Neurobehavioral effects of long-term exposure to pesticides: Results from the 4-year follow-up of the PHYTONER Study

Occupational and Environmental Medicine

Volumn 68, Issue 2, 2011, Pages 108-115

  Baldi, Isabelle ^a,b   Gruber, Anne ^a   Rondeau, Virginie ^b   Lebailly, Pierre ^c   Brochard, Patrick ^a   Fabrigoule, Colette ^d  

^a LSTE EA 3672   (France)

^b INSERM   (France)

^c UNIVERSITÉ DE CAEN   (France)

^d CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PESTICIDE; PSYCHOTROPIC AGENT;

ADULT; AGRICULTURAL WORKER; ALCOHOL CONSUMPTION; ARTICLE; COGNITIVE DEFECT; DEMENTIA; DEPRESSION; EDUCATIONAL STATUS; FEMALE; FOLLOW UP; FRANCE; HUMAN; LONG TERM EXPOSURE; MAJOR CLINICAL STUDY; MALE; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; SMOKING; VINEYARD;

ADULT; AGRICULTURAL WORKERS' DISEASES; COGNITION DISORDERS; CONFOUNDING FACTORS (EPIDEMIOLOGY); EPIDEMIOLOGIC METHODS; FEMALE; FRANCE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; OCCUPATIONAL EXPOSURE; PESTICIDES;

EID: 78751649068     PISSN: 13510711     EISSN: 14707926     Source Type: Journal    
DOI: 10.1136/oem.2009.047811     Document Type: Article

References (45)

