Neurotoxicity of pesticides

Journal of Agromedicine

Volumn 12, Issue 1, 2007, Pages 17-25

  Keifer, Matthew C ^a   Firestone, Jordan ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Fumigants; Insecticides; Nervous; Parkinson's Disease; Peripheral neuropathy; Pesticides; System diseases chemically induced; Toxicity

Indexed keywords

PESTICIDE;

CHEMICALLY INDUCED DISORDER; CONFERENCE PAPER; ENVIRONMENTAL EXPOSURE; HUMAN; NEUROLOGIC DISEASE;

ENVIRONMENTAL EXPOSURE; HUMANS; NERVOUS SYSTEM DISEASES; PESTICIDES;

EID: 34548486253     PISSN: 1059924X     EISSN: 15450813     Source Type: Journal    
DOI: 10.1300/J096v12n01_03     Document Type: Conference Paper

References (73)

1. Costa LG. Basic toxicology of pesticides. Occup Med. 1997 Apr-Jun;12(2):251-68.
2. Reigart JR, Roberts JR. Recognition and Management of Pesticide Poisonings. Fifth Edition. Environmental Protection Agency, 1999 Washington DC. Available from: http://www.epa.govlpesticides/safety/ healthcare/handbook/handbook.pdf [cited 2006 Jun 15].
3. Cannon SB, Veazey JM Jr, Jackson RS, Burse VW, Hayes C, Straub WE, Landrigan PJ, Liddle JA. Epidemic kepone poisoning in chemical workers. Am J Epidemiol. 1978 Jun;107(6):529-37.
4. Taylor JR. Neurological manifestations in humans exposed to chlordecone and follow-up results. Neurotoxicology. 1982 Oct;3(2):9-16.
5. Anderson JM, Cockburn F, Forfar JO, Harkness RA, Kelly RW, Kilshaw B. Neonatal spongioform myelopathy after restricted application of hexachlorophane skin disinfectant. J Clin Pathol. 1981 Jan;34(1):25-9.
6. Slamovits TL, Burde RM, Klingele TG. Bilateral optic atrophy caused by chronic oral ingestion and topical application of hexachlorophene. Am J Opthamol. 1980 May; 89(5):676-9.
7. Narahashi T, Frey JM, Ginsburg KS, Roy ML. Sodium and GABA-activated channels as the targets of pyrethroids and cyclodienes. Toxicol Lett. 1992 Dec; 64-65 Spec No:429-36.
8. Savage EP, Keefe TJ, Mounce LM, Heaton RK, Lewis JA, Burcar PJ. Chronic neurological sequelae of acute organophosphate pesticide poisoning. Arch Environ Health. 1988 Jan-Feb;43(1):38-45.
9. Rosenstock L, Keifer M, Daniell WE, McConnell R, Claypoole K. Chronic central nervous system effects of acute organophosphate pesticide intoxication. The Pesticide Health Effects Study Group. Lancet. 1991 Jul 27;338(8761):223-7.
10. Steenland K, Jenkins B, Ames RG, O'Malley M, Chrislip D, Russo J. Chronic neurological sequelae to organophosphate pesticide poisoning. Am J Public Health. 1994 May;84(5):731-6.
11. Wesseling C, Keifer M, Ahlbom A, McConnell R, Moon JD, Rosenstock L, Hogstedt C. Long-term neurobehavioral effects of mild poisonings with organophosphate and n-methyl carbarnate pesticides among banana workers. Int J Occup Environ Health. 2002 Jan-Mar;8(1):27-34.
12. Rosenstock L, Daniell W, Barnhart S, Schwartz D, Demers PA. Chronic neuropsychological sequelae of occupational exposure to organophosphate insecticides. Am J Ind Med. 1990;18(3):321-5.
13. Stallones L, Beseler C. Pesticide illness, farm practices, and neurological symptoms among farm residents in Colorado. Environ Res. 2002 Oct;90(2):89-97.
14. Stephens R, Spurgeon A, Calvert IA, Beach J, Levy LS, Berry H, Harrington JM. Neuropsychological effects of long-term exposure to organophosphates in sheep dip. Lancet. 1995 May 6;345(8958):1135-9.
15. Roldan-Tapia L, Parron T, Sanchez-Santed F. Neuropsychological effects of long-term exposure to organophosphate pesticides. Neurotoxicol Teratol. 2005 Mar-Apr;27(2):259-66.
