Animal models of chronic pesticide neurotoxicity

Human and Experimental Toxicology

Volumn 26, Issue 4, 2007, Pages 321-331

  Moser, Virginia C ^a,b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Animal studies; Epidemiology; Neurotoxicology; Pesticides

Indexed keywords

CARBAMIC ACID; CHOLINESTERASE INHIBITOR; INSECTICIDE; ORGANOPHOSPHORUS COMPOUND;

ANIMAL EXPERIMENT; BEHAVIOR; COGNITION; COGNITIVE DEFECT; CONFERENCE PAPER; CONTROLLED STUDY; HUMAN; MOOD DISORDER; NEUROPHYSIOLOGY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY;

ANIMALS; CHOLINESTERASE INHIBITORS; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; ENDPOINT DETERMINATION; HAND STRENGTH; HUMANS; HYDROCARBONS, CHLORINATED; NEUROTOXICITY SYNDROMES; PESTICIDES; PSYCHOMOTOR PERFORMANCE;

ANIMALIA; RODENTIA;

EID: 34248374181     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/0960327106072395     Document Type: Conference Paper

References (75)

1. Albers JW, Berent S, Garabrant DH, Giordani B, Schweitzer SJ, Garrison RP, Richardson RJ. The effects of occupational exposure to chlorpyrifos on the neurologic examination of central nervous system function: A prospective cohort study. J Occup Environ Med 2004; 46: 367-78.
2. Colosio C, Tiramani M, Maroni M. Neurobehavioral effects of pesticides: State of the art. Neurotoxicol 2003; 24: 577-91.
3. Farahat TM, Abdelrasoul GM, Amr MM, Shebl MM, Farahat FM, Anger WK. Neurobehavioural effects among workers occupationally exposed to organophsphorous pesticides. Occup Environ Med 2003; 60: 279-86.
4. Jamal GA, Hansen S, Pilkington A, Buchanan D, Gillham RA, Abdel-Azis M, Julu POO, Al-Rawas SF, Hurley F, Ballantyne JP. A clinical neurological, neurophysiological, and neuropsychological study of sheep farmers and dippers exposed to organophosphate pesticides. Occup Environ Med 2002; 59: 434-41.
5. Jamal GA, Hansen S, Julu POO. Low level exposures to organophosphorus esters may cause neurotoxicity. Toxicology 2002; 181-182: 23-33.
6. Kamel F, Hoppin JA. Association of pesticide exposure with neurologic dysfunction and disease. Environ Health Perspect 2004; 112: 950-58.
7. Brown MA, Brix KA. Review of health consequences from high-, intermediate, and low level exposure to organophosphorus nerve agents. J Appl Toxicol 1998; 18: 393-408.
8. Hayes WJ. Pesticides studied in man. Williams and Wilkins, 1982: 379-85.
9. Morgan DP. Organophosphate insecticides. In Recognition and management of pesticide poisonings, US EPA-5410/9-88-001, 1989: 1-16.
10. O'Malley M. Clinical evaluation of pesticide exposure and poisonings. Lancet 1997; 349: 1161-66.
11. Ehrich M, Shell L, Rozum M, Jortner BS. Short-term clinical and neuropathologic effects of cholinesterase inhibitors in rats. J Am Coll Toxicol 1993; 12: 55-68.
12. Mattsson JL, Wilmer JW, Shankar MR, Berdasco NM, Crissman JW, Maurissen JP, Bond DM. Single-dose and 13-week repeated-dose neurotoxicity screening studies of chlorpyrifos insecticide. Food Chem Toxicol 1996; 34: 393-405.
13. Moser VC. Comparisons of the acute effects of cholinesterase inhibitors using a neurobehavioral screening battery in rats. Neurotoxicol Teratol 1995; 17: 617-25.
14. Moser VC, McCormick JP, Creason JP, MacPhail RC. Comparison of chlordimeform and carbaryl using a functional observational battery. Fundam Appl Toxicol 1988; 11: 189-206.
15. Guzelian PS. The clinical toxicology of chlordecone as an example of toxicological risk assessment for man. Toxicol Lett 1992; 64-65: 589-96.
16. Ray DE, Forshaw PJ. Pyrethroid insecticides: poisoning syndromes, synergies, and therapy. J Toxicol Clin Toxicol 2000; 38: 95-101.
