The role of direct presentation by donor dendritic cells in rejection of minor histocompatibility antigen-mismatched skin and hematopoietic cell grafts

Transplantation

Volumn 91, Issue 2, 2011, Pages 154-160

  Fernandes, Eduardo ^a   Goold, Hugh D ^b   Kissenpfennig, Adrien ^c,d   Malissen, Bernard ^c   Dyson, Julian ^a   Bennett, Clare L ^b  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^d QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Dendritic cells; Langerhans cells; Minor H antigen; Skin

Indexed keywords

BLOOD GROUP H ANTIGEN; DIPHTHERIA TOXIN RECEPTOR; EPITOPE; RECEPTOR; UNCLASSIFIED DRUG;

ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA MATCHING; LANGERHANS CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; SKIN GRAFT; SKIN TRANSPLANTATION; T CELL DEPLETION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD11C; ANTIGENS, SURFACE; DENDRITIC CELLS; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; H-Y ANTIGEN; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOSUPPRESSION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LANGERHANS CELLS; LECTINS, C-TYPE; MALE; MANNOSE-BINDING LECTINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MINOR HISTOCOMPATIBILITY ANTIGENS; SKIN TRANSPLANTATION; TISSUE DONORS; TRANSPLANTATION TOLERANCE;

EID: 78751645216     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e318201ac27     Document Type: Article

References (38)

1. Issa F, Schiopu A, Wood KJ. Role of T cells in graft rejection and transplantation tolerance. Expert Rev Clin Immunol 2010; 6: 155.
2. Simpson E, Roopenian D. Minor histocompatibility antigens. Curr Opin Immunol 1997; 9: 655.
3. Simpson E, Scott D, James E, et al. Minor H antigens: Genes and pep-tides. Transpl Immunol 2002; 10: 115.
4. Lindahl KF, Wilson DB. Histocompatibility antigen-activated cyto-toxic T lymphocytes. II. Estimates of the frequency and specificity of precursors. J Exp Med 1977; 145: 508.
5. Suchin EJ, Langmuir PB, Palmer E, et al. Quantifying the frequency of alloreactive T cells in vivo: New answers to an old question. J Immunol 2001; 166: 973.
6. Jiang S, Herrera O, Lechler RI. New spectrum of allorecognition pathways: Implications for graft rejection and transplantation tolerance. Curr Opin Immunol 2004; 16: 550.
7. Bolton EM, Bradley JA, Pettigrew GJ. Indirect allorecognition: Not simple but effective. Transplantation 2008; 85: 667.
8. Lechler RI, Batchelor JR. Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells. J Exp Med 1982; 155: 31.
9. Roussey-Kesler G, Brouard S, Ballet C, et al. Exhaustive depletion of graft resident dendritic cells: Marginally delayed rejection but strong alteration of graft infiltration. Transplantation 2005; 80: 506.
10. WangZ, CastellanetaA, DeCreusA, etal. Heart, but not skin, allografts from donors lacking Flt3 ligand exhibit markedly prolonged survival time. J Immunol 2004; 172:5924.
11. Bevan MJ. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay. J Exp Med 1976; 143: 283.
12. Millrain M, Scott D, Addey C, et al. Identification of the immunodominant HY H2-D(k) epitope and evaluation of the role of direct and indirect antigen presentation in HY responses. J Immunol 2005; 175: 7209.
13. Bennett CL, Clausen BE. DC ablation in mice: Promises, pitfalls, and challenges. Trends Immunol 2007; 28: 525.
14. Bursch LS, Wang L, Igyarto B, et al. Identification of a novel population of Langerin+ dendritic cells. J Exp Med 2007; 204: 3147.
15. Nagao K, Ginhoux F, Leitner WW, et al. Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions. Proc Natl Acad Sci USA 2009; 106: 3312.
16. Jung S, Unutmaz D, Wong P, et al. In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8( +) T cells by exogenous cell-associated antigens. Immunity 2002; 17: 211.
17. McLachlan JB, Catron DM, Moon JJ, et al. Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin. Immunity 2009; 30: 277.
18. Baruah P, Simpson E, Dumitriu IE, et al. Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance. Eur J Immunol; doi 10.1002/eji.200940158.
19. Bennett CL, van Rijn E, Jung S, et al. Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J Cell Biol 2005; 169: 569.
20. Poulin LF, Henri S, de Bovis B, et al. The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells. J Exp Med 2007; 204: 3119.
21. Millrain M, Chandler P, Dazzi F, et al. Examination of HY response: T cell expansion, immunodominance, and cross-priming revealed by HY tetramer analysis. J Immunol 2001; 167: 3756.
22. Chai JG, James E, Dewchand H, et al. Transplantation tolerance induced by intranasal administration of HY peptides. Blood 2004; 103: 3951.
23. Robertson NJ, Chai JG, Millrain M, et al. Natural regulation of immunity to minor histocompatibility antigens. J Immunol 2007; 178: 3558.
24. Lakkis FG, Arakelov A, Konieczny BT, et al. Immunologic 'ignorance' of vascularized organ transplantsin the absence ofsecondary lymphoid tissue. Nat Med 2000; 6: 686.
25. McKay D, Shigeoka A, Rubinstein M, et al. Simultaneous deletion of MyD88 and Trif delays major histocompatibility and minor antigen mismatch allograft rejection. Eur J Immunol 2006; 36:1994.
26. Auchincloss H Jr, Lee R, Shea S, et al. The role of "indirect" recognition in initiating rejection of skin grafts from major histocompat-ibility complex class II-deficient mice. Proc Natl Acad Sci USA 1993; 90: 3373.
27. Fangmann J, Dalchau R, Fabre JW. Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides. J Exp Med 1992; 175: 1521.
28. Bennett CL, Noordegraaf M, Martina CA, et al. Langerhans cells are required for efficient presentation of topically applied hapten to T cells. J Immunol 2007; 179: 6830.
29. Kissenpfennig A, Malissen B. Langerhans cells-Revisiting the paradigm using genetically engineered mice.Trends Immunol 2006; 27: 132.
30. MeradM, HoffmannP, Ranheim E, et al. Depletion ofhost Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Nat med 2004; 10: 510.
31. Larsen CP, Steinman RM, Witmer-Pack M, et al. Migration and maturation of Langerhans cells in skin transplants and explants. J Exp Med 1990; 172: 1483.
32. Obhrai JS, Oberbarnscheidt M, Zhang N, et al. Langerhans cells are not required for efficient skin graft rejection. J Invest Dermatol 2008; 128: 1950.
33. Kaplan DH, KissenpfennigA, Clausen BE. Insights into Langerhans cell function from Langerhans cell ablation models. Eur J Immunol 2008; 38: 2369.
34. Kaplan DH, Jenison MC, Saeland S, et al. Epidermal Langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 2005; 23: 611.
35. Li JM, Giver CR, Lu Y, et al. Separating graft-versus-leukemia from graft-versus-host disease in allogeneic hematopoietic stem cell transplantation. Immunotherapy 2009; 1: 599.
36. Apostolou I, von Boehmer H. In vivo instruction of suppressor commitment in naive T cells. J Exp Med 2004; 199: 1401.
37. Kissenpfennig A, Henri S, Dubois B, et al. Dynamics and function of Langerhans cells in vivo: Dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 2005; 22: 643.
38. Billingham RaM, PB. The technique of free skin grafting in mammals. J Exp Biol 1951; 28: 385.