The introduction of multi-copy CpG motifs into an antiviral DNA vaccine strongly up-regulates its immunogenicity in fish

Vaccine

Volumn 29, Issue 6, 2011, Pages 1289-1296

  Martinez Alonso, S ^a   Martinez Lopez, A ^b   Estepa, A ^b   Cuesta, A ^a   Tafalla, C ^a  

^a Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria   (Spain)

^b MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

Author keywords

CpG motif; DNA vaccine; Immune response; Rainbow trout; Viral hemorrhagic septicemia virus (VHSV)

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; DNA VACCINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; UNCLASSIFIED DRUG; VIRAL HEMORRHAGIC SEPTICEMIA VIRUS VACCINE; VIRUS VACCINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; GENE; GENE DOSAGE; IMMUNOGENICITY; MUSCLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAINBOW TROUT; SPLEEN; UPREGULATION; VIRAL HEMORRHAGIC SEPTICEMIA; VIRAL HEMORRHAGIC SEPTICEMIA VIRUS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CELL PROLIFERATION; FISH DISEASES; GENE EXPRESSION; HISTOCOMPATIBILITY ANTIGENS CLASS I; INTERFERON TYPE I; INTERFERON-GAMMA; INTERLEUKIN-1BETA; LEUKOCYTES, MONONUCLEAR; NOVIRHABDOVIRUS; OLIGODEOXYRIBONUCLEOTIDES; ONCORHYNCHUS MYKISS; PLASMIDS; RHABDOVIRIDAE INFECTIONS; VACCINES, DNA; VIRAL VACCINES;

EID: 78751571197     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2010.11.073     Document Type: Article

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