17. Rosenstock L, Keifer M, Daniell WE, McConnell R, Claypoole K. Chronic central nervous system effects of acute organophosphate pesticide intoxication. Lancet 1991; 338: 223-27.
18. Savage EP, Keefe TJ, Mounce LM, Heaton RK, Lewis JA, Burcar PJ. Chronic neurological sequelae of acute organophosphate pesticide poisoning. Arch Environ Health 1988; 43: 38-45.
19. Steenland K, Jenkins B, Ames RG, O'Malley M, Chrislip D, Russo J. Chronic neurological sequelae to organophosphate pesticide poisoning. Am J Public Health 1994; 84: 731-36.
20. Stallones L, Beseler C. Pesticide illness, farm practices, and neurological symptoms among farm residents in Colorado. Envir Res Section A 2002; 90: 89-97.
21. Beach JR, Spurgeon A, Stephens R, Heafield T, Calvert IA, Levy LS, Harrington JM. Abnormalities on neurological examination among sheep farmers exposed to organophosphorous pesticides. Occup Environ Med 1996; 53: 520-25.
22. Pilkington A, Buchanan D, Jamal GA, Gillham R, Hansen S, Kidd M, Hurley JF, Soutar CA. An epidemiological study of the relations between exposure to organophosphate pesticides and indices of chronic peripheral neuropathy and neuropsychological abnormalities in sheep farmers and dippers. Occup Environ Med 2001; 58: 702-10.
23. Stephens R, Spurgeon A, Calvert IA, Beach J, Levy LS, Berry H, Harrington JM. Neuropsychological effects of long-term exposure to organophosphates in sheep dip. Lancet 1995; 345: 1135-39.
24. Stephens R, Spurgeon A, Berry H Organophosphates: The relationship between chronic and acute exposure effects. Neurotoxicol Teratol 1996; 18: 449-53.
25. Dick RB, Steenland K, Krieg EF, Hines CJ. Evaluation of acute sensory-motor effects and test sensitivity using termiticide workers exposed to chlorpyrifos. Neurotoxicol Teratol 2001; 23: 381-93.
26. Steenland K, Dick RB, Howell RJ, Chrislip DW, Hines CJ, Reid TM, Lehman E, Laber P, Krieg EF, Knott C. Neurologic function among termiticide applicators exposed to chlorpyrifos. Envir Health Perspect 2000; 108: 293-300.
27. Bazylewicz-Walczak B, Majczakowa W, Szymczak M. Behavioral effects of occupational exposure to organophosphorous pesticides in female greenhouse planting workers. Neurotoxicol 1999; 20: 819-26.
28. Kamel F, Rowland AS, Park LP, Anger WK, Baird DD, Gladen BC, Moreno T, Stallone L, Sandler DP. Neurobehavioral performance and work experience in Florida farmworkers. Environ Health Perspect 2003; 111: 1765-72.
29. Kamel F, Engel LS, Gladen BC, Hoppin JA, Alavanja MR, Sandler DP. Neurotoxicity of chronic pesticide exposure in licensed pesticide applicators in the Agricultural Health Study. Toxicologist 2005; 84: 273 (abstract #1333).
30. Levin HS, Rodnitzky RL, Mick DL. Anxiety associated witih exposure to organophosphate compounds. Arch Gen Psychiatry 1976; 33: 225-28.
31. London L, Nell V, Thompson M-L, Myers JE. Effects of long-term organophosphate exposures on neurological symptoms, vibration sense and tremor among South African farm workers. Scand J Work Environ Health 1998; 24: 18-29.
32. Roldán-Tapia L, Parrón T, Sánchez-Santed F. Neuropsychological effects of long-term exposure to organophosphate pesticides. Neurotoxicol Teratol 2005; 27: 259-66.
33. Wesseling C, Keifer M, Ahlbom A, McConnell R, Moon J-D, Rosenstock L, Hogstedt C. Long-term neurobehavioral effects of mild poisonings with organophosphate and n-methyl carbamate pesticides among banana workers. Int J Occup Health 2002; 8: 27-34.
34. Fiedler N, Kiepen H, Kelly-McNeil K, Fenske R. Long-term use of organophosphates and neuropsychological performance. Am J Ind Med 1997; 32: 487-96.
35. Eaton DL, Klaassen CD. Principles of toxicology. In Casarett and Doull's toxicology: the basic science of poisons (5th edition) Klaassen CD, Amdur MO, Doull J, eds. McGraw-Hill, 1996: 13-33.
