Chanock, S. J., and Chatterjee, N. (2010). Estimation of effect size distribution from genome-wide association studies and implications for future discoveries. Nat. Genet. 42, 570-575.
-
(2010)
Nat. Genet.
, vol.42
, pp. 570-575
-
-
Park, J.H.1
Wacholder, S.2
Gail, M.H.3
Peters, U.4
Jacobs, K.B.5
Chanock, S.J.6
Chatterjee, N.7
-
24
-
-
34548292504
-
PLINK: a tool set for whole-genome association and populationbased linkage analyses
-
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A., Bender, D., Maller, J., Sklar, P., de Bakker, P. I., Daly, M. J., et al. (2007). PLINK: a tool set for whole-genome association and populationbased linkage analyses. Am. J. Hum. Genet. 81, 559-575.
-
(2007)
Am. J. Hum. Genet.
, vol.81
, pp. 559-575
-
-
Purcell, S.1
Neale, B.2
Todd-Brown, K.3
Thomas, L.4
Ferreira, M.A.5
Bender, D.6
Maller, J.7
Sklar, P.8
de Bakker, P.I.9
Daly, M.J.10
-
25
-
-
34548039251
-
Gene expression profiling in the lung and liver of PFOAexposed mouse fetuses
-
Rosen, M. B., Thibodeaux, J. R., Wood, C. R., Zehr, R. D., Schmid, J. E., and Lau, C. (2007). Gene expression profiling in the lung and liver of PFOAexposed mouse fetuses. Toxicology 239, 15-33.
-
(2007)
Toxicology
, vol.239
, pp. 15-33
-
-
Rosen, M.B.1
Thibodeaux, J.R.2
Wood, C.R.3
Zehr, R.D.4
Schmid, J.E.5
Lau, C.6
-
26
-
-
37849025194
-
An extension of the regression of offspring on mid-parent to test for association and estimate locus-specific heritability: the revised ROMP method
-
Roy-Gagnon, M. H., Mathias, R. A., Fallin, M. D., Jee, S. H., Broman, K. W., and Wilson, A. F. (2008). An extension of the regression of offspring on mid-parent to test for association and estimate locus-specific heritability: the revised ROMP method. Ann. Hum. Genet. 72, 115-125.
-
(2008)
Ann. Hum. Genet.
, vol.72
, pp. 115-125
-
-
Roy-Gagnon, M.H.1
Mathias, R.A.2
Fallin, M.D.3
Jee, S.H.4
Broman, K.W.5
Wilson, A.F.6
-
27
-
-
77955633848
-
Toxicogenetics: population-based testing of drug and chemical safety in mouse models
-
Rusyn, I., Gatti, D. M., Wilshire, T., Kleeberger, S. R., and Threadgill, D. W. (2010). Toxicogenetics: population-based testing of drug and chemical safety in mouse models. Pharmacogenomics 11, 1127-1136.
-
(2010)
Pharmacogenomics
, vol.11
, pp. 1127-1136
-
-
Rusyn, I.1
Gatti, D.M.2
Wilshire, T.3
Kleeberger, S.R.4
Threadgill, D.W.5
-
28
-
-
0032784628
-
Cytochrome P450 3A proteins are expressed in B lymphocytes but not in T lymphocytes
-
Sempoux, C., Starkel, P., Stevens, M., Van Den Berge, V., and Horsmans, Y. (1999). Cytochrome P450 3A proteins are expressed in B lymphocytes but not in T lymphocytes. Pharmacogenetics 9, 263-265.
-
(1999)
Pharmacogenetics
, vol.9
, pp. 263-265
-
-
Sempoux, C.1
Starkel, P.2
Stevens, M.3
Van Den Berge, V.4
Horsmans, Y.5
-
29
-
-
77249135763
-
Coupling cytotoxicity biomarkers with DNA damage assessment in TK6 human lymphoblast cells
-
Shi, J., Springer, S., and Escobar, P. (2010). Coupling cytotoxicity biomarkers with DNA damage assessment in TK6 human lymphoblast cells. Mutat. Res. 696, 167-178.
