Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 3, 2011, Pages 1060-1063

  Shi, Wei ^a   Ma, Haikun ^a   Duan, Yuejiao ^a   Aubart, Kelly ^b   Fang, Yuhong ^b   Zonis, Rimma ^b   Yang, Liping ^a   Hu, Wenhao ^a  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Antibiotics; Drug resistant bacteria; PDF inhibitor; Pyrrolidine derivatives

Indexed keywords

3 METHYLENEPYRROLIDINE FORMYLHYDROXYAMINE DERIVATIVE; CIPROFLOXACIN; LINEZOLID; N (5 FLUORO 1 OXIDO 2 PYRIDINYL) 1 [2 (N FORMYL N HYDROXYAMINOMETHYL)HEXANOYL]PROLINAMIDE; PENICILLIN G; PEPTIDE DEFORMYLASE INHIBITOR; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; HAEMOPHILUS INFLUENZAE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PENICILLIN RESISTANCE; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION;

AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; ENZYME INHIBITORS; HAEMOPHILUS INFLUENZAE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; PYRROLIDINES;

HAEMOPHILUS INFLUENZAE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;

EID: 78751642670     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.102     Document Type: Article

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