36. Moser VC, Phillips PM, McDaniel KL, Marshall RS, Hunter DL, Padilla S. Neurobehavioral effects of chronic dietary and repeated high-level exposure to chlorpyrifos in rats. Toxicol Sci 2005; 86: 375-86.
37. Samsam TE, Hunter DL, Bushnell PJ. Effects of chronic dietary and repeated acute exposure to chlorpyrifos on learning and sustained attention in rats. Toxicol Sci 2005; 87: 460-68.
38. Moser VC. Applications of a neurobehavioral screening battery. J Am Coll Toxicol 1991; 10: 661-69.
39. Moser VC. Observational batteries in neurotoxicity testing. Int J Toxicol 2000; 19: 407-11.
40. Ross JF, Mattsson JL, Fix AS. Expanded clinical observations in toxicity studies: historical perspectives and contemporary issues. Regul Toxicol Pharmacol 1998; 28: 17-26.
41. Cohn J, MacPhail RC. Chlorpyrifos produces selective learning deficits in rats working under a schedule of repeated acquisition and performance. J Pharmacol Exp Ther 1997; 283: 312-20.
42. Llorens J, Crofton KM, Tilson HA, Ali SF, Mundy WR. Characterization of disulfoton-induced behavioral and neurochemical effects following repeated exposure. Fundam Appl Toxicol 1993; 20: 163-69.
43. Sarin S, Gill KD. Biochemical and behavioral deficits in adult rat following chronic dichlorvos exposure. Pharmacol Biochem Behav 1998; 59: 1081-86.
44. Abdel-Rahman A, Dechkovskaia AM, Goldstein LB, Bullman SH, Khan W, El-Masry EM, Abou-Donia, MB. Neurological deficits induced by malathion, DEET, and permethrin, alone or in combination in adult rats. J Toxicol Environ Health Part A 2004; 67: 331-56.
45. Abou-Donia MB, Abdel-Rahman A, Goldstein LB, Dechkovskaia AM, Shah DU, Bullman SL, Khan WA. Sensorimotor deficits and increased brain nicotinic acetylcholine receptors following exposure to chlorpyrifos and/or nicotine in rats. Arch Toxicol 2003; 77: 452-58.
46. Bushnell PJ, Kelly KL, Ward TR. Repeated inhibition of cholinesterase by chlorpyrifos in rats: Behavioral, neurochemical, and pharmacological indices of tolerance. J Pharmacol Exp Ther 1994; 270: 15-25.
47. Sheets LP, Hamilton BF, Sangha GK, Thyssen JH. Subchronic neurotoxicity screening studies with six organophosphate insecticides: An assessment of behavior and morphology relative to cholinesterase inhibition. Fundam Appl Toxicol 1997; 35: 101-19.
48. Terry Jr AV, Stone JD, Buccafusco JJ, Sickles DW, Sood A, Prendergast MA. Repeated exposure to subthreshold doses of chlorpyrifos in rats: Hippocampal damage, imparied axonal transport, and deficits in spatial learning. J Pharmacol Exp Ther 2003; 305: 375-84.
49. Dési I, Nagymajtényi L. Neurotoxicologic investigations of the pesticide dichlorvos (DDVP). Effects on the central and peripheral nervous system. Toxicol 1988; 49: 141-148.
50. Dési I, Nagymajtényi L. Electrophysiological biomarkers of an organophosphorous pesticide, dichlorvos. Tox Letters 1999; 107: 55-64.
51. Dési I, Gönczi L, Simon G, Farkas I, Kneffel Z. Neurotoxicological studies of two carbamate pesticides in subacute animal experiments. Toxicol Appl Pharmacol 1974; 27: 465-76.
52. Nagymajtenyi L, Desi I, Lorencz R. Neurophysiological markers as early signs of organoposphate neurotoxicity. Neurotoxicol Teratol 1988; 10: 429-34.
53. Schulz H, Desi I, Nagymajtenyi L Behavioral effects of subchronic intoxication with parathion-methyl in male wistar rats. Neurotoxicol Teratol 1990; 12: 125-27.
54. Lehotzky K, Szeberényi MJ, Horkay F, Kiss A. The neurotoxicity of organotin: Behavioural changes in rats. Acta Biol Acad Sci Hung 1982; 33: 15-22.
55. Gershon S, Shaw FB. Psychiatric sequelae of chronic exposure to organophosphate insecticides. Lancet 1961; 1: 1371-74.
