A lysine-free mutant of epidermal growth factor as targeting moiety of a targeted toxin

Life Sciences

Volumn 88, Issue 5-6, 2011, Pages 226-232

  Bachran, Christopher ^a   Schneider, Stefanie ^a   Riese, Sebastian B ^a,b   Bachran, Diana ^a   Urban, Romy ^a   Schellmann, Nicole ^a,b   Zahn, Claudia ^a,b   Sutherland, Mark ^c   Fuchs, Hendrik ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

Chemical coupling; Drug delivery; Ribosome inactivating protein; Saporin; Tumor therapy

Indexed keywords

ARGININE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR SAPORIN FUSION PROTEIN; HYBRID PROTEIN; LYSINE; MUTANT PROTEIN; SAPORIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BREAST CARCINOMA; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN VARIANT; RECEPTOR BINDING; UTERINE CERVIX CARCINOMA;

ANIMALS; ARGININE; DRUG DELIVERY SYSTEMS; EPIDERMAL GROWTH FACTOR; HUMANS; IMMUNOTOXINS; LYSINE; MICE; MUTATION; NIH 3T3 CELLS; PROTEIN BINDING; RIBOSOME INACTIVATING PROTEINS, TYPE 1;

EID: 78751645628     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2010.11.012     Document Type: Article

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