Dermorphin tetrapeptide analogs as potent and long-lasting analgesics with pharmacological profiles distinct from morphine

Peptides

Volumn 32, Issue 2, 2011, Pages 421-427

  Mizoguchi, Hirokazu ^a   Bagetta, Giacinto ^b   Sakurada, Tsukasa ^c   Sakurada, Shinobu ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF CALABRIA   (Italy)

^c DAIICHI UNIVERSITY OF PHARMACY   (Japan)

Author keywords

Opioid receptor; Opioid receptor; Analgesics; Dependence; Dermorphin analog; Dynorphins

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; ALANINE; ANALGESIC AGENT; ARGININE; DELTORPHIN; DERMORPHIN DERIVATIVE; DERMORPHIN[2 DEXTRO ARGININE 4 LYSINE]; DERMORPHIN[2 DEXTRO ARGININE]; DERMORPHIN[DIMETHYLTYROSINE 2 DEXTRO ARGININE 4 LYSINE]; DYNORPHIN; ENDOMORPHIN 1; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MORPHINE; MU OPIATE RECEPTOR; TETRAPEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; AMPHIBIA; ANTINOCICEPTION; CATALEPSY; CONSTIPATION; DRUG DEPENDENCE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; HUMAN; METABOLISM; NONHUMAN; PRIORITY JOURNAL; PRURITUS; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; RESPIRATION DEPRESSION; REVIEW; STRUCTURE ACTIVITY RELATION;

ANALGESICS, OPIOID; ANIMALS; HUMANS; MORPHINE; OLIGOPEPTIDES; OPIOID PEPTIDES;

AMPHIBIA;

EID: 78751648187     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2010.11.013     Document Type: Review

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