56. Metcalf DR, Holmes JH. EEG, psychological and neurological alterations in humans with organophosphorus exposure. Ann NY Acad Sci 1969; 160: 357-65.
57. Mearns J, Dunn J, Lees-Haley PR. Psychological effects of organophosphate pesticides: a review and call for research by psychologists. J Clin Psychol 1994; 50: 286-94.
58. London L, Flisher A, Major V, Kromhout H, Mergler D. Organophosphate exposure, depression and suicide: Matching epidemiological data to models based on animal studies and case series. Toxicologist 2005; 84: 273 (abstract #1334).
59. Parron T, Hernandez AF, Villanueva E. Increased risk of suicide with exposure to pesticides in an intensive agricultural area. A 12-year retrospective study. Forensic Sci Int 1996; 79: 53-63.
60. Ivens IA, Schmuck G, and Machemer L. Learning and memory of rats after long-term adminstration of low doses of parathion. Toxicol Sci 1998; 46: 101-11.
61. Temerowski M, van der Staay FJ. Absence of long-term behavioral effects after sub-chronic administration of low doses of methamidophos in male and female rats. Neurotoxicol Teratol 2005; 27: 279-98.
62. Anand M, Agrawal AK, Rehmani BN, Gupta GS, Rana MD, Seth PK. Role of GABA receptor complex in low dose lindane (HCH) induced neurotoxicity: neurobehavioural, neurochemical, and electrophysiological studies. Drug Chem Toxicol 1998; 21: 35-46.
63. Gilbert ME. Repeated exposure to lindane leads to behavioral sensitization and facilitates electrical kindling. Neurotoxicol Teratol 1995; 17: 131-41.
64. Palumbo G, Bacchi S, Coppolina MF, Pantaleoni GC. Neurochemical and behavioural effects of chronic aldicarb administration in rats. Pharmacol Toxicol 2001; 89: 249-54.
65. Van der Staay FJ, Hinz VC, Schmidt BH. Effects of metrifonate, its transformation product dichlorvos, and other organophosphorus and reference cholinesterase inhibitors on Morris water escape behavior in young-adult rats. J Phamacol Exp Ther 1996; 278: 697-708.
66. Imai H, Miyata M, Uga S, Ishikawa S. Retinal degeneration in rats exposed to an organophosphate pesticide (fenthion). Environ Res 1983; 30: 453-65.
67. Maxwell IC, LeQuesne PM. Neuromuscular effects of chronic administration of two organophosphorus insecticides to rats. Neurotoxicol 1982; 3: 1-10.
68. Institoris L, Papp A, Siroki O, Banerjee BD, Dési I. Immuno- and neurotoxicological investigation of combined subacute exposure with the carbamate pesticide propoxur and cadmium in rats. Toxicol 2002; 178: 161-73.
69. Lee C-C, Peters PJ. Neurotoxicity and behavioral effects of thiram in rats. Environ Health Perspec 1976; 17: 35-43.
70. Squibb RE, Tilson HA. Neurobehavioral changes in adult Fischer 344 rats exposed to dietary levels of chlordecone (Kepone): a 90-day chronic dosing study. Neurotoxicol 1982; 3: 59-65.
71. Dési I, Szlobodnyik J, Karmos-Varszegi M, Strohmayer A, Bako G. Neurotoxicological investigation of the new Hungarian pesticide Toxurazine. Acta Physiol Acad Sci Hung 1982; 60: 1-8.
72. Sobotka TJ, Brodie RE, Arnold A, West GL, O'Donnell MW. Neuromotor function in rats during subchronic dietary exposure to triphenyl phosphate. Neurobehav Toxicol Teratol 1986; 8: 7-10.
73. Mattsson JL, Charles JM, Yano BL, Cunny HC, Wilson RD, Bus JS. Single-dose and chronic dietary neurotoxicity screening studies on 2,4-dichlorophenoxyacetic acid in rats. Fundam Appl Toxicol 1997; 40: 111-19.
74. Paul V, Balasubramaniam E, Jayakumar AR, Kazi M. A sex-related difference in the neurobehavioral and hepatic effects following chronic endosulfan treatment in rats. Eur J Pharmacol 1995; 293: 355-60.
75. Mattsson JL, Albee RR, Eisenbrandt DL, Chang LW. Subchronic neurotoxicity in rats of the structural fumigant, sulfuryl fluoride. Neurotoxicol Teratol 1988; 10: 127-33.