16. Steenland K, Dick RB, Howell RJ, Chrislip DW, Hines CJ, Reid TM, Lehman E, Laber P, Krieg EF Jr, Knott C. Neurologic function among termiticide applicators exposed to chlorpyrifos. Environ Health Perspect. 2000 Apr; 108(4):293-300.
17. Fiedler N, Kipen H, Kelly-McNeil K, Fenske R. Long-term use of organophosphates and neuropsychological performance. Am J Ind Med. 1997 Nov;32(5): 487-96.
18. Ames RG, Steenland K, Jenkins B, Chrislip D, Russo J. Chronic neurologic sequelae to cholinesterase inhibition among agricultural pesticide applicators. Arch Environ Health. 1995 Nov-Dec;50(6):440-4.
19. Burgess JL, Morrissey B, Keifer MC, Robertson WO. Fumigant-related illnesses: Washington State's five-year experience. J Toxicol Clin Toxicol. 2000;38(1): 7-14.
20. Maddy KT, Edmiston S, Richmond D. Illness, injuries, and deaths from pesticide exposures in California 1949-1988. Rev Environ Contam Toxicol. 1990; 114:57-123.
21. Kishi R, Itoh I, Ishizu S, Harabuchi I, Miyake H. Symptoms among workers with long-term exposure to methyl bromide. An epidemiological study. Sangyo Igaku. 1991 Jul;33(4):241-50.
22. Bishop CM. A case of methyl bromide poisoning. Occup Med (Lond). 1992 May;42(2):107-9.
23. De Haro L, Gastaut JL, Jouglard J, Renacco E. Central and peripheral neurotoxic effects of chronic methyl bromide intoxication. J Toxicol Clin Toxicol. 1997;35(1):29-34.
24. Reidy TJ, Bolter JF, Cone JE. Neuropsychological sequelae of methyl bromide: A case study. Brain Inj. 1994 Jan;8(1):83-93.
25. Brashear A, Unverzagt FW, Farber MO, Bonnin JM, Garcia JG, Grober E. Ethylene oxide neurotoxicity: A cluster of 12 nurses with peripheral and central nervous system toxicity. Neurology. 1996 Apr;46(4):992-8.
26. Estrin WJ, Bowler RM, Lash A, Becker CE. Neurotoxicological evaluation of hospital sterilizer workers exposed to ethylene oxide. J Toxicol Clin Toxicol. 1990;28(1):1-20.
27. Centers for Disease Control (CDC). Fatalities resulting from sulfuryl fluoride exposure after home fumigation-Virginia. MMWR Morb Mortal Wkly Rep. 1987 Sep 18;36(36):602-4, 609-11.
28. Scheuerman EH. Suicide by exposure to sulfuryl fluoride. J Forensic Sci. 1986 Jul;31(3):1154-8.
29. Calvert GM, Mueller CA, Fajen JM, Chrislip DW, Russo J, Briggle T, Fleming LE, Suruda AJ, Steenland K. Health effects associated with sulfuryl fluoride and methyl brornide exposure among structural fumigation workers. Am J Public Health. 1998 Dec;88(12):1774-80.
30. Anger WK, Moody L, Burg J, Brightwell WS, Taylor BJ, Russo JM, Dickerson N, Setzer JV, Johnson BL, Hicks K. Neurobehavioral evaluation of soil and structural fumigators using methyl bromide and sulfuryl fluoride. Neurotoxicology. 1986 Fall;7(3):137-56.
31. Agin H, Calkavur S, Uzun H, Bak M. Amitraz poisoning: Clinical and laboratory findings. Indian Pediatr. 2004 May;41(5):482-6.
32. Yilmaz HL, Yildizdas DR. Arnitraz poisoning, an emerging problem: epidemiology, clinical features, management, and preventive strategies. Arch Dis Child. 2003 Feb;88(2):130-4.
33. Kalyoncu M, Dilber E, Okten A. Amitraz intoxication in children in the rural Black Sea region: Analysis of forty-three patients. Hum Exp Toxicol. 2002 May; 21(5):269-72.
34. National Pesticide Telecommunications Network web site. Fipronil. Available from: http://npic.orst.edulfactsheets/fipronil.pdf [cited 2006 Jun 19].