1. Alavanja MC, Hoppin JA, Kamel F. Health effects of chronic pesticide exposure: cancer and neurotoxicity. Annu Rev Public Health 2004;25:155-97.
2. Kamel F, Hoppin JA. Association of pesticide exposure with neurologic dysfunction and disease. Environ Health Perspect 2004;112:950-8.
3. Weselak M, Arbuckle TE, Foster W. Pesticide exposures and developmental outcomes: the epidemiological evidence. J Toxicol Environ Health B Crit Rev 2007;10:41-80.
4. London L, Flisher AJ, Wesseling C, et al. Suicide and exposure to organophosphate insecticides: cause or effect? Am J Ind Med 2005;47:308-21.
5. Colosio C, Tiramani M, Maroni M. Neurobehavioral effects of pesticides: state of the art. Neurotoxicology 2003;24:577-91.
6. Priyadarshi A, Khuder SA, Schaub EA, et al. Environmental risk factors and Parkinson's disease: a metaanalysis. Environ Res 2001;86:122-7.
7. Brown TP, Rumsby PC, Capleton AC, et al. Pesticides and Parkinson's disease - is there a link? Environ Health Perspect 2006;114:156-64.
8. Santibanez M, Bolumar F, Garcia AM. Occupational risk factors in Alzheimer's disease: a review assessing the quality of published epidemiological studies. Occup Environ Med 2007;64:723-32.
9. Keifer MC, Firestone J. Neurotoxicity of pesticides. J Agromedicine 2007;12:17-25.
10. Costa LG, Giordano G, Guizzetti M, et al. Neurotoxicity of pesticides: a brief review. Front Biosci 2008;13:1240-9.
11. Baldi I, Filleul L, Mohammed-Brahim B, et al. Neuropsychologic effects of long-term exposure to pesticides: results from the French Phytoner study. Environ Health Perspect 2001;109:839-44.
12. Folstein M, Folstein S, McHugh P. Mini-Mental State: A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98.
13. Wechsler D. WAIS-R manuel. Cleveland: Psychological Corporation, 1981.
14. Amieva H, Rouch-Leroyer I, Fabrigoule C, et al. Deterioration of controlled processes in the preclinical phase of dementia: a confirmatory analysis. Dement Geriatr Cogn Disord 2000;11:46-52.
15. Benton A. Manuel pour l'application du test de rétention visuelle. Applications cliniques et expérimentales. Paris: Centre de Psychologie Appliquée, 1965.
16. Dubois B, Touchon J, Portet F, et al. Les 5 mots: une épreuve simple et sensible pour le diagnostic de la maladie d'Alzheimer. Presse Med 2002;31:1696-9.
17. Reitan R. Validity of the Trail Making Test as an indicator of organic brain damage. Percep Mot Skills 1965;8:271-6.
18. Isaacs B, Kennie A. The Set Test as an aid to the detection of dementia in old people. Br J Psychiatry 1973;45:957-62.
19. Halstead WC. Brain and intelligence. Chicago: University of Chicago Press, 1947.
20. Stroop JR. Studies of interference in serial verbal reactions. J Exp Psychol 1935;18:643-62.
21. Amieva H, Lafont S, Rouch-Leroyer I, et al. Evidencing inhibitory deficits in Alzheimer's disease through interference effects and shifting disabilities on the Stroop test. Arch Clin Neuropsychol 2004;19:791-803.
22. Farahat TM, Abdelrasoul GM, Amr MM, et al. Neurobehavioural effects among workers occupationally exposed to organophosphorous pesticides. Occup Environ Med 2003;60:279-86.
23. Kamel F, Rowland AS, Park LP, et al. Neurobehavioral performance and work experience in Florida farmworkers. Environ Health Perspect 2003;111:1765-72.
24. Rothlein J, Rohlman D, Lasarev M, et al. Organophosphate pesticide exposure and neurobehavioral performance in agricultural and nonagricultural Hispanic workers. Environ Health Perspect 2006;114:691-6.
25. Daniell W, Barnhart S, Demers P, et al. Neuropsychological performance among agricultural pesticide applicators. Environ Res 1992;59:217-28.
26. Lizardi PS, O'Rourke MK, Morris RJ. The effects of organophosphate pesticide exposure on Hispanic childrens cognitive and behavioral functioning. J Pediatr Psychol 2008;33:91-101.
27. Stephens R, Spurgeon A, Calvert IA, et al. Neuropsychological effects of long-term exposure to organophosphates in sheep dip. Lancet 1995;345:1135-9.
28. Srivastava AK, Gupta BN, Bihari V, et al. Clinical, biochemical and neurobehavioural studies of workers engaged in the manufacture of quinalphos. Food Chem Toxicol 2000;38:65-9.
29. Calvert GM, Mueller CA, Fajen JM, et al. Health effects associated with sulfuryl fluoride and methyl bromide exposure among structural fumigation workers. Am J Public Health 1998;88:1774-80.
30. Cole DC, Carpio F, Julian J, et al. Neurobehavioral outcomes among farm and nonfarm rural Ecuadorians. Neurotoxicol Teratol 1997;19:277-86.
31. Rohlman DS, Lasarev M, Anger WK, et al. Neurobehavioral performance of adult and adolescent agricultural workers. Neurotoxicology 2007;28:374-80.
32. Roldan-Tapia L, Nieto-Escamez FA, Aguila EM, et al. Neuropsychological sequelae from acute poisoning and long-term exposure to carbamate and organophosphate pesticides. Neurotoxicology Teratol 2006;28:694-703.
33. Jacqmin-Gadda H, Fabrigoule C, Commenges D, et al. Longitudinal study of cognitive aging in non-demented elderly subjects. Rev Epidemiol Sante Publique 1997;45:363-72.
34. Le Carret N, Auriacombe S, Letenneur L, et al. Influence of education on the pattern of cognitive deterioration in AD patients: the cognitive reserve hypothesis. Brain Cogn 2005;53:120-6.
35. Stern Y. Cognitive reserve and Alzheimer disease. Alzheimer Dis Assoc Disord 2006;20:112-17.
36. McCauley LA, Anger WK, Keifer M, et al. Studying health outcomes in farmworker populations exposed to pesticides. Environ Health Perspect 2006;114:953-60.
37. London L, Myers JE, Nell V, et al. An investigation into neurologic and neurobehavioral effects of long-term agrichemical use among deciduous fruit farm workers in the Western Cape, South Africa. Environ Res 1997;73:132-45.
38. Gomes J, Lloyd O, Revitt MD, et al. Morbidity among farm workers in a desert country in relation to long-term exposure to pesticides. Scand J Work Environ Health 1998;24:213-19.
39. Bazylewicz-Walczak B, Majczakowa W, Szymczak M. Behavioral effects of occupational exposure to organophosphorous pesticides in female greenhouse planting workers. Neurotoxicology 1999;20:819-26.
40. Moser VC. Animal models of chronic pesticide neurotoxicity. Hum Exp Toxicol 2007;26:321-31.
41. Fabrigoule C, Rouch I, Taberly A, et al. Cognitive process in preclinical phase of dementia. Brain 1998;121:135-41.
42. Bäckman L. Memory and cognition in preclinical dementia: what we know and what we do not know. Can J Psychiatry 2008;53:354-60.
43. Dartigues JF, Commenges D, Letenneur D, et al. Cognitive predictors of dementia in elderly community residents. Neuroepidemiology 1997;16:29-39.
44. Tyas SL, Manfreda J, Strain LA, et al. Risk factors for Alzheimer's disease: a population-based, longitudinal study in Manitoba, Canada. Int J Epidemiol 2001;30:590-7.
45. Baldi I, Lebailly P, Mohammed-Brahim B, et al. Neurodegenerative diseases and exposure to pesticides in the elderly. Am J Epidemiol 2003;157:409-14.