-
(2010)
Mutat. Res.
, vol.696
, pp. 167-178
-
-
Shi, J.1
Springer, S.2
Escobar, P.3
-
30
-
-
37549069338
-
Transcription factor and drug-metabolizing enzyme gene expression in lymphocytes from healthy human subjects
-
Siest, G., Jeannesson, E., Marteau, J. B., Samara, A., Marie, B., Pfister, M., and Visvikis-Siest, S. (2008). Transcription factor and drug-metabolizing enzyme gene expression in lymphocytes from healthy human subjects. Drug Metab. Dispos. 36, 182-189.
-
(2008)
Drug Metab. Dispos.
, vol.36
, pp. 182-189
-
-
Siest, G.1
Jeannesson, E.2
Marteau, J.B.3
Samara, A.4
Marie, B.5
Pfister, M.6
Visvikis-Siest, S.7
-
31
-
-
46449122015
-
Generation of Epstein-Barr Virus (EBV)-immortalized B cell lines
-
Chapter 7, Unit 7, 22
-
Tosato, G., and Cohen, J. I. (2007). Generation of Epstein-Barr Virus (EBV)-immortalized B cell lines. Curr. Protoc. Immunol. Chapter 7, Unit 7.22.
-
(2007)
Curr. Protoc. Immunol.
-
-
Tosato, G.1
Cohen, J.I.2
-
32
-
-
0027439096
-
CYP1A1 mRNA levels as a human exposure biomarker: use of quantitative polymerase chain reaction to measure CYP1A1 expression in human peripheral blood lymphocytes
-
Vanden Heuvel, J. P., Clark, G. C., Thompson, C. L., McCoy, Z., Miller, C. R., Lucier, G. W., and Bell, D. A. (1993). CYP1A1 mRNA levels as a human exposure biomarker: use of quantitative polymerase chain reaction to measure CYP1A1 expression in human peripheral blood lymphocytes. Carcinogenesis 14, 2003-2006.
-
(1993)
Carcinogenesis
, vol.14
, pp. 2003-2006
-
-
Vanden Heuvel, J.P.1
Clark, G.C.2
Thompson, C.L.3
McCoy, Z.4
Miller, C.R.5
Lucier, G.W.6
Bell, D.A.7
-
33
-
-
4143078229
-
Genome-wide discovery of loci influencing chemotherapy cytotoxicity
-
Watters, J. W., Kraja, A., Meucci, M. A., Province, M. A., and McLeod, H. L. (2004). Genome-wide discovery of loci influencing chemotherapy cytotoxicity. Proc. Natl. Acad. Sci. U.S.A. 101, 11809-11814.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 11809-11814
-
-
Watters, J.W.1
Kraja, A.2
Meucci, M.A.3
Province, M.A.4
McLeod, H.L.5
-
34
-
-
40849137783
-
Compound cytotoxicity profiling using quantitative high-throughput screening
-
Xia, M., Huang, R., Witt, K. L., Southall, N., Fostel, J., Cho, M. H., Jadhav, A., Smith, C. S., Inglese, J., Portier, C. J., et al. (2008). Compound cytotoxicity profiling using quantitative high-throughput screening. Environ. Health Perspect. 116, 284-291.
-
(2008)
Environ. Health Perspect.
, vol.116
, pp. 284-291
-
-
Xia, M.1
Huang, R.2
Witt, K.L.3
Southall, N.4
Fostel, J.5
Cho, M.H.6
Jadhav, A.7
Smith, C.S.8
Inglese, J.9
Portier, C.J.10
-
35
-
-
34447093902
-
Differential expression of chicken hepatic genes responsive to PFOA and PFOS
-
Yeung, L. W., Guruge, K. S., Yamanaka, N., Miyazaki, S., and Lam, P. K. (2007). Differential expression of chicken hepatic genes responsive to PFOA and PFOS. Toxicology 237, 111-125.
-
(2007)
Toxicology
, vol.237
, pp. 111-125
-
-
Yeung, L.W.1
Guruge, K.S.2
Yamanaka, N.3
Miyazaki, S.4
Lam, P.K.5
|