35. Mohamed F, Senarathna L, Percy A, Abeyewardene M, Eaglesham G, Cheng R, Azher S, Hittarage A, Dissanayake W, Sheriff MH, Davies W, Buckley NA, Eddleston M. Acute human self-poisoning with the N-phenylpyrazole insecticide fipronil-a GABAA-gated chloride channel blocker. J Toxicol Clin Toxicol. 2004; 42(7):955-63.
36. Priyadarshi A, Khuder SA, Schaub EA, Shrivastava S. A meta-analysis of Parkinson's disease and exposure to pesticides. Neurotoxicology. 2000 Aug; 21(4):435-40.
37. Yang WL, Sun AY. Paraquat-induced cell death in PC 12 cells. Neurochem Res. 1998 Nov;23(11):1387-94.
38. Uversky VN, Li J, Bower K, Fink AL. Synergistic effects of pesticides and metals on the fibrillation of alpha-synuclein: Implications for Parkinson's disease. Neurotoxicology. 2002 Oct;23(4-5):527-36.
39. Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci. 2000 Dec;3(12):1301-6.
40. McCormack AL, Thiruchelvam M, Manning-Bog AB, Thiffault C, Langston JW, Cory-Slechta DA, Di Monte DA. Environmental risk factors and Parkinson's disease: Selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat. Neurobiol Dis. 2002 Jul;10(2):119-27.
41. Bhatt MH, Elias MA, Mankodi AK. Acute and reversible parkinsonism due to organophosphate pesticide intoxication: Five cases. Neurology. 1999 Apr 22; 52(7):1467-71.
42. Meco G, Bonifati V, Vanacore N, Fabrizio E. Parkinsonism after chronic exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate). Scand J Work Environ Health. 1994 Aug;20(4):301-5.
43. Rajput AH Uitti RJ, Stern W, Laverty W. Early onset Parkinson's disease in Saskatchewan - environmental considerations for etiology. Can J Neurol Sci. 1986 Nov;13(4):312-6.
44. Barbeau A, Roy M, Bernier G, Campanella G, Paris S. Ecogenetics of Parkinson's disease: Prevalence and environmental aspects in rural areas. Can J Neurol Sci. 1987 Feb;14(1):36-41.
45. Koller W, Vetere-Overfield B, Gray C, Alexander C, Chin T, Dolezal J, Hassanein R, Tanner C. Environmental risk factors in Parkinson's disease. Neurology. 1990 Aug;40(8):1218-21.
46. Lion HH Tsai MC, Chen CJ, Jeng JS, Chang YC, Chen SY, Chen RC. Environmental risk factors and Parkinson's disease: A case-control study in Taiwan. Neurology. 1997 Jun;48(6):1583-8.
47. Firestone JA, Smith-Weller T, Franklin G, Swanson P, Longstreth WT Jr, Checkoway H. Pesticides and risk of Parkinson disease: A population-based case-control study. Arch Neurol. 2005 Jan;62(1):91-5.
48. Gorell JM, Johnson CC, Rybicki BA, Peterson EL, Richardson RJ. The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living. Neurology. 1998 May;50(5):1346-50.
49. Semchuk KM, Love EJ, Lee RG. Parkinson's disease and exposure to agricultural work and pesticide chemicals. Neurology. 1992 Jul; 42(7):1328-35.
50. Hertzman C, Wiens M, Snow B, Kelly S, Calne D. A case-control study of Parkinson's disease in a horticultural region of British Columbia. Mov Disord. 1994 Jan;9(1):69-75.
51. Baldi I, Lebailly P, Mohammed-Brahim B, Letenneur L, Dartigues JF, Brochard P. Neurodegenerative diseases and exposure to pesticides in the elderly. Am J Epidemiol. 2003 Mar; 157(5):409-14.
52. Kamel F, Engel LS, Gladen BC, Hoppin JA, Alavanja MC, Sandler DP. Neurologic symptoms in licensed private pesticide applicators in the agricultural health study. Environ Health Perspect. 2005 Jul;113(7): 877-82.
53. Miranda J, Lundberg I, McConnell R, Delgado E, Cuadra R, Torres E, Wesseling C, Keifer M. Onset of grip- and pinch-strength impairment after acute poisonings with organophosphate insecticides. Int J Occup Environ Health. 2002 Jan-Mar;8(1):19-26.
54. Miranda J, McConnell R, Wesseling C, Cuadra R, Delgado E, Torres E, Keifer M, Lundberg I. Muscular strength and vibration thresholds during two years after acute poisoning with organophosphate insecticides. Occup Environ Med. 2004 Jan;61(1):e4.
55. Lotti M, Moretto A. Organophosphate-induced delayed polyneuropathy. Toxicol Rev. 2005;24(1):37-49.
56. Johnson MK. Sensitivity and selectivity of compounds interacting with neuropathy target esterase. Further structure-activity studies. Biochem Pharmacol. 1988 Nov 1;37(21):4095-104.
57. De Bleecker J, Van Den Neucker K, Willems J. The intermediate syndrome in organophosphate poisoning: Presentation of a case and review of the literature. J Toxicol Clin Toxicol. 1992;30(3):321-9; discussion 331-2.
58. Sudakin DL, Mullins ME, Horowitz BZ, Abshier V, Letzig L. Intermediate syndrome after malathion ingestion despite continuous infusion of pralidoxime. J Toxicol Clin Toxicol. 2000;38(1):47-50.
59. Tomizawa M, Casida JE. Selective toxicity of neonicotinoids attributable to specificity of insect and mammalian nicotinic receptors. Annu Rev Entomol. 2003;48:339-64.
60. Wu IW, Lin JL, Cheng ET. Acute poisoning with the neonicotinoid insecticide imidacloprid in N-methyl pyrrolidone. J Toxicol Clin Toxicol. 2001;39(6):617-21.
61. Bradberry SM, Watt BE, Proudfoot AT, Vale JA. Mechanisms of toxicity, clinical features, and management of acute chlorophenoxy herbicide poisoning: A review. J Toxicol Clin Toxicol. 2000;38(2):111-22.
62. Lifshitz M, Gavrilov V. Central nervous system toxicity and early peripheral neuropathy following dermal exposure to methyl bromide. J Toxicol Clin Toxicol. 2000;38(7):799-801.
63. Yang RS, Witt KL, Alden CJ, Cockerham LG. Toxicology of methyl bromide. Rev Environ Contam Toxicol. 1995;142:65-85.
64. Kuzuhara S, Kanazawa I, Nakanishi T, Egashira T. Ethylene oxide polyneuropathy. Neurology. 1983 Mar;33(3):377-80.
65. Saddique A, Peterson CD. Thallium poisoning: A review. Vet Hum Toxicol. 1983 Feb;25(1):16-22.
66. Desenclos JC, Wilder MH, Coppenger GW, Sherin K, Tiller R, VanHook RM. Thallium poisoning: An outbreak in Florida, 1988. South Med J. 1992 Dec;85(12): 1203-6.
67. LeWitt PA. The neurotoxicity of the rat poison vacor. A clinical study of 12 cases. N Engl J Med. 1980 Jan 10;302(2):73-7.
68. Souza MS, Magnarelli GG, Rovedatti MG, Cruz SS, De D'Angelo AM. Prenatal exposure to pesticides: Analysis of human placental acetylcholinesterase, glutathione S-transferase and catalase as biomarkers of effect. Biomarkers. 2005;10(5):376-89.
69. Young JG, Eskenazi B, Gladstone EA, Bradman A, Pedersen L, Johnson C, Barr DB, Furlong CE, Holland NT. Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates. Neurotoxicology. 2005;26(2):199-209.
70. Fenske RA, Lu C, Barr D, Needham L. Children's exposure to chlorpyrifos and parathion in an agricultural community in central Washington State. Environ Health Perspect. 2002;110(5):549-53.
71. Curl CL, Fenske RA, Kissel JC, Shirai JH, Moate TF, Griffith W, Coronado G, Thompson B. Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children. Environ Health Perspect. 2002;110(12):A787-92.
72. Curl CL, Fenske RA, Elgethun K. Organophosphorus pesticide exposure of urban and suburban preschool children with organic and conventional diets. Environ Health Perspect. 2003;111(3):377-82.
73. Lu C, Toepel K, Irish R, Fenske RA, Barr DB, Bravo R. Organic diets significantly lower children's dietary exposure to organophosphorus pesticides. Environ Health Perspect. 2006;114(2):260-3.